Nanoscale Range Research Articles

Chicoric acid inserted in protein Z cavity exhibits higher stability and better wound healing effect under oxidative stress

Oxidative stress is one of the limiting factors that inhibit wound healing. Phytochemicals especially chicoric acid have the potential to act as an antioxidant and scavenge reactive oxygen species, thereby promoting wound healing. However, most of the phytochemicals were easy to be degraded during storage or using due to the oxidative status in wound site. Herein, we introduce a high stable protein Z that can encapsulate chicoric acid during foaming. TEM results showed that the size of protein Z-chicoric acid is in the range of nanoscale (named PZ-CA nanocomposite), and protein Z encapsulation can significantly improve the stability of chicoric acid under oxidative stress. Moreover, PZ-CA nanocomposite exhibited favorable antioxidant properties, biocompatibility, and the ability to promote cell migration in vitro. The role of PZ-CA nanocomposite in skin regeneration was explored by a mice model. Results in vivo suggest that the PZ-CA nanocomposite promotes wound healing with a faster rate as compared with a commercial spray solution, mostly through attenuating the oxidative stress, promoting cell proliferation and collagen deposition. This work not only provides a delivery vector for bioactive molecules, but also develops a kind of nanocomposite with the property of promoting wound healing.

Nanomaterials Function in Additive Manufacturing

Nanomaterials are substances that have at least one dimension that falls within the three-dimensional nanoscale range or fundamental structural components made of substances that fall inside this range. Micro-nano 3D printing technology can realize the processing of 3D micro-nano structures with nanometer precision and has broad application prospects in many fields. Metals and polymers can be easily connected through bonding reactions to obtain metal-metal or covalent bonds in 3D printing. These potent chemical bonds make 3D-printed structures stable, and 3D printing of metals and plastics is developing rapidly. The review focuses on the latest developments in unique composite nanomaterials for different field applications, comprising nanomaterials and 3D printing technology. A summary of the mechanisms, functional characteristics, benefits, drawbacks, and applications of various nanomaterials used in scientific 3D printing includes metal-based nanomaterials, metal-organic frameworks, upconversion nanoparticles, and lipid-based nanoparticles. Finally, this study presents an overview and highlights the issues that need to be resolved for nanomaterials to continue to be developed for the advantages of 3D printing.

Evaluation of barium tungstate nanocrystals for the sorption of radioactive cobalt and europium from aqueous solutions

Herein, barium tungstate BaWO4 nanocrystals were chemically prepared and then estimated as inorganic sorbent material to eliminate the radioactive cobalt and europium from the waste stream. The characterization of BaWO4 nanocrystals is completed over several analytical techniques. TEM and SEM images show the formation of sphere-shaped BaWO4 structures in the nanoscale range. Also, XRD and FTIR revealed the successful preparation of BaWO4. Optimum factors affected by the sorption process are determined using batch mode. Sorption equilibrium was achieved after 60 min with the initial concentration of metal ion at 100 mg/L and at optimum pH five for both radionuclides, respectively. The different kinetic models are applied. The obtained data shows that the sorption process followed a pseudo-second order. The sorption capacity for 60Co at pH of 5 and 25 °C is 310.6 mg g−1, and 152+154Eu is 409.9 mg g−1. The thermodynamic studies illustrated that the sorption process was spontaneous and endothermic.

Development and evaluation of a protease inhibitor antiretroviral drug-loaded carbon nanotube delivery system for enhanced efficacy in HIV treatment

The primary objective of this study was to enhance the effectiveness of the protease inhibitor antiretroviral drug by designing a novel delivery system using carboxylated multiwalled carbon nanotubes (COOH-MWCNTs). To achieve this, Fosamprenavir calcium (FPV), a prodrug of amprenavir known for inhibiting the proteolytic cleavage of immature virions, was selected as the protease inhibitor antiretroviral drug, and loaded onto COOH-MWCNTs using a direct loading method. The structural specificity of the drug-loaded MWCNTs, the percent entrapment efficiency, and in vitro drug release were rigorously evaluated for the developed formulation, referred to as FPV-MWCNT. Fourier transform infrared (FTIR) spectroscopy, Field emission scanning electron microscopy (FE-SEM), Raman spectroscopy, and atomic force microscopy (AFM) techniques were employed to confirm the structural integrity and specificity of the FPV-MWCNT formulation. The results demonstrated a remarkable entrapment efficiency of 79.57 ± 0.4 %, indicating the successful loading of FPV onto COOH-MWCNTs. FE-SEM and AFM analyses further confirmed the well-dispersed and elongated structure of the FPV-MWCNT formulation, without any signs of fracture, ensuring the stability and integrity of the drug delivery system. Moreover, particle size analysis revealed an average size of 290.1 nm, firmly establishing the nanoscale range of the formulation, with a zeta potential of 0.230 mV, signifying the system's colloidal stability. In vitro drug release studies conducted in methanolic phosphate buffer saline (PBS) at pH 7.4 and methanolic acetate buffer at pH 5 demonstrated sustained drug release from the FPV-MWCNT formulation. Over a period of 96 h, the formulation exhibited a cumulative drug release of 91.43 ± 2.3 %, showcasing the controlled and sustained release profile. Furthermore, hemolysis studies indicated a notable reduction in the toxicity of both FPV and MWCNT upon conjugation, although the percent hemolysis increased with higher concentrations, suggesting the need for careful consideration of dosage levels.In conclusion, the findings from this study underscore the potential of the FPV-MWCNT formulation as an effective and promising drug-conjugated system for delivering antiretroviral drugs. The successful encapsulation, sustained drug release, and reduced toxicity make FPV-MWCNT a compelling candidate for enhancing the therapeutic efficacy of protease inhibitor antiretroviral drugs in the treatment of HIV. The developed delivery system holds great promise for future advancements in HIV treatment and paves the way for further research and development in the field of drug delivery utilizing carbon nanotube-based systems.

DSPE-PEG2000-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis.

Cancer is a life-threatening disease worldwide. Nanomedicine and nanodelivery systems are recently developed scientific field that employs specific materials in the nanoscale range to deliver drugs. Lipid-based nanoparticles are an ideal delivery system since they exhibit many advantages, including high bioavailability, self-assembly, formulation simplicity, and the ability to exhibit a plethora of physicochemical properties. Herein, we report that phenobarbital sodium can kill cancer cells by using the DSPE-PEG2000-methotrexate nanoparticle delivery system, which can target folate receptors that are usually overexpressed on a variety of cancer cells. The released phenobarbital then executes cancer cells by inducing pyroptosis. Results from our animal model further indicate that the nanomedicine of nanoparticle-encapsulated phenobarbital sodium is a promising anticancer therapy.

AN OVERVIEW OF CLASSIFICATION, SYNTHESIS AND CHARACTERIZATION OF NANOMATERIALS

Nanotechnology is the branch of science that deals with particles ranging from 1 to 100nm. Nanoparticles become technically advance over their parent material due to their adaptable characteristics and enhanced performance. They are mostly synthesized by reducing metal ion into uncharged nanoparticles by using hazardous reducing agents. In recent years, green technology for nanoparticles synthesis has received great attention due to its efficiency, less toxicity, safety and high productivity. Green synthesized particles at their nanoscale range are commercially and economically very beneficial for the environment. Moreover, this paper will discuss the nanoparticles, its types, synthesis methods, applications and prospects.

Cytotoxic Study of Zinc Oxide Nanoparticles on Cervical Cancer Cell Line

The advancement of nanomedicine drugs as an outcome of nanotechnology offers tremendous potential to enhance cancer-fighting tactics. Scientists have begun studying the role of NPs in immunotherapy, an area that is particularly beneficial in treating malignancies. Conventional treatment of cancer uses medications known as chemotherapy that frequently cause adverse effects on healthy tissues. Zinc is a vital micronutrient for the well-being of humans; therefore, nanomaterials such as zinc oxide nanoparticles (ZnO NPs) are progressively appealing as cutting-edge medical agents with implementations like anticancer properties. A bottom-up approach was utilized to chemically produce the ZnO NPs, which were characterized using Field Emission Scanning Electron Microscope (FESEM) and Energy Dispersive X-ray analysis (EDX). MTT assays have been carried out to study the cell viability percentage against multiple ZnO NPs concentrations and durations. The white ZnO NPs displayed a diverse morphology within the nanoscale range, featuring rod and spherical shapes. This synthesis was confirmed through EDX, which revealed distinct peaks corresponding to zinc and oxygen, affirming the formation of pure ZnO NPs. MTT assay data showed that ZnO NPs had a dose and time-dependent cytotoxicity against HeLa cells. This observation suggests that the ZnO NPs possess the potential to combat cancer and may hold promise for applications in biomedical research, particularly in the development of anticancer drugs.

Morphological and chemical characterisation of indoor quasi-ultrafine particles

Particles in the nanoscale range have intrinsic physicochemical characteristics that define their interaction with the human body and ultimately their toxicity. Whilst research has focused on engineered nanomaterials or ambient ultrafine particles, little is known about the morphology, size and elemental composition of particles in the nanoscale range collected in indoor environments, where humans spend the longest time. This study aims to characterise the physicochemical properties of quasi-ultrafine particles (qUFP), with an aerodynamic diameter <250 nm, collected with a Sioutas impactor from 5 indoor environments (3 homes and 2 offices). Morphology, size and elemental composition of individual particles were imaged using a Transmission Electron Microscope coupled with X-ray energy dispersive spectroscopy. Most of the single particles and their aggregates were of irregular shapes, and some fibrous rods, elongated rods, spheres and hexagons were also observed. ImageJ software was used to analyse the surface area, roundness and circularity of the particles, as well as individual particle diameter for the spherical particles. For the non-spherical shaped particle, the particles were manually measured to characterise the maximum Feret diameter. Particle main dimensions (i.e. diameter for spheroids and maximum Feret diameter for irregular particles) ranged from 35 ± 59 nm to 103 ± 160 nm. Shapes for non-spherical particles were assigned by visual description. Si, Fe and S were found in nanoparticles from all indoor locations. Other abundant constituents were K, Cr, Na, Ca, Cl found in 60–80% of locations. Minor constituents of indoor nanoparticles were Cu, Sn, Ti, Mo, Al, P, Be, F, Zn, Rb, Pb, Mn and Co. Sources were related to indoor emissions, e.g. printers, stainless-steel tools, electronics, cooking, house chores, particle re-suspension, aerosol and cleaning products as well as to penetration of outdoor nanoparticles from vehicular emissions, soil and secondary aerosols. Detailed investigation of the physicochemical properties of these particles can help understand their associated hazard and their fate in the human body.

Advances in Structural and Morphological Characterization of Thin Magnetic Films: A Review

The present review places emphasis on a comprehensive survey of experimental techniques to probe the structural and morphological features at the nanoscale range in thin magnetic films, incorporating those available at in-house laboratories as well as those at state-of-the-art synchrotron radiation facilities. This elucidating the range of available techniques, and the information they can yield represents a step for advancing the understanding of and for unlocking new possibilities in the design and optimization of thin magnetic films across a wide range of applications.

The Impact of Ambient Temperature on Electrothermal Characteristics in Stacked Nanosheet Transistors with Multiple Lateral Stacks.

With characteristic size scaling down to the nanoscale range, the confined geometry exacerbates the self-heating effect (SHE) in nanoscale devices. In this paper, the impact of ambient temperature (Tamb) on the SHE in stacked nanosheet transistors is investigated. As the number of lateral stacks (Nstack) increases, the nanoscale devices show more severe thermal crosstalk issues, and the current performance between n- and p-type nanoscale transistors exhibits different degradation trends. To compare the effect of different Tamb ranges, the temperature coefficients of current per stack and threshold voltage are analyzed. As the Nstack increases from 4 to 32, it is verified that the zero-temperature coefficient bias point (VZTC) decreases significantly in p-type nanoscale devices when Tamb is above room temperature. This can be explained by the enhanced thermal crosstalk. Then, the gate length-dependent electrothermal characteristics with different Nstacks are investigated at various Tambs. To explore the origin of drain current variation, the temperature-dependent backscattering model is utilized to explain the variation. At last, the simulation results verify the impact of Tamb on the SHE. The study provides an effective design guide for stacked nanosheet transistors when considering multiple stacks in circuit applications.

Preparation and in vitro evaluation of amphotericin B-loaded nano-formulations for both intravenous and ophthalmic administration using 3-aminophenylboronic acid-conjugated styrene-maleic acid copolymers

Amphotericin B (AmB) is a widely used antifungal drug. However, its insolubility in water and high toxicity pose challenges to its clinical application. The aim of this study was to improve the solubility, to reduce toxicity, and to confer albumin- and mucin-binding properties. Therefore, we developed an AmB nano-formulation (APB-SMA/AmB) using a styrene-maleic acid copolymer modified with 3-aminophenylboronic acid (APB-SMA). APB-SMA/AmB was characterized and evaluated for drug content, particle size, toxicity, antifungal activity, and albumin- and mucin-binding properties.APB-SMA contains APB molecules bound to styrene-maleic acid copolymer (SMA), which can form complexes with diols. APB-SMA/AmB exhibits a small and a large peak at approximately 330 nm and 410 nm respectively, in the UV–visible spectrum, indicating the presence of a large amount of monomeric AmB, which is less toxic than its oligomeric form. The particle size of the formulations was in the nanoscale range. APB-SMA/AmB showed reduced hemolytic activity compared with AmB and the other formulations. The antifungal activity of APB-SMA/AmB is derived from AmB, and a higher APB-SMA content in the formulation improves the therapeutic index. Furthermore, APB-SMA/AmB demonstrated in vitro albumin- and mucin-binding properties, suggesting its potential as a drug delivery system for improving in vivo blood circulation and corneal retention. In conclusion, APB-SMA/AmB is an effective water-soluble nano-formulation for fungal infections and may be applicable in both injectable and ophthalmic formulations.

Biomedical Relevance of Biological Smart Materials Approach for Synthesis of Selenium Nanoparticles by Agrobacterium

Nanotechnologies are making more efforts to develop new materials to use in different ways to be beneficial to human life. Their unique properties are constantly being improved to enhance more effective and perfect activity as per the requirement. Researchers are continuously producing highly useful materials with the help of different types of microorganisms and green technology for the synthesis of nanoparticles as per the requirement. Primarily Agrobacterium species are the most useful microorganisms for the synthesis of selenium nanoparticles in the diameter range of nanoscale. These are capable and more effective in making nanomaterials from selenium to use in medicinal and other applications. These are opening a new dimension in the field of medical science which is beneficial for multipurpose use directly or indirectly.

Cyclic Voltammetry and Photoluminescence Studies of Ag-doped ZnO Nanoparticles

Introduction: Herein, we prepared Zinc oxide (ZnO) and silver (Ag) doped ZnO nanoparticles (NPs) using a simple, fast, effective and economic coprecipitation method. The superior characteristics in the nanoscale range of ZnO encourage us to work on the ZnO NPs. Also, Ag has long been employed for its antibacterial qualities. X-ray diffraction (XRD) results indicate a hexagonal wurtzite structure of ZnO NPs and an additional peak corresponding to the metallic Ag phase in the Ag-ZnO sample. The EDAX elemental mapping confirms the uniform distribution of Ag in ZnO NPs. Photoluminescence (PL) spectroscopy investigates electronic structure and defects in NPs.ic co-precipitation method and study of Cyclic Voltammetry and Photoluminescence characteristics. Method: According to the PL study, the strong photoluminescence NBE observed at 393 nm, indicating the high crystalline quality of the material and broad blue-green emission at 467 nm and green-yellow emission at 560 nm were attributed to the Zn interstitial and oxygen vacancy defects present in ZnO NPs. Measurements from cyclic voltammetry (CV) demonstrate approximately symmetric peaks related to anodic and cathodic behaviours of the NPs based electrode. Result: For ZnO sample, the anodic peak was found at 0.49 V and cathodic at 0.29 V, whereas, for Ag-ZnO sample, the anodic peak was at 0.59 V, and the cathodic peak was present at 0.19 V, respectively. The separation between cathodic and anodic peaks enhanced with Ag-doping in ZnO, which could be associated with the variations in the transfer of electrons at the interface between the working electrode and the solution, confirming an increase in the reaction activity of Ag-ZnO NPs. Conclusion: The results indicate that Ag-doped ZnO NPs may be an efficient catalyst for waste water treatment and photocatalytic applications.

Nano-Warriors Against Cancer: Who Won?

One of nanotechnology's most rapidly expanding fields, nanomedicine has the potential to revolutionize healthcare and medicine by creating ground-breaking new diagnostic and therapeutic instruments. According to the definition of nanotechnology, it is the deliberate design, characterization, manufacture, and uses of materials, structures, devices, and systems by regulating their size and form in the nanoscale range (1 to 100 nm). Currently, nanomaterials are being developed to help molecules pass past biological barriers, to access molecules, to mediate interactions between molecules, and to detect molecular changes in a sensitive, highly efficient manner [1].

Exploring luminescent color tunability and efficient energy transfer mechanism of a single-phased hexagonal nanophosphor for white light emitting diodes (WLEDs) application

Nowadays, NUV-triggered phosphor-converted white light-emitting diodes (pc-WLEDs) have gained prominence as substantial alternatives to conventional incandescent and fluorescent lamps as a source of illumination. In this study, we have successfully developed a Tm3+ codoped La2O3:Sm3+ nanophosphor and investigated its potential suitability for application in white light-emitting diodes (WLEDs). X-ray diffraction (XRD) analysis was conducted to examine the phase impurity and structural characteristics of the synthesized nanophosphor. The analysis confirmed the formation of a single-phase La2O3 nanophosphor with a hexagonal crystal structure. The FT-IR spectrum of the synthesized nanophosphor exhibited distinct peaks associated with the vibrational frequencies of La-O bonds. The peaks observed in the fingerprint region of the spectrum, indicate the presence of La-O atoms in the nanophosphor. However, the HR-TEM analysis confirmed that the prepared nanophosphor had a polycrystalline nature and the observed particle sizes lay within the nanoscale range. The incorporation of Tm3+ ions into the host matrix led to a reduction in the optical band gap, leading to enhanced emission intensity. The photoluminescence (PL) study reveals that the Tm3+ ion exhibited blue emission upon excitation at 360 nm, whereas the Sm3+ ion emits reddish-orange light when excited at 379 nm and 408 nm, respectively. However, under 325 nm excitation, the nanophosphor exhibited a white emission color that resulted from the blending of colors emitted by both Tm3+ and Sm3+ ions. This unique finding suggests that this nanophosphor has the potential to generate white light specifically under this particular excitation wavelength. The efficient energy transfer between Tm3+ and Sm3+ ions was attributed to the electric multipolar interaction between the nearest neighbor ions, leading to a quenching phenomenon. Furthermore, the photometric analysis revealed that the correlated color temperatures (CCTs) associated with the emitted white light were found to be higher than 4000 K. Thus, based on these characteristics, it can be inferred that the prepared nanophosphor has the potential to be utilized as a cool white-emitting nanophosphor for single-phased WLEDs application.

Exploration of structural and morphological characteristics of Ag2+ substituted Zn-CuFe2O4 nanoparticles by green synthesis

The Ag-substituted copper-zinc ferrite Zn0.5Cu(0.5−x)AgxFe2O4, with changing compositions (x = 0, 0.02, 0.04, 0.06, 0.08 and 0.1), was prepared using the solution combustion technique. The solution combustion process is a straightforward, inexpensive and environmentally acceptable way to synthesise magnetic nanoparticles, as utilised in this present work. The structural, morphological, elemental analysis, magnetic and dielectric properties of the prepared samples were studied by X-ray diffraction, SEM, EDAX, TEM, VSM and impedance analysis. The cubic spinel structure was confirmed from the X-ray diffraction patterns and SEM analysis revealed that the samples were agglomerated with a spherical shaped morphology. The magnetic characteristics were examined by VSM measurements. The energy bandgap was determined by analysing the UV-Visible absorbance spectra. It confirms the samples are ferro-magnetic in nature and TEM shows that the particles’ sizes are in the nanoscale range. The samples have no contamination as determined by the EDAX analysis. The increment of the Ag2+ dopant in the place of Cu alters the crystallite size to be in the range 50–65 nm and micro-strain is designed within the samples. Doping by Ag2+ influences the properties of the nanostructured ferrite materials, as the obtained results demonstrate, and as the level of Ag doping increases, there is a pronounced enhancement in both the dielectric and magnetic properties of the material. These findings signify a promising avenue for the development of advanced EMI shielding materials with improved performance characteristics.

A Mini Review: Zinc Oxide NPs as a Promising Cancer Treatment Strategy: Insights into Synthesis Methodology and Mechanisms

Abstract: Cancer has become a major global public health concern, with millions of new cases and deaths reported annually. Conventional cancer treatments, such as chemotherapy and surgery, continue to be the standard of care; however, they frequently bear significant risks and high costs, necessitating the development of more cost-effective and safe alternatives. These limitations can be overcome by nanoparticle (NPs), composed of organic or inorganic substances in the nanoscale range, which offer benefits including enhanced pharmacokinetics, selective targeting of cancer cells, reduced toxicity, and decreased drug resistance. Green nanotechnology, which integrates nanotechnology with natural compounds, has emerged as a strategy for reducing toxicity on human health and the environment by functioning as reducing, capping, and stabilising agents. Compared to other NPs, Zinc oxide NPs (ZnO NPs) possess a unique selectivity and a potent capacity to target cancer cells, in addition to being biocompatible and considered safer for both humans and the environment. Due to the physiological function of zinc, an essential micronutrient, ZnO NPs have demonstrated greater bioavailability than other metal or metal oxide NPs. NP plays a more significant role in bioavailability than particle size, making ZnO NPs an attractive option for various applications. This mini review aims to comprehensively explore the synthesis methodology of ZnO NPs and the potential mechanisms underlying their anticancer properties. `

Generating a tunable narrow electron beam comb via laser-driven plasma grating

We propose a novel approach for generating a high-density, spatially periodic narrow electron beam comb (EBC) from a plasma grating induced by the interference of two intense laser pulses in subcritical-density plasma. We employ particle-in-cell (PIC) simulations to investigate the effects of cross-propagating laser pulses with specific angles overlapping in a subcritical plasma. This overlap results in the formation of a transverse standing wave, leading to a spatially periodic high-density modulation known as a plasma grating. The electron density peak within the grating can reach several times the background plasma density. The charge imbalance between electrons and ions in the electron density peaks causes mutual repulsion among the electrons, resulting in Coulomb expansion and acceleration of the electrons. As a result, some electrons expand into vacuum, forming a periodic narrow EBC with an individual beam width in the nanoscale range. To further explore the formation of the nanoscale EBC, we conduct additional PIC simulations to study the dependence on various laser parameters. Overall, our proposed method offers a promising and controlled approach to generate tunable narrow EBCs with high density.

Future perspectives of biopolymeric industry

Abstract Because of some specific properties such as hydrophilicity, poor mechanical strength, barrier properties, and other characteristics, biopolymers and biocomposite materials are not suitable for various important industrial applications. In the last few decades, the demand for biopolymers and their composites has increased continuously due to the extensive use of fossil resources or stock resources. Hence, eco-friendly biomaterials are highly essential for maintaining the sustainability of the environment. Now, biomaterials are considered highly promising materials that can be used as proper substitutes for fossil-based synthetic polymers and their composites through proper modification of the biopolymers. Recently, a novel non-biodegradable biomaterial (polythioesters) has been developed through microbial fermentation. Researchers throughout the globe are now developing improved biocomposite materials by incorporating different fillers in the nanoscale range that exhibit adequate mechanical properties and can be designed as future biomaterials that can replace traditional plastics. Now biopolymers and bionanocomposites are used noticeably in many countries throughout the world for food packaging, cosmetics, automobile industries, water purification, tissue engineering, textile industries, electronic industries, etc. For the industrialization of biobased polymeric materials and bionanocomposite materials, they should be synthesized in a sophisticated way by using green technology with improved geometry, good control in internal architecture, mechanical properties, and porosity. Chitin, alginate, pectin, zein, chitosan, poly-glutamic acid (-PGA), and other natural biopolymers are now found to be the future materials for various bioplastic industries. However, the future prospects of the biopolymer industry still pose challenges for industrialization and commercialization and should not be overlooked lightly.

Synthesis of Nanostructured Alumina from Byproduct Aluminum Filings: Production and Characterization

Aluminum oxide production from aluminum filings, which are a byproduct of several industrial machining processes and cannot be recycled to attain bulk aluminum (Al), is vital due to its wide use in scientific research and industry. The goal of this paper is to produce ultrafine and down-to-the-nanoscale alumina powder (Al2O3), starting from a waste Al filings. The microstructure and composition of the starting Al used were investigated using scanning electron microscopy (SEM), which was equipped with an attached energy dispersive spectrometer (EDS) unit. The results of this investigation confirmed that the starting Al was mainly Al–Mg alloy. Al2O3 was produced using two routes: The first involved the burning of aluminum hydroxide Al(OH)3 that was precipitated from aluminum chloride solution (AlCl3) resulting from dissolving the Al filings in 2M HCl. The second route involved direct precipitation as a reaction product of aluminum chloride with sodium carbonate solution. The Al2O3 produced using both routes, as well as the intermediate product Al(OH)3, were studied by SEM. The results demonstrate that the nanoscale range size was reached after milling of the produced Al2O3. Following thorough washing with distilled water, the EDS and the XRD techniques confirmed the formation of Al2O3, with no residual salt detected. The EDS results showed that the ratios of Al and O in the produced Al2O3 were about 96% of the ideal compound ratios. The XRD analysis also revealed the amorphous structure of the standard and the produced Al(OH)3, whereas the phases of the produced Al2O3 were either crystalline or amorphous. In our study, the Al2O3 percentage yield was about 77%, and this value obviously depends on the percentage of Al dross in the original Al filings. Overall, this research provides a novel contribution to the production of alumina powder in the nano-range starting from an aluminum filings byproduct, thereby reducing the dependence on known sources of aluminum.