Near-infrared Spectroscopy Imaging Research Articles

Characterization of plaque features exhibiting physiological mismatch between fractional flow reserve and resting index: near-infrared spectroscopy imaging analysis

Abstract Background In addition to fractional flow reserve (FFR), resting indexes (RI) have been shown as another physiological measure to evaluate myocardial ischemia. Despite the clinical usefulness of RI without the use of intravenous vasodilatory agent, discrepancy between FFR and RI infrequently occurs. Whether this physiological mismatch is derived by specific plaque feature remains unknown. Purpose To characterize coronary plaques associated with coronary physiological mismatch. Methods We analyzed 59 coronary arteries (LAD/RCA/LCX=49/4/6) with FFR≤0.80 in 57 stable CAD subjects receiving PCI. Following measurement of FFR and RI, culprit lesion was evaluated by near-infrared spectroscopy and intravascular ultrasound (NIRS/IVUS). The analyzed vessels were stratified according to FFR and RI values: FFR≤0.75+RI>0.89 (n=6: physiological mismatch), FFR>0.75+RI>0.89 (n=6), FFR≤0.75+RI≤0.89 (n=33) and FFR>0.75+RI≤0.89 (n=14). Results The median values of percent diameter stenosis, FFR and RI were 51%, 0.75 and 0.87, respectively. Physiological mismatch was observed in 10.1% (=6/59) of analyzed vessels. On IVUS imaging, maximum percent plaque area was greater than 70% in all groups (p=0.29). Furthermore, there were no significant differences in angiographic and IVUS-derived minimum lumen area across 4 groups (Table). However, culprit lesions exhibiting physiological mismatch contained a substantially larger amount of lipid plaque, reflected by a higher maximum 4-mm lipid-core burned index (maxLCBI4mm: p=0.04) on NIRS imaging (Table). Multivariate analysis demonstrated maxLCBI4mm as the only plaque feature associated with physiological mismatch (odds ratio=1.010, 95% CI: 1.001–1.019, p=0.02). Conclusion Plaque feature associated with coronary physiological mismatch was the extent of lipidic materials but not the quantity of coronary atheroma. Since the accumulation of lipidic plaque component is caused by endothelial dysfunction, this vascular substrate could impair baseline vasomotion, thereby causing a lower FFR despite preserved RI value. Evaluation of lipidic burden may be a potential option to avoid unnecessary deferral of revascularization in subjects with normal RI value. maxLCBI4mm in each group Funding Acknowledgement Type of funding source: None

Near-infrared Spectroscopy and Hyperspectral Imaging for Sugar Content Evaluation in Potatoes over Multiple Growing Seasons

Sugar content is one of the most important properties of potato tubers as it directly affects their processing and the final product quality, especially for fried products. In this study, data obtained from spectroscopic (interactance and reflectance) and hyperspectral imaging systems were used individually or fused to develop non-cultivar nor growing season-specific regression and classification models for potato tubers based on glucose and sucrose concentration. Data was acquired over three growing seasons for two potato cultivars. The most influential wavelengths were selected from the imaging systems using interval partial least squares for regression and sequential forward selection for classification. Hyperspectral imaging showed the highest regression performance for glucose with a correlation coefficient (ratio of performance to deviation) or r(RPD) of 91.8(2.41) which increased to 94%(2.91) when the data was fused with the interactance data. The sucrose regression results had the highest accuracy using data obtained from the interactance system with r(RPD) values of 74.5%(1.40) that increased to 84.4%(1.82) when the data was fused with the reflectance data. Classification was performed to identify tubers with either high or low sugar content. Classification performance showed accuracy values as high as 95% for glucose and 80.1% for sucrose using hyperspectral imaging, with no noticeable improvement when data was fused from the other spectroscopic systems. When testing the robustness of the developed models over different seasons, it was found that the regression models had r(RPD) values of 55(1.19)–90.3%(2.34) for glucose and 35.8(1.07)–82.2%(1.29) for sucrose. Results obtained in this study demonstrate the feasibility of developing a rapid monitoring system using multispectral imaging and data fusion methods for online evaluation of potato sugar content.

Chemical Treatment of Lignosulfonates Under DBD Plasma Conditions. I. Spectral Characterization

A new method for chemical modification of lignin product under dielectric barrier discharge (DBD) plasma at atmospheric pressure is proposed. The motivation of this study is to obtain from ammonium lignosulfonate powder (ALS) and carboxylic acids (oleic acid, OA and lactic acid, LA) and butyrolactone (BL), new products with improved functionalities (ALS-LA, ALS-OA and ALS-BL), which may be used in manufacturing of biocomposite materials. The chemical transformations on the surface of ALS were evaluated by elemental analysis, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), near-infrared (NIR) spectroscopy and near-infrared chemical imaging (NIR-CI), as well as nuclear magnetic resonance (1H-NMR and 13C-NMR), UV–VIS and fluorescence spectroscopies. The attachment of the monomeric chains to the macromolecular network of ALS was proved by the values of atomic ratios (C/H, C/O and O/C), calculated from elemental analysis, reveal. The spectral results confirmed that the grafting reaction of ammonium lignosulfonate took place under cold plasma conditions and various compounds with special structures and functionalities have been obtained. Moreover, the recorded NIR-CI images (RGB and PCA components) provide information about ALS product homogeneity.

In vivo imaging of vulnerable plaque with intravascular modalities: its advantages and limitations.

In vivo imaging of plaque instability has been considered to have a great potential to predict future coronary events and evaluate the stabilization effect of novel anti-atherosclerotic medical therapies. Currently, there are several intravascular imaging modalities which enable to visualize plaque components associated with its vulnerability. These include virtual histology intravascular ultrasound (VH-IVUS), integrated backscatter IVUS (IB-IVUS), optical coherence tomography (OCT), near-infrared spectroscopy and coronary angioscopy. Recent studies have shown that these tools are applicable for risk stratification of cardiovascular events as well as drug efficacy assessment. However, several limitation exists in each modality. The current review paper will outline advantages and limitation of VH-IVUS, IB-IVUS, OCT, NIRS and coronary angioscopy imaging.

The association of prefrontal cortex response during a natural reward cue-reactivity paradigm, anhedonia, and demoralization in persons maintained on methadone

Persons with opioid use disorder (OUD) often experience anhedonia and demoralization, yet there is relatively little research on the pathophysiology of anhedonia and demoralization in OUD treatment and recovery. In the current study, persons maintained on methadone (N = 29) underwent a natural reward-cue paradigm during functional near-infrared spectroscopy (fNIRS) imaging. Natural reward cues included highly palatable food, positive social interactions (e.g., a happy family at the dinner table), and emotional intimacy (e.g. couples embracing or kissing, but no erotic images). Participants also self-reported symptoms of anhedonia on the Snaith-Hamilton Pleasure Scale (SHPS) and demoralization on the Demoralization Scale II (DS-II). Participants who reported clinically-significant anhedonia on the SHPS displayed decreased neural activity in the right prefrontal cortex (PFC) in response to natural reward cues (F(1,25) = 3.612, p = 0.027, ηp2 = 0.302). In linear regression models of positive social cues, decreased neural activity in the right VMPFC was associated with increased SHPS total score (F(1,27) = 7.131, R2 = 0.209, p = .013), and decreased neural activity in an area encompassing the right lateral VMPFC and DLPFC was associated with increased DS-II total score (F(1,27) = 10.641, R2 = 0.283, p = 0.003). This study provides initial evidence that the prefrontal cortex is involved in the pathophysiology of anhedonia and demoralization in persons in recovery from OUD. Anhedonia and demoralization are important treatment outcomes that should be queried along with a constellation of physical and mental health outcomes, to assess areas of needed improvement in methadone maintenance and other OUD treatment modalities.

Decreased low-frequency brain effective connectivity in seafarers during voyages: a functional near-infrared spectroscopy study

Objective: During voyages, seafarers experience psychological problems that act to decrease operational safety. Psychological problems in seafarers can lead to changes in functional brain networks. This study investigated the low-frequency brain effective connectivity (EC) in seafarers during voyages by using the coupling strength (CS) of functional near-infrared spectroscopy (fNIRS) imaging. Approach: This study recruited 15 seafarers (seafarer group) working on a container ship and 15 healthy age-matched controls (control group). The EC was assessed using dynamic Bayesian inference (DBI) of the oxygenated hemoglobin concentration (delta HbO2) as measured through a 14-channel fNIRS system. These channels covered the left and right prefrontal cortices (LPFC/RPFC), left and right motor cortices (LMC/RMC), and left and right occipital lobes (LOL/ROL). Main results: The EC levels of LPFC to RMC (F = 4.239, p = 0.049), LPFC to ROL (F = 5.385, p = 0.028), LOL to RPFC (F = 11.128, p = 0.002), ROL to RPFC (F = 10.714, p = 0.003) and LMC to ROL (F= 6.136, p = 0.02) were significantly lower in the seafarer group than in the control group. Correlation analysis revealed that the patient health questionnaire-9 (PHQ-9) scores were positively correlated with the systolic blood pressure (SBP) values, delta HbO2 values and EC levels, respectively. Meanwhile, the correlation analysis revealed that the SBP values significantly positively correlated with the CS values. Significance: Decreased EC levels may be a marker of psychological subhealth in seafarers. The approach combines fNIRS and PHQ-9 scores, providing a quantitative method for the assessment of mental health problems and further help with better rehabilitation designs in seafarers during voyages.

Benefit-cost analysis of near-infrared spectroscopy technology adoption by Alberta hog producers

Feed cost is a significant component of livestock production costs, accounting for over half of total operating costs for hog producers. This provides an incentive to minimize feed costs while meeting dietary requirements. However, producers may not know the nutritional content of their feed grains with certainty. Near-infrared reflectance spectroscopy (NIRS) imaging technology can quickly and accurately estimate the nutritional content of different types of feed grain. Although the technology has been available for almost five decades, producer adoption has been slow due to issues with cost and usability. The objectives of this study are to estimate feed cost savings resulting from the adoption of NIRS on a representative Alberta hog farm and to conduct a benefit-cost analysis to investigate the potential viability of NIRS adoption. A joint mathematical programming-simulation approach is used to estimate the cost savings generated by adoption of NIRS technology. Results suggest mean annual savings of up to $4 per hog and benefit-cost results suggest that adopting NIRS technology may be viable, particularly for larger Alberta hog operations. However, initial investment requirements, uncertainty in the magnitude of benefits, and access to the technology from feed mills will likely continue to limit adoption.

Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. A randomized controlled clinical trial comparing conventional with hyperbaric oxygen treatment.

The aim of this study is to ascertain whether the simultaneous measurement of hemoglobin O2 saturation (StO2 ) and dimension of venous leg ulcers (VLU) by near infrared spectroscopy (NIRS) imaging can predict the healing course with protocols employing a conventional treatment alone or in combination with hyperbaric oxygen therapy (HBOT). NIRS 2D images of wound region were obtained in 81 patients with hard-to-heal VLU that had been assigned, in a randomized controlled clinical trial, to the following protocols: 30 HBOT sessions, adjunctive to the conventional therapy, either twice daily over 3 weeks (group A) or once daily over 6 weeks (group B), and conventional therapy without HBOT (group C). Seventy-three patients completed the study with a total of 511 NIRS images being analyzed. At the end of treatment, wound area was significantly smaller in all three groups. However, at the 3-week mark the wound area reduction tended to be less evident in group A than in the other groups. This trend continued up to the 6-week end-point when a significantly greater area reduction was found with group B (65.5%) and group C (56.8%) compared to group A (29.7%) (P < .01). Furthermore, a higher incidence of complete healing was noted with group B (20%) than with group A (4.5%) and group C (3.8%). When using a final wound reduction in excess of 40% to distinguish healing from nonhealing ulcers, it was found that only the former present NIRS StO2 values abating over the study period both at center and edge of lesions. In conclusion, NIRS analysis of StO2 and wound area can predict the healing course of VLU. Adjunctive HBOT significantly facilitates VLU healing compared to the conventional treatment alone. This positive action, however, becomes manifest only with a longer and less intensive treatment schedule.

Global maps of the magnetic field in the solar corona.

Understanding many physical processes in the solar atmosphere requires determination of the magnetic field in each atmospheric layer. However, direct measurements of the magnetic field in the Sun's corona are difficult to obtain. Using observations with the Coronal Multi-channel Polarimeter, we have determined the spatial distribution of the plasma density in the corona and the phase speed of the prevailing transverse magnetohydrodynamic waves within the plasma. We combined these measurements to map the plane-of-sky component of the global coronal magnetic field. The derived field strengths in the corona, from 1.05 to 1.35 solar radii, are mostly 1 to 4 gauss. Our results demonstrate the capability of imaging spectroscopy in coronal magnetic field diagnostics.

The magnetic field in the Sun's corona

Solar Physics The solar corona is the outermost layer of the Sun's atmosphere, consisting of hot, diffuse, and highly ionized plasma. The magnetic field in this region is expected to drive many of its physical properties but has been difficult to measure with observations. Yang et al. used near-infrared imaging spectroscopy to determine the electron density and magnetohydrodynamic wave speed in the corona. By combining these measurements, they derived maps of the magnetic field throughout the entire observable corona. The method could potentially be used to produce routine magnetic field maps for the corona that are similar to those already available for the Sun's surface. Science , this issue p. [694][1] [1]: /lookup/doi/10.1126/science.abb4462

Dynamic microcirculation PIPE model for functional neuroimaging, non-neuroimaging, and coherent hemodynamics spectroscopy: blood volume and flow velocity variations, and vascular autoregulation.

We present a dynamic microcirculation PIPE model for functional neuroimaging, non-neuroimaging, and coherent hemodynamics spectroscopy. The temporal evolution of the concentration and oxygen saturation of hemoglobin in tissue, comprised of the contributions from the arterioles, capillaries, and venules of microvasculature, is determined by time-resolved hemodynamic and metabolic variations in blood volume, flow velocity, and oxygen consumption with a fluid mechanics treatment. Key parameters regarding microcirculation can be assessed, including the effective blood transit times through the capillaries and the venules, and the rate constant of oxygen release from hemoglobin to tissue. The vascular autoregulation can further be quantified from the relationship between the resolved blood volume and flow velocity variations. The PIPE model shows excellent agreement with the experimental cerebral and cutaneous coherent hemodynamics spectroscopy (CHS) and fMRI-BOLD data. It further identifies the impaired cerebral autoregulation distinctively in hemodialysis patients compared to healthy subjects measured by CHS. This new dynamic microcirculation PIPE model provides a valuable tool for brain and other functional studies with hemodynamic-based techniques. It is instrumental in recovering physiological parameters from analyzing and interpreting the signals measured by hemodynamic-based neuroimaging and non-neuroimaging techniques such as functional near-infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI) in response to brain activation, physiological challenges, or physical maneuvers.

Exercise-Based Cardiac Rehabilitation Modulates Prefrontal Cortex Oxygenation during Submaximal Exercise Testing in Cardiovascular Disease Patients.

The purpose of this study was to investigate if prefrontal cortex (PFC) oxygenation during incremental exercise is altered among cardiovascular disease (CVD) patients who completed 6 weeks of exercise-based cardiac rehabilitation (CR). Nineteen (male = 14, female = 5; 65.5 ± 11.5 years) participants from an outpatient CR program were enrolled in the study. Each participant completed a submaximal graded treadmill evaluation at intake and again upon completion of 18 individualized CR sessions. Functional near-infrared spectroscopy (fNIRS) imaging was used to measure left- and right- PFC (LPFC and RPFC) oxygenation parameters during the submaximal exercise evaluations. Patients showed improvements in cardiorespiratory capacity (pre 5.5 ± 2.5 vs. post 6.9 ± 2.8 metabolic equivalents (METs)). A significant decrease in LPFC and RPFC oxygenation was observed during the post-CR exercise test compared to pre-CR. CVD patients enrolled in 6 weeks of CR showed significant improvements in functional capacity along with decreased cortical oxygenation during submaximal exercise. Exercise training may cause distribution of cortical resources to motor regions that support sustained exercise.

Coronary plaque redistribution after stent implantation is determined by lipid composition: A NIRS-IVUS analysis.

The composition of plaque impacts the results of stenting. The following study evaluated plaque redistribution related to stent implantation using combined near-infrared spectroscopy and intravascular ultrasound (NIRS-IVUS) imaging. The present study included 49 patients (mean age 66 ± 11 years, 75% males) presenting with non-ST elevation myocardial infarction (8%), unstable angina (49%) and stable coronary artery disease (43%). The following parameters were analyzed: mean plaque volume (MPV, mm3), plaque burden (PB, %), remodeling index (RI), and maximal lipid core burden index in a 4 mm segment (maxLCBI4mm). High-lipid burden lesions (HLB) were defined as by maxLCBI4mm > 265 with positive RI. Otherwise plaques were defined as low-lipid burden lesions (LLB). Measurements were done in the target lesion and in 4 mm edges of the stent before and after stent implantation. MPV and maxLCBI4mm decreased in both HLB (MPV 144.70 [80.47, 274.25] vs. 97.60 [56.82, 223.45]; maxLCBI4mm: 564.11 ± 166.82 vs. 258.11 ± 234.24, p = 0.004) and LLB (MPV: 124.50 [68.00, 186.20] vs. 101.10 [67.87, 165.95]; maxLCBI4mm: 339.07 ± 268.22 vs. 124.60 ± 160.96, p < 0.001), but MPV decrease was greater in HLB (28.00 [22.60, 57.10] vs. 13.50 [1.50, 28.84], p = 0.019). Only at the proximal stent edge of LLB, maxLCBI4mm decreased (34 [0, 207] vs. 0 [0, 45], p = 0.049) and plaque burden increased (45.48 [40.34, 51.55] vs. 51.75 [47.48, 55.76], p = 0.030). NIRS-IVUS defined HLB characterized more significant decreases in plaque volume by stenting. Plaque redistribution to the proximal edge of the implanted stent occurred only in LLB.

An infrared study of the high-mass, multistage star-forming region IRAS 12272−6240

ABSTRACT IRAS 12272−6240 is a complex star-forming region with a compact massive dense clump (DC) and several associated masers, located at a well-determined distance of d = 9.3 kpc from the Sun. For this study, we obtained sub-arcsec broad- and narrow-band near-infrared (near-IR) imaging and low-resolution spectroscopy with the Baade/Magellan telescope and its camera PANIC. Mosaics of size 2 × 2 arcmin2 in the JHKs bands and with narrow-band filters centred in the 2.12 μm H2 and 2.17 μm Br γ lines were analysed in combination with Hi-GAL/Herschel and archive IRAC/Spitzer and WISE observations. We found that the compact DC houses two Class I young stellar objects (YSOs) that probably form a 21000 -au-wide binary system. Its combined 1–1200 μm spectral energy distribution is consistent with an O9V central star with a $10^{-2} \, \mathrm{M}_\odot$ disc and a $1.3 \times 10^4 \, \mathrm{M}_\odot$ dust envelope. Its total luminosity is $8.5 \times 10^4 \, \mathrm{L}_\odot$. A series of shocked H2 emission knots are found in its close vicinity, confirming the presence of outflows. IRAS 12272−6240 is at the centre of an embedded cluster with a mean age of 1 Myr and 2.6 pc in size that contains more than 150 stars. At its nucleus, we found a more compact and considerably younger subcluster containing the YSOs. We also identified and classified the O-type central stars of two dusty radio/IR H ii regions flanking the protostars. Our results confirm that these elements form a single giant young complex where massive star formation processes started some 1 Myr ago and are still active.

OCT-NIRS Imaging for Detection of Coronary Plaque Structure and Vulnerability.

A combination optical coherence tomography and near-infrared spectroscopy (OCT-NIRS) coronary imaging system is being developed to improve the care of coronary patients. While stenting has improved, complications continue to occur at the stented site and new events are caused by unrecognized vulnerable plaques. An OCT-NIRS device has potential to improve secondary prevention by optimizing stenting and by identifying vulnerable patients and vulnerable plaques. OCT is already in widespread use world-wide to optimize coronary artery stenting. It provides automated lumen detection and can identify features of coronary plaques not accurately identified by angiography or intravascular ultrasound. The ILUMIEN IV study, to be completed in 2022, will determine if OCT-guided stenting will yield better clinical outcomes than angiographic guidance alone. While the superb spatial resolution of OCT enables the identification of many plaque structural features, the detection by OCT of lipids, an important component of vulnerable plaques, is limited by suboptimal specificity and interobserver agreement. In contrast, NIRS has been extensively validated for lipid-rich plaque detection against the gold-standard of histology and is the only FDA-approved method to identify coronary lipids. Studies in patients have demonstrated that NIRS detects lipid in culprit lesions causing coronary events. In 2019, the positive results of the prospective Lipid-Rich Plaque Study led to FDA approval of NIRS for detection of high-risk plaques and patients. The complementarity of OCT for plaque structure and NIRS for plaque composition led to the sequential performance of NIRS and OCT imaging in patients. NIRS identified lipid while OCT determined the thickness of the cap over the lipid pool. The positive results obtained with OCT and NIRS imaging led to development of a prototype combined OCT-NIRS catheter that can provide co-registered OCT and NIRS data in a single pullback. The data will provide structural and chemical information likely to improve stenting and deliver more accurate identification of vulnerable plaques and vulnerable patients. More precise diagnosis will then lead to OCT-NIRS guided treatment trials to improve secondary prevention. Success in secondary prevention will then facilitate development of improved primary prevention with invasive imaging and effective treatment of patients identified by non-invasive methods.

Review of pathological index detection and new rehabilitation technique of drug addicts

There are two major research issues with regard to detoxification; one is pathological testing of drug users and the other is rehabilitation methods and techniques. Over the years, domestic and foreign researchers have done a lot of work on pathological changes in the brain and rehabilitation techniques for drug users. This article discusses the research status of these two aspects. At present, the evaluation of brain function in drug addicts is still dominated by a single electroencephalography (EEG), near-infrared spectroscopy (NIRS), or magnetic resonance imaging scan. The multimodal physiological data acquisition method based on EEG–NIRS technique is relatively advantageous for actual physiological data acquisition. The traditional drug rehabilitation method is based on medication and psychological counseling. In recent years, psychological correction (e.g., emotional ventilation, intelligent physical and mental decompression, virtual reality technique and drug addiction suppression system, sports training, and rehabilitation) and physical therapy (transcranial magnetic stimulation) have gradually spread. These rehabilitations focus on comprehensive treatment from the psychological and physical aspects. In recent years, new intervention ideas such as brain–computer interface technique have been continuously proposed. In this review, we have introduced multimodal brain function detection and rehabilitation intervention, which have theoretical and practical significance in drug rehabilitation research.

Compact Optical Probe for Time-Resolved NIRS-Imaging

We present the design of a standalone optical probe integrated with a Time-Gated Single Photon Detection module and Pulsed Light Emission unit. The detection module is capable of detecting photons in specific time windows, thus enabling the measurement of very faint optical signals. The pulse repetition frequency extends up to 100 MHz with a gate-ON time range up to 35ns. The module is user-configurable via a PC interface and can be integrated in any optical setup. The pulsed light emission unit uses a 50 GHz GaAs Vertical Cavity Surface Emitting Laser diode. Experimental characterization was conducted for all the building blocks of the module to ensure its proper functioning. The module was also employed in a real-life application, heart rate monitoring by illuminating the index finger of a volunteer. The novelty of the proposed miniaturized optode lies in the development of a simplified interface for portable Brain-computer interfaces which can be effectively used in applications such as Near-Infrared Spectroscopy and functional brain imaging.

Feasibility and efficacy of remotely supervised cranial electrical stimulation for pain in older adults with knee osteoarthritis: A randomized controlled pilot study

Cranial electrical stimulation (CES) is a noninvasive brain stimulation technique that has been shown to improve pain. However, few studies have investigated the potential benefits associated with remotely supervised CES in older adults with knee osteoarthritis (OA). The aim of this study was to examine the feasibility and preliminary efficacy of remotely supervised CES via secure videoconferencing software on clinical pain severity, experimental pain sensitivity, and pain-related cortical response in older adults with knee OA. Thirty participants with symptomatic knee OA pain were randomly assigned to receive 10 daily sessions (60 min each) of remotely supervised CES (n = 15) or sham CES (n = 15) over two weeks. We measured clinical pain severity via a Numeric Rating Scale, experimental pain sensitivity (e.g., heat pain sensitivity, pressure pain sensitivity, and conditioned pain modulation) using quantitative sensory testing, and pain-related cortical response via functional near-infrared spectroscopy imaging. We also measured participant satisfaction with treatment using the Client Satisfaction Questionnaire. Active CES significantly reduced scores on the Numeric Rating Scale and increased heat pain threshold, pressure pain thresholds, and conditioned pain modulation. We also found significant changes in pain-related cortical hemodynamic activity after CES. Participants tolerated CES well without serious adverse effects and were satisfied with the treatment. Our findings demonstrate promising clinical efficacy of remotely supervised CES for older adults with knee OA.

Near-infrared (NIR) spectroscopic imaging analysis of poly (lactic acid)-nanocomposite using disrelation mapping

Molecular-level interaction between poly(lactic acid) (PLA) and clay was probed by near-infrared (NIR) imaging based on disrelation mapping. Sets of NIR imaging data were measured under varying temperature. The spectra were subjected to null-space projection to remove overwhelming baseline changes arising from light scattering. Disrelation maps derived from baseline-corrected spectra revealed that the disrelation intensity between 5785 and 5825 cm−1 becomes especially significant around the boundary between the PLA and clay, suggesting the predominant development of crystalline structure in the region. Further disrelation intensities around the boundary appeared when additional heating was applied to the system. The emergence of such additional disrelation pattern reveals the growth of the PLA crystals and propagation of the crystalline region caused by the heating. Consequently, conclusive evidence on the nucleation induced by the clay is provided by the NIR imaging analysis of the PLA sample.

A low-cost multichannel NIRS oximeter for monitoring systemic low-frequency oscillations

Systemic low-frequency oscillations (sLFOs) are non-neuronal oscillations at 0.01–0.15 Hz. These sLFOs travel through the entire body and the brain with symmetrical (across the midline of the body) and highly predictable delays, where they can be observed with functional near-infrared spectroscopy (fNIRS) and blood oxygen level-dependent functional magnetic resonance imaging. Their characteristics may serve as useful biomarkers for detecting and monitoring circulatory dysfunction. Pure sLFOs can be collected in the periphery (e.g., fingers, toes, earlobes). Here we present a 7-channel NIRS oximeter [MNO] for sLFOs detection and analysis in the periphery, which we named concurrent continuous wave fNIRS system (CON-CW fNIRS). Our CON-CW fNIRS is small (10 × 10 × 20 cm3), highly portable, has low-power consumption and is highly cost-effective (below $300). We show that our device is highly reliable and can reproduce values acquired with a commercial fNIRS device with direct comparison (rmax = 0.908 ∆[HbO] and rmax = 0.841 ∆[Hb]) and when compared to previously published data.