Negative Cues Research Articles

EMOTION-MOTION INTERACTIONS IN CONVERSION DISORDER: AN FMRI STUDY

ObjectiveTo evaluate the neural correlates of implicit processing of negative emotions in motor conversion disorder (CD) patients compared to healthy controls. We predicted increased amygdala responses in CD patients with...

Prescribing Generic Medication in Chronic Musculoskeletal Pain Patients: An Issue of Representations, Trust, and Experience in a Swiss Cohort.

ObjectiveParallel to an ever stronger advocacy for the use of generics, various sources of information report concerns regarding substitution. The literature indicates that information regarding substitution is not univocal. The aim of this qualitative study was to explore patients’ representations regarding generics in patients suffering from non-specific disabling chronic musculoskeletal pain, as these patients are confronted with the issue of the prescription and/or substitution of original formulations with generics.MethodsQualitative methods were selected because the aim was to access the range of patients' representations and to consider their conceptions. Standardized face-to-face semi-structured interviews were used, and transcripts were submitted to content analysis.ResultsPatients’ representations suggest that they might be confident in taking a generic medication: when he/she has an understanding of generics as resulting from a development process that has become part of the public domain; the generic medication is prescribed by the physician; each prescription is discussed, i.e., the patient is prescribed the generic version of a given medication and not a generic medication.DiscussionEconomic arguments are not sufficient to justify substitution, and may even raise issues calling upon cognitive dissonance. Even in non-life-threatening diseases, negative cues require attention and need be de-emphasized - in particular lower price as an indication of lower quality, and generic status as contradictory with advocating individualization of medication.

Neural activity patterns evoked by a spouse's incongruent emotional reactions when recalling marriage-relevant experiences.

Resonance with the inner states of another social actor is regarded as a hallmark of emotional closeness. Nevertheless, sensitivity to potential incongruities between one's own and an intimate partner's subjective experience is reportedly also important for close relationship quality. Here, we tested whether perceivers show greater neurobehavioral responsiveness to a spouse's positive (rather than negative) context-incongruent emotions, and whether this effect is influenced by the perceiver's satisfaction with the relationship. Thus, we used fMRI to scan older long-term married female perceivers while they judged either their spouse's or a stranger's affect, based on incongruent nonverbal and verbal cues. The verbal cues were selected to evoke strongly polarized affective responses. Higher perceiver marital satisfaction predicted greater neural processing of the spouse's (rather than the strangers) nonverbal cues. Nevertheless, across all perceivers, greater neural processing of a spouse's (rather than a stranger's) nonverbal behavior was reliably observed only when the behavior was positive and the context was negative. The spouse's positive (rather than negative) nonverbal behavior evoked greater activity in putative mirror neuron areas, such as the bilateral inferior parietal lobule (IPL). This effect was related to a stronger inhibitory influence of cognitive control areas on mirror system activity in response to a spouse's negative nonverbal cues, an effect that strengthened with increasing perceiver marital satisfaction. Our valence-asymmetric findings imply that neurobehavioral responsiveness to a close other's emotions may depend, at least partly, on cognitive control resources, which are used to support the perceiver's interpersonal goals (here, goals that are relevant to relationship stability).

Depressive Symptoms Are Associated with the Phenomenal Characteristics of Imagined Positive and Negative Future Events

SummaryDepressive symptoms are often found to be associated with the number of imagined positive and negative future episodes. Whereas most previous studies investigated the number of imagined events within a limited time period, our study focused on the phenomenal nature of future episodes and their relationships to depressive symptoms, as measured by the Beck Depression Inventory (BDI). Nonclinical participants (n = 183) rated the phenomenal qualities (vividness, contextual/sensory details, felt, importance, accessibility, and certainty) of future episodes generated in response to negative and positive cue words. We found that lower ratings on the phenomenal characteristics of the positive events were associated with higher BDI scores, while an opposite pattern was observed for the negative events. However, there was no relationship between the proportion of imagined episodes that were specific and the BDI scores. Altogether, these results suggest that depressive symptom severity is associated with a wide range of phenomenal characteristics of imagined future episodes.Copyright © 2015 John Wiley & Sons, Ltd.

Minding Your Matters: Predicting Satisfaction, Commitment, and Conflict Strategies From Trait Mindfulness

This exploratory study sought to uncover whether trait mindfulness, an individual’s aptitude for focusing on the present moment while refraining from passing negative judgments or processing external cues in a habitual manner, is predictive of more constructive and less destructive approaches to relational conflict. In addition, we looked at its predictive role in relational satisfaction and commitment. Ninety-one participants completed self-report measures on trait mindfulness, relational satisfaction, commitment, and conflict strategies. Results revealed that aspects of mindfulness predict the type of conflict strategy in which people reportedly engage. Mindfulness subscales were also related positively to satisfaction and commitment. In concluding, we discuss limitations and potential avenues for future inquiry in this area.

Child Maltreatment and Neural Systems Underlying Emotion Regulation

The strong associations between child maltreatment and psychopathology have generated interest in identifying neurodevelopmental processes that are disrupted following maltreatment. Previous research has focused largely on neural response to negative facial emotion. We determined whether child maltreatment was associated with neural responses during passive viewing of negative and positive emotional stimuli and effortful attempts to regulate emotional responses. A total of 42 adolescents aged 13 to 19 years, half with exposure to physical and/or sexual abuse, participated. Blood oxygen level-dependent (BOLD) response was measured during passive viewing of negative and positive emotional stimuli and attempts to modulate emotional responses using cognitive reappraisal. Maltreated adolescents exhibited heightened response in multiple nodes of the salience network, including amygdala, putamen, and anterior insula, to negative relative to neutral stimuli. During attempts to decrease responses to negative stimuli relative to passive viewing, maltreatment was associated with greater recruitment of superior frontal gyrus, dorsal anterior cingulate cortex, and frontal pole; adolescents with and without maltreatment down-regulated amygdala response to a similar degree. No associations were observed between maltreatment and neural response to positive emotional stimuli during passive viewing or effortful regulation. Child maltreatment heightens the salience of negative emotional stimuli. Although maltreated adolescents modulate amygdala responses to negative cues to a degree similar to that of non-maltreated youths, they use regions involved in effortful control to a greater degree to do so, potentially because greater effort is required to modulate heightened amygdala responses. These findings are promising, given the centrality of cognitive restructuring in trauma-focused treatments for children.

Generic Medication In Chronic Musculoskeletal Pain Patients: An Issue of Representations, Trust, and Experience

Chronic pain patients are frequently confronted with the issue of the prescription and/or substitution of original formulations with generic medications. Information regarding generic substitution is not univocal and room for the expression of contradictory opinions is ample. Along with an ever stronger advocacy for the use of generics, various sources of information report concerns regarding substitution. Semistructured interviews explored patients’ representations (N = 25) regarding generics in patients suffering from chronic musculoskeletal pain. Patients’ interviews were transcribed and submitted to content analysis. Patients’ representations suggest that they might be confident in taking a generic medication: when a) he/she has an understanding of generics as resulting from the loss of original trading license; b) the generic medication is prescribed by the physician (supported by the pharmacist); c) each prescription is discussed, that is, the patient is prescribed the generic version of a given medication and not a generic medication; and d) the prescription is individualized. Information and trust are central considerations; the concept of “copy” was frequently mentioned to define generics, from an identical to a forged medication. Using a copy might not be questioned when the medications are perceived as being identical and efficient; however, it might become a problem in cases in which the copy indicates that the patient thinks he/she is receiving a second-choice medication. Our results provide support for generic medication raising many concerns and much lesser perceived need. For patients, economic arguments per se are not sufficient to justify substitution, and may even raise issues calling upon cognitive dissonance. In this context, positive cues require further attention and negative cues need be de-emphasized - in particular lower price as an indication of lower quality, and generic status as contradictory with advocating individualization of medication.

Does Trapping Influence Decision-Making under Ambiguity in White-Lipped Peccary (Tayassu pecari)?

The white-lipped peccary (Tayassu pecari) is an endangered species whose bold anti-predator behaviour in comparison to related species may increase its vulnerability to hunting and predation. We used a judgement bias test to investigate whether captive peccaries that had recently experienced a trapping event made more ‘pessimistic’ decisions under ambiguity. If so, this would indicate (i) that the procedure may induce a negative affective state and hence have welfare implications, and (ii) that the species is able to adopt a cautious response style despite its bold phenotype. Eight individuals were trained to ‘go’ to a baited food bowl when a positive auditory cue (whistle; CS+) was given and to ‘no-go’ when a negative cue (horn A; CS-) was sounded to avoid a loud sound and empty food bowl. An ‘ambiguous’ auditory cue (bell; CSA) was presented to probe decision-making under ambiguity. Individuals were subjected to three tests in the order: T1 (control-no trap), T2 (24h after-trap procedure), and T3 (control-no trap). In each test, each animal was exposed to 10 judgement bias trials of each of the three cue types: CS+,CS-,CSA. We recorded whether animals reached the food bowl within 60s (‘go’ response) and their response speed (m/s). The animals varied in their responses to the CSA cue depending on test type. In all tests, animals made more ‘go’ responses to CS+ than CSA. During control tests (T1 and T3), the peccaries showed higher proportions of ‘go’ responses to CSA than to CS-. In T2, however, the animals showed similar proportions of ‘go’ responses to CSA and CS-, treating the ambiguous cue similarly to the negative cue. There were differences in their response speed according to cue type: peccaries were faster to respond to CS+ than to CS- and CSA. Trapping thus appeared to cause a ‘pessimistic’ judgement bias in peccaries, which may reflect a negative affective state with implications for the welfare and management of captive individuals, and also function to increase caution and survival chances following such an event in the wild environment.

Genome-wide predictors of NF-κB recruitment and transcriptional activity.

BackgroundInducible transcription factors (TFs) mediate transcriptional responses to environmental cues. In response to multiple inflammatory signals active NF-κB dimers enter the nucleus and trigger cell-type-, and stimulus-specific transcriptional programs. Although much is known about NF-κB inducing pathways and about locus-specific mechanisms of transcriptional control, it is poorly understood how the pre-existing chromatin landscape determines NF-κB target selection and activation. Specifically, it is not known which epigenetic marks and pre-bound TFs serve genome-wide as positive (negative) cues for active NF-κB.ResultsWe applied multivariate and combinatorial data mining techniques on a comprehensive dataset of DNA methylation, DNase I hypersensitivity, eight epigenetic marks, and 34 TFs to arrive at genome-wide patterns that predict NF-κB binding. Strikingly, we observed NF-κB recruitment to accessible and nucleosome-bound sites. Within nucleosomal DNA NF-κB binding was primed by H3K4me1 and H2A.Z, but also hyper-methylated DNA outside of promoters and CpG-islands. Many of these predictors showed combinatorial cooperativity and statistically significant interactions. Recruitment to pre-accessible sites was more frequent and influenced by chromatin-associated TFs. We observed that specific TF-combinations are greatly enriched for (or depleted of) NF-κB binding events.ConclusionsWe provide evidence of NF-κB binding within genomic regions that lack classical marks of activity. These pioneer binding events are relatively often associated with transcriptional regulation. Further, our predictive models indicate that specific combinations of epigenetic marks and transcription factors predetermine the NF-κB cistrome, supporting the feasibility of using statistical approaches to identify “histone codes”.Electronic supplementary materialThe online version of this article (doi:10.1186/s13040-015-0071-3) contains supplementary material, which is available to authorized users.

A machine‐learning approach to negation and speculation detection for sentiment analysis

Recognizing negative and speculative information is highly relevant for sentiment analysis. This paper presents a machine‐learning approach to automatically detect this kind of information in the review domain. The resulting system works in two steps: in the first pass, negation/speculation cues are identified, and in the second phase the full scope of these cues is determined. The system is trained and evaluated on the Simon Fraser University Review corpus, which is extensively used in opinion mining. The results show how the proposed method outstrips the baseline by as much as roughly 20% in the negation cue detection and around 13% in the scope recognition, both in terms of F1. In speculation, the performance obtained in the cue prediction phase is close to that obtained by a human rater carrying out the same task. In the scope detection, the results are also promising and represent a substantial improvement on the baseline (up by roughly 10%). A detailed error analysis is also provided. The extrinsic evaluation shows that the correct identification of cues and scopes is vital for the task of sentiment analysis.

Negative emotion provides cues for orienting auditory spatial attention.

The auditory stimuli provide information about the objects and events around us. They can also carry biologically significant emotional information (such as unseen dangers and conspecific vocalizations), which provides cues for allocation of attention and mental resources. Here, we investigated whether task-irrelevant auditory emotional information can provide cues for orientation of auditory spatial attention. We employed a covert spatial orienting task: the dot-probe task. In each trial, two task-irrelevant auditory cues were simultaneously presented at two separate locations (left–right or front–back). Environmental sounds were selected to form emotional vs. neutral, emotional vs. emotional, and neutral vs. neutral cue pairs. The participants’ task was to detect the location of an acoustic target that was presented immediately after the task-irrelevant auditory cues. The target was presented at the same location as one of the auditory cues. The results indicated that participants were significantly faster to locate the target when it replaced the negative cue compared to when it replaced the neutral cue. The positive cues did not produce a clear attentional bias. Further, same valence pairs (emotional–emotional or neutral–neutral) did not modulate reaction times due to a lack of spatial attention capture by one cue in the pair. Taken together, the results indicate that negative affect can provide cues for the orientation of spatial attention in the auditory domain.

Psychometric evaluation of a standardized set of alcohol cue photographs to assess craving

IntroductionResearch using alcohol-related visual stimuli has been limited due to a lack of published studies examining the psychometric properties of alcohol cues. The primary aim of the current study was to examine the factor structure, validity, and reliability of craving ratings following exposure to alcohol cues (including beer, wine, hard liquor, and mixed drinks) in an alcohol cue-reactivity paradigm. MethodsU.S. adults ages 21-69 [N = 195; Mage = 32.19, SD = 10.63; 74.4% male; 56.4% Asian/Pacific Islander, 34.9% White (non-Hispanic), 4.6% Other, 2.0% Hispanic/Latino, 1.5% Native American/Alaskan Native, and 0.5% African-American] completed questionnaires and provided craving, arousal, and valence ratings following alcohol, positive, negative and neutral cues in a web-based study. ResultsThe alcohol craving ratings following alcohol cues formed one internally consistent factor. Convergent and incremental validity was supported as alcohol cue craving ratings were positively correlated with general craving, past-year hazardous alcohol use, and behavioral activation facets, even while controlling for neutral cue craving ratings and other related variables. Alcohol craving was significantly higher following alcohol cues compared to neutral cues and unrelated to behavioral inhibition, supporting discriminant validity. ConclusionsThese findings provide support that the alcohol cues we developed are reliable and valid stimuli for the use in alcohol cue reactivity paradigms. Future research assessing alcohol cue reactivity using this validated photographic cue set may facilitate a greater understanding of the affective processes associated with alcohol use and allow for more targeted behavioral change interventions for alcohol-related problems.

Fear of Negative Evaluation, Social Anxiety and Response to Positive and Negative Online Social Cues

High social anxiety is associated with negative interpretations of social feedback, maladaptive attributions for success and failure, and excessive attention to internal and external threat cues. In the present study, 40 undergraduate participants with either high or low levels of social anxiety engaged in a series of social interactions with varying types of social feedback: negative, mixed-negative, mixed-positive, and positive. Given the increasing engagement in computer-mediated communication among individuals with high levels of social anxiety, these interactions took place via instant messaging software. Compared to participants with low social anxiety, participants with high social anxiety experienced more self-focused thoughts, negative thoughts, and state anxiety in response to increases in negative feedback. Participants with low social anxiety experienced fewer self-focused thoughts in response to increased negative feedback, resulting in a significant crossover interaction. Qualitative and quantitative differences regarding cognitive processes and computer-mediated communication among individuals with high and low social anxiety are discussed.

The divergent effects of fear and disgust on unconscious inhibitory control

Previous studies have shown that negative emotional distracters impair conscious inhibitory control. Recent research has shown that inhibitory control can be triggered unconsciously; therefore, in Experiment 1, we aimed to investigate whether negative emotional distracters affect unconscious inhibitory control. Furthermore, in Experiment 2, we examined whether fearful and disgusting distracters have differential effects on unconscious inhibitory control. Participants were instructed to perform a masked Go/No-Go task superimposed on a negative or neutral image cue (Experiment 1) or on a fearful, disgusting or neutral image cue (Experiment 2). Results showed that negative emotional distracters impaired unconscious inhibitory control; furthermore, disgusting distracters impeded unconscious inhibitory control when compared to fearful ones. This study is the first to provide evidence that fear and disgust may affect unconscious inhibitory control differently. These results expand the understanding of the relationship between emotions and inhibitory control.

Valence asymmetries in the human amygdala: task relevance modulates amygdala responses to positive more than negative affective cues.

Organisms must constantly balance appetitive needs with vigilance for potential threats. Recent research suggests that the amygdala may play an important role in both of these goals. Although the amygdala plays a role in processing motivationally relevant stimuli that are positive or negative, negative information often appears to carry greater weight. From a functional perspective, this may reflect the fact that threatening stimuli generally require action, whereas appetitive stimuli can often be safely ignored. In this study, we examine whether amygdala activation to positive stimuli may be more sensitive to task goals than negative stimuli, which are often related to self-preservation concerns. During fMRI, participants were presented with two images that varied on valence and extremity and were instructed to focus on one of the images. Results indicated that negative stimuli elicited greater amygdala activity regardless of task relevance. In contrast, positive stimuli only led to a relative increase in amygdala activity when they were task relevant. This suggests that the amygdala may be more responsive to negative stimuli regardless of their relevance to immediate goals, whereas positive stimuli may only elicit amygdala activity when they are relevant to the perceivers' goals. This pattern of valence asymmetry in the human amygdala may help balance approach-related goal pursuit with chronic self-preservation goals.

Interaction between valence of empathy and familiarity: is it difficult to empathize with the positive events of a stranger?

BackgroundEmpathy in humans is thought to have evolved via social interactions caused by the formation of social groups. Considering the role of empathy within a social group, there might be a difference between emotional empathy for strangers and familiar others belonging to the same social group. In this study, we used the global field power (GFP) index to investigate empathic brain activity during observation of a cue indicating either a negative or positive image viewed by a stranger or close friend.MethodsSixteen healthy participants observed a partner performing an emotional gambling task displayed on a monitor. After the partner's choice-response, a frowning or smiling face symbol was simultaneously presented to the participant’s monitor while a negative or positive emotional image was presented to the partner’s monitor. All participants observed a control condition (CT) showing a computer trial, a stranger-observation condition (SO) showing the trial of a stranger, and a friend-observation condition (FO) to observe the trial of a close friend. During these observations, participants’ event-related potentials (ERPs) were recorded to calculate GFP, and after the task, a subjective assessment of their feelings was measured.ResultsPositive emotion was significantly larger under the FO compared to the CT and the SO. Significantly larger negative emotion was found under the SO and FO compared to the CT. In response to a positive cue, significantly larger GFP during 300 to 600 ms was observed under the FO compared to the CT and SO. In response to a negative cue, significantly larger GFP was observed under the FO and SO compared to the CT. A significantly larger GFP under the SO was found in response to only a negative cue. Topographic map analysis suggested that these differences were related to frontal-occipital dynamics. GFP was significantly correlated with empathic trait.ConclusionThese results revealed that familiarity with another person has different effects depending on the valence of empathy. Negative empathy, including the danger perception function, might easily occur even among strangers, whereas positive empathy related to nursing and supporting an inner group does not happen easily with strangers.

MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling

AbstractHematopoietic stem cell (HSC) self-renewal and multilineage reconstitution are controlled by positive and negative signaling cues with perturbations leading to disease. Lnk is an essential signaling adaptor protein that dampens signaling by the cytokine thrombopoietin (Tpo) to limit HSC expansion. Here, we show that MERIT40 (Mediator of RAP80 Interactions and Targeting 40 kDa [M40]), a core subunit of an Lnk-associated Lys63 deubiquitinating (DUB) complex, attenuates HSC expansion. M40 deficiency increases the size of phenotypic and functional HSC pools. M40−/− HSCs are more resistant to cytoablative stress, and exhibit superior repopulating ability and self-renewal upon serial transplantation. M40−/− HSCs display increased quiescence and decelerated cell cycle kinetics accompanied by downregulation of gene sets associated with cell division. Mechanistically, M40 deficiency triggers hypersensitivity to Tpo stimulation and the stem cell phenotypes are abrogated on a background null for the Tpo receptor Mpl. These results establish M40-containing DUB complexes as novel HSC regulators of HSC expansion, implicate Lys63 ubiquitination in HSC signaling, and point to DUB-specific inhibitors as reagents to expand stem cell populations.

A Neuro-psychological Model of Violence Propensity in Schizophrenia

Introduction Schizophrenia is associated with an increased risk of violence. The successful identification of the illness specific factors that contribute to that risk could lead to the development of novel therapeutic risk management strategies. Objectives/Aims To identify cognitive and emotion processing deficits that are linked to violence risk in schizophrenia. Methods Fifty male patients with DSM-IV schizophrenia and thirty-nine healthy controls were assessed across a range of intellectual, executive, emotion and social processing domains. Lifetime propensity to violence was quantified in terms of frequency, severity and victim outcome. Results General intellectual ability and memory were not significantly associated with violence propensity. Violent patients showed significantly poorer response inhibition, after accounting for relevant clinical variables. A greater lifetime propensity to violence was associated with an attentional bias towards anger, a heightened sensitivity to the recognition of fear, with poorer complex Theory of Mind performance. Conclusions Our results allow us to propose a hypothetical model of the risk of violence in schizophrenia. We suggest that heightened sensitivity to environmental negative emotional cues and poorer understanding of complex social situations, combined with a poorer ability both to quickly process but also inhibit pre-potent responses, results in a greater propensity to violence in schizophrenia. We propose that this model sits alongside risk associated with other factors such as illicit drug use. These findings need replication but could have implications for more effective treatment and management of patients with schizophrenia.

Morning rapid eye movement sleep naps facilitate broad access to emotional semantic networks.

The goal of the study was to assess semantic priming to emotion and nonemotion cue words using a novel measure of associational breadth for participants who either took rapid eye movement (REM) or nonrapid eye movement (NREM) naps or who remained awake; assess relation of priming to REM sleep consolidation and REM sleep inertia effects. The associational breadth task was applied in both a priming condition, where cue-words were signaled to be memorized prior to sleep (primed), and a nonpriming condition, where cue words were not memorized (nonprimed). Cue words were either emotional (positive, negative) or nonemotional. Participants were randomly assigned to either an awake (WAKE) or a sleep condition, which was subsequently split into NREM or REM groups depending on stage at awakening. Hospital-based sleep laboratory. Fifty-eight healthy participants (22 male) ages 18 to 35 y (Mage = 23.3 ± 4.08 y). The REM group scored higher than the NREM or WAKE groups on primed, but not nonprimed emotional cue words; the effect was stronger for positive than for negative cue words. However, REM time and percent correlated negatively with degree of emotional priming. Priming occurred for REM awakenings but not for NREM awakenings, even when the latter sleep episodes contained some REM sleep. Associational breadth may be selectively consolidated during REM sleep for stimuli that have been tagged as important for future memory retrieval. That priming decreased with REM time and was higher only for REM sleep awakenings is consistent with two explanatory REM sleep processes: REM sleep consolidation serving emotional downregulation and REM sleep inertia.

Chemosensory Cues for Mosquito Oviposition Site Selection.

Gravid mosquitoes use chemosensory (olfactory, gustatory, or both) cues to select oviposition sites suitable for their offspring. In nature, these cues originate from plant infusions, microbes, mosquito immature stages, and predators. While attractants and stimulants are cues that could show the availability of food (plant infusions and microbes) and suitable conditions (the presence of conspecifics), repellents and deterrents show the risk of predation, infection with pathogens, or strong competition. Many studies have addressed the question of which substances can act as positive or negative cues in different mosquito species, with sometimes apparently contradicting results. These studies often differ in species, substance concentration, and other experimental details, making it difficult to compare the results. In this review, we compiled the available information for a wide range of species and substances, with particular attention to cues originating from larval food, immature stages, predators, and to synthetic compounds. We note that the effect of many substances differs between species, and that many substances have been tested in few species only, revealing that the information is scattered across species, substances, and experimental conditions.