Neem Research Articles

Effect of neem (Azadirachta indica), girawa (Vernonia amygdalina) leaves meal and garlic (Allium sativum) on performance and egg qualities of layer chickens

Effect of neem (Azadirachta indica), girawa (Vernonia amygdalina) leaves meal and garlic (Allium sativum) on performance and egg qualities of layer chickens

Pediatric Neem powder poisoning: a report of two cases and a review of toxicity mechanisms

Neem (Azadirachta indica) is a plant known for its wide array of therapeutic properties, derived from its diverse phytochemical makeup. Despite its medicinal benefits, neem can pose significant toxicity risks, especially in children. This report presents two pediatric cases of neem powder poisoning. The first case involves a two-year-old boy who ingested neem powder with milk, resulting in seizures and fatal cardiac arrest. The second case describes a six-year-old boy who experienced vomiting after consuming neem powder with milk. Prompt medical intervention, including gastric lavage and supportive care, led to his stabilization and discharge. Neem’s toxicity is attributed to compounds like azadirachtin, which disrupt mitochondrial function, leading to symptoms such as seizures, vomiting, and hepatic stress. These cases highlight the importance of recognizing the potential dangers of neem and underscore the need for public health education and regulatory oversight to prevent such adverse outcomes in pediatric populations.

Formulation and evaluation of herbal wet wipes using non-woven fabrics

Herbal wet wipes are a viable substitute for conventional wipes, tackling worries regarding chemical composition and ecological effects while offering advantages for skin health. This research uses non-woven fabric as the substrate and focuses on the formulation and assessment of herbal wet wipes. Selected plant extracts or essential oils with antibacterial and skin-soothing qualities are incorporated into the recipe. Testing the herbal wet wipes' antimicrobial activity against common skin bacteria and fungus allows for an evaluation of their effectiveness. Testing for skin sensitivity is done to determine safety and suitability for different skin types. To guarantee product integrity under various storage circumstances, stability testing is carried out by incorporating extracts of Azadirachta indica (Neem), Aloe barbadensis, Tulsi, and Clove Extract. Thus, the final cloth will include qualities like softness, antimicrobial, and anti-allergy for adults and infants. The intended application of the fabric material is to improve skin health through the use of wet wipes.

Impact of Weather Factors on Colony Inhabitation and Abundance of the Asian Weaver Ant <i>Oecophylla smaragdina</i> (F)

Colony inhabitation and abundance of Oecophylla smaragdina (F) nest have been explored in the Krishnagiri district of Tamil Nadu through field studies. Twenty-seven species of plants under 17 families were observed to inhabit O. smaragdina. Colony inhabitation occurred in 20 plant hosts for all the six months: in Pongamia pinnata it was observed for only two months. Number of nests were maximum with Mangifera indica (42.67), Citrus limon (29.17), Azadirachta indica (23.50). Temperature has a significant relationship with colony inhabitation and nesting. Rainfall, rainy days, cloud and relative humidity substantially reduce the colony's composition. The colonies does not appear to be influenced by the maximum wind speed, average gust or UV Index.

Green synthesis of zinc oxide nanoparticles for the removal of phenol from textile wastewater

This study investigated the use of zinc oxide nanoparticles (ZnO NPs) as an adsorbent for removing total phenols from textile wastewater. The ZnO NPs were synthesized by reducing Zn(NO3)2⋅6H2O using an extract from Neem leaves (Azadirachta indica). Characterization of the adsorbent was performed using Fourier Transform Infrared (FTIR) spectroscopy to identify functional group modifications, high-resolution scanning electron microscopy (HRSEM) for structural orientation, energy dispersive spectroscopy (EDS) for elemental analysis, and X-Ray diffraction analysis (XRD) for crystallinity, revealing particle crystallinity around 200 nm. Adsorption experiments were conducted over contact times of 20–60 min, with adsorbent loadings between 0.2 and 1 g/100 mL, and temperatures ranging from 30 to 50 °C. Optimal phenol removal, achieving 55.93% (0.67 mg/L), occurred at 43.40 min, 33.70 °C, and an adsorbent dosage of 0.69 g/L of textile wastewater. The phenol adsorption process using ZnO NPs was exothermic, spontaneous, and required low energy, fitting well with the Langmuir isotherm and following a pseudo-second-order kinetic model.

Novel Recycling, Defibrillation, and Delignification Methods for Isolating α-Cellulose from Different Lignocellulosic Precursors for the Eco-Friendly Fiber Industry.

Alpha-cellulose, a unique, natural, and essential polymer for the fiber industry, was isolated in an ecofriendly manner using eleven novel systems comprising recycling, defibrillation, and delignification of prosenchyma cells (vessels and fibers) of ten lignocellulosic resources. Seven hardwood species were selected, namely Conocorpus erectus, Leucaena leucocephala, Simmondsia chinensis, Azadirachta indica, Moringa perigrina, Calotropis procera, and Ceiba pentandra. Moreover, three recycled cellulosic wastes were chosen due to their high levels of accumulation annually in the fibrous wastes of Saudi Arabia, namely recycled writing papers (RWPs), recycled newspapers (RNPs), and recycled cardboard (RC). Each of the parent samples and the resultant alpha-cellulose was characterized physically, chemically, and anatomically. The properties examined differed significantly among the ten resources studied, and their mean values lies within the cited ranges. Among the seven tree species, L. leucocephala was the best cellulosic precursor due to its higher fiber yield (55.46%) and holocellulose content (70.82%) with the lowest content of Klasson lignin (18.86%). Moreover, RWP was the best α-cellulose precursor, exhibiting the highest holocellulose (87%) and the lowest lignin (2%) content. Despite the high content of ash and other additives accompanied with the three lignocellulosic wastes that were added upon fabrication to enhance their quality (10%, 11%, and 14.52% for RWP, RNP, and RC, respectively), they can be considered as an inexhaustible treasure source for cellulose production due to the ease and efficiency of discarding their ash minerals using the novel CaCO3-elimination process along with the other innovative techniques. Besides its main role for adjusting the pH of the delignification process, citric acid serves as an effective and environmentally friendly additive enhancing lignin breakdown while preserving cellulose integrity. Comparing the thermal behavior of the ten cellulosic resources, C. procera and C. pentandra exhibited the highest moisture content and void volume as well as having the lowest specific gravity, crystallinity index, and holocellulose content and were found to yield the highest mass loss during their thermal degradation based on thermogravimetric and differential thermal analysis in an inert atmosphere. However, the other resources used were found to yield lower mass losses. The obtained results indicate that using the innovative procedures of recycling, defibrillation, and delignification did not alter or distort either the yield or structure of the isolated α-cellulose. This is a clear indicator of their high efficiency for isolating cellulose from lignocellulosic precursors.

Effects of solvent extraction on the phytoconstituents and in vitro antioxidant activity properties of leaf extracts of the two selected medicinal plants from Malawi

This study evaluated and compared the phytochemical and antioxidant properties of the solvent extracts of Azadirachta indica A. Juss and Vernonia amygdalina Del leaves. Methanolic and aqueous extracts showed high (P ≤ 0.05) extract yields (in %), compared to chloroform and ethyl acetate extracts from both V. amygdalina and A. indica leaves. The study exhibited high phytochemical content in methanol and aqueous extracts compared to chloroform and ethyl acetate extracts, confirming the potential for medicinal use. V. amygdalina methanol and aqueous extracts had higher (P ≤ 0.05) total phenolic content (TPC), in mg GAE/gDW, (158.810±0.846 and 217.883±0.265, respectively) than chloroform (37.574±0.118) and ethyl acetate (104.758±0.236) but higher ethyl acetate content in A. indica extracts. Low polar solvents extracted high (P ≤ 0.05) total flavonoids, in mgQE/gDW, (367.051±0.858 and 149.808±0.009) compared to high polar solvents (14.863±0.071 and 54.226±0.014 ) in V. amygdalina while as in A. indica leaf extracts, low polar solvents showed high TFC ( 658.469±3.451 and 275.288±10.490) compared to high polar solvents (26.312±0.063 and 48.858±0.063) respectively. In vitro total antioxidant capacity, in mg/g, was higher in polar solvents than in low-polar solvents, ranging from 34.300±1.784 to 121.015±6.839 for A. indica ethyl acetate and methanolic extracts. A strong correlation between TPC and tannic acid content was observed, except in A. indica methanolic extracts of A. indica. Ferric reducing power was high, except for V. amygdalina chloroform and methanol leaf extracts, which were lower (P≤ 0.05) than that of the standard ascorbic acid. The study revealed that high polar solvents, such as methanol and water, are more efficient in the extraction of antioxidants from A. indica but lower in V. amygdalina extracts. High phytochemical content and antioxidative capacity could be significant in treating various diseases in humans.

Enhancing sandalwood growth: Host plant selection and salinity stress tolerance

Being a semi-root parasitic nature, sandalwood steals water and nutrients from host species. Therefore, it is crucial to research the influence of salinity stress on host-parasite relationships both theoretically and practically, for the successful establishment of sandalwood plantations. To find out the best suited host species for sandalwood, a RBD experiment was conducted to identify the effect of salt stress on sandalwood planted with two selected host species (Alternanthera sp. and Azadirachata indica) and without host species. After 300 days of establishment, morphological traits were recorded and noted that plant height, collar diameter and root length was higher in Azadirachta indica as compared to other host species. Significant reduction in morphological traits was recorded under salt stress condition. Similarly, higher root biomass was noted in Azadirachta indica under control as well as in saline conditions. On the other side, shoot biomass was higher in sandalwood grown with Alternanthera sp. Sandalwood grown in the absence of host plant showed no survival under salinity stress. Plant water traits were higher when sandalwood cultivated with A. indica while lowest in sandalwood grown in the absence of host species. Na+/K+ ratio and other nutrients (viz., Nitrogen, Phosphorus and Potassium) was higher sandalwood planted with A. indica while poorer in Sandalwood planted without host species. The results revealed that A. indica could be best host for sandalwood under stress as well as control conditions which enhances the growth and physiology of sandalwood.

Elucidating the effect of dietary neem (Azadirachta indica) on growth performance, haemato-biochemical, immunonological response, and anti-pathogenic capacity of Nile tilapia juveniles.

This investigation attempts to evaluate the effect of diet additives via aqueous or ethanolic herbal extracts from Azadirachta indica leaves on Nile tilapia, Oreochromis niloticus. Five dietary categories were assigned to the fish: the first category (N1, with no extract) was kept under control conditions; two categories contained aqueous extract (N2 (1.0g/kg) and N3 (2.0g/kg); and two categories contained ethanolic extract, N4 (1.0g/kg) and N5 (2.0g/kg), with each group being fed for 60 days. After the feeding trial, Aeromonas hydrophila was injected intraperitoneally into fish for 14 days; fish mortality was recorded during this period. The results showed that the fish-fed dietary A. indica significantly improved growth performance and intestinal health (digestive enzymes and intestinal morphology), especially in the N4 and N5 categories. However, N4 and N5 categories demonstrated a significant decrease in AST and ALT activities and an increase in total protein, serum albumin, globulin, growth hormone (GH), leptin hormone (LEP), hemoglobin, white blood cells, and hematocrit (P < 0.05) in comparison with the control category (N1). Compared to the control category, the N4 and N5 categories have revealed a significant reduction in MDA activity and improvements in immunological activities (lysozyme, complement C3, and nitric oxide) and antioxidant enzymes (CAT, SOD, and GPX). Moreover, in tilapia-fed A. indica, the expression of IL-8, IL-1β, and Nf-κb genes was downregulated partially in the N4 and N5 categories than the control category. In contrast, the lysozyme, C3, GPX, and CAT genes were upregulated partially at N4 and N5 compared to the control category. Following the bacterial challenge, fish in the N4 and N5 categories also displayed the lowest fish mortality compared to the control category. The ethanolic extract displayed a more potent resistance against the parasite Cichlidogyrus tilapia in vitro than the aqueous and control categories, partially at 2g/L. According to these findings, an ethanolic neem extract (2.0g/kg feed) activates the immune system and antioxidant response in Nile tilapia fingerlings, improving growth and fish resistance to parasitic and bacterial infections.

Thermal, chemical and mechanical characterization of Azadirachta indica tree gum

This study focuses on the comprehensive thermal, chemical, and mechanical characterization of neem gum, a natural, colorless, tasteless polysaccharide obtained from Azadirachta indica tree’s trunk. The collection process of gum involves manual extraction from crude neem tree exudates, followed by thorough cleaning and homogenization with water. A portion of the resulting gum is then filtered, allowed to thicken, and naturally dried for subsequent mechanical testing. Various analytical techniques, such as thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) to determine the thermal properties, Fourier transform infrared spectrometry (FTIR) to find the functional groups, scanning electron microscopy (SEM), and micro-X-ray fluorescence analysis (µ-XRF) to decide the elemental composition, microhardness, tensile, flexural, and compression tests to determine the mechanical properties, are employed in this study. The thermal and mechanical properties of neem gum have been relatively unexplored, and this highlights the novelty and importance of this research. The results are analyzed and compared with other natural tree gums. The pH of 5.07 shows that the gum is slightly acidic in nature, and the peaks obtained from thermal analysis demonstrate that it doesn’t have a melting point. The microhardness value, tensile strength, flexural strength, and compressive strength of neem gum are 238.64 MPa, 1.0155 MPa, 1.899 MPa, and 1.1023 MPa, respectively. This research provides valuable insights into the diverse characteristics and potential applications of neem gum in various fields. It is being used in the pharmaceutical industry. It can also be used as a cap for cutting tools, such as drill bits, after manufacturing, during transportation to protect their sharp edges from damage.

Fabrication of antibacterial bio‐composite from polyvinyl alcohol incorporated with Azadirachta indica

Fabrication of antibacterial bio‐composite from polyvinyl alcohol incorporated with <i>Azadirachta indica</i>

Fabrication and Characterization of Azadirachta indica oil Induced Nanoemulgel Using 33 Central Composite Design (CCD): Assessment of Antibacterial Activity

Fabrication and Characterization of Azadirachta indica oil Induced Nanoemulgel Using 33 Central Composite Design (CCD): Assessment of Antibacterial Activity

Application and valorization of novel indigenous Azadirachta indica leaf in leather processing

This study investigated the viability of locally available organic sources of Azadirachta indica leaf as vegetable tannin agent in leather processing to promote green leather manufacturing. Leather tanned with Azadirachta indica leaf powder (NPT), extract (NET) and conventional vegetable tanned leather (CVT) was characterized with FTIR, DLS, HPLC, DSC, TGA, and SEM. Total soluble solid, pH, tannin content, and tanning strength of Azadirachta indica leaf extract were found to be 24 %, 4.81, 12.34 % and 1.81 respectively. Moisture content, fat content, and water-soluble content of Azadirachta indica leaf extract tanned leather (NET) were 12.26 %, 10.8 % and 7.2 % respectively. The shrinkage temperature, tensile strength, stitch tear strength, grain crack load, and finished film bond strength of NET leather were 86 °C, 282.52 kg/cm2, 139.53 kg/cm, 24 kg, and 414 g/cm respectively. NET leather exhibited better anti-microbial sensitivity against E. coli, S. aureus, and P. aeruginosa than NPT and NET leather. Overall, the experimental results of this study indicate the A. indica leaf could serve as a prime renewable tanning agent, substituting hazardous chromium and imported conventional vegetable tannin chemicals in leather manufacturing. Thus, developed A. indica leaf tannin material from plant sources could provide sustainable leather production, contributing to eco-friendly and viable green leather processing options.

Azadirachta indica (Neem) and its Active Ingredients' Therapeutic Significance in the Prevention and Treatment of Diseases

Neem (Azadirachta indica) belongs to the Meliaceae family and is known for its health-promoting effects due to its high antioxidant content. It has been extensively utilised in Chinese, Ayurvedic, and Unani remedies globally, particularly in the Indian Subcontinent, for the treatment and prevention of several ailments. Prior research has established that neem and its components are involved in the removal of free radicals and the prevention of disease development. Research conducted using animal models has demonstrated that neem and its primary components play a crucial role in the management of cancer by influencing numerous molecular pathways, such as p53, pTEN, NF-𝜅B, PI3K/Akt, Bcl-2, and VEGF. Medicinal plants are often regarded as safe and have the ability to regulate many biological processes without causing any negative effects. This article provides an overview of the role of Azadirachtaindica in the prevention and treatment of illnesses by regulating different biological and physiological pathways

Evaluation of the corrosion inhibition potential of Azadirachta indica leaves on thermo mechanically treated steel rebars using an artificial neural network, electrochemical and spectroscopic approach

Evaluation of the corrosion inhibition potential of <i>Azadirachta indica</i> leaves on thermo mechanically treated steel rebars using an artificial neural network, electrochemical and spectroscopic approach

Determination of the sources of heavy metals pollution using neem tree (azadirachtaindica) stem barks in Maiduguri, Borno State, Nigeria

Determination of the sources of heavy metals pollution using neem tree (azadirachtaindica) stem barks in Maiduguri, Borno State, Nigeria

Characterization of Azadirachta indica Natural Cellulosic Fiber and Its Polymer Composites

Characterization of Azadirachta indica Natural Cellulosic Fiber and Its Polymer Composites

Evaluation of Azadirachta indica leaf extracts efficacy against gill flukes parasites with a focus on oxidative stress, pathological changes, and immune gene response in infected Nile tilapia

Evaluation of Azadirachta indica leaf extracts efficacy against gill flukes parasites with a focus on oxidative stress, pathological changes, and immune gene response in infected Nile tilapia

Effectiveness of natural herbs on sewage and treated municipal wastewater: A comparative study

Improperly handled sewage is the main cause of water pollution. Nearly 62% of wastewater in urban India remains untreated or partially treated, which further gets disposed of in the natural water bodies. The usual treatment methods include the activated sludge process, oxidation ponds, aerated lagoons, and trickling filters. These methods need spacious areas, a lot of energy and time, which drives up the cost of the treatment. The expense of the treatment process can be decreased by using natural coagulants. The indigenous medical system uses plants, which are abundant in secondary metabolites, to treat a variety of illnesses. The purpose of this study was to comprehend how these indigenous plants can be utilized for treating sewage water, as a low-cost accessible method that can be used by citizens to get access to clean drinking water. Material &amp;amp; Methods: A quick and low-cost method was created to investigate the efficacy of Moringa oleifera (Moringa), Ocimum sanctum (Tulsi), and Azadirachta indica (Neem) in the treatment of sewage water. This herb treated water was then compared to municipal treated water from the Ghatkopar Wastewater treatment facility, managed by the Municipal Corporation of Greater Mumbai (MCGM), Mumbai, India. All the herb-based components were bought from regional markets, and water samples from a lagoon found in the nearby Ghatkopar lagoon in Mumbai. Results: When compared to the lagoon-treated water, the efficacy of the sewage water treated with herbs was higher or comparable. Coliform and copper levels decreased considerably in the treated sample. Herb-treated samples showed a reduction in the Chemical Oxygen Demand (COD) levels as compared to the treated water. Conclusion: When combined, the herbs had a significant impact on lowering the COD, Copper, and coliform levels, making the native plants a valuable source for the treatment of sewage water.

The Effect of Azadirachta Indica (Neem) &amp; Moringa Olifera Leaves on Control of Anopheles Mosquito Larvae

The Effect of Azadirachta Indica (Neem) &amp; Moringa Olifera Leaves on Control of Anopheles Mosquito Larvae