Wetting and evaporation characteristics of sessile nanofluid nanodroplet (SNFND) were investigated by molecular dynamics simulation. Results show that for lyophilic surface, with the increase of nanoparticle energy coefficient, contact angle of SNFND increases and total evaporation decreases. Effects of nanoparticle volume percentage on the wetting and evaporation behaviors of SNFND are related to surface wettability. For lyophilic surface, the greater the nanoparticle volume percentage, the greater the contact angle, and the slower the evaporation. For neutral and lyophobic surfaces, nanoparticle volume percentage has obviously strengthening effect on evaporation, and the strengthening effect decreases as nanoparticle volume percentage increases.