Natural Settings Research Articles

Impacts of packed bed polydispersity and deformation on fine particle transport

AbstractStatic granular packings play a central role in numerous industrial applications and natural settings. In these situations, fluid or fine particle flow through a bed of static particles is heavily influenced by the narrowest passage connecting the pores of the packing, commonly referred to as pore throats, or constrictions. Existing studies predominantly assume monodisperse rigid particles, but this is an oversimplification of the problem. In this work, we illustrate the connection between pore throat size, polydispersity, and particle deformation in a packed bed of spherical particles. Simple analytical expressions are provided to link these properties of the packing, followed by examples from Discrete Element Method (DEM) simulations of fine particle percolation demonstrating the impact of polydispersity and particle deformation. Our intent is to emphasize the substantial impact of polydispersity and particle deformation on constriction size, underscoring the importance of accounting for these effects in particle transport in granular packings.

Joystick-Operated Ride-On Toy Navigation Training for Children With Hemiplegic Cerebral Palsy: A Pilot Study.

Children with hemiplegic cerebral palsy (HCP) require intensive task-oriented training to make meaningful gains in affected upper extremity (UE) motor function. To evaluate the acceptability and utility of single joystick-operated ride-on toy (ROT) navigation training incorporated into a modified constraint-induced movement therapy (CIMT) camp for children with HCP. Single group pretest-posttest design. Three-wk structured CIMT camp. Eleven children with HCP between ages 3 and 14 yr. Children received group-based CIMT for 6 hr/day, 5 days/wk, for 3 wk. As part of camp activities, children also received ROT navigation training for 20 to 30 min/day, 5 days/wk, for 3 wk. We assessed children's acceptance of ROT training by monitoring adherence and evaluating child engagement (affect and attention) during training sessions. The effects of ROT training combined with other camp activities on children's affected UE motor function were also assessed with the standardized Quality of Upper Extremity Skills Test (QUEST) and training-specific measures of ROT maneuvering accuracy. Children demonstrated high levels of training adherence, positive affect, and task-appropriate attention across weeks. Positive engagement during ROT sessions was correlated with independent navigation. We also found medium- to large-sized improvements in QUEST scores and toy-maneuvering capabilities after the combined program. Our pilot data support the use of joystick-operated ROTs as child-friendly therapy adjuncts that can be incorporated into intensive UE training programs to improve adherence and motivation in therapy programs, boost treatment dosing, and promote affected UE motor function in children with HCP. Plain-Language Summary: This pilot study offers promising evidence that supports the use of modified single joystick-operated ride-on toys (ROTs) for children with hemiplegic cerebral palsy (HCP). The study used ROTs as one of several interventions that were part of a constraint-induced movement therapy (CIMT) camp program for children with HCP. The ROTs boosted children's motivation, their engagement with and adherence to training, and their practice in using their affected upper extremity (UE) for goal-directed activities in their natural settings. ROTs are accessible, age-appropriate, and easy-to-use devices for both occupational therapy clinicians and families to encourage children to use their affected UEs by challenging their perceptual, motor-planning, problem-solving, and movement-control skills in an enjoyable and engaging way. ROTs can be used within and outside conventional rehabilitation settings.

A systematic review of mobile brain/body imaging studies using the P300 event-related potentials to investigate cognition beyond the laboratory.

The P300 ERP component, related to the onset of task-relevant or infrequent stimuli, has been widely used in the Mobile Brain/Body Imaging (MoBI) literature. This systematic review evaluates the quality and breadth of P300 MoBI studies, revealing a maturing field with well-designed research yet grappling with standardization and global representation challenges. While affirming the reliability of measuring P300 ERP components in mobile settings, the review identifies significant hurdles in standardizing data cleaning and processing techniques, impacting comparability and reproducibility. Geographical disparities emerge, with studies predominantly in the Global North and a dearth of research from the Global South, emphasizing the need for broader inclusivity to counter the WEIRD bias in psychology. Collaborative projects and mobile EEG systems showcase the feasibility of reaching diverse populations, which is essential to advance precision psychiatry and to integrate varied data streams. Methodologically, a trend toward ecological validity is noted, shifting from lab-based to real-world settings with portable EEG system advancements. Future hardware developments are expected to balance signal quality and sensor intrusiveness, enriching data collection in everyday contexts. Innovative methodologies reflect a move toward more natural experimental settings, prompting critical questions about the applicability of traditional ERP markers, such as the P300 outside structured paradigms. The review concludes by highlighting the crucial role of integrating mobile technologies, physiological sensors, and machine learning to advance cognitive neuroscience. It advocates for an operational definition of ecological validity to bridge the gap between controlled experiments and the complexity of embodied cognitive experiences, enhancing both theoretical understanding and practical application in study design.

Developing prediction algorithms for late-life depression using wearable devices: a cohort study protocol

IntroductionDespite the high prevalence of major depressive disorder (MDD) among the elderly population, the rate of treatment is low due to stigmas and barriers to medical access. Wearable devices such...

Nature prescribing: emerging insights about reconciliation-based and culturally inclusive approaches from a tricultural community health centre.

This commentary highlights the importance of social and nature prescribing programs reflecting culturally diverse perspectives and practices. Creating and holding space for Indigenous and other worldviews should be a key priority of nature prescribing, a relatively recent practice in Canada that recognizes and promotes health benefits associated with engaging in a variety of activities in natural settings. Central to designing and delivering nature prescribing that is culturally inclusive and grounded in fulfilling obligations of reconciliation is recognizing the ongoing dominance of Western worldviews and their associated implications for decolonizing and Indigenizing nature-based programming. Consciously working to expand Western values, with the aim of extending nature prescribing practices beyond mere nature exposure to fostering emotional connections to nature, is a critically important part of the ongoing development of nature-based interventions and nature prescribing.

Dimensionless dynamics: Multipeak and envelope solitons in perturbed nonlinear Schrödinger equation with Kerr law nonlinearity

In this work, the dimensionless form of the improved perturbed nonlinear Schrödinger equation with Kerr law of fiber nonlinearity is solved for distinct exact soliton solutions. We examined the multi-wave solitons and rational solitons of the governing equation using the logarithmic transformation and symbolic computation using an ansatz functions approach. Multi-wave solitons in fluid dynamics describe the situation in which a fluid flow shows several different regions (or peaks) of high concentration or intensity of a particular variable (e.g., velocity, pressure, or vorticity). Multi-wave solitons in turbulent flows might indicate the existence of several coherent structures, like eddies or vortices. These formations are areas of concentrated energy or vorticity in the turbulent flow. Understanding how these peaks interact and change is essential to comprehending the energy cascade and dissipation in turbulent systems. Furthermore, a sub-ordinary differential equation approach is used to create solutions for the Weierstrass elliptic function, periodic function, hyperbolic function, Chirped free, dark-bright (envelope solitons), and rational solitons, as well as the Jacobian elliptic function, periodic function, and rational solitons. Also, as the Jacobian elliptic function's' modulus m approaches values of 1 and 0, we find trigonometric function solutions, solitons-like solutions, and computed chirp free-solitons. Envelope solitons can arise in stratified fluids and spread over the interface between layers, such as layers in the ocean with varying densities. Their research aids in the management and prediction of wave events in artificial and natural fluid settings. In fluids, periodic solitons are persistent, confined wave structures that repeat on a regular basis, retaining their form and velocity over extended distances. These structures occur in a variety of settings, including internal waves in stratified fluids, shallow water waves, and even plasma physics.

Different Effects of Behavioral-Based Strategies for Sustaining Attention of an Elementary Student with Intellectual Disability

<p>智能障礙學生常伴隨注意力缺陷等問題，導致學習歷程困難，影響學習表現和成就。根據國內外文獻和實務報告，為改善注意力與學習問題，兩個常見的行為策略為：（一）增加專注口語提示策略，及（二）暫時移除偏好的教材刺激。然而，國內研究鮮少比較行為策略對於注意力的成效，也缺乏融合應用多媒體動畫影片教材，因此，本研究旨在針對智能障礙伴隨注意力缺陷學生在學習多媒體動畫影片教材時，這兩種行為策略對於學生注意力時間之影響，並比較兩種策略的成效差異。</p> <p>本研究採用單一受試實驗研究法之交替比較設計，針對一位就讀於國小集中式特教班，並經醫療診斷為智能障礙伴隨注意力缺陷的學生，藉由交替設計比較教學者於自然情境中執行上述兩種行為策略時學生注意力維持時間的變化，以呈現自然教學場域中的真實樣貌。研究過程分為基線期、交替介入期，以及最佳介入期，研究數據採取單一受試研究法之視覺分析探究成效。</p> <p>研究結果顯示，研究對象在交替介入期間，無論使用哪種行為策略，注意力維持時間皆高於基線期不使用任何介入策略的情境，並達六次成效複製，顯示兩者對於改善注意力的維持皆具有功能關係，其中，暫時移除偏好的教材刺激策略優於增加專注口語提示策略之成效，為該研究對象之最佳介入策略。</p> <p> </p><p>Attention function is a multi-facet concept that is critical for learning. Students with intellectual disability (ID) are often accompanied by problems such as attention deficit, which leads to difficulties in the learning process and affects academic performance and achievement. According to related studies, in order to improve attention and learning problems, two common behavioral strategies are: (a) using verbal prompt for on-task attention, and (b) removing preferred stimulus. However, there are few domestic studies that compare the effectiveness of behavioral strategies on attention, and there is also a lack of integrated application of multimedia video teaching materials. Therefore, this study aims to explore the impact of these two behavioral strategies on sustaining attention time when ID students with attention deficit learn multimedia animation video teaching materials, and to compare the effectiveness of the two strategies.</p> <p>This was a single subject research using alternating treatment design to compare the two behavioral-based strategies implemented by the student’s teacher in natural educational setting. It focuses on a participant who is studying in a self-contained special education class in an elementary school and has been medically diagnosed with intellectual disability and attention deficit. The research process is divided into baseline, intervention, and better intervention phases. The research data adopts visual analysis of single subject research method to explore the effectiveness.</p> <p>The results of the study showed that during the alternating intervention phases, no matter which behavioral strategies was used, the attention maintenance time of the research participant was higher than that of the baseline phases when no intervention strategy was used, and the effect was replicated six times, showing that both are effective in improving attention. There is a functional relationship between them. Among them, the strategy of temporarily removing the preferred teaching material stimulus is more effective than adding the strategy of focusing on verbal prompts, and is the best intervention strategy for this research participant. Social validity survey also indicated that teachers and parent were satisfied with the intervention outcome.</p> <p> </p>

Designing eco-evolutionary experiments for restoration projects: Opportunities and constraints revealed during stickleback introductions.

Eco-evolutionary experiments are typically conducted in semi-unnatural controlled settings, such as mesocosms;yet inferences about how evolution and ecology interact in the real world would surely benefit from experiments in natural uncontrolled settings. Opportunities for such experiments are rare but do arise in the context of restoration ecology-where different "types" of a given species can be introduced into different "replicate" locations. Designing such experiments requires wrestling with consequential questions. (Q1) Which specific "types" of a focal species should be introduced to the restoration location? (Q2) How many sources of each type should be used-and should they be mixed together? (Q3) Which specific source populations should be used? (Q4) Which type(s) or population(s) should be introduced into which restoration sites? We recently grappled with these questions when designing an eco-evolutionary experiment with threespine stickleback (Gasterosteus aculeatus) introduced into nine small lakes and ponds on the Kenai Peninsula in Alaska that required restoration. After considering the options at length, we decided to use benthic versus limnetic ecotypes (Q1) to create a mixed group of colonists from four source populations of each ecotype (Q2), where ecotypes were identified based on trophic morphology (Q3), and were then introduced into nine restoration lakes scaled by lake size (Q4). We hope that outlining the alternatives and resulting choices will makethe rationales clear for future studies leveraging our experiment, while also proving useful for investigators considering similar experiments in the future.

Plasmodium falciparum infection in humans and mosquitoes influence natural Anopheline biting behavior and transmission

The human infectious reservoir of Plasmodium falciparum is governed by transmission efficiency during vector-human contact and mosquito biting preferences. Understanding biting bias in a natural setting can help target interventions to interrupt transmission. In a 15-month cohort in western Kenya, we detected P. falciparum in indoor-resting Anopheles and human blood samples by qPCR and matched mosquito bloodmeals to cohort participants using short-tandem repeat genotyping. Using risk factor analyses and discrete choice models, we assessed mosquito biting behavior with respect to parasite transmission. Biting was highly unequal; 20% of people received 86% of bites. Biting rates were higher on males (biting rate ratio (BRR): 1.68; CI: 1.28–2.19), children 5–15 years (BRR: 1.49; CI: 1.13–1.98), and P. falciparum-infected individuals (BRR: 1.25; CI: 1.01–1.55). In aggregate, P. falciparum-infected school-age (5–15 years) boys accounted for 50% of bites potentially leading to onward transmission and had an entomological inoculation rate 6.4x higher than any other group. Additionally, infectious mosquitoes were nearly 3x more likely than non-infectious mosquitoes to bite P. falciparum-infected individuals (relative risk ratio 2.76, 95% CI 1.65–4.61). Thus, persistent P. falciparum transmission was characterized by disproportionate onward transmission from school-age boys and by the preference of infected mosquitoes to feed upon infected people.

Antimicrobial resistance in the wild: Insights from epigenetics.

Spreading of bacterial and fungal strains that are resistant to antimicrobials poses a serious threat to the well-being of humans, animals, and plants. Antimicrobial resistance has been mainly investigated in clinical settings. However, throughout their evolutionary history microorganisms in the wild have encountered antimicrobial substances, forcing them to evolve strategies to combat antimicrobial action. It is well known that many of these strategies are based on genetic mechanisms, but these do not fully explain important aspects of the antimicrobial response such as the rapid development of resistance, reversible phenotypes, and hetero-resistance. Consequently, attention has turned toward epigenetic pathways that may offer additional insights into antimicrobial mechanisms. The aim of this review is to explore the epigenetic mechanisms that confer antimicrobial resistance, focusing on those that might be relevant for resistance in the wild. First, we examine the presence of antimicrobials in natural settings. Then we describe the documented epigenetic mechanisms in bacteria and fungi associated with antimicrobial resistance and discuss innovative epigenetic editing techniques to establish causality in this context. Finally, we discuss the relevance of these epigenetic mechanisms on the evolutionary dynamics of antimicrobial resistance in the wild, emphasizing the critical role of priming in the adaptation process. We underscore the necessity of incorporating non-genetic mechanisms into our understanding of antimicrobial resistance evolution. These mechanisms offer invaluable insights into the dynamics of antimicrobial adaptation within natural ecosystems.

Challenges of Undular Jump Modelling

The study of open channel flow hydraulics extends beyond supercritical and subcritical flow states to include a distinct state known as near-critical flows. This category encompasses various hydraulic phenomena, with some of the most notable being solitary waves, cnoidal waves, and undular jumps. This paper specifically addresses the phenomenon of undular jumps, providing a brief overview of its characteristics and discussing instances of undular jump formation in natural rivers settings and during the operation of various hydraulic structures. When there is a sudden change in flow depth from a lower level to a higher one, it typically leads to a sudden increase in the water surface, known as a hydraulic jump. However, if the jump is relatively small, meaning the depth change is minor, the water does not rise noticeably and abruptly. Instead, it will traverse from the lower to the higher stage through a sequence of gradually diminishing undulations that extend over a considerable distance. Such phenomenon is called an undular jump.The occurrence of undular hydraulic jumps can be observed in various open channels such as irrigation and water supply channels, beneath vertical sluice gates, within estuaries during specific tide periods, and in narrow or shallow passages affected by strong currents. Additionally, this phenomenon often manifests downstream of low drop structures or in transitional zones from steep to gently sloping channels. In channels where undular jumps occur, waves with significant amplitudes develop and travel downstream of the jump. Accounting for the propagation of these downstream free-surface waves is essential for canal design and natural channel maintenance. The wave height serves as a crucial design parameter that dictates the necessary sidewall height of the canal. In natural channels, the embankment height must exceed the crest of the free-surface undulations to prevent overtopping and subsequent erosion, which could ultimately lead to bank destruction. Moreover, the propagation of free-surface waves may subject downstream canal structures, such as gates, locks, and weirs, to additional impact loads, perturbations, and vibrations.In recent years, different scientists have made various attempts to investigate and describe this phenomenon using physical, mathematical and computer modelling. However, this phenomenon has a number of peculiarities that are not always taken into account. An objective of this article is to present the particularities of different type of undular jump modelling and to compare the obtain results.

Long-term effectiveness and generality of practical functional assessment and skill-based treatment.

There are several considerations to address when conducting functional communication training for challenging behavior in a school setting, such as the need for schedule thinning and maintenance across staff and the need to establish a variety of appropriate classroom skills. There are several strategies for conducting schedule thinning following functional communication training and for transferring effects across people or settings. However, there are few examples of these processes in natural settings with relevant caregivers and with long-term maintenance of effects. We implemented a functional assessment and skill-based treatment process with six children with autism in a specialized school setting and extended treatment until challenging behavior was reduced to near-zero levels across multiple staff and settings. Follow-up data indicate that effects were still observed 1 year posttreatment and the use of crisis procedures (e.g., physical restraint) was eliminated for all participants.

Flexible-circuit-based 3-D aware modular optical brain imaging system for high-density measurements in natural settings.

Functional near-infrared spectroscopy (fNIRS) presents an opportunity to study human brains in everyday activities and environments. However, achieving robust measurements under such dynamic condition remains a significant challenge. The modular optical brain imaging (MOBI) system is designed to enhance optode-to-scalp coupling and provide real-time probe 3-D shape estimation to improve the use of fNIRS in everyday conditions. The MOBI system utilizes a bendable and lightweight modular circuit-board design to enhance probe conformity to head surfaces and comfort for long-term wearability. Combined with automatic module connection recognition, the built-in orientation sensors on each module can be used to estimate optode 3-D positions in real-time to enable advanced tomographic data analysis and motion tracking. Optical characterization of the MOBI detector reports a noise equivalence power (NEP) of 8.9 and 7.3 at 735 nm and 850 nm, respectively, with a dynamic range of 88 dB. The 3-D optode shape acquisition yields an average error of 4.2 mm across 25 optodes in a phantom test compared to positions acquired from a digitizer. Results for initial in vivo validations, including a cuff occlusion and a finger-tapping test, are also provided. To the best of our knowledge, the MOBI system is the first modular fNIRS system featuring fully flexible circuit boards. The self-organizing module sensor network and automatic 3-D optode position acquisition, combined with lightweight modules (18 g/module) and ergonomic designs, would greatly aid emerging explorations of brain function in naturalistic settings.

Maternal and neonatal outcome in pregnant women undergone induction of labor at Muhimbili National Hospital, Dar Es Salaam, Tanzania

IntroductionLabor induction is a common obstetric intervention aimed at initiating labor when spontaneous onset is delayed or deemed necessary for maternal or fetal well-being. Despite its widespread use, the practice’s impact on maternal and neonatal outcomes remains a subject of ongoing research and debate. This study aims to evaluate the maternal and neonatal outcomes associated with labor induction in a tertiary hospital setting in Tanzania.MethodologyA descriptive analytical cross-sectional study was conducted over a seven-month period from January 2021 to July 2021 at Muhimbili National Hospital in Dar es Salaam, Tanzania. A total of 120 pregnant women who underwent labor induction during this period were included in the analysis. Data on maternal demographics, obstetric characteristics, indications for induction, methods of induction, labor outcomes, and neonatal outcomes were collected from medical records and analyzed descriptively.ResultsAmong 4773 deliveries during the study period, 120 women underwent labor induction, accounting for 120 (2.5%) of all deliveries. The most common indications for induction were postdate pregnancy 60 (50%), hypertensive disorders of pregnancy 38 (31.7%), and premature rupture of membranes 22 (17.5%). The majority of induced women 74 (61.7%) delivered vaginally, with 46 (38.3%) undergoing cesarean section. Maternal complications were minimal, with the most common being failed induction of labor 17 (14.2%). Neonatal outcomes were generally positive, with 120 (100%) of neonates having Apgar scores of 7 or higher at five minutes, although 10 (8.3%) required admission to the neonatal ward for further care.ConclusionLabor induction at Muhimbili National Hospital demonstrated favorable maternal and neonatal outcomes, with low rates of maternal complications and positive neonatal Apgar scores. Postdate pregnancy emerged as the most common indication for induction. While the study highlights the benefits of labor induction, its retrospective nature and single-center setting limit the generalizability of findings. Prospective studies with larger sample sizes are warranted to validate these findings and inform evidence-based obstetric practices.

Transmission of Oyster Mushroom Spherical Virus to Progeny via Basidiospores and Horizontally to a New Host Pleurotus floridanus.

Mycoviruses are usually transmitted horizontally via hyphal anastomosis and vertically through sporulation in natural settings. Oyster mushroom spherical virus (OMSV) is a mycovirus that infects Pleurotus ostreatus, with horizontal transmission via hyphal anastomosis. However, whether OMSV can be vertically transmitted is unclear. This study aimed to investigate the transmission characteristics of OMSV to progeny via basidiospores and horizontally to a new host. A total of 37 single-basidiospore offspring were obtained from OMSV-infected P. ostreatus and Pleurotus pulmonarius for Western blot detection of OMSV. The OMSV-carrying rate among monokaryotic isolates was 19% in P. ostreatus and 44% in P. pulmonarius. Then, OMSV-free and OMSV-infected monokaryotic isolates were selected for hybridization with harvested dikaryotic progeny strains. Western blot analyses of the offspring revealed that the OMSV transmission efficiency was 50% in P. ostreatus and 75% in P. pulmonarius, indicating vertical transmission via sexual basidiospores. Furthermore, we observed the horizontal transfer of OMSV from P. pulmonarius to Pleurotus floridanus. OMSV infection in P. floridanus resulted in significant inhibition of mycelial growth and yield loss. This study was novel in reporting the vertical transmission of OMSV through basidiospores, and its infection and pathogenicity in a new host P. floridanus.

Rural Appalachian Adolescent Alcohol Misuse and the Triple Threat for Marginalization

Rural Appalachian adolescents are disproportionately affected by alcohol misuse, depression, and mortality rates. Disparities in Appalachia influence national health indicators and the social determinants of health, which may lead to marginalization and vulnerability to poorer health outcomes. Geographic and social isolation often results in missed opportunities for preventative and mental health care. There are an estimated 35% fewer mental health providers in rural areas to deal with these issues. This article examines the influence of marginalization on rural Appalachian adolescents. A case example was used to describe rural Appalachian adolescent alcohol misuse within the context of the Triple Threat for Marginalization, utilizing conversation within a natural setting. Marginalization contributes to alcohol misuse and adverse health outcomes. Nurses must advocate for marginalized rural adolescent patients to decrease alcohol misuse, depression, and mortality rates in this vulnerable population.

Sources, transmissionand hospital-associated outbreaks of nontuberculous mycobacteria: a review.

Nontuberculous mycobacteria (NTM) are widespread environmental organisms found in both natural and man-made settings, such as building plumbing, water distribution networks and hospital water systems. Their ubiquitous presence increases the risk of transmission, leading to a wide range of human infections, particularly in immunocompromised individuals. NTM primarily spreads through environmental exposures, such as inhaling aerosolized particles, ingesting contaminated food and introducing it into wounds. Hospital-associated outbreaks have been linked to contaminated medical devices and water systems. Furthermore, the rising global incidence, prevalence and isolation rates highlight the urgency of addressing NTM infections. Gaining a thorough insight into the sources and epidemiology of NTM infection is crucial for devising novel strategies to prevent and manage NTM transmission and infections.

Empirical uncertainty evaluation for the pose of a kinematic LiDAR-based multi-sensor system

Abstract Kinematic multi-sensor systems (MSS) describe their movements through six-degree-of-freedom trajectories, which are often evaluated primarily for accuracy. However, understanding their self-reported uncertainty is crucial, especially when operating in diverse environments like urban, industrial, or natural settings. This is important, so the following algorithms can provide correct and safe decisions, i.e. for autonomous driving. In the context of localization, light detection and ranging sensors (LiDARs) are widely applied for tasks such as generating, updating, and integrating information from maps supporting other sensors to estimate trajectories. However, popular low-cost LiDARs deviate from other geodetic sensors in their uncertainty modeling. This paper therefore demonstrates the uncertainty evaluation of a LiDAR-based MSS localizing itself using an inertial measurement unit (IMU) and matching LiDAR observations to a known map. The necessary steps for accomplishing the sensor data fusion in a novel Error State Kalman filter (ESKF) will be presented considering the influences of the sensor uncertainties and their combination. The results provide new insights into the impact of random and systematic deviations resulting from parameters and their uncertainties established in prior calibrations. The evaluation is done using the Mahalanobis distance to consider the deviations of the trajectory from the ground truth weighted by the self-reported uncertainty, and to evaluate the consistency in hypothesis testing. The evaluation is performed using a real data set obtained from an MSS consisting of a tactical grade IMU and a Velodyne Puck in combination with reference data by a Laser Tracker in a laboratory environment. The data set consists of measurements for calibrations and multiple kinematic experiments. In the first step, the data set is simulated based on the Laser Tracker measurements to provide a baseline for the results under assumed perfect corrections. In comparison, the results using a more realistic simulated data set and the real IMU and LiDAR measurements provide deviations about a factor of five higher leading to an inconsistent estimation. The results offer insights into the open challenges related to the assumptions for integrating low-cost LiDARs in MSSs.

Support Systems for children with disability in alternative care system in Ibadan Metropolis, Nigeria

Nigeria maintains residential homes as a form of alternative care for children with disability (CWD) despite its reversal in developed nations. This cross-sectional study profiled the nature of care for CWDs in alternative residential homes (ARHs) in Ibadan, Nigeria. The study administered 131 copies of a standardized questionnaire to CWDs, while eight interviews were conducted among staff of residential homes and regulatory bodies. The male (54.2%) population dominated the homes. Satisfaction in healthcare services (61%) and in quality of feeding (73%) were reported, while 32% CWDs expressed willingness to leave the residential homes for reasons of inadequate support structures. There was no significant relationship between respondents’ duration of stay and the likelihood of recommending residential homes as the best model for supporting CWD (P<0.05). Residential homes provided in-group solidarity and basic survival needs for CWDs, but lacked formal mechanisms for reporting and responding to abuses. Social workers can play a pivotal role in public sensitization to challenge the placing of CWDs in deficient ARHs and can also be at the forefront of advocating for social welfare programmes for parents of CWDs to enable the children to grow within their natural family settings.

Spatial interactions modulate tumor growth and immune infiltration.

Lenia, a cellular automata framework used in artificial life, provides a natural setting to implement mathematical models of cancer incorporating features such as morphogenesis, homeostasis, motility, reproduction, growth, stimuli response, evolvability, and adaptation. Historically, agent-based models of cancer progression have been constructed with rules that govern birth, death and migration, with attempts to map local rules to emergent global growth dynamics. In contrast, Lenia provides a flexible framework for considering a spectrum of local (cell-scale) to global (tumor-scale) dynamics by defining an interaction kernel governing density-dependent growth dynamics. Lenia can recapitulate a range of cancer model classifications including local or global, deterministic or stochastic, non-spatial or spatial, single or multi-population, and off or on-lattice. Lenia is subsequently used to develop data-informed models of 1) single-population growth dynamics, 2) multi-population cell-cell competition models, and 3) cell migration or chemotaxis. Mathematical modeling provides important mechanistic insights. First, short-range interaction kernels provide a mechanism for tumor cell survival under conditions with strong Allee effects. Next, we find that asymmetric interaction tumor-immune kernels lead to poor immune response. Finally, modeling recapitulates immune-ECM interactions where patterns of collagen formation provide immune protection, indicated by an emergent inverse relationship between disease stage and immune coverage.