An experimental and numerical study of the nanosecond electrical explosion dynamics of bare and dielectric coated metallic wires in vacuum is reported. A table top Z-pinch generator down-tuned to generate a peak current of 40 kA with a rise time of 60 ns is implemented for the experiments in the skin effect mode. Optical probing diagnostics as well as multiphysics–multiphase simulations are used to study the spatiotemporal dynamics of the exploded wire from the solid to the plasma phase. The results show that the inclusion of the dielectric coating mitigates the electro–thermo–mechanical instability growth developed prior to plasma formation, which results in a subsequent reduced magnetohydrodynamic instability growth in the plasma phase. The study offers valuable insights into the understanding of the seeding mechanisms for the generation of plasma instabilities and the efforts for their growth rate suppression.