Near-infrared Absorption Research Articles

Exploring the potential of carbon-coated MoSe2 nanoparticles as a photothermal therapy for ovarian cancer

Molybdenum selenide (MoSe2) as a nano near-infrared absorber has been widely studied in the field of photothermal therapy of cancer. However, there are few studies on its application in the treatment of ovarian cancer. In this paper, a new type of carbon-coated MoSe2 (MEC) nanoparticle was prepared by a one-step hydrothermal method. MEC was successfully synthesized as avidenced by chemical characterization. A large number of biological experiments confirmed that MEC + Laser group had the lowest cell viability (61.6 % ± 8.9 %), inhibited the proliferation of human ovarian cancer (SKOV-3) cells in G2/M phase, induced apoptosis (apoptosis rate: 43.24 % ± 0.85 %), and increased the intracellular ROS level (93.86 % ± 1.42 %). Furthermore, MEC nanoparticles displayed excellent photothermal therapy in tumor-bearing mice with no obvious side effects on major organs. Finally, the therapeutic mechanism of MEC nanoparticles was explored, and it was found that they had higher absorbance and could generate more heat during laser irradiation, thereby improving their therapeutic effect on ovarian cancer. MEC nanoparticles, as photothermal agents, have good anticancer ability. And they have the potential to become an important candidate for the treatment of ovarian cancer.

Panchromatic and Perturbed Absorption Spectral Features and Multiredox Properties of Dicyanovinyl- and Dicyanobutadienyl-Appended Cobalt Corroles.

Four new β-functionalized π-extended cobalt corroles with one and two dicyanovinyl (DCV) or dicyanobutadienyl (DCBD) moieties at the 3- and 3,17-positions have been synthesized and characterized by various spectroscopic techniques. Interestingly, the synthesized DCV- and DCBD-appended cobalt corroles displayed panchromatic and near-infrared absorption in the range 300-1100 nm in CH2Cl2 and pyridine solvents. (MN)2-(Cor)Co and A2MN2-(Cor)Co exhibited 8-9 times enhancement in the molar absorptivity of the Q band compared to the parent corrole ((Cor)Co). The unique absorption spectral features of these β-functionalized cobalt corroles are splitting, broadening, and red-shifting in the Soret and Q bands. One DCV unit brings a 30-46 nm red shift, whereas one DCBD unit brings a 40-75 nm red shift in the Q band compared to the corresponding precursors. This is rare that the intensity of the longest Q band is greater than or equal to the Soret-like bands. These corrole derivatives exhibit UV-vis spectral features similar to those of chlorophyll a. A 220 mV positive shift per DCV group and 160 mV positive shift per DCBD group were observed in the first oxidation potentials compared to (Cor)Co in the desired direction for the utility of these cobalt complexes in electrocatalysis. DFT studies revealed that HOMO and LUMO were stabilized after appending DCV and DCBD groups on the corrole macrocycle and exhibited a "push-pull" behavior leading to promising material applications in nonlinear optics (NLO) and catalysis.

Amino acid-mediated amorphous copper sulphide with enhanced photothermal conversion efficiency for antibacterial application

Pathogenic bacteria in daily life, such as Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), often seriously affect human life and health. The extensive use of antibiotics has led to the emergence of drug-resistant bacteria, so it is urgent to develop efficient and non-drug-resistant sterilization methods. Here, we use small-molecule cysteine (Cys) as an auxiliary agent to synthesize spherical porous amorphous CuS-Cysteine (CuS-C) nanoparticles, which have good dispersion in aqueous solutions, and explore the reaction mechanism of Cys-induced CuS synthesis. The synthesized composite nanomaterials have strong near-infrared light absorption ability and efficient photothermal conversion ability and can effectively ablate pathogenic bacteria under the irradiation of an 808 nm laser. In addition, antibacterial experiments showed that CuS-C composites had no bactericidal effect without near-infrared light, but they had a good photothermal bactericidal effect on S. aureus and E. coli under radiation conditions. Considering the simple synthesis process, strong photothermal conversion ability, low cost, and suitability for large-scale production, CuS-C nanocomposites, as a promising antibacterial material, will provide a feasible scheme for the treatment of drug-resistant pathogens.

Thienothiophene-centered ladder-type π-systems that feature distinct quinoidal π-extension

Quinoidal π-conjugated structures, a kind of fundamental subunits for organic π-systems, may produce some intriguing optical, electronic and magnetic properties of polycyclic hydrocarbons (PHs). Herein, we report two thienothiophene-centered ladder-type polycyclic molecules (1 and 2), which possess one quinoidal thienothiophene moiety and two para-quinodimethane (p-QDM) subunits, respectively. As theoretically and experimentally studied, while 1 is a fully closed-shell molecule, 2 owns an open-shell structure along with partial contribution of tetraradical state that is induced by the resonance of p-QDM. Moreover, although 2 has a larger π-conjugated skeleton and open-shell electronic state, it exhibits larger bandgap and blue-shifted absorption. On the other hand, the reversible oxidation activity of 1 enables the preparation of its dication 12+, and the studies on its single-crystal and aromatic structures demonstrate that its two positive charges are delocalized onto the oxygen atoms, thus achieving fully π-extended structure and near-infrared absorption. This study not only gains insight into quinoidal π-subunits, but also provides an important basis for the development of antiaromatic and open-shell π-electron materials.

Pyrrole-Doped Polydopamine-Pyrrole (PDA-nPY) Nanoparticles with Tunable Size and Improved NIR Absorption for Photothermal Therapy.

Polydopamine (PDA) as a melanin-like biomimetic material with excellent biocompatibility, full spectrum light absorption capacity and antioxidation property has been extensively applied in the biomedical field. Based on the high reactivity of dopamine (DA), exploiting new strategies to fabricate novel PDA-based nano-biomaterials with controllable size and improved performance is valuable and desirable. Herein, we reported a facile way to synthesize pyrrole-doped polydopamine-pyrrole nanoparticles (PDA-nPY NPs) with tunable size and enhanced near-infrared (NIR) absorption capacity through self-oxidative polymerization of DA with PY in an alkaline ethanol/H2O/NH4OH solution. The PDA-nPY NPs maintain excellent biocompatibility and surface reactivity as PDA. By regulating the volume of added PY, PDA-150PY NPs with a smaller size (<100 nm) and four-fold higher absorption intensity at 808 nm than that of PDA can be successfully fabricated. In vitro and in vivo experiments effectively further demonstrate that PDA-150PY NPs can effectively inhibit tumor growth and completely thermally ablate a tumor. It is believed that these PY doped PDA-nPY NPs can be a potential photothermal (PT) agent in biomedical application.

Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy

Imaging-guided photothermal therapy (PTT) for cancers recently gathered increasing focus thanks to its precise diagnosis and potent therapeutic effectiveness. Croconaine (CR) dyes demonstrate potential in expanding utility for near infrared (NIR) dyes in bio-imaging/theranostics. However, reports on CR dyes for PTT are scarce most likely due to the short of the efficacious delivery strategies to achieve specific accumulation in diseased tissues to induce PTT. Extracellular vesicles (EVs) are multifunctional nanoparticle systems that function as safe platform for disease theragnostics, which provide potential benefits in extensive biomedical applications. Here, we developed a novel delivery system for photothermal molecules based on a CR dye that exerts photothermal activity through CDH17 nanobody-engineered EVs. The formed CR@E8-EVs showed strong NIR absorption, excellent photothermal performance, good biological compatibility and superb active tumor-targeting capability. The CR@E8-EVs can not only visualize and feature the tumors through CR intrinsic property as a photoacoustic imaging (PAI) agent, but also effectively retard the tumor growth under laser irradiation to perform PTT. It is expected that the engineered EVs will become a novel delivery vehicle of small organic photothermal agents (SOPTAs) in future clinical PTT applications.

Synthesis and photothermal conversion properties of sandwich N-fused porphyrin rhodium-μ-dichloride dimer complexes: π-extended analog of pentamethylcyclopentadienyl dirhodium(III)-μ-dichloride dimer

Anionic cyclopentadienyl (Cp) and its pentamethyl-substituted derivative (Cp*) serve as crucial ligands for creating stable π-coordinated materials, including catalysts. From a structural perspective, the π-extended analog of Cp, known as an N-fused porphyrin (NFP), is recognized as an intriguing 18π aromatic chromophore, offering near-infrared (NIR) optical properties that can be fine-tuned through metal complexation. When coordinated with rhodium at the central NFP core, it forms a sandwich binuclear rhodium(III) complex along with terminal and bridging chloride ligands, denoted as Rh-1, and its bromo derivative, Rh-1-Br. In contrast to the bis-NFP complex of iron(II) reported previously by our team, both Rh-1 and Rh-1-Br complexes exhibit strong NIR optical properties and narrow HOMO-LUMO energy gaps, attributed to minimal orbital interactions between the two co-facial NFP ligands. Leveraging these NIR absorption properties, we assessed the photothermal conversion properties of Rh-1 and ligand 1, revealing high conversion efficiency. This suggests their potential application as photothermal agents for use in photothermal therapy.

InN@In2S3 Core-Shell nanorod for oxygen-free and penetration depth-unrestricted photodynamic therapy against glioblastoma

Photodynamic therapy (PDT) is among the most promising antineoplastic protocols for glioblastoma (GBM). Nonetheless, GBM is a deep-seated intracranial tumor with a serious hypoxic microenvironment; thus, ensuring a sufficient light penetration depth and oxygen (O2) supply are crucial to achieving a positive therapeutic outcome against GBM using PDT. Herein, InN@In2S3 core–shell nanorods are designed to serve as novel and indispensable PDT agents for GBM treatment. Unlike other PDT agents, InN@In2S3 features wide and strong near-infrared absorption that may improve the penetration depth. Moreover, InN@In2S3 exhibits high electron–hole separation efficiency owing to its Ⅱ heterojunction. The separated holes catalyze the generation of O2 from H2O, thereby ensuring sufficient O2 supply for generating reactive oxygen species through a redox reaction between the generated O2 and separated electrons. Our study demonstrates an O2-free and penetration depth-unrestricted PDT strategy that will promote the clinical treatment of GBM with PDT.

Near-Infrared Conjugated Polymers Containing Thermally Activated Delayed Fluorescence Units Enable Enhanced Photothermal Therapy.

Photothermal therapy (PTT) using near-infrared (NIR) conjugated polymers as photosensitizers has exhibited enormous potential for tumor treatment. However, most NIR conjugated polymers have poor therapeutic efficacy due to their faint absorbance in the NIR region and low photothermal conversion efficiency (PCE). Herein, a valuable strategy for designing NIR polymeric photosensitizer PEKBs with an enhanced PCE accompanied by strong NIR absorbance is proposed by means of inserting TPA-AQ as a thermally activated delayed fluorescence unit into a polymeric backbone. In these PEKBs, PEKB-244 with the appropriate molar content of the TPA-AQ unit displays the strongest NIR absorbance and the highest PCE of 64.5%. Theoretical calculation results demonstrate that the TPA-AQ unit in the polymeric backbone can modulate the intramolecular charge transfer effects and the excited energy decay routes for generating higher heat. The prepared nanoparticles (PEKB-244 NPs) exhibit remarkable photothermal conversion capacities and great biocompatibility in aqueous solutions. Moreover, PEKB-244 NPs also show outstanding photothermal stability, displaying negligible changes in the absorbance within 808 nm irradiation of 1 h (800 mW cm-2). Both in vitro and in vivo experimental results further indicate that PEKB-244 NPs can substantially kill cancer cells under NIR laser irradiation. We anticipate that this novel molecular design strategy can be employed to develop excellent NIR photosensitizers for cancer photothermal therapy.

High efficiency photothermal synergistic degradation of toluene achieved through the utilization of a nickel foam loaded Pt-CeO2 monolithic catalyst

Recent research highlights the pressing need for innovative and practical oxidation degradation technologies for volatile organic compounds (VOCs). In this study, a monolithic catalyst was successfully developed by loading Pt-CeO2 onto nickel foam (NF) matrix through hydrothermal and reduction methods. The photothermal catalytic performance was investigated at room temperature for varying Pt content, toluene concentration, light source type, and water content. Remarkably, the toluene removal efficiency and CO2 selectivity stabilized at 98.8 % and 74.6 %, respectively, within less than 10 min of light activation. The d-d transition thermal effect of CeO2 and plasma effect of Pt enhanced light-to-heat conversion and active free radical generation (•O2– and •OH) through light absorption, respectively. The NF matrix's excellent thermal conductivity ensured a rapid increase in catalyst temperature upon visible light irradiation, reaching 173 °C. The study demonstrated that both the Mars-van Krevelen (Mvk) oxidation process, driven by temperature increase from near-infrared (NIR) absorption, and the free radical oxidation process, induced by higher energy illumination, synergistically contributed to toluene decomposition and mineralization. The catalyst's morphology, physical and chemical properties, surface synergistic oxidation process involving gaseous oxygen and free radicals, and toluene degradation pathway were thoroughly analyzed. We believe that this coexistence of thermocatalytic and photocatalytic mechanisms in a monolithic catalyst driven by renewable solar energy holds significant potential for practical applications and warrants further exploration.

Large-area nanofiber membrane of NIR photothermal Cs0.32WO3 for flexible and all-weather solar thermoelectric generation

Harvesting heat or solar energy to directly generate affordable and sustainable electricity holds great promise toward both fundamental science and practical applications in self-powered wearable electronics. However, solar thermoelectric (STE) devices remain challenging in establishing a stable and significant temperature gradient (ΔT) across thermoelectric materials for cost-effective electricity generation. Herein, a wearable STE generator with all-weather and high-performance electricity generation was elaborately designed and synthesized sandwiched by a thermogalvanic cell and a large-area nanofiber membrane of Cs0.32WO3 (CWO) nanoparticles with strong near-infrared (NIR) absorption. These prepared CWO membranes, which were prepared via an electrostatic spinning technique, present a high photothermal conversion efficiency of 42.7 % with no degradation after running for 10 cycles. Notably, a significant ΔT of 31.5 K across the thermoelectric modular was achieved for STE generation via the thermal concentration of these photothermal membranes under natural sunlight. Owing to the high thermopower of 2.87 mV K−1 for each p-n pair, STE generation demonstrates a maximum output voltage of 200 mV under natural solar irradiance during the time period of noon. This work explores a new strategy to achieve efficient heat management of STE devices for high electricity generation under all-weather conditions, which demonstrates great potential for self-powered wearable electronics.

Ultra-broadband near-infrared absorption enhancement of monolayer graphene by multiple-resonator approach

We theoretically study how to achieve an ultra-broadband near-infrared absorption enhancement of monolayer graphene through the multiple-resonator approach. The monolayer graphene (about 0.34 nm in thickness) is on nanostructured metal surfaces with multiple one-dimensional nanogrooves. The investigated nanostructure has an advantage of easy fabrication, because the monolayer graphene needs not to be sandwiched between different material layers. The metallic nanogrooves are able to support magnetic plasmon resonances whose resonance wavelengths are largely tuned, by changing the nanogroove depth from 70 to 210 nm or the nanogroove width from 20 to 40 nm. In a very wide near-infrared wavelength range from 850 nm to 1500 nm, the light absorption efficiency of graphene is enhanced to be more than 60 %, by carefully designing multiple magnetic plasmon resonances to be partly overlapped in optical spectra. Our work is of interest for some photoelectric devices, for example infrared photodetectors.

Constructing MoO3-x/Mn0.3Cd0.7S S-scheme heterojunction with LSPR and photothermal effects for enhanced full spectrum hydrogen evolution

Some nonstoichiometric semiconductors exhibit excellent near-infrared (NIR) absorption due to their unique localized surface plasmon resonance (LSPR) effect, which is conducive to improving efficiency of light energy conversion to make them promising candidates for efficient photocatalytic hydrogen (H2) evolution. Herein, we constructed a novel 1D/1D MoO3-x/Mn0.3Cd0.7S (MO/MCS) S-scheme heterojunction with LSPR and photothermal double effects for boosted full solar spectrum-driven H2 evolution. The light absorption of MO/MCS was expanded to NIR region through the LSPR effect of MO. Meanwhile, the impressive photothermal effect of MO can increase the surface temperature of the photocatalyst particles under light irradiation, which can further accelerate the photoreaction. According to the experimental and theoretical calculation results, the formation of S-scheme heterojunction was confirmed, which boosted the separation of photo-induced carriers. Consequently, the H2 evolution performance of judiciously designed MO/MCS composites was significantly enhanced with an optimal H2 evolution of 2.235 mmol·g−1·h−1, 30.6 times that of pure MCS. This work provides a valuable insight into the development of highly efficient full solar spectrum-driven photocatalysts through utilizing the synergetic effects of LSPR effect, photothermal effect, and S-scheme heterojunction.

Single Atom Stabilization of Phosphinate Ester-Containing Rhodamines Yields Cell Permeable Probes for Turn-On Photoacoustic Imaging.

Photoacoustic imaging (PAI) is an emerging imaging technique that uses pulsed laser excitation with near-infrared (NIR) light to elicit local temperature increases through non-radiative relaxation events, ultimately leading to the production of ultrasound waves. The classical xanthene dye scaffold has found numerous applications in fluorescence imaging, however, xanthenes are rarely utilized for PAI since they do not typically display NIR absorbance. Herein, we report the ability of Nebraska Red (NR) xanthene dyes to produce photoacoustic (PA) signal and provide a rational design approach to reduce the hydrolysis rate of ester containing dyes, affording cell permeable probes. To demonstrate the utility of this approach, we construct the first cell permeable rhodamine-based, turn-on PAI imaging probe for hypochlorous acid (HOCl) with maximal absorbance within the range of commercial PA instrumentation. This probe, termed SNR700 -HOCl, is capable of detecting exogenous HOCl in mice. This work provides a new set of rhodamine-based PAI agents as well as a rational design approach to stabilize esterified versions of NR dyes with desirable properties for PAI. In the long term, the reagents described herein could be utilized to enable non-invasive imaging of HOCl in disease-relevant model systems.

Green-Solvent Processed Blade-Coating Organic Solar Cells with an Efficiency Approaching 19% Enabled by Alkyl-Tailored Acceptors

HighlightsAlkyl-tailored Y-SMAs named YR-SeNF series with near-infrared absorption, different molecular crystallinity and self-assembly abilities are developed.The related organic solar cells (OSCs) with an active layer processed from halogen-free solvents and spin-coating-free technologies achieve a ~ 19% efficiency.Ternary OSCs offer a robust operating stability under MPP tracking and well-keep > 80% of the initial efficiency for even over 400 h.

Advancing perovskite solar cell performance: Enhanced efficiency and stability through superimposed PbS QDs

This study investigates enhancing efficiency in thin-film photovoltaic devices by incorporating varying-sized superimposed PbS colloidal quantum dots (CQDs). These CQDs offer tunable near-infrared absorption, multiple exciton generation effects, and solution processability, rendering them promising for improved performance. Superimposing QDs of different sizes extends the device's absorption spectrum beyond conventional limits, utilizing tailored absorption coefficients for broader sunlight wavelength utilization and increased solar energy conversion efficiency. Each QD group exhibits a unique absorption coefficient, with a peak at its central wavelength from the Schrödinger equation solution. Spectral analysis reveals strategic enhancement in light absorption across visible and near-infrared regions, broadening the perovskite absorption range beyond 800 nm. These QDs enhance both infrared and visible spectra, improving light harvesting. Summing the absorption of single QD groups creates a continuous spectrum, enhancing perovskite film stability and morphology. Rigorous optical analysis and comprehensive electrical modeling investigate charge carrier interactions within the photovoltaic framework. The study verifies around 24 % efficacy enhancement compared to QD-absent configurations, surpassing uniformly dispersed QDs by 11 %. Optical and electrical analyses yield a short-circuit current of 26.7 mA/cm2, open-circuit voltage of 1.13 V, fill factor of 0.88, and overall efficiency of 25.12 % in superimposed configurations. Results underscore the significance of varied QD dimensions and layered structures for enhanced absorption, offering a promising route for advancing thin-film solar technology. The study showcases the potential of PbS CQDs with varying radii in photovoltaics, contributing to improved efficiency and stability, with implications for the future of solar energy technology.

Polyphenolic Carbon Quantum Dots with Intrinsic Reactive Oxygen Species Amplification for Two-Photon Bioimaging and In Vivo Tumor Therapy.

Recent studies indicate that mitochondrial dysfunctions and DNA damage have a critical influence on cell survival, which is considered one of the therapeutic targets for cancer therapy. In this study, we demonstrated a comparative study of the effect of polyphenolic carbon quantum dots (CQDs) on in vitro and in vivo antitumor efficacy. Dual emissive (green and yellow) shape specific polyphenolic CQDs (G-CQDs and Y-CQDs) were synthesized from easily available nontoxic precursors (phloroglucinol), and the antitumor property of the as-synthesized probe was investigated as compared to round-shaped blue emissive CQDs (B-CQDs) derived from well-reported precursor citric acid and urea. The B-CQDs had a nuclei-targeting property, and G-CQDs and Y-CQDs had mitochondria-targeting properties. We have found that the polyphenol containing CQDs (at a dose of 100 μg mL-1) specifically attack mitochondria by excess accumulation, altering the metabolism, inhibiting branching pattern, imbalanced Bax/Bcl-2 homeostasis, and ultimately generating oxidative stress levels, leading to oxidative stress-induced cell death in cancer cells in vitro. We show that G-CQDs are the main cause of oxidative stress in cancer cells because of their ability to produce sufficient •OH- and 1O2 radicals, evidenced by electron paramagnetic resonance spectroscopy and a terephthalic acid test. Moreover, the near-infrared absorption properties of the CQDs were exhibited in two-photon (TP) emission, which was utilized for TP cellular imaging of cancer cells without photobleaching. The in vivo antitumor test further discloses that intratumoral injection of G-CQDs can significantly augment the treatment efficacy of subcutaneous tumors without any adverse effects on BalB/c nude mice. We believe that shape-specific polyphenolic CQD-based nanotheranostic agents have a potential role in tumor therapy, thus proving an insight on treatment of malignant cancers.

Construction of localized state levels and near-infrared light absorption of silicon: B/P doping and first-principles calculations

Theoretically, the light wavelength that a silicon-based detector can detect is less than 1100 nm. After silicon (Si) is singly doped or co-doped with phosphorus (P) and boron (B) impurities, the localized state levels are formed in forbidden band, which makes it possible to absorb long wavelength light for the doped Si. Although the ionization energy of both P and B as shallow level impurities in Si is close to each other, the first-principles study in this paper shows that the near-infrared light absorption of n-Si is weaker than that of p-Si for the same concentration of impurities. After the impurity compensation of p-/n-Si based on P and B co-doping, the localized state levels are constructed by B− and P+ ions in the forbidden band of Si. The near-infrared absorption of n-Si can be significantly enhanced by impurity compensation, whereas the opposite case is true for p-Si. Moreover, even if p-/n-Si is fully compensated by impurities, it still has a strong near-infrared light absorption, which is different from intrinsic Si. Possible reasons on the difference of the above-mentioned light absorption were discussed.

Influence of PEGylation on WS2 Nanosheets and Its Application in Photothermal Therapy.

Photothermal therapy (PTT) is an alternative cancer therapy with minimal side effects and higher efficiency and selectivity. In this study, WS2 nanosheets were developed by ultrasonic exfoliation with different ratios of polyethylene glycol (PEG), and their effects on physicochemical properties were studied. The utilization of PEG during sonication significantly influenced the size and thickness of the resulting WS2 nanosheet layers, which was confirmed through scanning electron microscopy, atomic force microscopy, and dynamic light scattering analyses. PEG functionalization also improved the dispersibility of WS2 in aqueous solution by making its surface hydrophilic, which resulted in better biocompatibility. The intrinsic near-infrared absorbance of the nanosheets positions them as valuable agents for PTT. The study further explores the efficacy of these nanosheets as photothermal agents in the ablation of MDAMB-231 breast cancer cells. Although the use of PEG to demonstrate exfoliation and biocompatibility for WS2 has been reported previously, the effect of PEGylation on various physicochemical properties has not been studied in-depth until now. This study paves the way for the use of highly versatile PEG across a range of 2D material systems.

POSS engineering of squaraine nanoparticle with high photothermal conversion efficiency for photothermal therapy

Photothermal therapy (PTT) has been extensively studied due to its promising therapeutic effects and potential for development in cancer treatments. Central to PTT is the development of photothermal agents (PTAs). This study presents a novel nanoparticle called POSS-SQ, which satisfies the necessary conditions to function as a PTA. Comprised of squaraine (SQ) and polyhedral oligomeric sesquisiloxane (POSS), POSS-SQ NPs exhibit strong near-infrared (NIR) absorption and high photothermal conversion efficiency (PCE) attributable to the intermolecular electron transfer in SQ. Furthermore, POSS when modified with polyethylene glycol (PEG) through “click” chemistry, effectively enhances cell permeability and biocompatibility of the nanoparticles. Photothermal experiments reveal that POSS-SQ NPs demonstrate concentration and laser power dependence, with a PCE of 67.2%. In vitro and in vivo experiments confirm the excellent biosafety and tumor growth inhibition potential of POSS-SQ NPs under laser irradiation, attributed to the synergistic effects of enhanced cell permeability and exceptional photothermal properties. This research highlights the possibility of obtaining PTAs with high PCE and excellent biocompatibility by combining SQ-N and POSS, offering a new approach for designing and developing more efficient PTAs to enhance better PTT outcomes.