Abstract An adaptive control chart is one of the most effective techniques in Statistical Process Control (SPC). The coefficient of variation (CV) is common in many real life applications, especially in manufacturing and materials engineering, finance, medical and biological sciences. This paper proposes three adaptive charts to monitor the multivariate coefficient of variation (MCV), in order to improve the sensitivity of the standard MCV chart, in detecting small and moderate MCV shifts. The proposed charts are designed using the Markov chain approach and they are compared with the existing standard MCV chart using the average time to signal (ATS), standard deviation of the time to signal (SDTS) and expected average time to signal (EATS) criteria. The performance comparison shows that the proposed adaptive MCV charts, particularly the variable sample size and sampling interval (VSSI) MCV chart, outperform the existing MCV charts, in terms of the ATS and EATS criteria. By allowing the sample size and sampling interval to be varied in the VSSI MCV chart, process engineers will have better control in process monitoring and at the same time are able to detect an out-of-control signal quicker. Illustrative examples are presented by considering the VSSI MCV chart to show the chart’s implementation.