The subject of this research is the history of life, professional and social activity of the Mikhailov spouses – county physicians and philanthropists in the Southern Coast of Crimea throughout several decades of the first half of the XX century. The circumstances of this history, reconstructed in historiography for the first time based on comprehensive examination of the newly introduced into the scientific discourse sources (archives, materials from the museum funds, periodicals, sources of personal origin),  are placed into the context of large-scale sociocultural shifts that took place in the region and nationwide at the turn of the XIX – XX centuries and the first half of the XX century. The scientific novelty consists in reconstruction of the important page in the history of development of county medicine and philanthropy in the Southern Coast of Crimea in the early XX century. Due to the fact that in accordance with the modern requirements of historiographical direction of “ego-history”, the dynamics of personal fate of the heroes is viewed against the background of social correlations, The new data is acquired on the history of development of the Southern Coast of Crimea in the early XX century by the representatives of different strata of the Russian society – nobility, merchantry, and intelligentsia, as well as on establishment of the special sociocultural environment in the region.