Multiple Portals Research Articles

Content Creator Strategy as Tourism Journalism for Post-Covid-19 Pandemic Recovery

Pikiran Rakyat Media Networks (PRMN) engaged in the digital media business, develops its business by creating a media ecosystem through multiple portals. The PRMN sub-domain news portal is managed and filled with content by content creators as PRMN partners. The phenomenon of content creators on news portals creates opportunities for strategies in tourism recovery. This research was conducted with the aim of looking at strategies for utilizing content creators as a form of journalism to advocate for tourism recovery in Indonesia. This study aims to get an overview of tourism journalism patterns carried out by content creators which can be a strategy for recovery and increasing the attractiveness of tourist destinations. This study uses a constructivist approach by finding qualitative data to be analyzed and categorized so that it becomes a pattern of tourism communication through journalism in digital media. The results of the study show that the strategy to restore the tourism sector after the Covid-19 pandemic requires the role of mass media and social media. The collaboration business strategy carried out by PRMN with the google algorithm supports the creation of positive tourism content in marketing tourist destinations according to tourist targets.

Micro "Hyper-Channels" on Laser-Refined Cellulose Structures.

Controlled liquid transportation is widely applied in both academia and industry. However, liquid transport applications are limited by parameters such as driving forces, precision, and velocity. Herein, a simple laser-refining technology is presented to produce micro "hyper-channels". A cellulose substrate is rendered hydrophobic through silanization and refined with a laser to produce both hierarchical nanostructures and a wettability contrast simultaneously. Such a method enables faster ("hyper"-channel) aqueous liquid transportation (≈25X, 50mms-1 ) compared to conventional methods. Complex patterns can be readily produced at different scales with spatial resolution as low as 50µm. This technique also controls the refining depth on the thin paper substrate. Shallow channels can be fabricated on thin paper substrates that enable fluidic channel-crossover without liquid mixing. With certain parameters, the technique creates "portals" through the substrate, allowing trans-dimensional liquid transportation between two layers of a single sheet of substrate. The fluid throughput can be increased, while also permitting fluidic channel crossover without liquid mixing. By introducing multiple portals, the controlled fluid can transfer trans-dimensionally several times, enabling further fluidic complexity. The real-life utility of the method is demonstrated by creating a trans-dimensional microfluidic device for colorimetric detection.

FAXDC2 inhibits the proliferation and invasion of human liver cancer HepG2cells.

The reprogramming of lipid metabolism serves an important role in occurrence and development of liver cancer. Fatty acid hydroxylase domain containing 2 (FAXDC2) is a hydroxylase involved in the synthesis of cholesterol and sphingomyelin and downregulated in various types of cancer. There are no reports on the relationship between FAXDC2 and liver carcinogenesis. The present study used multiple portals and publicly available tools to explore its correlation with liver cancer. The results showed that the expression of FAXDC2 decreased in liver cancer and the methylation level near the promoter increased. Patients with liver cancer and with low expression of FAXDC2 had a poor prognosis. Gain of function and loss of function strategies were performed to evaluate its roles in liver cancer cells. CCK-8 assay showed that overexpression of FAXDC2 inhibited the viability of liver cancer cells (HepG2). Flow cytometry analysis indicated that HepG2 cells with overexpressing FAXDC2 showed an S phase arrest, associated with cyclin-dependent kinase 2 decreased. Transwell experiments showed that increasing FAXDC2 inhibited HepG2 cell invasion ability, accompanied by the upregulation of E-cadherin. Notably, knockdown of FAXDC2 had no significant effect on cell cycle and invasion functions. Based on the cBioPortal platform, FAXDC2 was predicted to closely correlate to the ERK signal in tumorigenesis. Western blotting results showed that overexpression of FAXDC2 decreased the phosphorylation level of ERK in liver cancer cells. The present study first identified FAXDC2 as a liver cancer suppressor, which might inhibit the proliferation and invasion of liver cancer cells through the mechanism associated with ERK signaling. The present study provided a possible new target for the diagnosis and treatment of liver cancer.

Oncological and functional outcomes of modified arthroscopic resection for intra-articular tenosynovial giant cell tumor of the knee using multiple portals.

Arthroscopic resection of tenosynovial giant cell tumor (TS-GCT) presents favorable outcomes. However, there are reportedly higher recurrence rates in patients who had incomplete resection. To minimize incomplete resection, we established a multiple portal approach depending on the location of the disease. In this study, we aimed to retrospectively evaluate the clinical outcomes of arthroscopic resection for both localized and diffuse types of TS-GCT of the knee. From 2009 to 2019, 13 patients who underwent arthroscopic synovectomy of the knee and were histologically diagnosed with TS-GCT were included in this study. The pre- and postoperative range of motion (ROM) of the knee was measured. The Japanese Orthopaedic Association (JOA) score and the Knee Injury and Osteoarthritis Outcome Score (KOOS) were assessed at the final follow-up examination. Magnetic resonance imaging was performed to detect incomplete resection or local recurrence. Among the 13 patients, seven and six had localized and diffuse type TS-GCT, respectively. Regarding the knee ROM, preoperative knee flexion in patients with the localized type was limited compared with that in those with the diffuse type. However, the ROM was significantly improved in patients with both types postoperatively. The JOA score and KOOS of patients with both types at the final follow-up were favorable, and there were no significant differences between both types. There was neither recurrence nor incomplete resection in any patient for both types. All patients, regardless of the TS-GCT type, achieved favorable outcomes after arthroscopic surgery; especially, the failure rate was 0%.

Preventing Laboratory-Acquired Brucellosis in the Era of MALDI-TOF Technology and Molecular Tests: A Narrative Review

Brucellosis is one of the most common etiologies of laboratory-acquired infections worldwide, and handling of living brucellae should be performed in a Class II biological safety cabinet. The low infecting dose, multiple portals of entry to the body, the wide variety of potentially contaminated specimens, and the unspecific clinical manifestations of human infections facilitate the unintentional transmission of brucellae to laboratory personnel. Work accidents such as spillage of culture media cause only a small minority of exposures, whereas >80% of events result from unfamiliarity with the phenotypic features of the genus, misidentification of isolates, and unsafe laboratory practices such as working on an open bench without protective goggles or gloves or the aerosolization of bacteria. The bacteriological diagnosis of brucellae by traditional methods is simple and straightforward but requires extensive manipulation of the isolates, and, nowadays, many laboratory technicians are not familiar with the genotypic features of the genus, resulting in inadvertent exposure and contagion. Detection of brucellar infections by culture-independent molecular methods is safe, but the identification of the organism using MALDI-TOF technology is not hazard-free, requiring an initial bacterial inactivation step to avoid transmission. Unfortunately, these novel and safer methods are costly and frequently unavailable in resource-limited endemic countries.

Needle arthroscopy for exploration of the elbow joint: a case series of six dogs with preliminary cadaveric study

Case history: Dogs (n = 6) suffering from elbow-associated lameness for a median of 3.5 (min 2, max 12) months duration requiring arthroscopic exploration according to imaging results were prospectively included in this study. Clinical findings: Dogs that met the inclusion criteria were of various breeds with a median body weight of 18 (min 13.2, max 34.5) kg and median age at presentation of 11 (min 6, max 96) months. Results of imaging modalities (radiographs and/or CT) were consistent with developmental elbow disease in all of the dogs. Arthroscopic findings: Feasibility of the needle arthroscopy procedure was first assessed in a preliminary cadaveric study. Disease-free cadaveric forelimbs (n = 12) were collected from adult dogs (n = 6) euthanised for reasons unrelated to the present study. Elbow exploration was performed, beginning with needle arthroscopy (1 mm, 0° angle scope) followed by standard arthroscopy (2.4 mm, 30° angle scope) through a medial approach. The ease of introduction, range of motion and the quality of visualisation were assessed subjectively and presence of iatrogenic introduction lesions and extent of field of vision (assessed by the number of anatomical structures visualised) were scored and statistically compared. Needle arthroscopy allowed inspection of all structures at risk for medial/caudal compartment disease in all joints considering the occasional need for multiple portals. In the clinical setting, elbow exploration was found to be similar to that in cadaver joints in 4/6 dogs. The lower quality of vision provided by needle arthroscopy was a limitation of the technique, and 2/6 clinical cases required conversion to standard arthroscopy for full visualisation of the joint. No introduction lesions were noted with needle arthroscopy in either the cadaveric or clinical studies. Conclusions and clinical relevance: Needle arthroscopy allowed safe visualisation of all the structures of the medial and caudal compartment in disease-free cadaveric elbows, suggesting that needle arthroscopy is an appropriate technique for diagnosis and assessment of lesions of developmental elbow disease. However, the low quality of vision provided by the 1 mm scope, and the small diameter of the sleeve, which limited fluid inflow, combined with fragility of the device were major drawbacks that prevented consistent full exploration of the joint and detailed lesion assessment in clinical situations. Improvement of the device is thus necessary before use of the technique in clinical practice can be recommended.

A-Z Database List review: Getting started and keeping the momentum

Libraries have multiple portals to access their electronic resources. At Queens College, the two access portals are the catalog, Ex-Libris’ Primo, and Springshare’s A-Z Database List. The most recent comprehensive review of the A-Z Database List was conducted five years ago by the previous electronic resources librarian. As such, the list had multiple formats for displaying information and lacked consistency. The supporting information for the overall layout of the list was not helpful to users nor library staff. Users should be able to search for the resources they want without getting bogged down by unnecessary jargon, inconsistencies, and fluff. It was not difficult to get buy in for a comprehensive review. Librarians agreed that the list lacked consistency and a review would be beneficial. Beyond that there was little consensus. Where do we start? How do we approach this?

A case series of intra-articular diffuse pigmented villonodular synovitis of the knee: Prognosis of complete synovectomy under arthroscopic surgery.

The purpose of this study is to evaluate the outcome and prognosis of complete synovectomy performed under arthroscopic surgery in the treatment of diffuse pigmented villonodular synovitis (DPVNS) of the knee. We retrospectively reviewed 7 cases (6 female and 1 male) diagnosed with diffuse pigmented villonodular synovitis (DPVNS) of knee from 2013 to 2017. All of these cases were treated with knee arthroscopy-assisted complete synovectomy. The follow-up period ranged from 36 months to 60 months (average: 48.0 months). The pain score, range of motion and functional outcome of the knee joint were evaluated after surgery. Symptoms and signs were monitored and magnetic resonance imaging (MRI) were routinely requested to note for possible recurrence during clinical follow up. During and after the surgeries of complete synovectomy under arthroscope by the same surgeon, no complications were noted in the ward or the clinic. Significant improvements were achieved in terms of the range of motion and Lysholm knee function score. There was no recurrence of DPVNS observed in our patients during a follow-up of 4 years. Intra-articular DPVNS of the knee can successfully be treated by complete synovectomy under arthroscope. This case series emphasized the technique of multiple portals and cycling different shavers to achieve satisfactory outcomes.

Novel Multi-Perspective Usability Evaluation Framework for Selection of Open Source Software Based on BWM and Group VIKOR Techniques

Increasing demand for open-source software (OSS) has raised the value of efficient selection in terms of quality; usability is an essential quality factor that significantly affects system acceptability and sustainability. Most large and complex software packages partitioned across multiple portals and involve many users — each with their role in the software package; those users have different perspectives on the software package, defined by their knowledge, responsibilities, and commitments. Thus, a multi-perspective approach has been used in usability evaluation to overcome the challenge of inconsistency between users’ perspectives; the inconsistency challenge would lead to an ill-advised decision on the selection of a suitable OSS. This study aimed to assist the public and private organizations in evaluating and selecting the most suitable OSS. The evaluation of the OSS software packages to choose the best one is a challenging task owing to (a) multiple evaluation criteria, (b) criteria importance, and (c) data variation; thus, it is considered a sophisticated multi-criteria decision making (MCDM) problem; moreover, the multi-perspective usability evaluation framework for OSS selection lacks in the current literature. Hence, this study proposes a novel multi-perspective usability evaluation framework for the selection of OSS based on the multi-criteria analysis. Integration of best-worst method (BWM) and VIKOR MCDM techniques has been used for weighting and ranking OSS alternatives. BWM is utilized for weighting of evaluation criteria, whereas VIKOR is applied to rank OSS-LMS alternatives. Individual and group decision-making contexts, and the internal and external groups aggregation were used to demonstrate the efficiency of the proposed framework. A well-organized algorithmic procedure is presented in detail, and a case study was examined to illustrate the validity and feasibility of the proposed framework. The results demonstrated that BWM and VIKOR integration works effectively to solve the OSS software package benchmarking/selection problems. Furthermore, the ranks of OSS software packages obtained from the VIKOR internal and external group decision making were similar; the best OSS-LMS based on the two ways was ‘Moodle’ software package. Among the scores of groups in the objective validation, significant differences were identified; this indicated that the ranking results of internal and external VIKOR group decision making were valid, which pointed to the validation of the framework.

Accuracy of arthroscopic fluid pump systems in shoulder surgery: a comparison of 3 different pump systems

Extra-articular fluid extravasation is a known complication during shoulder arthroscopy. The risk and amount of extravasation to a large degree is dependent on the fluid pressure delivered to the surgical site. Accurate measurement, knowledge, and control of the pressure delivered is thus important to surgeons, anesthetists, and the patient. The purpose of this study was to compare the pressure measurement accuracy of 3 arthroscopic fluid pumps, with 2 of them having 2 different settings. Twenty-five patients (n = 5 per group) undergoing shoulder arthroscopy were selected. Three different arthroscopic fluid pumps (ConMed 24K, Stryker Crossflow, Arthrex Dual Wave) were tested in 5 different operational settings (Stryker, standard and dynamic mode; ConMed, with and without TIPS; Arthrex Dual Wave). In each operation, the set pump pressures and the subsequently delivered intra-articular surgical site fluid pressures were measured by a spinal needle connected to an anesthetic standard pressure transducer attached to the anesthetic machine. Independent measures of the surgical site pressures were obtained before multiple portals were created or extravasation had occurred. Measurements were taken at the beginning of surgery. Measurements of the mean intra-articular pressure were found to not be significantly different from the set pressure for the ConMed 24K with TIPS (0.98 ± 0.02-fold) and Stryker Crossflow in standard mode (0.98 ± 0.02-fold). However, actual pressure was significantly greater than the set pressure for the ConMed 24K without TIPS (by 1.30 ± 0.13-fold), Stryker Crossflow in dynamic mode (by 1.82 ± 0.08-fold), and Arthrex Dual Wave (by 2.19 ± 0.06-fold). Independently measured intra-articular pressure can be more than double the set pressure for some arthroscopic pumps. Measuring intra-articular pressure can thus aid in adjusting the set pressure. This could minimize the risk of intraoperative complications.

A 360° Labral Repair Using Two Portals and a Percutaneous Cannula

Pan-labral tears are relatively uncommon, but they present significant challenges to arthroscopists. The difficulty lies in the need to access the glenoid rim circumferentially for proper anchor placement. Traditionally, this requires that multiple portals and percutaneous access be established as needed. Additionally, proper preoperative planning is needed to accurately reduce the labrum. In this Technical Note, we demonstrate a technique that accomplishes circumferential access and a well-planned approach with 2 portals and a percutaneous cannula.

Enterococcus Bacteremia

Enterococcus Bacteremia

Functional organization of cytoplasmic portals controlling access to the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel pore

The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl- channel that apparently has evolved from an ancestral active transporter. Key to the CFTR's switch from pump to channel function may have been the appearance of one or more "lateral portals." Such portals connect the cytoplasm to the transmembrane channel pore, allowing a continuous pathway for the electrodiffusional movement of Cl- ions. However, these portals remain the least well-characterized part of the Cl- transport pathway; even the number of functional portals is uncertain, and if multiple portals do exist, their relative functional contributions are unknown. Here, we used patch-clamp recording to identify the contributions of positively charged amino acid side chains located in CFTR's cytoplasmic transmembrane extensions to portal function. Mutagenesis-mediated neutralization of several charged side chains reduced single-channel Cl- conductance. However, these same mutations differentially affected channel blockade by cytoplasmic suramin and Pt(NO2)42- anions. We considered and tested several models by which the contribution of these positively charged side chains to one or more independent or non-independent portals to the pore could affect Cl- conductance and interactions with blockers. Overall, our results suggest the existence of a single portal that is lined by several positively charged side chains that interact electrostatically with both Cl- and blocking anions. We further propose that mutations at other sites indirectly alter the function of this single portal. Comparison of our functional results with recent structural information on CFTR completes our picture of the overall molecular architecture of the Cl- permeation pathway.

Ubiquitous Access to Digital Cultural Heritage

The digitization initiatives in the past decades have led to a tremendous increase in digitized objects in the cultural heritage domain. Although digitally available, these objects are often not easily accessible for interested users because of the distributed allocation of the content in different repositories and the variety in data structure and standards. When users search for cultural content, they first need to identify the specific repository and then need to know how to search within this platform (e.g., usage of specific vocabulary). The goal of the EEXCESS project is to design and implement an infrastructure that enables ubiquitous access to digital cultural heritage content. Cultural content should be made available in the channels that users habitually visit and be tailored to their current context without the need to manually search multiple portals or content repositories. To realize this goal, open-source software components and services have been developed that can either be used as an integrated infrastructure or as modular components suitable to be integrated in other products and services. The EEXCESS modules and components comprise (i) Web-based context detection, (ii) information retrieval-based, federated content aggregation, (iii) metadata definition and mapping, and (iv) a component responsible for privacy preservation. Various applications have been realized based on these components that bring cultural content to the user in content consumption and content creation scenarios. For example, content consumption is realized by a browser extension generating automatic search queries from the current page context and the focus paragraph and presenting related results aggregated from different data providers. A Google Docs add-on allows retrieval of relevant content aggregated from multiple data providers while collaboratively writing a document. These relevant resources then can be included in the current document either as citation, an image, or a link (with preview) without having to leave disrupt the current writing task for an explicit search in various content providers’ portals.

Scanning electron microscopic examination of resected root apices obtained from endodontic microsurgery.

This study was designed to examine the morphological features of the resected root apices obtained from endodontic microsurgery using a scanning electron microscope (SEM) as well as their anatomical effect on the clinical outcome of the surgical treatment. One-hundred-six resected root apices from 91 patients/surgeries were obtained by endodontic microsurgery, and fixed immediately for storage. The resected apices were prepared for SEM to examine their morphological features, such as the number and size of the apical foramina. The patients were periodically checked up at least 1 year and the clinical outcome of the microsurgery was judged as a success or failure according to the Molven's criteria. The SEM findings and the clinical outcome of apical surgery were evaluated to see any potential correlation between them. The SEM examination revealed that 60.4% of specimens had more than two portals of exit on the resected root apices and the size of the major foramen was at least 386 micrometer and 334 micrometer from maxillary and mandibular molar, respectively. With a recall rate of 72.9%, 91.9% of the surgical cases were decided to have successful outcomes. Based on this SEM study, a relatively high frequency of multiple portals of exit was existed and the sizes of major foramina were bigger than that were reported in previous reports. The clinical outcomes of endodontic microsurgery were not correlated with the anatomical features of resected apical root apices. SCANNING 38:455-461, 2016. © 2016 Wiley Periodicals, Inc.

Nanopotentiated combination cancer therapy: Chemotherapeutic and chemosensitizer (2C approach)

An insight into the complex cancer pathophysiology reveals that a dependable amelioration of the disease could only be envisaged with a multipronged treatment approach. It is highly evident that singular chemotherapeutic agents used in clinical practice have shown limitations like severe side effects, MDR and are often associated with poor QOL while combinations of drugs have yielded better therapeutic outcomes. The current hypothesis takes it a step forward wherein a chemotherapeutic agent is combined with a natural chemosensitizer, both loaded into a nanopotentiated particulate system, which would eventually deliver the drug cargo at the target site with certitude. The encapsulated natural bioactive would then favorably act on the tumor milieu through multiple portals and chemosensibilize the cells towards cytotoxic action of the synthetic drug moiety. This 2C (chemotherapeutic and chemosensitizer) approach along with nanosystem’s attributes like high payload, prolonged action and diminished side effects would proffer a more dependable treatment modality. In conclusion, the proposed system would be a value addition to the currently available armamentarium of cancer treatment tools.

Arthroscopic image distortion-part II: the effect of lens angle and portal location in a 3D knee model.

Distortion in arthroscopic views can interfere with accurate graft placement in ACL reconstruction, yet the effect of arthroscopic lens angle and portal location on image distortion is unknown. The purpose of this study was to quantify the image distortion resulting from the use of angulated arthroscope lenses through multiple portals, thereby identifying the optimal parameters to minimize distortion. A uniform grid of dots was attached to the lateral wall of the intercondylar notch of a Sawbones(®) knee model. The inferior half of the lateral wall was divided equally along the distoproximal axis into three regions-shallow, central, and deep. Each region was imaged using five different arthroscopic configurations [0° arthroscope through anteromedial (AM) portal, 30° arthroscope through AM and anterolateral (AL) portals, 70° arthroscope through AM and AL portals]. For each configuration, the differences in magnification and deformity ratios between the three regions were calculated. Less than 100% of central region magnification was observed in the deep region, while more than 100% was found in the shallow region. The AL approach produced larger magnification errors in the shallow region, as compared to the AM approach. Deformity ratios less than 100% were found with both 0° and 30° arthroscopes, whereas deformity ratios exceeding 100% were found with 70° arthroscopes. The least distorted and the most consistent image of the femoral ACL insertion is provided through the AM portal using either a 30° or 70° arthroscope lens. Surgeons should carefully select the arthroscope and portal to minimize image distortion and ensure accurate surgical procedure.

Multi-portal association based dispatching and a virtual-queue method in wireless mesh networks

Single-portal association has long been adopted as the basic assumption in wireless mesh network (WMN) research. Whereas this assumption can simplify the overall design, it cannot meet the increasing growth of traffic volume. We propose the use of multi-portal association in this paper, which allows traffic to go through multiple mesh portals so as to ease the performance bottleneck problem caused by single-portal association. We propose the multi-portal association scheme, and a method using the virtual-queue concept to support traffic dispatching within such multi-portal association scheme. The operation of the virtual-queue method is based on the centralized link state estimation and virtual queue emulation. The simulation results show that the proposed multi-portal association outperforms the conventional single-portal association. For the UDP traffic, in the simple-structured and short-distanced networks, the use of multi-portal association (with the virtual-queue dispatching method) is able to reduce 99% of packet loss and increase 500% of throughput, when comparing to the case of using single-portal association. In the more-complex structured networks, it can provide 60% reduction in packet loss and achieve 1500% increase of throughput. On the other hand, for the TCP traffic, in the simple-structured networks, the proposed solution can achieve 92% reduction in latency and 91% increase of throughput.

AB0343 Arthroscopic synovectomy for the rheumatoid elbow (short-term outcome)

Objectivesto evaluate effectiveness, the clinical outcomes and quality of life before and after arthroscopic synovectomy in patients with rheumatoid arthritisMethodsArthroscopic synovectomy of elbow was performed on in 21 patients with...

Crossing the digital divide: an interoperable solution for sharing time series and coverages in Earth sciences

Abstract. In a world driven by the Internet and the readily accessible information it provides, there exists a high demand to easily discover and collect vast amounts of data available over several scientific domains and numerous data types. To add to the complexity, data is not only available through a plethora of data sources within disparate systems but also represents differing scales of space and time. One clear divide that exists in the world of information science and technology is the disjoint relationship between hydrologic and atmospheric science information. These worlds have long been split between observed time series at discrete geographical features in hydrologic science and modeled or remotely sensed coverages or grids over continuous space and time domains in atmospheric science. As more information becomes widely available through the Web, data are being served and published as Web services using standardized implementations and encodings. This paper illustrates a framework that utilizes Sensor Observation Services, Web Feature Services, Web Coverage Services, Catalog Services for the Web and GI-cat Services to index and discover data offered through different classes of information. This services infrastructure supports multiple servers of time series and gridded information, which can be searched through multiple portals, using a common set of time, space and concept query filters.