The purpose of this study is to verify the moderating effect of P-O fit and flight characteristics in the relationship between an airline"s safety climate and cabin crew’s safety behaviors. To meet that purpose, empirical data were gathered from a survey of national and non-national airline`s cabin crew. The analysis of the airline`s safety climate from the cabin crew’s perspective was carried out first, and five factors were derived: management value, supervision, safety rule/system, training/education, communication. Secondly, the analysis showed that the safety climate had a significant influence on the safety behaviors. In addition, the hypothesis of an influential relationship between the safety climate and safety behaviors was accepted. Thirdly, the moderating effect of P-O fit and flight characteristic between safety climate and safety behaviors was verified as the sub-factor communication was found to have significant influence on safety behaviors. Finally, the conclusions drawn from this study indicated that the safety climate in the airline should be re-examined from the cabin crew’s perspective to enhance in-flight safety behaviors and ultimately motivate the cabin crew to be more safety-oriented.