The research aims to investigate Pakistan’s geographic, historic, political, riparian, and socio-economic factors that lead to Pakistan as a Land of Penta Mesopotamia. Pakistan is situated in South Asia along the coast of Arabian Sea, bordering Afghanistan in west, China in north, Iran in southwest, Arabian Sea in South and Hindustan (India) lies in the east. Historically, the land of Pakistan has been the host of Neolithic period’s South Asian multi Indus valley civilization (IVC) that includes Gandhara, Harappan, Mehrgarh, Mohenjo-Daro, Takht-i-Bahi and Texila civilizations that emerged during 3,300 BCE to 1300 BCE. Muslim Civilizations emerged from 712 to 1857 and British colonial culture also developed from 1857-1947 in this area. The Indus valley civilization flourished parallel to the Mesopotamian civilizations. Mesopotamian civilization includes the Assyrian and Babylonian Civilization that emerged in Iraq in between the two rivers of Euphrates and Tigris from 3,100 B.C. to 332 B.C. and is referred to the “Cradle of Civilizations”. Since Mesopotamian civilization attracted all the ancient civilizations in West Asia to nourish because of its friendly ecological environments, fertile land and rich alluvium soils. Pakistan’s geography also attracted the Indus valley civilizations that emerged in the confluence of seven perennial rivers i.e. Sutlej, Ravi, Chenab, Jhelum, Indus, Swat and Kabul rivers, credited as the “Cradle of South Asian Indus valley Civilizations”. Pakistan’s strategic location in the region, her favorable ecosystem for biodiversity, favorable multi seasons, fertile land, friendly ecological conditions, rich agricultural environment, rich alluvium soils, strategic multiple riparian potentials that originate from Himalayan, Karakorum, and Hindu-Kush mountain ranges, remained lucrative for South Asian Indus valley civilizations. Pakistan’s geography also remained very attractive to the sub regions of Asia i.e. Central, South and West Asia because it has provided and has been providing the Mesopotamians agrarian transit economy to landlocked countries of Afghanistan and Central Asian States from the shortest possible sea route of Arabian Sea and visa-vi to oil rich states of Middle East via China Pakistan Economic Corridor (CPEC). Mesopotamian’s cultural, ecological, geographic, historic, riparian, socio-economic, socio-political equilibrium and similar factors are founded in the Indus valley civilizations that erect the sufficient evidence to prove that “Pakistan is a Land of Penta Mesopotamia”. Keywords: Civilizations, Confluence, Fertile land, Mesopotamia, Riparian potentials.