Multiple Primary Malignant Tumors Research Articles

Multiple primary malignant tumors

Members of colon cancer-prone nonpolyposis families who had multiple primary malignant tumors were analyzed to determine the frequencies, locations, and stages of their cancers, and the duration of their survival. Colon cancers tended to be more proximal, were in a less advanced stage than in the general population, and in a majority of instances were associated with colonic adenomas. The multiple primary malignant tumors were more common in women, and occurred at a younger age than in the general population. Six or more multiple primary malignant tumors occurred in each of 4 patients. All patients survived for more than 10 yr after the diagnosis of the first cancer. Extracolonic cancers were most frequent in the breast and endometrium.

口腔と結腸の重複癌症例ならびに本邦における口腔領域重複悪性腫ようの統計的観察

A case of multiple primary malignant tumors with squamous cell carcinoma of the mandibular gingiva and adenocarcinoma of the transverse colon which occurred in a 82-year-old female was reported and the Japanese literature from 1975 to 1984 on multiple primary malignant tumors involving the oral region was reviewed.The results of 72 cases documented statistically were as follows; The average age at first examination which almost consisted with cancer age, was 36.1% in the 7th decade, 25.0% in the 6th decade and 22.2% in the 8th decade individually.The ratio of male to female was 2.8:1. As for the diagnostic period of first cancer and secondary cancer, the synchronous cancer represented 31.9% and 68.1% in the metachronous cancer. Regard with the pairing of double cancer on oral region and other organs, digestive system such as, stomach, esophagus occupied the largest half of the pairing.Histologically, squamous cell carcinoma (scc) and carcinoma of the glandular origin or scc in their separate organ showed the highest pairing rate.

Synchronous Multiple Primary Malignant Tumors accompanied by Glioblastoma

A case of synchronous multiple primary malignant tumors accompanied by glioblastoma is reported. The patient, a 27-year-old woman, was admitted with nausea, vomiting, and a slight consciousness disturbance. Five months before, she had noticed a lump in both breasts, and 1 month later, an abnormal shadow was noted on chest X-ray. Computed tomography scan showed a cystic lesion with ring-like enhancement in the left frontal lobe. Chest X-ray and the tomogram showed a tumor shadow in the right upper lung field. The brain tumor was totally removed. Histologically, it was glioblastoma (first primary focus). One month following brain surgery, a bilateral mastectomy with lymph-node dissection was performed. Histopathological examination revealed ductal carcinoma without metastasis to lymph-node, and they were diagnosed as bilateral primary breast carcinomas (second and third primary foci). Lung tumors gradually progressed in spite of chemotherapy, and she expired due to respiratory insufficiency. Histopathological examination of the autopsied lungs revealed primary papillary adenocarcinoma of apical portion of the upper lobe of right lung with numerous small hematogenously disseminated metastatic tumor nodules in entire lobes of both lungs (fourth primary focus). Moreover, an occult sclerosing carcinoma of papillary type was found in the thyroid (fifth primary focus). There have been no previous reports on five synchronous primary malignant tumors in which one of the primary sites was within the brain.

Five Cases of Multiple Primary Malignant Tumors

Five cases of multiple primary malignant tumors were examined in this clinic in last 5 years. Case 1 (64-year-old man) had adenocarcinoma of the rectum and squamous cell carcinoma of the larynx. Case 2 (72-year-old man) was with squamous cell carcinoma of the larynx and adenocarcinoma of the stomach. Case 3 (53-year-old man) had adenocarcinoma of the rectum and squamous cell carcinoma of the maxilla. Case 4 (69 year-old man) was affected by squamous cell carcinoma of the maxilla and malignant lymphoma of the testes. Case 5 (72-year-old man) had squamous cell carcinoma of the larynx and malignant lymphoma of the inguinal lymph node. Literary speculations on multiple tumors have been made also, especially on incidence, age at onset, sex difference, affected organs and interval of cancerous pathogenity.

肺と下がく歯肉にみられた重複がんの１例

肺と下がく歯肉にみられた重複がんの１例

Multiple primary malignant tumors involving the large bowel.

We reviewed 5680 autopsy protocols in order to determine the frequency of Multiple Primary Malignant Tumors (MPMT) in different organs. The large bowel was the organ most frequently involved, making up to 32 per cent of all MPMT cases. Of 26 patients with colorectal MPMT, six were multicentric in the large bowel, and 20 were associated with extracolonic malignancies. The tissues harboring primary malignancies were, in order of decreasing frequency, liver, lung, and female and male reproductive organs. We compared the exact location of large bowel cancers in patients with and without a prior cholecystectomy; there was no statistically significant difference between the two groups, especially for right-sided colonic carcinoma in women.

Thorotrast-Induced Multiple Primary Malignant Tumors of the Liver—Cholangiocarcinoma and Malignant Hemangioendothelioma

A case of multiple primary malignant tumors of the liver (cholangiocarcinoma and malignant hemangioendothelioma) that developed 40 years after Thorotrast administration is described, with radiological and autoradiographic findings. The estimated organ dose to the liver was approximately 580 rads.

Multiple primary malignant neoplasms in breast cancer patients in Israel.

The data of an epidemiologic study of multiple primary malignant neoplasms in breast cancer patients in Israel are presented. During the 18-year period of the study 12,302 cases of breast carcinoma were diagnosed, and, of these, 984 patients (8%) had multiple primary malignant tumors. Forty-seven of these patients developed two multiple primary cancers. A significantly higher than expected incidence of second primary cancers occurred at the following five sites: the opposite breast, salivary glands, uterine corpus, ovary, and thyroid. Cancers of the stomach and gallbladder were fewer than expected. Treatment of the breast cancer by irradiation was associated with an increased risk of subsequent cancers of lung and hematopoietic system. The prognosis was mainly influenced by the site and malignancy of the second primary cancer. The incidence of multiple primary malignancies justifies a high level of alertness to this possibility in the follow-up of breast cancer patients.

Multiple Primary Malignant Tumors of the Stomach and Large Intestine

Multiple Primary Malignant Tumors of the Stomach and Large Intestine

Multiple primary malignant tumors (MPMT): study of 68 autopsy cases (1963-1980).

Review of 8428 autopsies (1870 for known cancer) showed that 68 patients had had multiple primary malignant tumors (MPMT). Those 68 cases represented 0.8 per cent of all autopsies done, 3.6 per cent of all cancer autopsies. Diagnosis of MPMT was made only at autopsy in 24 cases (35.3 per cent). Thirty-six patients were male, 32 female. Their average age was 64 +/- 2.3 years. Cancers were "synchronous" (diagnosed within a six-month period) in 15 patients, "metachronous" (diagnosed at greater than six-month intervals) in 49, and "combined" in four. Metastatic foci were seen in 53 patients. Fifty-nine patients had two primary malignant tumors (PMTs); seven had three PMTs; one had four PMTs; and one had five PMTs, for a total of 148 tumors. Over half (53.1 per cent) of the second PMTs occurred within five years of the first PMTs. First PMTs were most common in the hematopoietic system and the cervix; second PMTs were most common in the lungs and the hematopoietic system. Second PMTs were less well differentiated than index PMTs. Forty-four deaths had not been directly tumor-related. Nineteen patients with metachronous MPMT lived more than ten years. Of 23 patients with one pulmonary PMT, 22 died within two years. Concomitant findings of pulmonary artery embolism, gallstone(s), thyroid or prostatic hyperplasia, and benign tumor were common in these patients. It is hoped that accumulation of data from this and other series of MPMT will provide insight into the clinicopathologic characteristics, the causes, and the interrelationships of these lesions that constitute primarily a disease of the elderly.

Multiple primary carcinomas of the colon and associated extracolonic primary malignant tumors.

A review of 308 cases of colorectal carcinoma showed 12 cases (3.9%) of colorectal multiple primary malignant tumors and 14 cases (4.5%) of colorectal primary malignant tumor associated with extracolonic primary malignant tumor. A total of 60 tumors was involved: 14 each in the sigmoid and transverse colon; eight in the cecum; six in the rectum; one each in the ascending and descending colons; three each in the bladder and prostate; two each in the breast, cervix, and lung; and one each in the skin, nasopharynx, kidney, and endometrium. Three of the four patients with multifocal cancer were found to have in situ cancer, and 12.7% of concomitant adenomas had malignant changes. Seven patients had regional lymph node metastases. Of the six patients with rectocolonic multiple tumors who had adequate follow-up data, survival in three ranged from 19.5 to 60 months; three were alive and well 15 to 51 months after resection. Survival of patients with primary rectocolonic and extracolonic tumors was similar. From these data and the pathologic study of the resected specimens, we recommend for any patient with cancer of the rectocolon that the entire colon be searched for multiple primary malignant tumors, that extracolonic tumors be considered second primary tumors unless proved to be metastases, and that follow-up be long and include frequent rectocolonic examinations for a second primary tumor.

Multiple primary malignant tumors of the head and neck

Multiple primary malignant tumors associated with an index cancer in the head and neck are gaining attention as more patients survive their initial primary disease, the longevity of the population at large increases, health care delivery becomes more readily available, and sophisticated diagnostic technology is developed. Forty-four patients with multiple primary cancer in whom the index neoplasm was inthe head and neck are reported. This group comprises 17 per cent of the patients with head and neck cancer treated at the Detroit General Hospital in the last 10 years. Forty-seven per cent of the cancers occurred simultaneously, 10 per cent were synchronous (discovered within six months), and 43 per cent were metachronous (discovered later than six months). Eighty-six per cent of the patients are dead; 75 per cent died within one year after the diagnosis of the secondary primary cancer. Patients with simultaneously occurring malignant tumors appeared to have a somewhat poorer prognosis than those with metachronously occurring tumors. Although the highest incidence of multiple primary malignant tumors occurs in the first year, a consistent high incidence puts the patient with a solitary neoplasm at risk well beyond the three to five years of survival usually considered as "cure." Although no factor other than coincidence has been proved to be involved in the pattern of occurrence of multiple primary neoplasms of different tissues or organs, this study does corroborate other reported data that emphasize that patients with head and neck cancer are at greater risk of developing a second primary malignant tumor in the multicentric vicinity of the original lesion, and in the esophagus and lung than the general population. A program of management and post-treatment surveillance is presented. The potential for new primary malignant neoplasms to develop in the multicentric vicinity of the original lesion and in remote organs cannot be approached with detached curiosity.

The Diagnosis of Breast Cancer

The Diagnosis of Breast Cancer

Multiple and multifocal carcinomas in female genital organs and breast

Sixty-seven cases of multiple primary malignant tumors of the genital organs and breast were analyzed in their different combinations. A percentage of 5.4% of multiple primary tumors was found in a cancer population of 1235. In addition, cases of multifocal primary carcinoma in symmetrical organs (breasts and ovaries) were discussed. A higher incidence of multiple primary cancers was found in embryologically related organs, such as vulva, vagina and uterine exocervix, or endometrium and ovary. Endometriosis with malignant foci was frequently found associated with the multiple primary tumors of the mullerian derived organs. Carcinoma <i>in situ</i> was found synchronously with overt multiple and multifocal carcinoma of the female genital organs and breasts and therefore considered as a previous stage of the carcinomatous progression. The area response of the embryologically related organs was discussed as a factor in the genesis of the multiple and multifocal multiple primary tumors of the female genital organs and breast.

Two Cases of Multiple Primary Malignant Tumor

Two Cases of Multiple Primary Malignant Tumor

Breast cancer and associated extramammary malignant neoplasms

The phenomenon of multiple primary malignant neoplasms has interested students of oncology for many years. Since the report of Billroth [I] appeared in 1870 numerous compilations of multiple primary malignant tumors have been made [2-41. Few investigators, however, have dealt specifically with the association of breast cancer, either unilateral or bilateral, and extramammary malignant neoplasms. Recently Schoenberg, Greenberg, and Eisenberg [5] reported an excess of at least 50 per cent observed over expected second primary lesions when the initial primary tumor was in the breast and the second primary tumor was in either the digestive system or the genital organs. Further, Schottenfeld and Berg [6] have concluded that there is an increased risk for patients ‘with ovarian and endometrial cancer to incur metachronous cancer of the breast. Inasmuch as breast cancer is one of the most prevalent malignant neoplasms in women, I thought that a study of its association with extramammary malignant neoplasia might contribute to the understanding of some aspects of breast cancer. It would be of interest to determine what patterns emerge and the effect of subsequent neoplasms on prognosis and longevity; also to correlate the menstrual patterns, blood groups, and familial history of neoplasia with breast and nonmammary malignant tumors.

Multiple primary malignant neoplasms.

Almost a century ago Billroth1described two patients in both of whom developed more than one primary malignant neoplasm. Although not published until 1869, one of these patients was reported in 1860 according to Warren and Gates2and Judge.3Since that time, there has been a permutation of the occurrence rate of this disease from that of a rare medical curiosity to a commonplace medical enigma today. Although Renaud4in 1847 and Rokitansky5in 1855 apparently reported the first patients with multiple primary malignant tumors, these are poorly documented and Billroth is usually credited with the first reports which stimulated interest in this phenomenon. Selection of Patients The patients of this study were derived from the Tumor Registry of the West Virginia University Medical Center between August 1960 and July 1967. The diagnosis of multiple primary malignant disease was determined by the criteria established by

Six Cases of Multiple Primary Malignant Tumors

Six Cases of Multiple Primary Malignant Tumors

Multiple Primary Malignant Tumors

Multiple Primary Malignant Tumors

Multiple Primary Malignant Tumors Involving the Female Genital Tract

Multiple Primary Malignant Tumors Involving the Female Genital Tract