The Normalized Difference Vegetation Index (NDVI) is the most common index to measure vegetation in agriculture and create classified prescription maps used for several purposes. It is obtained as the ratio between information from the visible and near infrared spectral bands. The calculation of NDVI often uses very expensive hyperspectral and multispectral optical sensors. This study aims to develop an efficient model to extract NDVI data from RGB images. During the work were acquired images, of different plant species at different vegetation status, through a snapshot hyperspectral camera (Specim IQ) featuring natively superimposed RGB sensor whose images were calibrated a posteriori (sRGB). NDVI was predicted from sRGB images using a Shallow-regressive neural network that performs a pixel-pixel regression. The model has been then tested on around 1000 drone images acquired by a 6x Sentera sensor to test the efficiency of the applied model. The model has been used to estimate the numerical value of NDVI and the classes produced by a clustering method (k-means). The results of this work showed that the calibrated images had a very high correlation with the NDVI in validation (r = 0.91), maintaining good performances (r = 0.71) when applied to a set of data acquired with a different non-co-registered sensor. Therefore, for the first time this work has shown that the health of vegetation through the NDVI could be calculated using unexpensive RGB device adopting a pixel-pixel regression AI approach. The approach shows its importance especially for small-sized farms where profit would not allow for the budget to access multispectral cameras and heavy carriers (i.e., UAV).