To solve the problem of controlling mining in the open-pit mine end slope fire-burned area, applying multivariate function fitting to the roof and floor modeling of multi-coal seam open pit mines, introducing the factor of coal quality changes in the fire-burned area, determining coal quality information at each location through proximate analysis of coal, to establish the net profit model of the mining area, it is determined the net profit of each mining position by numerical integration, the final mining position was determined without failure by calculating the slope stability based on the numerical simulation of strength reduction. Taking the Dananhu No. 2 open-pit mine in Hami, Xinjiang, China as the engineering background, the fire-burned area III within the southern end slope boundary of the first mining area is 240 m. It was finally determined that the optimal mining position is when the advancement degree is 182 m, the ultimate pit slope angle is 25°, the three-dimensional slope stability is 1.305, the profit is 671.96 million yuan, The deep boundary of the southern end slope fire-burned area of the slope is reduced by 58 m. This paper solves the problem of end slope mining in Dananhu No. 2 mine, and maximizes its net profit under the condition of ensuring safe production.