Nasobronchial Allergy Research Articles

Distributive pattern of aero-allergen sensitivity among patients with naso-bronchial allergy in a tertiary care center of North India

Distributive pattern of aero-allergen sensitivity among patients with naso-bronchial allergy in a tertiary care center of North India

A Study of Skin Sensitivity for Common Allergens in Patients of Nasobronchial Allergy in North India

A Study of Skin Sensitivity for Common Allergens in Patients of Nasobronchial Allergy in North India

Aeroallergen Sensitivity in Subjects with Nasobronchial Allergy: Contemporary Trends in Kerala

Aeroallergen Sensitivity in Subjects with Nasobronchial Allergy: Contemporary Trends in Kerala

M114 SEVEN CASES OF LTP SYNDROME FROM FOODS RELATED TO PROSOPIS JULIFLORA & HALOPTELEA INTERGRIFOLIA SENSITIZATION

We report a case series of seven patients of non-specific Lipid Transfer Protein (nsLTP) syndrome in whom the history of Urticaria, Angioedema and Anaphylaxis was induced by ingested foods like nuts, lentils and citrus foods within 30 minutes with signs & symptoms of Naso-bronchial allergy due to sensitization to tree pollen (Prosopis juliflora and Haloptelea intergrifolia). Our diagnosis of LTP Syndrome (Urticaria, Angioedema and Anaphylaxis) was due to cross reactivity of ns-LTP with peanut (Ara h 9), walnut (Jug r 3), lentils-Len c 3, citrus foods (lemon-Cit i 3 and orange-Cit s 3) and sensitization due to Prosopis juliflora and Haloptelea intergrifolia with co-factor.

Common allergens causing Naso bronchial allergy in patients attending a tertiary care centre in South India

Introduction: Patients who seek medical care because of the symptoms of naso bronchial allergies are increasing. The distribution of allergens and its effect on the population differs in different parts of India. For the management and effective treatment of allergen induced respiratory illnesses, it is very important to find out the specific allergens responsible. To determine the common allergens causing naso-bronchial allergy in atopic patients. Materials and Methods: Atopic patients who attended a tertiary care centre as outpatients for an year with symptoms of naso-bronchial allergy for more than a year who were not responding to regular medications were selected for the study after taking a detailed history. An intradermal allergy test was done in the volar aspect of the patients arm and forearm with antigens of the common allergens prevalent in south India. Results: Out of 51patients tested by 39 allergens, 47 persons turned positive for at least one antigen. Among pollen antigens, Acacia species showed highest number of positive reactions. Among dust, house dust and wheat dust showed higher positivity. Among antigens of animal origin, house fly was highest and among fungal origin, Aspergillus fumigatius showed high positivity. Conclusion: The commonest antigen identified was that of house dust followed by house fly.

Correlation between Total Serum Immunoglobulin E (IgE) and Absolute Eosinophil Count (AEC) in Allergic Diseases In Children

Allergy, is a clinical expression of soluble factors like IgE, histamine or eosinophils found in serum or plasma of such patients. The products that are responsible for allergy are called as Allergens. Allergens normally induce IgE production which leads to type 1 hypersensitivity response on subsequent exposure to the same allergen. The target organs are mostly nose, lung, skin and gastrointestinal tract. Atopy is also considered as a triad of Atopic dermatitis, allergic rhinitis and bronchial asthma. Raised serum IgE and AEC are proven indicators of allergic phenomenon. Various studies show relationship between serum Immunoglobulin E level and total eosinophil count in population suffering from allergic diseases. Serum total Immunoglobulin E, total eosinophil count and specific IgE are all helpful for the diagnosis and treatment of allergic diseases. Objectives: 1.To Evaluate Serum Total IgE level in Children with allergic diseases.2. To Evaluate Absolute Eosinophil Count (AEC) in children with allergic diseases.3. To Correlate Serum Total Immunoglobulin E Level and Absolute Eosinophil Count (AEC) with allergic diseases. Methodology: Cross sectional study with 100 children in the age group 2-12 years with nasopharyngeal allergies (like bronchial asthma and atopic rhinitis) and skin allergies (like atopic dermatitis, urticaria) ,eye allergies were enrolled and serum IgE levels and AEC levels was done. Results: In present study Absolute eosinophil count was raised in 58% of cases Serum IgE was raised in 54% of cases. In present study, of 58% cases with raised Absolute eosinophil count 81% (47 cases) showed raised serum IgE levels. Conclusion: Absolute eosinophil count and serum Total IgE has been considered as a significant marker of allergic state and can be used as a marker of allergic response in atopic individuals. Raised serum IgE and AEC are more in nasobronchial allergy as compare to other systemic allergies. The elevated level of serum Total IgE and Absolute Eosinophil Count both shows Significant Correlation thus can be considered as a dependable laboratory investigation in diagnosing and categorizing allergic diseases.

Allergic sensitization in nasobronchial allergy patients and its correlation with total immunoglobulin E level

INTRODUCTION: Bronchial asthma (BA) and allergic rhinitis (AR) are immunoglobulin (Ig) E-mediated hypersensitivity phenomena. The objective of the study is to assess the association between total serum IgE level and skin prick test (SPT) in Indian patients who presented with different nasobronchial allergy symptoms. MATERIALS AND METHODS: This was an observational prospective study conducted in the Allergy and Asthma Clinic, Motihari, Bihar. A total of 183 patients diagnosed as BA and AR undergo SPT against different allergens between January 2017 and July 2018. Serum total IgE was measured in all patients. All statistical analyses were performed using statistical software SPSS version 20 (SPSS Inc., Chicago, IL, USA). P RESULTS: The study patients included 95 males and 88 females (total 183) with a mean age of 27.15 ± 12.64 years. SPT was positive in 99 out of 183 (54.09%) study patients. BA and AR were associated with skin sensitization in 30.60% and 15.30% of patients, respectively, while 54.09% of patients were associated with both AR and asthma. Forty-four out of 99 (44.44%) patients were sensitized to single allergen, while 40.40% and 15.15% of patients were sensitized to 2–5 allergens and >5 allergens, respectively. Except 11 patients, all the study patients had high total IgE level (>150 IU/ml). More than half of the study patients (51.36%) were associated with more than 1000 serum total IgE level. Total IgE level was not affected with the number of allergen sensitization. SPT-positive patients had higher IgE value than SPT-negative patients but statistically not significant (P > 0.05), and there was also poor correlation between SPT result and serum total IgE level (r = 0.102). CONCLUSION: SPT should be performed in all clinical allergic patients irrespective of serum total IgE level.

A study of skin prick test sensitivity to common allergens in patients of nasobronchial allergy

BACKGROUND: Nasobronchial allergy accounts for a significant burden of allergy all over the world. The prevalence of nasobronchial allergy is increasing, so we conducted an observational study of common allergens by skin prick test (SPT) method in this group of patients.OBJECTIVE: The objective is to study skin sensitivity to various allergens in patients of nasobronchial allergy, using SPT method.MATERIALS AND METHODS: A total of 6000 SPTs were done using 60 allergens on 100 patients of nasobronchial allergy.RESULTS: Males were the predominant group of patients, and nasobronchial allergy was most common in 21–30 years' age group in our study. Among various groups of allergens studied, insects (24%) were the most common offending allergens, followed by dust mite (20%), airborne dust (11.3%), pollens (7.75%), fungi (6%), dander (6%), silk (4%), juicy foods (2.4%), and nonjuicy foods (2.25%). Among insects, moth (30) was the common allergen. Among dust, grain dust (30) was the common allergen. Among pollens, Cassia siamea (20) was most common. Aspergillus fumigatus (16) was the most common fungus to which sensitivity was elicited. Among miscellaneous foods (juicy and nonjuicy), milk, almonds, and cashew nut (4 each) were the common allergens.CONCLUSION: Skin prick testing forms an essential part of a comprehensive approach for allergy remediation. Our study determined skin sensitivity to various allergens for avoidance therapy and immunotherapy in affected patients. Allergy to insects as found in our study to be most common is likely because of prevailing poor sanitation and overcrowded dwellings in the Indian milieu.

Pollen and spores in yellow rain from Lucknow, northern India

ABSTRACTThis paper presents the results of pollen and spore concentration of yellow drops in the Lucknow environs during the summer of 2014. The yellow spots were procured from the surface of a number of leaves and other objects from three different localities of Lucknow District of Uttar Pradesh. The size and shapes of these spots vary, ranging from linear to circular. Pollen grains recovered in good frequencies chiefly belong to angiosperms, whereas some gymnosperm pollen was also observed in trace frequencies. Other microbiota include fern spores, fungal remains and insect body parts in lower values. The study broadly suggests that palynomorphs recovered from yellow droppings are not fully airborne; rather, they are the types that honey bees gather from crop fields to feed their young. Brassica campestris and Asteroideae are the dominant plant taxa recorded in yellow rain samples. On investigation, it was noticed that yellow drop falling occurred for a few minutes on limited days during the summer of 2014, when the atmosphere experienced optimal temperature conditions with relatively humid environs. The observation also confirms that the yellow spots are nothing but faecal droppings, as suggested by the bee faeces theory which proposed that the origin of yellow rain is a phenomenon of nature. The study, in addition to aiding in understanding yellow rain occurrence, could also be helpful in aerobiological research, especially in examining the allergenicity of various pollen grains/spores in the area of investigation, causing bronchial asthma, hay fever (allergic rhinitis/pollinosis), nasobronchial allergy and other respiratory disorders along with conjunctivitis, contact dermatitis, eczema, food allergies and other health ailments. A multivariate principal component analysis (PCA) was applied to quantified data obtained from pollen frequency analyses of different areas of Lucknow, which clearly revealed a significant group variation in vegetation type on the basis of dispersal and deposition of pollen in yellow spots.

Pattern of Intradermal Antigen Sensitivity in Patients with Nasobronchial Allergy in a Tertiary Care Centre in South Kerala

Pattern of Intradermal Antigen Sensitivity in Patients with Nasobronchial Allergy in a Tertiary Care Centre in South Kerala

Effectiveness of selected Yoga postures and procedures for improvement in pulmonary functions in 8-14 year old children of Nasobronchial allergy

Introduction: Yoga postures can be effective way to regularize immune functions. Nasobronchial allergy appears when immune mechanisms go haywire and start behaving autonomously. Yoga has been used in many centers in India to cure asthma and other allergic ailments. This systematic prospective control trial study was done on school going children of Amritsar District., India. Material & Methods: Study done on 150 school going 8-14 year old children taken from Paediatrics ward of GND hospital, Amritsar. 75 children were included in study group and another 75 children were taken as controls. Both study and control group was further divided into three groups each. Sub-group-A- Allergic Rhinitis, Sub-group-B- Bronchial Asthma, Sub-group-C- Allergic Rhinitis and Bronchial Asthma both. Study group were taught certain Yoga postures like Virassna, Stupassna etc. and were followed for 6-12 weeks and results were recorded at 0, 6 and 12 weeks. Pulmonary functions tests were done on computerized spirometer. Results: In sub-group A and B highly significant (p<0.001) results were seen in study group in terms of improvements in FVC, FEV1and PEFR as compared to control group. Conclusion: Yoga postures and its variant breathing exercises can effectively improve pulmonary functions and modulate immune functions for cure of allergy.

Polysensitization to Aeroallergens in Patients with Nasobronchial Allergy in Kashmir Valley

Polysensitization to Aeroallergens in Patients with Nasobronchial Allergy in Kashmir Valley

Pollen analysis of spider web samples from Korba District, Chhattisgarh (central India): an aerobiological aspect

Pollen analyses of spider web samples, collected from the recently planted Tectona grandis (T. grandis, teak)-dominated tropical deciduous forest of Bhulsidih Village, Korba District (Chhattisgarh, central India), shed light on the relationship between the extant vegetation and pollen rain. The study revealed the dominance of pollen of herbs and trees, whereas shrubs, fern spores and algal remains are meagre. Among the tree taxa, Sapotaceae, Syzygium, Holoptelea, Lannea coromandelica, Shorea robusta and Grewia are dominating with moderate to low and intermittent presence of Madhuca indica, Terminalia, Mitragyna, Schleichera, Anacardiaceae, Diospyros, Emblica officinalis and Flacourtia. However, the rest of the forest constituents are either not represented at all despite their presence in the floristics, which could be attributed to their low pollen productivity owing to entomophily as well as their poor pollen preservation pattern. On the other hand, the ground vegetation is represented by the very high frequency of grasses (Poaceae) along with Tubuliflorae, Chenopodiaceae/Amaranthaceae and Cerealia, however, Artemisia, Xanthium, Malvaceae, Caryophyllaceae and Justicia in moderate to lower values. Ferns, which occur abundantly along the adjoining stream banks, are marked by the sporadic retrieval of trilete spores that could be ascribed to the prevailing damp condition around the sampling provenance. The study, in addition to understanding the pollen–vegetation relationship, could also be helpful in aerobiological study, especially in assessing the allergenicity of various pollen grains/spores in the area of investigation, causing bronchial asthma, hay fever (allergic rhinitis/pollinosis), naso-bronchial allergy and other respiratory disorders along with conjunctivitis, contact dermatitis, eczema, food allergies and other health disorders.

An unusual case of a very large Ameloblastic fibroma

Background: Prevalence of nasobronchial allergy is increasing globally. Several genetic, environmental and other associated factors are responsible for this increase. This study is designed to investigate profile of different allergens sensitivities and associated factors involved in the prevalence of naso-bronchial allergy. Methods: 4312 skin prick tests with 77 allergens in 56 patients of nasobronchial allergy were studied using parameters like age, temporal association between asthma and allergic rhinitis, most common type of allergens, age of onset, sex, residence and family history of atopy. Results: It was found that the age groups 12-40 years are more prone to nasobronchial allergy. 75% patients have shown temporal association between asthma and allergic rhinitis. Most common offending allergens were insects (33.3%), followed by pollens (30.3%), fungi (13.6%), dust (8.3%), non-juicy foods (6.8%), juicy foods (4.16%) and dander (3.03%). Males have shown more prevalence of nasobronchial allergy than that of the females. 32% patients have shown genetic disposition. Conclusions: Overall, this study unravels different associated factors and profile of allergens in patients’ of nasobronchial allergy which will be helpful in diagnosis, management and treatment of asthma.

Hypersensitivity to aeroallergens in patients with nasobronchial allergy.

ABSTRACTBackground:Aeroallergens are the most common causes of allergy.Aim:The aim of this study was to determine hypersensitivity to aeroallergens in patients with nasobronchial allergy. Methods:This retrospective population study included 2254 patients with nasobronchial allergy, from late adolescents to adults. Their response to aeroallergens was assessed by skin prick tests.Results:More patients had rhinitis (72.7%), than asthma (27.6%). Although majority of patients were female, allergy is more common in men than in women (p<0.05). Both groups of patients had the greatest number of positive skin prick tests for Dermatophagoides pteronyssinus (27.5%) and weed pollens (21.9%), followed by grass (18.3%) and tree pollens (10.1%). Ragweed is the most common positive weed pollen in both groups, more in patients with rhinitis (p=0.022). The cocksfoot is the most common grass pollen in rhinitis group (15.3%), but meadow grass (12.6%) in asthma patients. Birch is the most common tree allergen in the both groups.Conclusions:More patients with nasobronchial allergy have rhinitis than asthma. Skin prick tests are usually positive for Dermatophagoides pteronyssinus and weed pollens, followed by grass and tree pollens, and they are more common positive in patients with rhinitis than asthma.

Different types of aero-allergens causing nasobronchial allergy in District Kupwara of Jammu and Kashmir State -India

Nasobronchial allergy is one important type of respiratory disorder. Aero allergens like pollen, dust, fungus, dander and many others play important role in nasobronchial allergies particularly in asthma and rhinitis. The prevalence of nasobronchial allergy among populations all over the world has been increasing rapidly. The role of different inhalant allergens in nasobronchial allergy varies with environmental conditions, type of allergen and degree of exposure. The awareness on the prevalence of allergens and seasonal variations is essential for better diagnosis and immunotherapy. The present study was aimed to assess the prevalence of fungal, pollen and dust allergens by intradermal skin test in nasobronchial allergenic patients in district Kupwara of Jammu and Kashmir State. Key words: Allergens, nasobronchial allergy, intradermal skin test, immunoglobulin-E.

221 Allergenic Significance of Airborne Rhizopus Stolonifer (ehrenb.) Vuill, a Common Bread Mold

BackgroundAirborne fungi, a significant constituent of atmospheric bioaerosol, are well-known source of allergens and can cause allergic rhinitis and bronchial asthma in sensitive subjects. Rhizopus stolonifer, the filamentous fungus is a widely distributed thread-like Mucoralean mold. Commonly found on bread surfaces, it takes food and nutrients from the bread and causes damage to the surface where it lives. Although a significant exposure risk is assumable in indoor environment, the role of this fungus in provoking allergic symptoms in pre-sensitized individuals, however, was poorly investigated. We conducted this study to monitor airborne R. stolonifer and to evaluate its potential as an aeroallergen causing nasobronchial allergy in sensitized individuals.MethodsSeasonal periodicity of R. stolonifer was studied for 2 years (March, 2009-Feb.11) by Andersen air sampler. The relationships between meteorological parameters and airborne R. stolonifer concentration were explored by linear regression models. The allergic potential of R. stolonifer extract was studied on 389 respiratory allergic patients by performing skin prick tests (SPT) and measuring the allergen-specific IgE levels in SPT positive patient's sera by Enzyme-linked Immunosorbent Assay. SDS-PAGE and immunoblotting with pooled patient sera were performed to identify its IgE-binding components.ResultsAirborne R. stolonifer concentration range was 4 to 47 CFU/m3 and reached the peak concentration in March. Relative humidity was found to be a significant predictor for occurrence of R. stolonifer in air. Positive skin reaction was observed in 105 patients (27%) including 10 (9.5%) showing markedly high (2+ to 3+) skin sensitization. Crude antigenic extract of R. stolonifer was resolved in 16 protein bands in the molecular weight range of 12 to 72 kDa on SDS-PAGE (12% gel). Three IgE-binding protein bands (17, 21and 67.12 kDa) were detected by immunoblot analysis.ConclusionsExposures to R. stolonifer in environments where it naturally occurs may confer risk of IgE-mediated sensitization in sensitive individuals.

Prevalance of skin reactivity to fungal antigens in patients of nasobronchial allergy of Jalandhar and neighbouring area in Punjab

Atmospheric allergens play an important role in the pathogenesis of naso-bronchial allergy. It is important to know the prevalence of allergens in one's area.for proper diagnosis and effective management The data of positive reaction to fungi on 1500 patients of nasobronchial allergy has been included in this study. Allergy test (skin testing with intradermal injection of antigen) was conducted on patients and the results were interpreted by comparing the wheal produced by the test substance in relation to the control. While analyzing the results 60 patients were excluded because of (±) or one plus (+) cutaneous reaction to fungal antigens. Topping the list, cladosporium was positive in 158 patients (11%) followed by Alternaria tenuis in 144 (10%), Curvularia lunata in 108 (75%), Helminthosporium sp. in 115 (8%). Moderate positives were Rhizopus nigricans in 92 (6.4%) patients, Candida albicans in 86 (6%), Aspergillus fumigatus in 86 (6%), Mucor mucedo in 83 (5.8%), Aspergillus niger in 81 (5.6%), Phoma batae 79 patients (5.5%), Aspergillus tamarii 72 (5.5%), Trichoderma 72 (5%). The low positives were Penicillium in 50 patients(3.5%), Aspergillus flavus 43 (3%), Nigerospora 41 (2.5%), Neurospora sitophila 41 (2.5%), Epicoccum purpurascens 31 (22%), Aspergillus versicolor 30 (2%) and Fusarium solani 28 (2%) patients. Information about fungal antigen positivity is being provided in the present article, which would serve as a reference to the physicians dealing with allergy patients as well as those studying environmental sciences.

Skin Prick Testing and Immunotherapy in Nasobronchial Allergy: Our Experience

In the present study of 331 patients suffering from signs/symptoms of nasal allergy, 9 nasal polyps, allergic conjunctivitis and allergic asthma, who were referred by clinician, were taken up for diagnosis of allergy with skin prick test (Ten et al. Mayo Clin Proc 70(8):783-784, 1995) and subjective improvement of patients by immunotherapy. Out of 331 patients tested 321 patients showed significant positive results and rest of them tested negative for allergy. High incidences of positive results were noted in third and fourth decade age of patients. Dust and pollen allergens were positive in most of the patients compare to insect's antigens. Among the pollen antigens tested, those of Parthenium hysterophorus was found to be the most common (30%) followed by Prosopis julifora (25%). 75.22% patients were positive to house dust, 19.33% patients were positive to Aspergillusmoulds. D. farinae was the most common offender amongst the mites. Patients who attended, allergy clinic in Kamineni Hospitals during the last 4years were referral patients, who had been on prolonged treatment without much relief. Immunotherapy was advised to patients who were having perineal allergy, in whom, medical treatment had become only palliative. Immunotherapy injections were administered subcutaneously, and their results were monitored.

A study of skin sensitivity to various allergens by skin prick test in patients of nasobronchial allergy.

Objective:To study skin sensitivity to various allergens in patients of nasobronchial allergy.Materials and Methods:2880 skin prick tests with 60 allergens were performed in 48 patients of nasobronchial allergy.Results:Most common offending allergens were insects (21.2%), followed by dusts (12.0%), pollens (7.8%), animal dander (3.1%), and fungi (1.3%). The common insect antigen were locust female (33.3%) followed by locust male (25%), grasshopper (20.8%), cricket (16.7%), cockroach female (16.7%) and cockroach male (14.6%). Common dust allergens were house dust, wheat dust, cotton mill and paper dust. Among pollens, Amaranthus spinosus, Argemone mexicana, Adhatoda vasica, Ailanthus and Cannabis were found to be common allergens. In animal danders common offending allergens were cow dander and dog dander. Among fungi Aspergillus fumigatus, Aspergillus flavus, Alternaria teneis and Fusarium sodani were common allergens. Patients of bronchial asthma had associated allergic rhinitis in 80% cases.Conclusion:Common allergens in patients of nasobronchial allergy were identified. The data may prove useful in of allergen avoidance and immunotherapy in these patients.