In this work, an effective Fault Detection and Diagnosis (FDD) strategy designed to increase the performance and accuracy of fault diagnosis in grid-connected photovoltaic (GCPV) systems is developed. The evolved approach is threefold: first, a pre-processing of the training dataset is applied using a multiscale scheme that decomposes the data at multiple scales using high-pass/low-pass filters to separate the noise from the informative attributes and prevent the stochastic samples. Second, a principal component analysis (PCA) technique is applied to the newly obtained data to select, extract, and preserve only the more relevant, informative, and uncorrelated attributes; and finally, to distinguish between the diverse conditions, the extracted attributes are utilized to train the NNs classifiers. In this study, an effort is made to take into consideration all potential and frequent faults that might occur in PV systems. Thus, twenty-one faulty scenarios (line-to-line, line-to-ground, connectivity faults, and faults that can affect the normal operation of the bay-pass diodes) have been introduced and treated at different levels and locations; each scenario comprises various and diverse conditions, including the occurrence of simple faults in the PV1 array, simple faults in the PV2 array, multiple faults in PV1, multiple faults in PV2, and mixed faults in both PV arrays, in order to ensure a complete and global analysis, thereby reducing the loss of generated energy and maintaining the reliability and efficiency of such systems. The obtained outcomes demonstrate that the proposed approach not only achieves good accuracies but also reduces runtimes during the diagnosis process by avoiding noisy and stochastic data, thereby removing irrelevant and correlated samples from the original dataset.