National Research Research Articles

COLLABORATIVE GOVERNANCE MODEL IN INDONESIAN INNOVATION STARTUP PROGRAM: THE MASKIT STARTUP CASE STUDY

This study aims to identify, describe, and analyze collaborative governance models of public services in the Indonesian Innovation Startup (SII) program conducted by the Directorate of Technology-Based Start-ups, National Research and Innovation Agency (BRIN). This study uses the Integrative Framework for Collaborative Governance in realizing organizational goals. This concept is used in order to analyze the role of stakeholders in participating in realizing collaborative government governance in the implementation of the Indonesian Innovation Startup program. This research uses qualitative research with the case study method of the Maskit startup in the Indonesian Innovation Startup (SII) program. The data sources come from documents regarding the SII program and the concept of collaborative governance as well as interviews from various sources. The data are collected through interviews, observations, and documentation carried out by involving related parties, namely the program organizers (government), participants (startup companies), and incubators. The results of the study show that the collaborative governance process in the SII program followed by the Maskit startup, has generally implemented the concept of the Integrative Framework for Collaborative Governance. All elements within the framework, including principled engagement, shared motivation, and joint capacity, have been implemented by all stakeholders involved, namely BRIN as the organizer of the SII program, Maskit as the startup participating in SII, and University of Indonesia as the incubator. This research is expected to enrich academic studies on collaborative governance in the realm of public policy and can be used as a reference for those who wish to conduct similar research or create collaborative programs with elements of government, universities, SMEs, and various other relevant parties.

A novel machine learning based algorithm to predict 1-year mortality after ventricular tachycardia ablation

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): -Project no. NVKP_16-1–2016-0017 (’National Heart Program’) has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund of Hungary, financed under the NVKP_16 funding scheme. -Project no. MEC_R-141548 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the MEC_R_21 funding scheme. Background Catheter ablation constitutes an established therapeutic option in patients with monomorphic ventricular tachycardia (VT). VT patients have high comorbidity burden and high mortality, however there is big heterogenity among individual patients. Therefore, effective postprocedural risk assessment systems, prediciting the mortality of patients undergoing VT ablation are highly needed. Purpose We aimed to develop a risk stratification algorithm predicting the 1-year all-cause mortality of patients undergoing VT ablation, and to identify the most important input factors of the model. Methods Between 2005 and 2020, 272 consecutive patients underwent VT ablation due to sustained monomorphic VT at our institution. We processed their procedural, demographic and medical history data, in addition to their laboratory and echocardiographic findings. For the training of different supervised learning models, we used 63 pre-procedural and procedural variables. We performed 5-fold cross validation and calculated the area under the receiver operating characteristic (ROC) curve (AUC), to assess the performance of the models. Finally, with calculating Shapley values we determined the most important factors of the mortality prediction for the best performing model. Results After a follow up of one year, total all-cause mortality was 22% (59). In predicting 1-year mortality, the best performance was shown by the random forest model [AUC: 0,73 (0,68-0,78)] among the machine learning models we had trained. This model significantly outperformed the traditional score systems like I-VT [AUC: 0,63 (0,55-0,70) vs. 0,73 (0,68-0,78), p<0,001] and PAINESD [AUC: 0,63 (0,55-0,71) vs. 0,73 (0,68-0,78), p=0,009] in our dataset. The predictive factors with the biggest effect on mortality were mitral E wave deceleration time, presence of cardiac resynchronization therapy, age, electric storm and hemoglobin concentration. Conclusion We were able to establish a supervised machine learning based system which managed to predict the 1-year mortality of VT ablation patients with high accuracy and turned out to be superior when compared to the use of existing risk scores. This enables us to identify the patients in need of a more thorough follow-up, which could reduce their mortality.

Evaluation of electrocardiographic repolarization parameters in patients with polycystic ovary syndrome

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): National Research, Development and Innovation Office Introduction Polycystic ovary syndrome (PCOS) is a multifactorial, endocrine disease associated with metabolic disturbances (e.g. hyperinsulinemia, insulin resistance) and increased cardiovascular risk. Recent data strongly suggest that different QT variability parameters characterizing cardiac repolarization instability represent novel markers in proarrhythmic risk assessment. Purpose In the present study we investigated ECG repolarization parameters, including QT variability parameters in patients with polycystic ovary syndrome. Methods Fifty-five PCOS patients (age: 29±6 years) and 55 age-matched healthy volunteers (age: 29±10 years) were enrolled in the study. Five-minute 12-lead resting electrocardiograms were recorded, the ECGs were digitized and evaluated off-line using the Cardiosys-A01 system (Cardiosys-A01). The following parameters were determined: the frequency corrected QT interval (QTc) using Bazett’s, Fridericia, Framingham and the Hodges formulas; QT dispersion (QTd) and T wave peak-to-end distance (Tpeak-Tend). Among QT variability parameters we analyzed the QT variance (QTv), the QT variability index (QTVI), the short-term beat-to-beat QT and RR interval variability (STV-QT, STV-RR) based on constructed Poincaré plots and the variability ratio (VR). Results The RR interval did not differ significantly in PCOS patients compared to controls (821±129 ms vs. 847±99 ms), however the QT interval (373±30 ms vs. 391±27 ms, p<0.01), the QTc calculated with Bazett’s, Framingham, Fridericia and Hodges correction formulas (QTc Bazett’s: 413±18 ms vs. 426±21 ms, p<0.01) and the Tpeak-Tend intervals were significantly shorter (76±10 ms vs. 83±12 ms, p<0.01). The QTd, QTv, and STV-RR did not differ significantly. However, the VR (0.3±0.4 vs. 0.2±0.2, p<0.05), the QTVI (-0,9±0.5 vs. -1,3±0.4, p<0.001), and importantly, the STV-QT were significantly higher in PCOS patients compared to controls (4.0±0.9 ms vs. 3.2±0.9 ms, p<0.0001). Conclusion Some of the alterations in repolarization parameters and the significant increase in the short-term beat-to-beat QT interval variability and the QT variability index may indicate increased repolarization instability in patients with polycystic ovary syndrome compared to age-matched controls, however, further studies are needed to establish the exact relation of this finding to increased arrhythmia propensity in this population.

Pacemaker upgrade to Cardiac Resynchronization Therapy-defibrillator or Cardiac Resynchronization Therapy-pacemaker without prior ventricular arrhythmias

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): This work was supported by the ÚNKP-21-3-II-SE-47, ÚNKP-20-3-I-SE-43 New National Excellence Program if the Ministry for Innovation and Technology in Hungary. Project no. NVKP_16-1–2016-0017 (’National Heart Program’) has been implemented with the support provided by the National Research, Development and Innovation Fund of Hungary, funded under the NVKP_16 funding scheme. The research was financed by the Thematic Excellence Programme (2020-4.1.1.-TKP2020) of the Ministry for Innovation and Technology in Hungary, within the framework of the Therapeutic Development and Bioimaging thematic programmes of the Semmelweis University. This work was also supported by the Semmelweis 250+ Excellence PhD Scholarship (EFOP-3.6.3-VEKOP-16-2017-00009). Background Cardiac Resynchronization Therapy (CRT) can reverse the harmful effects of right ventricular pacing (RVP). Data are scarce on comparing long-term survival among patients who undergone CRT-defibrillator (CRT-D) or CRT-pacemaker (CRT-P) upgrade from pacemakers (PM) without prior ventricular arrhythmias (VAs). Purpose We compared the differences in long-term all-cause mortality among PM patients receiving CRT-D or CRT-P upgrade. Methods Patients with conventional PMs developing heart failure despite optimal medical treatment and a high rate of RVP with no prior VAs were included. Altogether 326 patients were investigated, 117 (36%) upgraded to CRT-D, 209 (64%) to CRT-P in our retrospective registry. The primary endpoint was all-cause mortality. Subgroup analyses were performed by comorbidities and CRT device types. Using topological data analysis, we identified risk groups based on the primary endpoint. Results During the median follow-up time of 3.6 years, 33 (28%) CRT-D and 145 (69%) of CRT-P upgrade patients reached the primary endpoint. The CRT-D upgrade group showed a lower risk of all-cause mortality in the total cohort (HR: 0.55; 95% CI: 0.38-0.81; p=0.002) and by ischaemic aetiology (HR: 0.47; 95% CI: 0.29-0.76; p=0.002) compared to CRT-P. After adjustment, CRT-D, male gender and loop diuretics proved as independent predictors of all-cause mortality. Patients upgraded with CRT-D demonstrated favourable survival in the high-risk group over CRT-P. Conclusions Patients had survival benefit after CRT-D upgrade, compared to CRT-P, in the high-risk group and with ischaemic heart failre aetiology. However, no difference could be observed between the two groups among low- and intermediate-risk patients.

Collaborative governance in handling covid-19 for elderly social services

In 2050, Indonesia will enter an ageing population of around 21.1% of the total population. Life expectancy has increased significantly despite having a high vulnerability to neglect due to elderly poverty in the COVID-19 pandemic. This condition encourages the need for inclusive service design to promote health and empower ageing in collaborative governance. In this paper, the author presents a study on how collaborative governance interventions in inclusive services for long-term elderly care in the COVID-19 pandemic. As a representation of national strategic research, this research uses research and development designs through interviews, observations, focus group discussions, analysis of elderly data documentation in 2021. The findings show collaborative governance in inclusive services during the COVID-19 pandemic can increase social resilience and empowerment of the elderly. Although, the elderly mortality rate during the COVID-19 pandemic is still high, there is a strengthening of stakeholder participation, social inclusion, and long-term policy support. So, the adoption of collaborative governance in inclusive services can improve the social welfare of the elderly in the long term care post-COVID-19. The implication is that it is necessary to strengthen the role capacity and participation of stakeholders at the local level based on social capital.

Mental health and the resources sector: findings from a research program to promote effective mental health solutions

This paper outlines a multifaceted national workplace mental health research program that incorporated assessment of individual level, work characteristics and organisational factors on mental health among workers in the resources sector within Australia and internationally. This multistep program included: identification of level of mental health and substance use problems in an Australian national study; examination of risk and protective factors (work roles, social networks and location); attitudes to seeking mental health assistance; organisational policies regarding mental health within a workplace health and safety framework; piloting a resources-specific workplace mental health program for team leaders and supervisors and a workplace suicide prevention program; and application of digital mental health interventions to this sector. Additional linked studies in New South Wales and Queensland in the resources sector assessed personal factors influencing perception of workplace physical risks and hazards, risk behaviours and opportunities for risk mitigation; and links between mental and physical health factors. A summary of the key findings are presented within the context of a program of research addressing mental health within remote settings in the resources sector. Mental health-related problems are highly prevalent among workers in remote resource settings, which has significant implications for workplace health and safety. Strategies to address prevention and effective intervention need to be tailored to the industry and employee characteristics, and address models of mental health care that are feasible and accessible in often remote and challenging environments.

Medullary astrocytes mediate irregular breathing patterns generation in chronic heart failure through purinergic P2X7 receptor signalling.

SummaryBackgroundBreathing disorders (BD) (apnoeas/hypopneas, periodic breathing) are highly prevalent in chronic heart failure (CHF) and are associated with altered central respiratory control. Ample evidence identifies the retrotrapezoid nucleus (RTN) as an important chemosensitivity region for ventilatory control and generation of BD in CHF, however little is known about the cellular mechanisms underlying the RTN/BD relationship. Within the RTN, astrocyte‐mediated purinergic signalling modulates respiration, but the potential contribution of RTN astrocytes to BD in CHF has not been explored.MethodsSelective neuron and/or astrocyte-targeted interventions using either optogenetic and chemogenetic manipulations in the RTN of CHF rats were used to unveil the contribution of the RTN on the development/maintenance of BD, the role played by astrocytes in BD and the molecular mechanism underpinning these alterations.FindingsWe showed that episodic photo-stimulation of RTN neurons triggered BD in healthy rats, and that RTN neurons ablation in CHF animals eliminates BD. Also, we found a reduction in astrocytes activity and ATP bioavailability within the RTN of CHF rats, and that chemogenetic restoration of normal RTN astrocyte activity and ATP levels improved breathing regularity in CHF. Importantly, P"X/ P2X7 receptor (P2X7r) expression was reduced in RTN astrocytes from CHF rats and viral vector-mediated delivery of human P2X7 P2X7r into astrocytes increases ATP bioavailability and abolished BD.InterpretationOur results support that RTN astrocytes play a pivotal role on BD generation and maintenance in the setting CHF by a mechanism encompassing P2X7r signalling.FundingThis study was funded by the National Research and Development Agency of Chile (ANID).

MO897: Diabetic Retinopathy and Risk of Macrovascular Complications in Patients Undergoing Hemodialysis: A National Population-Based Cohort Study

Abstract BACKGROUND AND AIMS The association of diabetic retinopathy (DR) with macrovascular complications in patients with end-stage kidney disease undergoing hemodialysis is unclear. METHOD We conducted a nationwide cohort study of 44 514 incident hemodialysis patients who were enrolled in Taiwan's national health insurance research database between 1 January 2010 and 31 December 2014 and had follow-up data until 31 December 2015. Patients with and without DR were matched by propensity score in a 1:1 ratio. The primary outcomes were acute coronary syndrome (ACS), acute ischemic stroke and hospitalizations for peripheral artery disease (PAD). RESULTS Of the 27 286 patients with type 2 diabetes, 10 537 (38.1%) had DR at baseline. We matched 9164 patients without DR (mean age, 63.7 years; 44.0% women) by propensity score to 9164 patients with DR (mean age, 63.5 years; 43.8% women). Over a median follow-up of 2.8 years, 2781 patients (15.2%) experienced ACS. Stroke occurred in 1613 patients (8.8%), and 1938 patients (10.6%) were hospitalized for PAD. In a multivariable Cox model accounting for the competing risk of death, the presence of DR was associated with an increased risk of stroke {subdistribution hazard ratio (sHR) 1.30 [95% confidence interval (95% CI) 1.17–1.44]; P < 0.0001} and PAD (sHR 1.17, 95% CI 1.08–1.29; P = 0.0006) but not ACS (sHR 0.99, 95% CI 0.91–1.07; P = 0.9168). The observations were consistent across patient subgroups. CONCLUSION Our findings support early identification and close monitoring and management of hemodialysis patients with DR to prevent the development of stroke and PAD.

Is Post-Burn Scarring a Research Priority?

National and international research budgets are insufficient to approve all requests for funding, even if a methodology is of high quality and the outputs are likely to have an impact on improving patient outcomes [...]

Occupational Health Center as a Novel Model of Health Care Organization in Tertiary Educational Setting.

The activity of the Occupational Health Center of the University of Miskolc was awarded the Best practice in Occupational Medicine by the European Network for Workplace Health Promotion in 2013. This study presents the model, which promotes multidisciplinary health service, combined with education and research as a novel element, and will outline its impact on national and international research.

An Analysis of GRU-LSTM Hybrid Deep Learning Models for Stock Price Prediction

Investment and national policy researchers are studying stock price forecasting, which has proven to be a challenging problem given the multi-noise, nonlinearity, high-frequency, and chaotic nature of stocks. Most forecasting models will not be successful in mining actual data from stocks if these characteristics are present. Stock pricing data has the characteristics of time series. It is evident from different studies that deep learning models perform better than machine learning models on time series data in particular. So, in this paper, we will focus on Long Short Term Memory (LSTM), Gated Recurrent Unit (GRU), and a hybrid model of them to predict the price of HDFCBANK stock. The first hidden layer is GRU and the other three hidden layers of LSTM. A hybrid model is validated using MSE, RMSE, and MAE and it outperforms all other models.

Study on the Physical Health Status of Preschool Children in China

From the survey results of children's health level in China in recent years, the health level of children's residents has been continuously improved, but compared with the health level of children in some developed countries, there is still room for improvement. In recent years, China has done a lot of research on children's physical health and accumulated rich experience, but there are still deficiencies in the research on preschool children's physical health; at the same time, there is still a lack of national relevant research on the index system of comprehensive evaluation of preschool children's physical health. Therefore, this study aims to make a preliminary review of the physical health of Chinese preschool children, put forward some problems found in the physical health evaluation, and provide a theoretical reference for better developing the physical health evaluation of preschool children in China in the future.

Penyederhanaan birokrasi di Kebun Raya Purwodadi BRIN

This study aims to analyze the simplification of the bureaucracy in the Purwodadi Botanical Gardens, National Research and Innovation Agency (BRIN). This study uses a qualitative approach. Data collection techniques were carried out by reviewing legislation, interviews, and observations. The data analysis technique used by the author in this research is interactive model analysis. Bureaucratic simplification is a mandate from the Regulation of the Minister for Empowerment of State Apparatus and Bureaucratic Reform of the Republic of Indonesia Number 25 of 2021 concerning Simplification of Organizational Structure in Government Agencies for Bureaucratic Simplification. Simplification of the bureaucracy aims to realize effective and efficient government governance by optimizing the use of an electronic-based government system. The implementation of bureaucratic simplification presents its problems and challenges, especially related to employee adaptation.

Surgical treatment of patients with lymph node involvement in recurrent ovarian cancer: immediate and long-term results

Objective: analysis of the immediate and long-term results of surgical treatment of patients with lymph node (Ln) involvement in recurrent ovarian cancer (OC), as well as the search for prognostic factors for progression-free survival (PfS) and overall survival (OS).Materials and methods. The retrospective analysis included patients under the age of 75 who underwent surgery for recurrence of OC with Ln involvement at n.n. Blokhin national medical Research Center of Oncology in the period from 2005 to 2020. All patients had previously received combined treatment due to a primary diagnosis of OC. Exclusion criteria: the presence of concomitant pathology in the decompensation phase, primary multiple malignant tumors and recurrences of non-epithelial ovarian tumors. The analysis of the main operational characteristics, the frequency of postoperative complications according to Clavien–Dindo within 30 days after surgery, PfS, OS, as well as parameters affecting the long-term results of treatment were performed.Results. The study included 123 patients: a cohort of isolated lesions of the Ln (n = 65) and a group of combined recurrence in the Ln and other anatomical locations (n = 58). The frequency of complete cytoreduction was significantly higher in the group of patients with isolated recurrence in the Ln: 86.62 % versus 53.4 % in patients with combined relapse, p <0.0001. The median duration of the operation was also significantly higher in patients with combined recurrence: 245 min versus 180 min in a cohort of patients with isolated recurrence in the Ln, p <0.0001. Postoperative complications of grade III B were more often observed in the group of combined recurrence: 6.8 % versus 1.5 % in the group of isolated recurrence in the Ln, p = 0.148. none of the patients in the group of isolated recurrence in the Ln had postoperative mortality, while in the group of combined recurrence 2 (3.4 %) patients died after surgery from developed complications. In patients with isolated recurrence in the Ln and combined recurrence of OC, the median PfS was significantly higher when complete cytoreduction was achieved: 31.0 months and 18.0 months versus 10.0 months and 9.0 months with incomplete repeated cytoreduction, p <0.0001. In patients with isolated recurrence in the Ln and combined recurrence of OC, the median OS was identically significantly higher when complete repeated cytoreduction was achieved: 97.0 months and 60.0 months versus 34.0 months and 27.0 months with incomplete cytoreduction, p <0.0001.Conclusion. Surgical treatment of recurrence of OC is justified only if it is possible to achieve complete cytoreduction and platinum-sensitive type of recurrence of OC. Low grade tumor, platinum-sensitive type of recurrence, absence of marker recurrence of OC, isolated recurrence in Ln, complete repeated cytoreduction and lymphodissection were identified as predictors of PfS in multivariate analysis. The following factors had an independent favorable effect on OS in multivariate analysis: low tumor grade, platinum-sensitive type of recurrence, satisfactory overall status on the ECOg scale (0–1 points) at the time of detection of relapse, isolated recurrence in the Ln and complete repeated cytoreduction.

Genome Profiling of SARS-CoV-2 in Indonesia, ASEAN and the Neighbouring East Asian Countries: Features, Challenges and Achievements

Whole-genome sequencing (WGS) has played a significant role in understanding the epidemiology and biology of SARS-CoV-2 virus. Here, we investigate the use of SARS-CoV-2 WGS in Southeast and East Asian countries as a genomic surveillance during the COVID-19 pandemic. Nottingham–Indonesia Collaboration for Clinical Research and Training (NICCRAT) initiative has facilitated collaboration between the University of Nottingham and a team in the Research Center for Biotechnology, National Research and Innovation Agency (BRIN), to carry out a small number of SARS-CoV-2 WGS in Indonesia using Oxford Nanopore Technology (ONT). Analyses of SARS- CoV-2 genomes deposited on GISAID reveal the importance of clinical and demographic metadata collection and the importance of open access and data sharing. Lineage and phylogenetic analyses of two periods defined by the Delta variant outbreak reveal that: (1) B.1.466.2 variants were the most predominant in Indonesia before the Delta variant outbreak, having a unique spike gene mutation N439K at more than 98% frequency, (2) Delta variants AY.23 sub-lineage took over after June 2021, and (3) the highest rate of virus transmissions between Indonesia and other countries was through interactions with Singapore and Japan, two neighbouring countries with a high degree of access and travels to and from Indonesia.

Trends in Homicide Hospitalization and Mortality in Taiwan, 1998-2015.

In Taiwan, the national research on homicide is rare, mostly discussing the issue of child abuse. We sought to better understand the characteristics and risk factors of homicide through a retrospective cohort study from 1998 to 2015. “Child battering and other maltreatment” ranked first for the 0–4 age group and second for the 5–14 age group. The hospital mortality was 511 deaths. We found that the 25–44 age group had the highest risk and accounted for 44.76% of hospitalization. The most common causes were “fight, brawl, and rape” (49.12%), “cutting and piercing instruments,” (13.16%) and “child battering and other forms of maltreatment” (4.72%). Additionally, the percentages of “fight, brawl, and rape,” “firearms and explosives,” and “cutting and piercing instruments” were significantly higher among males than among females. The percentages of “hanging and strangulation,” “corrosive or caustic substance,” “child battering and other maltreatment,” “submersion,” and “poisoning” were significantly higher among females than males. Factors associated with homicide in-hospital mortality included gender, age, low income, catastrophic disease, Charlson comorbidity index score, urbanization level, hospital level, classification of hospitalization, and surgery. Overall, the trend of hospitalization rates due to homicide decreased both by gender and age group, except for the 0–4 age group: cause of homicide first, hanging and strangulation second, firearms and explosives third; type of injury, hospitalized patients with “vascular injuries” first, joint and muscle sprain, and intracranial, chest, and abdominal pelvic injuries second, and “burns” third with a higher risk of death. Homicide reduction requires a comprehensive strategy beyond specific victim groups. Interagency collaboration should be strengthened, especially between law enforcement/criminal justice and public health.

Preface

The 3rd International Conference on Advanced Material and Clean Energy (ICAMCE 2022) was held on March 25-27, 2022 as a virtual conference due to the growing concerns over the coronavirus outbreak (COVID-19), and in order to protect the well-being of our attendees, partners, and staff as our number one priority. This conference mainly focused on the latest research on “Advanced Material and Clean Energy”. On the one hand, it mainly studied the conversion of hydrogen storage materials and clean energy to solve the problems of energy conversion, energy storage and functional materials. We warmly welcomed authors in relevant fields to submit their new research or technical contributions to ICAMCE 2022 and share their valuable experiences with scientists and scholars from all over the world. It provided a platform for experts and scholars in related fields, engineers and technicians, and technical R&D personnel to share scientific research achievements and cutting-edge technologies, understand academic development trends, broaden research ideas, strengthen academic research and discussion, and promote cooperation in the industrialization of academic achievements. The conference sincerely invites experts, scholars, business people and other relevant personnel from domestic and foreign universities, research institutions to participate in the exchange. This scientific event brings together more than 80 national and international researchers in advanced material and clean energy. On top of the local participants coming from different national universities, international participants are also registered from different countries, namely India, Ireland, Malaysia and Pakistan. During the conference, the conference model was divided into three sessions, including oral presentations, keynote speeches, and online Q&A discussion. In the first part, some scholars, whose submissions were selected as the excellent papers, were given about 5-10 minutes to perform their oral presentations one by one. Then in the second part, keynote speakers were each allocated 30-45 minutes to hold their speeches. In the second part, we invited three professors as our keynote speakers. Prof. Jianbin Zhou, Nanjing Forestry University of Material Science and Engineering College. His research field is the teaching, research and industrialization of biomass pyrolysis (energy) and carbon materials. And then we had Assoc. Prof. Maiyong Zhu, Jiangsu University, China. His research interest covers magnetic nanocatalysts, environmental treatment, metal organic frameworks and their derivatives as electrode for supercapacitors. Prof. Weimin Yang, our finale keynote speaker, from Beijing University of Chemical Technology. Their insightful speeches had triggered heated discussion in the third session of the conference. Every participant praised this conference for disseminating useful and insightful knowledge. The proceedings are a compilation of the accepted papers and represent an interesting outcome of the conference. Topics include but are not limited to the following areas: New Semiconductor Materials, Hydrogen Storage Materials, Superconductor, Material Testing, Processing and Characterization and more related topics. All the papers have been through rigorous review and process to meet the requirements of International publication standard. We would like to acknowledge all of those who supported ICAMCE 2022. The help and contribution of each individual and institution was instrumental in the success of the conference. In particular, we would like to thank the organizing committee for its valuable inputs in shaping the conference program and reviewing the submitted papers. The Committee of ICAMCE 2022 Committee member are available in the pdf

HSRPP 2022 Bath – Foreword

Welcome to the third virtual HSRPP conference in this 28th anniversary of the conference. We hope to provide you with an enjoyable and interesting conference. Little did we know when we were invited to host this conference that we would be unable to welcome you in-person to the lovely city of Bath. After much deliberation in Summer 2021, with too many unknowns due to the COVID-19 pandemic, we had to make the call to run the conference online. By October 2021 we doubted ourselves. As we write this in January 2022, with the Omicron wave upon us, it feels like it was probably the right decision. We do all of course hope that HSRPP 2023 can bring us all together again in-person, but until then, we hope you enjoy our online event.HSRPP 2022 continues to provide an environment for researchers and practitioners, both new and experienced, to come together to share research and exchange ideas. Our conference theme is ‘Delivering impact for patients and other stakeholders’. We chose this theme because we believe it is central to why most of us do health services and pharmacy practice research. The days are long gone when research could remain within the pages of academic journals. We need to be able to demonstrate to our patients, our funders and the public how we will turn our findings into something that improves care. We need to work with patients and the public to make sure our research is relevant to them and efficient in its spend of what is, very often, public money. In short, it is what gets us up in the morning and through the tough times of research, of which there are many!The COVID-19 pandemic has shown just how valuable pharmacists are, whether that be delivering vaccinations, caring for critically ill hospitalised patients or coping with the huge pressure that community colleagues have faced from the worried public. These contributions to the pandemic cause are of course on top of the ‘day job’. There is much learned and to be learned about how we move forward to deliver healthcare that is sustainable, patient-centred and fit for purpose. Research is the tool from which this learning comes.We are going to hear real world evidence under our conference theme from our three keynote speakers: Dr Barbara Farrell, a pharmacist with the Bruyère Continuing Care Geriatric Day Hospital, and Senior Investigator with the Bruyère Research Institute in Ottawa, Ontario, Canada, will discuss her research experience with engaging stakeholders and users to promote the uptake and impact of deprescribing guidelines. She will highlight how her research has influenced and contributed to change in how people approach deprescribing and what difference this has made. Professor Mahendra Patel, University of Bradford, is the national Pharmacy and Ethnic Minority Communities Research Lead with the PRINCIPLE trial, University of Oxford, the world’s largest randomized clinical trial investigating COVID-19 treatment in the community. He will talk to us about promoting inclusion and diversity in clinical trials, which is critical if trial results are to be meaningful and successful when implemented to bring about change. Mr Ade Williams, lead pharmacist and independent prescriber at the multi-award-winning Bedminster Pharmacy in Bristol will discuss how researchers can work with practising pharmacists to co-develop “real-life’’ impact programmes. He will also highlight how transformations in the NHS governance structure, Long Term Plan ambitions and COVID-19 legacy work are unique opportunities for community pharmacy to play a vital role. Mahendra and Ade were both recognised in the New Year Honours List 2022 for their outstanding contributions to Pharmacy.We would like to thank all those who have contributed to making HSRPP 2022 a success. They include those who have submitted abstracts, the conference steering committee, Pharmacy Research UK, our keynotes speakers, workshop leaders, session chairs and prize judges, our sponsor Day Lewis, our colleagues at University of Bath, and you – research presenters and conference delegates. We would like to offer our special thanks to our Vice Chancellor, Professor Ian White for welcoming delegates to our University. We sincerely hope you enjoy the conference, make the most of the chance to meet researchers from the UK and elsewhere, and leave feeling inspired and excited for new research possibilities that lie ahead. Jenny Scott and Matthew Jones, HSRPP 2022 Conference hosts

Biomarkers of iodine deficiency, methods of its prevention and treatment

The review article focuses on the issue of iodine deficiency, which is very common in the world and leads to a significant number of health problems, including mental, intellectual, thyroid, and non-thyroid in all age groups. Today, in most countries, the introduction of iodine prevention has resulted in more than 60% of the population overcoming iodine deficiency disorders, but the only category of the population even in these countries that still has such a deficit is pregnant and breastfeeding women. At this time, Ukraine has failed programs to provide the population with sufficient iodine, national research on this problem has not been conducted for several decades, so since 2021, on the maps of iodine status, Ukraine is already listed as a “white spot”. Therefore, iodine prevention is becoming a problem for the population of our country, every resident who wants to be healthy and have healthy offspring, must do it yourself. The best way to overcome iodine deficiency pathology is the daily use of a combination of iodine, selenium in WHO recommended and vitamin D in individual doses, constantly throughout the year with periodic laboratory monitoring of TSH (a marker of thyroid function, including screening), thyroglobulin as an individual marker iodine deficiency, and vitamin D, a marker of wealth, which determines the state of the musculoskeletal and parathyroid systems. Several studies have shown that the use of excessive doses of iodine can increase the development of thyroid pathology, but not all of them have a perfect design that takes into account other factors of such pathology. Today in Ukraine, there is a drug that contains a combination of iodine (150 mcg) and selenium (75 mcg) for adults. This safe ratio in the recommended doses for people aged over 12 years is the most optimal for the prevention and treatment of iodine deficiency pathology and conditions, is well established, popular among physicians and patients. Its simultaneous and long-term use with vitamin D preparations in individual doses over the years with periodic monitoring of laboratory parameters and ultrasound examination of the thyroid gland allows achieving in most cases these medical goals and objectives.

Institutionally Embedded Professionals’ Perspectives on Knowledge Mobilization: Findings from a Developmental Evaluation

Intentional efforts to advance the societal impacts of research are known as knowledge mobilization (KMb). Despite increas-ing pressure on researchers and higher education institutions (HEIs) to engage in KMb activities, capacity building in this area is constrained by a limited understanding of the role of HEIs from the perspective of embedded KMb professionals. This study presents findings from a developmental evaluation of Research Impact Canada’s efforts to build institutional capacity for KMb. Through semi-structured interviews (n = 20) with KMb professionals from 15 Canadian HEIs, we share (a) approaches for how KMb professionals can thrive in institutional environments, and (b) essential questions about KMb for the higher edu-cation sector. From that basis, we discuss how there is a need for skilled KMb professionals within HEIs and a need for (inter)national research and practice collaborations.