Aggregation Of Nanoparticles Research Articles

Timescale dependent homogeneous assembly of lipid-polymer hybrid nanoparticles in laminar mixing for enhanced lung cancer treatment

The homogeneity of core–shell structure lipid-polymer hybrid nanoparticles (HNPs) is crucial for efficient intracellular cargo delivery. While microfluidic techniques have been recognized for their capabilities in precisely controlling the size and drug encapsulation efficiency, there is little research exploring the impact of mass transfer behavior within microchannels on the homogeneous assembly process of HNPs. Here, we manipulated the laminar flow state within TrM device to achieve controlled assembly of HNPs and explored a timescale dependent assembly technique to ensure the homogeneity of folate modified HNPs (FHNPs). Our founding indicate that this method enabled the control over the growth kinetics of PLGA cores within a timescale (τgrow) of 1–15 ms. The homogeneous ligand assembly on the surface of FHNPs can only be achieved when τgrow exceeds the timescale of functional lipid coating (τcoating). Compared to conventional bulk mixing methods, this strategy significantly reduces the risk of heterogeneous assembly in FHNPs fabrication and ensures consistent reproducibility across batches. The homogeneous FHNPs (HFHNPs) fabricated through this method exhibit precise control over particle size (ranging from 75 nm to 150 nm), low polydispersity index, and consistent core–shell structure. Furthermore, this strategy enhances the density of available folate ligands on the surface of FHNPs. In subsequent in vitro and in vivo anti-tumor assays, the icariside Ⅱ (IS) loaded HFHNPs (IS@HFHNPs) exhibited enhanced cellular uptake and tumor accumulation behavior. the timescale dependent homogeneous assembly method for HNPs developed in this research presents a promising avenue for maintaining quality in the synthesis of self-assembly composite nanomecidine.

Crystallization-dictated assembly of block copolymers and nanoparticles under three-dimensional confinement.

Crystallization-dictated self-assembly of crystalline block copolymers (BCPs) in solution has been utilized to produce many impressive nanostructures. However, when the assembly of crystalline BCPs happens in a three-dimensional (3D) confined space, predicting the self-assembly structure of BCPs becomes challenging due to the competition between crystallization and microphase separation. In this feature article, we summarize the recent progress in the self-assembly of crystalline BCPs under confinement, emphasizing the impact of crystallization behavior on the assembly structure. Furthermore, we highlight the crystallization-directed assembly of inorganic nanoparticles (NPs), either by pre-assembling crystalline polymers as templates or using crystalline polymer chain segments as ligands. By exploring the impact of crystallization behavior on the assembled structure of BCPs and NPs, it is helpful to predict and manipulate the properties of polymer/nanoparticle composites, thereby enabling the precise design of polymer metamaterials.

Biocompatibility and corrosion resistance of drug coatings with different polymers for magnesium alloy cardiovascular stents

Recently, advances in enhancing corrosion properties through various techniques, and the clinical application of biodegradable cardiovascular stents made from magnesium (Mg) alloys face challenges to corrosion resistance, blood compatibility, and biocompatibility. Drug-eluting stents (DES) offer a solution to enhance the corrosion resistance of Mg alloys while simultaneously reducing the occurrence of restenosis. In this study, WE43 Mg alloy was pretreated using electropolishing technology, and different polymers (PEG and PLLA) were used as drug-polymer coatings for the Mg alloy. At the same time, PTX, an anticoagulant, was incorporated to achieve drug coating of different polymers on WE43 Mg alloy. The corrosion resistance of different polymer-drug coatings was assessed using a plasma solution. Furthermore, in vitro and in vivo tests were used to evaluate the blood biocompatibility of these coatings. The results indicated the PTX-PEG-coated WE43 Mg alloy exhibited the highest corrosion resistance and the most stable drug release profile among the tested coatings. Its hemolysis rate of 0.6 % was within the clinical requirements (<5 %). The incorporation of PEG prevents non-specific protein adsorption and nanoparticle aggregation, enhancing the surface hemocompatibility of WE43 Mg alloy. Therefore, the PTX-PEG coating shows promising potential for application in the development of drug-coated Mg alloy.

Electrophoretic mobility of nanoparticle aggregates: Independence from aggregate size

The zeta potential is a widely used parameter to categorize particle-particle interaction and aggregation. This parameter is often determined by the measurement of electrophoretic mobility. For single particles, various approximations allow a direct correlation between the mobility and the zeta potential. However, for aggregates, which are often found in the environment and in industrial applications, such approximations are less utilized. The relation between the size of aggregates and the resulting electrophoretic mobility has not yet been extensively explored and is often not considered. Here, we control the aggregate size additive-free of two fumed silica types with different primary particle diameters for comprehensive electrophoretic and dynamic light scattering measurements. We evaluate the influence of primary particle diameter and aggregate size on electrophoretic mobility. Our results reveal that the primary particle diameter is the defining factor for the electrophoretic mobility of the aggregates. This finding provides new insights into the electrokinetic behavior of aggregates and emphasizes the importance of primary particle properties in predicting colloidal interactions.

Magnetite Nanoparticle Assemblies and Their Biological Applications: A Review.

Magnetite nanoparticles (Fe3O4 NPs) have garnered significant attention over the past twenty years, primarily due to their superparamagnetic properties. These properties allow the NPs to respond to external magnetic fields, making them particularly useful in various technological applications. One of the most fascinating aspects of Fe3O4 NPs is their ability to self-assemble into complex structures. Research over this period has focused heavily on how these nanoparticles can be organized into a variety of superstructures, classified by their dimensionality-namely one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) configurations. Despite a wealth of studies, the literature lacks a systematic review that synthesizes these findings. This review aims to fill that gap by providing a thorough overview of the recent progress made in the fabrication and organization of Fe3O4 NP assemblies via a bottom-up self-assembly approach. This methodology enables the controlled construction of assemblies at the nanoscale, which can lead to distinctive functionalities compared to their individual counterparts. Furthermore, the review explores the diverse applications stemming from these nanoparticle assemblies, particularly emphasizing their contributions to important areas such as imaging, drug delivery, and the diagnosis and treatment of cancer.

Tunable crystalline assemblies using surface-engineered protein cages.

Assembly of nanoparticles into superlattices yields nanomaterials with novel properties. We have recently shown that engineered protein cages are excellent building blocks for the assembly of inorganic nanoparticles into highly structured hybrid materials, with unprecedented precision. In this study, we show that the protein matrix, composed of surface-charged protein cages, can be readily tuned to achieve a number of different crystalline assemblies. Simply by altering the assembly conditions, different types of crystalline structures were produced, without the need to further modify the cages. Future work can utilize these new protein scaffolds to create nanoparticle superlattices with various assembly geometries and thus tune the functionality of these hybrid materials.

N-doped carbon confined ternary Pt2NiCo intermetallics for efficient oxygen reduction reaction

Developing high performance electrocatalysts for the cathodic oxygen reduction reaction (ORR) is essential for the widespread application of fuel cells. Herein, a promising Pt2NiCo atomic ordered ternary intermetallic compound with N-doped carbon layer coating (o-Pt2NiCo@NC) has been synthesized via a facile method and applied in acidic ORR. The confinement effect provided by the carbon layer not only inhibits the agglomeration and sintering of intermetallic nanoparticles during high temperature process but also provides adequate protection for the nanoparticles, mitigating the aggregation, detachment and poisoning of nanoparticles during the electrochemical process. As a result, the o-Pt2NiCo@NC demonstrates a mass activity (MA) and specific activity (SA) of 0.65 A/mgPt and 1.41 mA/cmPt2 in 0.1 mol/L HClO4, respectively. In addition, after 30,000 potential cycles from 0.6 V to 1.0 V, the MA of o-Pt2NiCo@NC shows much lower decrease than the disordered Pt2NiCo alloy and Pt/C. Even cycling at high potential cycles of 1.5 V for 10,000 cycles, the MA still retains ∼70%, demonstrating superior long-term durability. Furthermore, the o-Pt2NiCo@NC also exhibits strong tolerance to CO, SOx, and POx molecules in toxicity tolerance tests. The strategy in this work provides a novel insight for the development of ORR catalysts with high catalytic activity, durability and toxicity tolerance.

Increasing Light-Induced Forces with Magnetic Photonic Glasses

In this work, we theoretically and experimentally study the induction of electromagnetic forces in an opal-based magnetic photonic glass, where light normally impinges onto a disordered arrangement of SiO2 spheres by the aggregation of Fe3O4 nanoparticles. The working wavelength is 633 nm. Experimental evidence is presented for the force that results from forced oscillations of the photonic structure. Finite-element method simulations and a theoretical model estimate the magnetic force volumetric density value, peak displacement, and velocity of oscillations. The magnetic force is of the order of 56 microN, which is approximately 500-times higher than forces induced in dielectric optomechanical photonic crystal cavities.

Responsive and traceless assembly of iron nanoparticles and 131I labeled radiopharmaceuticals for ferroptosis enhanced radio-immunotherapy

Ferroptosis is an iron-dependent form of programmed cell death with the potential to reverse traditional cancer therapy resistance. The combination of ferroptosis with chemotherapy, photodynamic therapy and X-ray therapy has demonstrated remarkably improved therapeutic efficiency. Radiopharmaceutical therapy (RPT) is an emerging approach that achieves precise radiation to diseased tissues via radionuclide delivery. However, insufficient accumulation and retention of therapeutic radiopharmaceuticals in tumor region as well as cancer radioresistance impact treatment efficacy. Here, a nanoassembly of renal clearable ultrasmall iron nanoparticles (USINPs) and 131I-aPD-L1 is prepared via the affinity of fluorophenylboronic acid modified on the USINPs with 131I-aPD-L1. The 150 nm USINAs(131I-aPD-L1) nanoassembly is stable in blood circulation, effectively targets to the tumor and disassembles in the presence of ATP in the tumor microenvironment. Both in vitro and in vivo experiments prove that USINPs-induced ferroptosis boosted the tumor radiosensitization to 131I while 131I-mediated RPT further enhanced ferroptosis. Meanwhile, the immunogenic cell death caused by RPT and ferroptosis combined with PD-L1 immune checkpoint blockade therapy exhibits a strong antitumor immunity. This study provides a novel way to improve the tumor accumulation of ferroptosis inducer and radiopharmaceuticals, insights into the interaction between RPT and ferroptosis and an effective SPECT-guided ferroptosis-enhanced radio-immunotherapy.

Thermal dynamics of nanoparticle aggregation in MHD dissipative nanofluid flow within a wavy channel: Entropy generation minimization

This paper examines how nanoparticle aggregation and a consistent magnetic field influence the peristaltic movement of a dissipative nanofluid, which is caused by the sinusoidal deformation of the boundary. The viscosity of TiO2/H2O nanofluids is accurately determined by the Krieger-Dougherty model with nanoparticle aggregation, while thermal conductivity (TC) is estimated through the Bruggeman model. The set of governing equations are modeled in a fixed frame by utilizing the conservation laws of energy, mass and momentum. Galilean transformation is utilized to transform the system of equations into a wave frame, which is then converted into a dimensionless form. The assumption of a small Reynolds number and long wavelength serve to further simplify the set of equations, which are subsequently addressed through the implementation of the differential quadrature method (DQM), a highly effective numerical technique. Quantities of interest, namely velocity, pressure gradient, temperature, trapping phenomena, heat transfer, and volumetric entropy generation are analyzed across a range of physical parameters, including the solid volume fraction (Φ=0.01−0.04), Eckert number (Ec=0.0−0.1), Hartman number (Mh=0.2−2.2), Grashof number (Gr=1.0−3.0) and temperature ratio parameter (θd=0.5−2.5). A comparative analysis is conducted between the scenario involving aggregation and the one without aggregation. It is observed that nanoparticle aggregation significantly alters these quantities.

Application of PLGA-PEG-PLGA Nanoparticles to Percutaneous Immunotherapy for Food Allergy.

Compared with oral or injection administration, percutaneous immunotherapy presents a promising treatment modality for food allergies, providing low invasiveness and safety. This study investigated the efficacy of percutaneous immunotherapy using hen egg lysozyme (HEL)-loaded PLGA-PEG-PLGA nanoparticles (NPs), as an antigen model protein derived from egg white, compared with that of HEL-loaded chitosan hydroxypropyltrimonium chloride (CS)-modified PLGA NPs used in previous research. The intradermal retention of HEL in excised mouse skin was measured using Franz cells, which revealed a 2.1-fold higher retention with PLGA-PEG-PLGA NPs than that with CS-modified PLGA NPs. Observation of skin penetration pathways using fluorescein-4-isothiocyanate (FITC)-labeled HEL demonstrated successful delivery of HEL deep into the hair follicles with PLGA-PEG-PLGA NPs. These findings suggest that after NPs delivery into the skin, PEG prevents protein adhesion and NPs aggregation, facilitating stable delivery deep into the skin. Subsequently, in vivo percutaneous administration experiments in mice, with concurrent iontophoresis, demonstrated a significant increase in serum IgG1 antibody production with PLGA-PEG-PLGA NPs compared with that with CS-PLGA NPs after eight weeks of administration. Furthermore, serum IgE production in each NP administration group significantly decreased compared with that by subcutaneous administration of HEL solution. These results suggest that the combination of PLGA-PEG-PLGA NPs and iontophoresis is an effective percutaneous immunotherapy for food allergies.

A simple method for preparing Sb2S3/short-cut carbon fiber foam for the electrocatalytic degradation of dyes

The unstarched short-cut carbon fiber (SCF) foam modified with Sb2S3 nanoparticles (Sb2S3/SCF foam) was synthesized by melamine foam as a template to apply in electro-degradation of methyl orange (MO) and a mixture of dyes. This process takes full advantage of the self-supported 3D SCF foam's mechanical stability and electrical conductivity while preventing the aggregation of unstarched SCF and Sb2S3 nanoparticles. The in-situ deposition and good dispersion of Sb2S3 nanoparticles expose catalytic active sites synergy with stable free-standing 3D SCF foam resulting in efficient degradation capability. The morphology, composition, structure, and hydrophilicity of Sb2S3/SCF foam were analyzed using SEM, EDS, XPS, XRD, Raman, PL, BET and contact angle tests. The Sb2S3/SCF foam is highly effective for degrading MO, with a degradation rate of 97.92 % achieved in just 4 hours at 2.4 V (vs. SCE). Additionally, it could simultaneously degrade mixed dyes including methyl orange (MO), crystal violet (CV), and methylene blue (MB) within 5 hours, achieving complete fade. Furthermore, the Sb2S3/SCF foam also possesses desirable features for large-scale practical applications and recycling in dye degradation.

Regulation of surface oxygen vacancy of Cu-CeO2/TiO2 heterostructures via fast Joule heating method for enhanced CO2 electrochemical reduction

Strict control of carbon emissions is crucial for expediting the achievement of carbon neutrality. However, the current CO2RR electrocatalytic exhibits numerous shortcomings that impede the enhancement of catalytic activity. Issues such as lengthy catalyst preparation times, and high levels of precious metal content. Additionally, the aggregation of ultrafine nanoparticles contributes to a rapid deterioration in catalytic performance. Herein, a Joule-heating method is efficiently utilized to synthesize heterostructures nano-catalysts for CO2 electroreduction on carbon cloth substrates. This method takes advantage of the thermoelectric coupling of the carbon cloth to achieve carbothermal reduction, while also regulating phase composition and introduction of oxygen vacancies. The Cu-CeO2/TiO2/CC catalyst synthesized in this method showed a current density in CO2 of −32 mA·cm−2 at −1.0 V (vs. RHE). Notably, this catalyst demonstrated high CO selectivity and Faraday efficiency (FECO) of up to 82.5 % at a low potential of −0.3 V (vs. RHE). Optimal electrochemical performance is achieved at a power of 40 W. The ultra-fast temperature change process prevented the agglomeration of catalyst particles and facilitated the construction of a stable heterogeneous interface with a high oxygen vacancy concentration. In conclusion, this study presents a promising approach, particularly for the rapid preparation of low-cost, highly selective non-precious metal electrocatalysts.

Superior Single-Entity Electrochemistry Performance of Capping Agent-Free Gold Nanoparticles Compared to Citrate-Capped Gold Nanoparticles.

In observing the electrocatalytic current of nanoparticles (NPs) using single-entity electrochemistry (SEE), the surface state of the NPs significantly influences the SEE signal. This study investigates the influence of capping agents on the electrocatalytic properties of gold (Au) NPs using SEE. Two inner-sphere reactions, hydrazine oxidation and glucose oxidation, were chosen to explore the SEE characteristics of Au NPs based on the capping agent presence. The results revealed that "capping agent-free" Au NPs exhibited signal magnitudes and frequencies consistent with theoretical expectations, indicating superior stability and catalytic performance in electrolyte solutions. In contrast, citrate-capped Au NPs showed signals varying depending on the applied potential, with larger magnitudes and lower frequencies than expected, likely due to an aggregation of NPs. This study suggests that capping agents play a crucial role in the catalytic performance and stability of Au NPs in SEE. By demonstrating that minimizing capping agent presence can enhance effectiveness in SEE, it provides insights into the future applications of NPs, particularly highlighting their potential as nanocatalysts in energy conversion reactions and environmental applications.

Construction of Ru-doped Co nanoparticles loaded on carbon nanosheets in-situ grown on carbon nanofibers as self-supported catalysts for efficient hydrogen evolution reaction

Exploring efficient and economical electrocatalysts to replace noble metal electrocatalysts has become a major research focus nowadays. In this paper, Ru-doped Co nanoparticles loaded on carbon nanosheet (CNS) in-situ grown on carbon nanofibers (Ru–Co@CNS/CNFs) were constructed as a self-supporting working electrode for high-efficiency hydrogen evolution. The prepared Ru–Co@CNS/CNFs possessed excellent catalytic activity with only 78 mV overpotential at 10 mA cm−2 current density and good stability with only 102 mV voltage attenuation at 100 mA cm−2 current density for 100 h continuous operation. The excellent catalytic performance could be attributed to the unique microstructure of the nanosheets in-situ grown on the nanofibers, it resulted in a higher Co surface density of 1.28 mg cm−2, indicating more loading of metal to improve catalytic activity of HER, and the formed Ru-doped Co nanoparticles could be evenly distributed on the carbon nanosheets to prevent the aggregation of nanoparticles, which could expose more active sites. Additionally, the density functional theory (DFT) calculations revealed Ru doping could accelerate the dissociation of water, optimize the adsorption energy of hydrogen intermediates and improve the kinetics of the HER reaction. This work provides a new approach to reduce the use of noble metals while improving the catalytic performance of catalysts.

MOF-derived molybdenum carbide-copper as an electrocatalyst for the hydrogen evolution reaction

We have used molybdenum-copper metal-organic framework (Mo-Cu MOF) as a precursor, and its porous structure as a spatially confined environment to suppress the overgrowth and aggregation of nanoparticles during high-temperature carbonization for synthesis of MOF-derived molybdenum carbide-copper. The Mo-Cu-MOF precursor was carbonized at high temperature under a predefined gas flow condition (nitrogen → 20 % methane/hydrogen mixed gas) and the product was transformed from MoO2-Cu to ŋ-MoC-Cu. Then, by changing the process temperature (800°C → 1000°C), ŋ-MoC-Cu was transformed into β-Mo2C-Cu. The microstructure analysis by transmission electron microscopy (TEM) revealed a gradual change of octahedral structure of MoxC-Cu with the increase of temperature. X-ray diffraction (XRD) analysis identify the phase composition and the grain size of carbide molybdenum inside the MoxC-Cu structure. The carbide molybdenum grain size increased and transformed from ŋ-MoC to β-Mo2C with the increase of the carbonization temperature from 800 °C to 1000 °C. ŋ-MoC-Cu obtained at a carbonization temperature of 800°C showed the best electrochemical performance, with η10 mA = −233 mV and Tafel slope = 73 mV/dec.

Assembly of Differently Sized Supercharged Protein Nanocages into Superlattices for Construction of Binary Nanoparticle-Protein Materials.

This study focuses on the design and characterization of binary nanoparticle superlattices: Two differently sized, supercharged protein nanocages are used to create a matrix for nanoparticle arrangement. We have previously established the assembly of protein nanocages of the same size. Here, we present another approach for multicomponent biohybrid material synthesis by successfully assembling two differently sized supercharged protein nanocages with different symmetries. Typically, the ordered assembly of objects with nonmatching symmetry is challenging, but our electrostatic-based approach overcomes the symmetry mismatch by exploiting electrostatic interactions between oppositely charged cages. Moreover, our study showcases the use of nanoparticles as a contrast enhancer in an elegant way to gain insights into the structural details of crystalline biohybrid materials. The assembled materials were characterized with various methods, including transmission electron microscopy (TEM) and single-crystal small-angle X-ray diffraction (SC-SAXD). We employed cryo-plasma-focused ion beam milling (cryo-PFIB) to prepare lamellae for the investigation of nanoparticle sublattices via electron cryo-tomography. Importantly, we refined superlattice structure data obtained from single-crystal SAXD experiments, providing conclusive evidence of the final assembly type. Our findings highlight the versatility of protein nanocages for creating distinctive types of binary superlattices. Because the nanoparticles do not influence the type of assembly, protein cage matrices can combine various nanoparticles in the solid state. This study not only contributes to the expanding repertoire of nanoparticle assembly methods but also demonstrates the power of advanced characterization techniques in elucidating the structural intricacies of these biohybrid materials.

Plasmon-driven chemical transformation of a secondary amide probed by surface enhanced Raman scattering

Plasmon-driven chemical conversion is gaining burgeoning interest in the field of heterogeneous catalysis. Herein, we study the reactivity of N-methyl-4-sulfanylbenzamide (NMSB) at nanocavities of gold and silver nanoparticle aggregates under plasmonic excitation to gain understanding of the respective reaction mechanism. NMSB is a secondary amide, which is a frequent binding motive found in peptides and a common coupling product of organic molecules and biomolecules. Surface-enhanced Raman scattering (SERS) is used as a two-in-one in-situ spectroscopic tool to initiate the molecular transformation process and simultaneously monitor and analyze the reaction products. Supported by dissociative electron attachment (DEA) studies with the gas phase molecule, a hot electron-mediated conversion of NMSB to p-mercaptobenzamide and p-mercaptobenzonitrile is proposed at the plasmonic nanocavities. The reaction rate showed negligible dependence on the external temperature, ruling out the dominant role of heat in the chemical transformation at the plasmonic interface. This is reflected in the absence of a superlinear relationship between the reaction rate constant and the laser power density, and DEA and SERS studies indicate a hot-electron mediated pathway. We conclude that the overall reaction rate is limited by the availability of energetic hot electrons to the NMSB molecule.

Interfacial Cooperative Assembly of Surfactants and Opposite Wettability Nanoparticles Stabilizes Water-in-Oil Emulsions at High Temperature.

Pickering emulsions have promising applications in the development of unconventional oil and gas resources. However, the high-temperature environment of the reservoir is not conducive to the stabilization of Pickering emulsions. In addition, the preparation of Pickering emulsions under low-energy emulsification and low-concentration emulsifier conditions is a difficult challenge. Here, we report a high-temperature resistant water-in-paraffin oil Pickering emulsion, which is synergistically stabilized by polyglycerol ester (PGE) and nanoparticles with opposite wettability (lipophilic silica and hydrophilic alumina). This emulsion can be prepared under mild stirring (500 rpm) conditions and can be stable at 140 °C for at least 30 days. The synergistic effects of surfactant, silicon nanoparticles (MSNPs) with different wettability, and alumina nanoparticles (AONPs) on the stability of both emulsions and water-oil interfacial membranes were investigated through bottle experiments, cryogenic scanning electron microscopy (cryo-SEM), optical microscopy, fluorescence microscopy, etc. The results showed that both hydrophobic MSNPs and hydrophilic AONPs are adsorbed together at the water-oil interface to stabilize the W/O emulsion, which can be prepared by 500 rpm stirring. The stability of emulsions strongly depends on the wettability of MSNPs, and the MSNP with moderate hydrophobicity (for example, aqueous phase contact angle of 136°) makes the emulsion exhibit the highest stability against aggregation and settling at elevated temperatures. The emulsion stabilization mechanism was revealed in terms of the adsorption capacity of the surfactant by MSNPs, the adsorption morphology and desorption energy of nanoparticles at the water-oil interface adsorption layer, and emulsion rheology. These findings demonstrate a novel and simple strategy to prepare Pickering W/O emulsions with high-temperature stability at low shear strength.

Significance of nanoparticle aggregation for thermal transport over magnetized sensor surface

Abstract This article explores the dynamics of nanofluids consisting of copper (TiO2) nanoparticles suspended in water, as they interact with sensor surfaces between two parallel squeezing plates with porous characteristics. This research specifically targets applications involving enhanced heat transfer and magnetohydrodynamic (MHD) control in nanofluid systems. The primary aim is to analyze the effects of nanoparticle aggregation and non-aggregation on sensor surfaces, considering MHD formations and heat transfer in the energy and momentum equations. The research adopts a steady-state fluid condition and utilizes similarity transformations to convert partial differential equations into more manageable ordinary differential equations. The methodology involves shooting methods for solving these nonlinear ordinary differential equations and employs graphical analyses to study the impacts of various parameters such as permeability, magnetic influence, squeeze flow, and radiation on the temperature and velocity profiles of the nanofluid. The results reveal significant dependencies of temperature and velocity profiles on the studied parameters, illustrating varied behaviors in scenarios of both aggregation and non-aggregation of nanoparticles. The findings emphasize how each parameter distinctively influences the heat and flow characteristics of the nanofluid, offering insights into optimizing conditions for better performance and control in practical applications. Future research could focus on extending the model to include transient fluid states and exploring the effects of other nanoparticle materials and shapes. There is also potential to investigate the interactions under different environmental conditions and to incorporate more complex boundary conditions to simulate real-world applications more accurately. Further experimental validation of the theoretical predictions would be beneficial to enhance the reliability and applicability of the findings.