ABSTRACT This research assesses the dynamic modulus (E*) as a pivotal rheological attribute for characterizing viscoelastic behaviour in various indigenous asphalt mixtures across diverse scenarios. An exhaustive investigation involving 32 laboratory-designed asphalt mixes and two field mixes explores the influence of traffic loading patterns, air voids, binder sources, and climatic conditions on E*. Utilizing Superpave gyratory compaction, 68 E*-specimens are compacted and subjected to E*-testing, leading to master curve development. Evaluation of NCHRP 1-37A and NCHRP 1-40D Witczak models demonstrates their fair to excellent accuracy in predicting E* for Egyptian mixes. The NCHRP 1-40D model stands out with an R² of 0.94, showcasing superior accuracy and minimal bias. This study integrates AASHTOW are Pavement ME Design (PMED) to analyse pavement sections, revealing the impact of design factors, characterized by measured E*, on predicted pavement performance, encompassing asphalt concrete rutting, alligator cracking, longitudinal cracking, and terminal international roughness index. The investigation highlights the marginal impact of substituting predicted E* for measured E* on AASHTOWare pavement performance indicators for Egyptian mixes under default binder characteristic values. This research contributes valuable insights into the interplay of E* and pavement performance, facilitating wellinformed decisions in pavement design and analysis across diverse conditions in the Egyptian context.