Nail Products Research Articles

Genotoxicity and glucose tolerance induction by acetyltriethylcitrate, substitute plasticizer compared to di(2-ethylhexyl)phthalate

As di(2-ethylhexyl) phthalate (DEHP), one of phthalates, is classified as probable human carcinogens in EPA, acetyltriethyl citrate(ATEC), one of aliphatic esters, could be applied to DEHP substitute. ATEC is used as plasticizers in cosmetics and nail products. Here, we studied whether ATEC might have genotoxic potential and induce glucose tolerance as compared to DEHP. Genotoxicity was determined by Ames test with histidine-requiring Salmonella typhimurium (TA98, TA100, TA1535 and TA1537) and tryptophan-requiring Escherichia coli (WP2uvrA(pKM101)) strains, chromosomal aberration assay with Chinese hamster lung(CHL/IU) cells, and micronucleus test with bone marrow cells of CD-1 mice. The number of revertants was not significantly changed in Ames test. The frequency of cells with chromosome aberrations was less than 5% in ATEC- or DEHP-treated cells for 6 or 24 h. In addition, no statistically significant increase was observed for the incidence of micronucleated polychromatic erythrocytes (MNPCE) in polychromatic erythrocytes (PCE) and for the ratio of PCE among total erythrocytes at 24 or 48 h after the treatment of mice with ATEC or DEHP. In the meanwhile, blood glucose level (BGL) was increased by the treatment of mice with DEHP or ATEC for 5 consecutive days. Additional 7 days later, BGL by DEHP was recovered to normal level, but not that by ATEC. Then, taken together, our results suggest that ATEC could disrupt glucose metabolism under our experimental conditions. Therefore, although DEHP and ATEC may not be genotoxic, our data should be helpful for persons with the problem in glucose metabolism to choose products containing DEHP or ATEC.

C&EN talks with Lupita Montoya, air-quality crusader

When nail salons are in the news, the coverage is rarely pretty. A 2015 New York Times investigation, for example, uncovered details about the industry’s underpaid workers—overwhelmingly immigrants—and their health complaints. The series prompted swift legislation in New York State. However, it also sparked backlash from salon owners who felt that the costly new mandates would harm their small businesses and that the series went too far in generalizing about their industry. Lupita Montoya, an environmental engineer at the University of Colorado Boulder, is taking a different approach to the issue by involving both nail salon owners and workers from the start. At local nail salons, her team measured pollutants in the air generated through the use of nail polishes, polish removers, and artificial nail products. The researchers captured pollutants in specially designed vessels and quantified them using a variety of analytical techniques. Carmen Drahl spoke with Montoya—an immigrant herself—about

Autoregressive Integrated Moving Average (ARIMA) Model of Forecast Demand in Distribution Centre

Demand forecasting is very important to be done in order to meet the demand for nail products that are available in every DC. This article tries to present the basic method of time series analysis and forecasting performance of Autoregressive Integrated Moving Average (ARIMA) Model. The study uses this ARIMA model because this model can include the variables used and the type of time series data. Calculation of forecasting errors to be used is Mean Square Error (MSE). From the results of data processing analysis, the best ARIMA model for DC Aceh demand forecasting is ARIMA (3,0,2) with 63,578 units of nails, DC Padang is ARIMA (3.0,3) with a forecasting result of 59,853 units of nails, DC Pekanbaru is ARIMA (1,0,2) with forecasting results of 53,043 units of nails, DC Palembang is ARIMA (3.0,1) with forecasting results of 57,682 units of nails, and DC Medan is ARIMA (2.0,1) with results forecasting 63,699 units of nails.

Formaldehyde in "Nontoxic" Nail Polish.

Nail polish is known to contain potentially hazardous chemicals that have been linked to adverse health effects after overexposure. Formaldehyde is used as an antimicrobial, preservative, and nail hardener in select nail products, yet it is a recognized carcinogen and potent allergen in allergic contact dermatitis. The aim of this study was to investigate whether formaldehyde is present in nail polishes marketed as formaldehyde-free. Twenty-nine cosmetic nail polishes were purchased for analysis; of these, 28 were advertised as formaldehyde-free and/or did not declare formaldehyde in their ingredient lists. Initial testing was pursued using the chromotropic acid method, which uses a red-purple color change to indicate the presence of formaldehyde. Products were subsequently analyzed at least twice using high-performance liquid chromatography, quantifying formaldehyde amount above the detection limit of 2 ppm. High-performance liquid chromatography analysis found 5 of 29 products containing formaldehyde, 4 of which were advertised as formaldehyde-free. All other products were negative for formaldehyde (<2 ppm). Further investigation is warranted among brands testing positive and whether multiple products within the same line contain formaldehyde. Nail products must be labeled appropriately to avoid adverse reactions among individuals with cutaneous sensitivities.

COSMETICS AND THEIR ASSOCIATED ADVERSE EFFECTS: A REVIEW

The word ‘cosmetics’ is taken from a Greek word “kosmeticos” which means to adorn. Since early days materials used for beautification or improvement of appearance comes under the category of cosmetics. People want to look beautiful and the concept of cosmetics is as old as mankind and civilization. The urge to beautify one’s own body and look beautiful has been an urge in the human race since the tribal days. Assorted beauty products such as skincare products, hair products, fragrances, oral hygiene, and nail products, which may contain toxic chemicals that can be harmful to health are used especially by women. Since long time cosmetics have been known to enhance the appearance of the human body. In a society obsessed with beauty, people are lured to fake their appearance as a cure for their insecurities. The estimated value of cosmetic industry today is around 20 billion dollar globally. As a consumer, we are constantly attracted to using beauty and personal care products. But these products, which are supposed to make us feel healthy and look beautiful, have a deep dark side. Various toxic ingredients and hazardous chemicals used in cosmetics are incorporated in beyond acceptable limits. These chemicals may cause serious ill effects on skin and may also enter the skin and other organs causing carcinogenicity. Cosmetics have not only seeped into the fashion world but are also playing a prominent role in one’s day-to-day life. Thus, it becomes a necessity to make people aware of the various harmful effects of cosmetics and chemicals used in cosmetics.

A Study on the Legal Limit of the Labeling of Full Ingredients in Nail Products and the Regulation of the Law

A Study on the Legal Limit of the Labeling of Full Ingredients in Nail Products and the Regulation of the Law

"Green" UV-LED gel nail polishes from bio-based materials.

Gel nail polishes represent an advanced class of nail polishes, with the ability to cure under ultraviolet (UV) radiation, and consequently demonstrate improved properties and greater durability compared to conventional nail polishes. Most gel nail polishes available today are based on petrochemical resources, making them unsustainable. Bio-based materials are excellent renewable resources, with high potential for meeting final-product performance, cost, and environmental needs. In addition, bio-based materials can be modified to make them amenable to being cured by advanced Light Emitting Diode (LED) resources that consume low energy and are safer for human exposure compared to conventional UV-mercury lamps. Consumer preference for use of products made from bio-based sources has been clearly growing. On the other hand, according to the U.S. Department of Energy (DOE) technology roadmap, a considerable amount of basic chemical building blocks should be derived from plant-based renewable materials in near future. However, to the best of our knowledge, bio-based nail products have not been sufficiently explored. Therefore, to keep pace with environmental regulations and consumer preference, there is an unmet opportunity to develop novel, sustainable nail gel polishes with considerable bio-renewable content. In this study, two sustainable UV-LED curable gel nail polish prototypes-one high-solids zero-volatile organic content (VOC) and the other waterborne, both with considerable bio-renewable content, were designed. Both formulations were cured under both UV-mercury and UV-LED radiation sources in order to evaluate their curing efficiency under a UV-LED source. Also, their performance was compared with a commercial petro-based benchmark. The high-solids formulation demonstrated promising performance, exceeding that of the benchmark in opacity, chemical properties, gloss, and pendulum hardness, while the waterborne formulation met most of the desirable requirements with some significant technical benefits, including low odour and higher renewable raw material content. These novel gel nail polishes are greener alternatives to the current products in the market with high potential for promising consumer acceptance.

VOC sources and exposures in nail salons: a pilot study in Michigan, USA.

Exposures of nail salon technicians have received attention due to the potentially toxic materials used in nail products, which include volatile organic compounds (VOCs) such as formaldehyde and methyl methacrylate (MMA). This study characterized area and personal concentrations and other indoor air parameters in 17 nail salons in fall and winter seasons in three areas of Michigan. VOC samples were analyzed using thermal desorption, gas chromatography and mass spectroscopy, and the VOC composition of 35 nail products (e.g., polish, top coat, base coat) was measured using headspace sampling. Ventilation rates were derived using CO2 concentrations, occupancy and building information, and VOC sources were apportioned by a novel application of chemical mass balance models. We detected ethyl acetate, propyl acetate, butyl acetate, MMA, n-heptane and toluene in most salons, and benzene, D-limonene, formaldehyde, and ethyl methacrylate in some salons. While MMA was not measured in the consumer and professional products, and the use of pure MMA in salons has been not been permitted since the 1970s, MMA was found in air at concentrations from 100 to 36,000µg/m3 in 15 of 17 salons; thus its use appears to be commonplace in the industry. Personal measurements, representing exposures to workers and clients, were about twice those of the area measurements for many VOCs. This study identifies the products responsible for emissions, shows the widespread presence of MMA, and documents low ventilation rates in some salons. It also demonstrates that "informal" short-term sampling approaches can evaluate chemical exposures in nail salons, providing measurements that can be used to protect a potentially susceptible and vulnerable population. Additional controls, including restrictions on the VOC compositions and improved ventilation, can reduce exposures to salon workers and clients.

Evaluating an owner-to-worker training intervention in California nail salons using personal air monitoring.

Chemicals in nail products have been linked to numerous health concerns. We recruited Vietnamese-American nail salon owners and workers in California and randomized salons into an intervention or control group. Owners in the intervention group received training and then provided education to workers in their salons on best practices to reduce workplace chemical exposures. Methyl methacrylate (MMA), toluene, and total volatile organic compounds (TVOCs) were measured using personal air monitors worn by workers during the work-shift. We enrolled 77 salons (37 intervention and 40 control) and 200 workers. There was no significant intervention effect between the two groups. However, MMA and TVOCs were higher for workers who used gel polish and acrylic nails as well as in busy salons. Although the intervention did not show reductions in chemical levels, identifying worker tasks and salon characteristics that predict chemical levels can inform future interventions to reduce exposures.

Improving the knowledge and behavior of workplace chemical exposures in Vietnamese-American nail salon workers: a randomized controlled trial.

We assessed the efficacy of trainings with Vietnamese nail salon owners and workers on knowledge and behaviors that could reduce exposures to toxic chemicals in nail products. We trained Vietnamese salon owners in California (n = 77) who then trained their workers (n = 200) on best practices. In a cluster randomized controlled trial, we assessed the efficacy of the training on change in knowledge and self-reported behaviors. Data were collected from 2013 to 2016 and analyzed from 2016 to 2017. Compared to the control group, the intervention group had significantly greater increases in knowledge about: safer nail polishes [odds ratio (OR) 3.7 (95% confidence interval (CI) 1.9, 7.2)]; proper ventilation methods (OR 4.2; 95% CI 2.2, 8.1); recommended glove types (OR 3.4; 95% CI 1.9, 6.3); and recommended product handling and storage (OR 4.1; 95% CI 1.7, 9.9). The intervention also increased best practices: using safer nail polishes (OR 3.6; 95% CI 1.9, 6.8); reading product labels (OR 2.6; 95% CI 1.3, 5.0); and wearing long sleeves (OR 2.4; 95% CI 1.3, 4.2). The owner-to-worker intervention with culturally and linguistically appropriate training for salon owners who then trained workers was effective in promoting knowledge and self-reported behaviors that can reduce workplace chemical exposures.

Evaluation of the bacterial burden of gel nails, standard nail polish, and natural nails on the hands of health care workers

Acrylic nails harbor more bacteria than natural nails, and wear is not recommended for health care workers (HCWs). Little is known about the new and popular gel nail products. This study sought to evaluate the bacterial burden of gel nails, standard nail polish, and natural nails on the hands of HCWs. The study was conducted at 3 health centers. Nails on the dominant hand of 88 HCWs were painted with gel polish and standard polish. Cultures were obtained on days 1, 7, and 14 of wear and before and after hand hygiene with alcohol hand gel. A total of 741 cultures were obtained. Bacterial burden increased over time for all nail types (P ≤ .0001). Reductions in the bacterial burden of natural nails and standard polish, but not gel polish, (P = .001, P = .0028, and P = .98, respectively) were seen after hand hygiene. All 3 nail types become more contaminated with bacteria over time. Standard polish and natural nails may be more amenable to hand hygiene than gel polish. This study did not show an increased number of microorganisms on nails with gel polish; however, gel nails may be more difficult to clean using alcohol hand gel.

Assessing indoor air quality in New York City nail salons

ABSTRACTNail salons are an important business and employment sector for recent immigrants offering popular services to a diverse range of customers across the United States. However, due to the nature of nail products and services, salon air can be burdened with a mix of low levels of hazardous airborne contaminants. Surveys of nail technicians have commonly found increased work-related symptoms, such as headaches and respiratory irritation, that are consistent with indoor air quality problems. In an effort to improve indoor air quality in nail salons, the state of New York recently promulgated regulations to require increased outdoor air and “source capture” of contaminants. Existing indoor air quality in New York State salons is unknown. In advance of the full implementation of the rules by 2021, we sought to establish reliable and usable baseline indoor air quality metrics to determine the feasibility and effectiveness of the requirement. In this pilot study, we measured total volatile organic compounds (TVOC) and carbon dioxide (CO2) concentrations in 10 nail salons located in New York City to assess temporal and spatial trends. Within salon contaminant variation was generally minimal, indicating a well-mixed room and similar general exposure despite the task being performed. TVOC and CO2 concentrations were strongly positively correlated (ρ = 0.81; p < 0.01) suggesting that CO2 measurements could potentially be used to provide an initial determination of acceptable indoor air quality for the purposes of compliance with the standard. An almost tenfold increase in TVOC concentration was observed when the American National Standards Institute/American Society of Heating, Refrigerating and Air-Conditioning Engineers (ANSI/ASHRAE) target CO2 concentration of 850 ppm was exceeded compared to when this target was met.

Non-occupational allergic contact dermatitis caused by long-lasting nail polish kits for home use: 'the tip of the iceberg'.

Allergic contact dermatitis (ACD) from (meth)acrylates caused by long lasting nail polish (also known as "permanent", "semi-permanent" or "gel nail polish") has been described both in occupational and non-occupational settings. Inexpensive kits for home use have been available for purchase in many stores or through the Internet. To report on several further cases of consumers sensitised to these nail products. Patch test results and evaluation of ingredient labelling of products brought in by the patients. Four new cases are presented. Three of the patients reacted to 2-hydroxypropyl methacrylate, 2-hydroxyethyl methacrylate and ethyleneglycol dimethacrylate (EGDMA), and all 4 to 2-hydroxy ethylacrylate. Acrylates are present in a wide range of products including medical materials. Sensitization from (meth)acrylates caused by a merely aesthetic procedure might significantly impact health by jeopardizing access to several types of medical interventions. Policies should be implemented restricting the use of long-lasting nail polishes to qualified professionals and banning the indiscriminate sale of kits for home use.

Safety and Efficacy of Nail Products

Over the past several decades, the commercialization of nail cosmetics has increased. From nail polishes to artificial nails, different methods of nail beautification have become popularized. However, the impact of these products remains largely unknown. Governments have passed legislation in attempts to regulate nail cosmetics, but these regulations may not be adequate and are difficult to enforce. Knowledge of the safety and efficacy of nail products remains limited due to the relative dearth of literature published on the topic. This review serves to summarize and interpret the data available regarding common nail products and their safety and efficacy. Nail products such as nail polish, nail polish removers, and artificial nails have shown to have some adverse effects through case reports and studies. Harmful substances such as toluenesulfonamide-formaldehyde resin and methacrylates have been identified in commercial nail products, leading to several adverse effects, but in particular, allergic contact dermatitis. Exposure to substances such as acetonitrile found in removers may have more toxic and caustic effects, especially if ingested. In addition, for nail technicians there are negative effects linked with occupational exposure. Compounds used in nail products may become aerosolized and lead to asthma, eye and throat irritation, and even neurocognitive changes.

Study on the safety review and management system of Hazardous substances in nail products

Study on the safety review and management system of Hazardous substances in nail products

Allergic contact dermatitis from acrylic nails in a flamenco guitarist

Acrylates are molecules that are well known for their strong sensitizing properties. Historically, many beauticians and individuals using store-bought artificial nail products have developed allergic contact dermatitis from acrylates. More recently, the use of acrylic nails among flamenco guitarists to strengthen their nails has become very popular. A 40-year-old non-atopic male patient working as a flamenco guitarist developed dystrophy, onycholysis and paronychia involving the first four nails of his right hand. The lesions were confined to the fingers where acrylic materials were used in order to strengthen his nails to play the guitar. He noticed improvement whenever he stopped using these materials and intense itching and worsening when he began reusing them. Patch tests were performed and positive results obtained with 2-hydroxyethyl methacrylate (2-HEMA), 2-hydroxyethyl acrylate (2-HEA), ethyleneglycol-dimethacrylate (EGDMA) and 2-hydroxypropyl methacrylate (2-HPMA). The patient was diagnosed with occupational allergic contact dermatitis likely caused by acrylic nails. Artificial nails can contain many kinds of acrylic monomers but most cases of contact dermatitis are induced by 2-HEMA, 2-HPMA and EGDMA. This is the first reported case of occupational allergic contact dermatitis from acrylates in artificial nails in a professional flamenco guitar player. Since the practice of self-applying acrylic nail products is becoming very popular within flamenco musicians, we believe that dermatology and occupational medicine specialists should be made aware of the potentially increasing risk of sensitization from acrylates in this setting.

Safety Assessment of Nitrocellulose and Collodion as Used in Cosmetics.

The Cosmetic Ingredient Review Expert Panel (the Panel) assessed the safety of nitrocellulose and collodion as used in cosmetics, concluding that these ingredients are safe in the present practices of use and concentration in cosmetic formulations. Both ingredients are used almost exclusively in nail product formulations. The maximum concentration of use of nitrocellulose in nail polish and enamels is 22%; for collodion, the maximum reported concentration of use in nail polish and enamel is 14%. The Panel reviewed available animal and clinical data in making its determination of safety.

Simultaneous determination of cosmetics ingredients in nail products by fast gas chromatography with tandem mass spectrometry

A rapid and sensitive gas chromatography with tandem mass spectrometry (GC–MS/MS) method has been developed and validated to quantitatively determine cosmetic ingredients, such as toluene, N-methylpyrrolidone, 2,4-dihydroxybenzophenone (benzophenone-1, BP-1), and diethylene glycol dimethacrylate, in nail products. In this procedure, test portions were extracted with acetone, followed by vortexing, sonication, centrifugation, and filtration. During the extraction procedure, BP-1 was derivatized making it amenable to GC–MS analysis, using N,O-​bis(trimethylsilyl)​trifluoroacetamide. The four ingredients were quantified by GC–MS/MS in an electron ionization mode. Four corresponding stable isotopically labeled analogues were selected as internal standards, which were added at the beginning of the sample preparation to correct for recoveries and matrix effects. The validated method was used to screen 34 commercial nail products for these four cosmetic ingredients. The most common ingredients detected in the nail products were toluene and BP-1. Toluene was detected in 26 products and ranged from 1.36 to 173,000μg/g. BP-1 ranged from 18.3 to 2,370μg/g in 10 products.

The Association Between Urinary Benzophenone Concentrations and Personal Care Product Use in Korean Adults.

Benzophenone (BP) derivatives are widely used in personal care products (PCPs) for protection from ultraviolet radiation. Because of their broad applications, BP derivatives have been found in various human bodily fluids. In the present study, we investigated the relationship between urinary concentrations of BP derivatives and PCP use in Korean adults. A urinary BP biomonitoring survey was conducted in Korea by the Ministry of Food and Drug Safety in 2014. BP derivatives (BP-1, BP-3, and 4-OH-BP) were measured in urine samples from 168 Korean adults (mean age, 43.2 ± 15.4 years) by high-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. Information about the use of PCPs in the past 7 days was obtained by direct interviews. The mean levels of BP-1, BP-3, and 4-OH-BP were 0.87, 5.87, and 0.13 ng/g creatinine, respectively. The geometric mean levels of BP-1, BP-3, and 4-OH-BP were significantly higher in female than those in male. The medians of the urinary concentration of BP derivatives were significantly higher among users of the following PCPs than those in non-users; the PCPs included sunscreen, skin care products, functional cosmetics, makeup base, makeup, lip cosmetics, eye cosmetics, color cosmetics, perfume products, and nail products. A regression analysis revealed a significant linear association between urinary BP-3 concentrations and the number of additional cosmetic products used. These findings provide evidence of a positive association between exposure to PCPs and urinary BP derivative concentrations in Korean adults.

네일 융복합보강제의 사용실태 및 인식도 조사

As the nail industry has grown, concerns on damages to natural nails due to nail services and interests on nail products have been increased. This study is on nail convergent strengtheners which reduce damages on natural nails, and especially focused on the use and awareness of nail strengtheners by nail technicians. First, documentary research on previous studies was conducted to define nail services, nail damages, and nail strengtheners. Preliminary survey and main survey was conducted by KSDC on-line survey tool and the result was analyzed by frequency analysis, cross analysis, and correlation analysis by KSDC advanced statistical program. As a result, nail technicians have the high level of awareness on characteristics, effects, how to use, and application process of nail strengtheners. Nail technicians are the mid level of awareness on the ingredients of nail strengtheners.