Multiple Hydrogen Bonds Research Articles

Biomimetic Hydrogen-Bonded G ⋅ C ⋅ G ⋅ C Quadruplex within a Tetraphenylethene-Based Octacationic Spirobicycle in Water.

In biological systems, nucleotide quadruplexes (such as G-quadruplexes) in DNA and RNA that are held together by multiple hydrogen bonds play a crucial functional role. The biomimetic formation of these hydrogen-bonded quadruplexes captured by artificial systems in water poses a significant challenge but can offer valuable insights into these complex functional structures. Herein, we report the formation of biomimetic hydrogen-bonded G ⋅ C ⋅ G ⋅ C quadruplex captured by a tetraphenylethene (TPE) based octacationic spirobicycle (1). The spirobicyclic compound possesses a three-dimensional (3D) crossing dual-cavity structure, which enables the encapsulation of four d(GpC) dinucleotide molecules, thereby realizing 1 : 4 host-guest complexation in water. The X-ray structure reveals that four d(GpC) molecules further form a two-layer G ⋅ C ⋅ G ⋅ C quadruplex with Watson-Crick hydrogen bonds, which are stabilized within the dual hydrophobic cavities of 1 through the cooperative non-covalent interactions of hydrogen bonds, CH⋅⋅⋅π interactions, and hydrophobic effect. Due to the dynamically-rotational propeller chirality of TPE units, 1 with adaptive chirality can further serve as a chiroptical sensor to exhibit opposite Cotton effects with mirror-image CD spectra for the pH-dependent hydrogen-bonded assemblies of d(GpC) including the Watson-Crick G ⋅ C ⋅ G ⋅ C (pH 9.22) and Hoogsteen G ⋅ C+ ⋅ G ⋅ C+ (pH 5.74) quartets through the host-guest chirality transfer in water.

Self-healing, antioxidant, and antibacterial Bletilla striata polysaccharide-tannic acid dual dynamic crosslinked hydrogels for tissue adhesion and rapid hemostasis

Biomaterials capable of achieving effective sealing and hemostasis at moist wounds are in high demand in the clinical management of acute hemorrhage. Bletilla striata polysaccharide (BSP), a natural polysaccharide renowned for its hemostatic properties, holds promising applications in biomedical fields. In this study, a dual-dynamic-bonds crosslinked hydrogel was synthesized via a facile one-pot method utilizing poly(vinyl alcohol) (PVA)-borax as a matrix system, followed by the incorporation of BSP and tannic acid (TA). Chemical borate ester bonds formed around borax, coupled with multiple physical hydrogen bonds between BSP and other components, enhanced the mechanical properties and rapid self-healing capabilities. The catechol moieties in TA endowed the hydrogel with excellent adhesive strength of 30.2 kPa on the surface of wet tissues and facilitated easy removal without residue. Benefiting from the synergistic effect of TA and the preservation of the intrinsic properties of BSP, the hydrogel exhibited outstanding biocompatibility, antibacterial, and antioxidant properties. Moreover, it effectively halted acute bleeding within 31.3 s, resulting in blood loss of 15.6 % of that of the untreated group. As a superior hemostatic adhesive, the hydrogel in this study is poised to offer a novel solution for addressing future acute hemorrhage, wound healing, and other biomedical applications.

Doping heteroatoms to form multiple hydrogen bond sites for enhanced interfacial reconstruction and separations

Interfacial challenges in unconventional oil extraction include heavy oil–water–solid multiphase separation and corrosion inhibition. Herein, a novel strategy based on interfacial hydrogen bonding reconstruction is proposed for constructing multifunctional interfacially active materials (MIAMs) to address multi-interfacial separation needs. A simple one-pot method is applied to successfully synthesize four different MIAM varieties, integrating site groups (–NH2, OSO, –COOH, and Si–O–Si) with multiple hydrogen bonds (HBs) into allyl polyether chains. The results indicate that all synthesized MIAMs excel in demulsification, detergency, and corrosion inhibition simultaneously, even at 25 °C. Their dehydration efficiency for different water-in-oil emulsions (even heavy oil emulsion) surpasses 99.9 % even at 16 °C, showing their excellent energy-saving potential for field applications. Furthermore, they demonstrate effective, nondestructive static cleaning (up to 86 %) of adhered oil from solid surfaces at 25 °C and provide corrosion inhibition effects (up to 92.09 %) on mild steel immersed in saturated brine. Mechanistic tests reveal that incorporating multiple HB sites in MIAMs dramatically enhances their effectiveness in interfacial separations. Based on these findings, an HB-dominated noncovalent interaction reconstruction strategy is tentatively proposed to develop advanced materials for low-carbon, efficient interfacial separations.

PH-responsive bioadhesive with robust and stable wet adhesion for gastric ulcer healing

Development of bioadhesives that can be facilely delivered by endoscope and exhibit instant and robust adhesion with gastric tissues to promote gastric ulcer healing remains challenging. In this study, an advanced bioadhesive is prepared through free radical polymerization of ionized N-acryloyl phenylalanine (iAPA) and N-[tris (hydroxymethyl) methyl] acrylamide (THMA). The precursory polymer solution exhibits low viscosity with the capability for endoscope delivery, and the hydrophilic-hydrophobic transition of iAPA upon exposure to gastric acid can trigger gelation through phenyl groups assisted multiple hydrogen bonds formation and repel water molecules on tissue surface to establish favorable environment for interfacial interactions between THMA and functional groups on tissues. The in-situ formed hydrogel features excellent stability in acid environment (14 days) and exhibits firm wet adhesion to gastric tissue (33.4 kPa), which can efficiently protect the wound from the stimulation of gastric acid and pepsin. In vivo studies reveal that the bioadhesive can accelerate the healing of ulcers by inhibiting inflammation and promoting capillary formation in the acetic acid-induced gastric ulcer model in rats. Our work may provide an effective solution for the treatment of gastric ulcers clinically.

Recyclable and mechanically tough nanocellulose reinforced natural rubber composite conductive elastomers for flexible multifunctional sensor

The development of flexible wearable multifunctional electronics has gained great attention in the field of human motion monitoring. However, developing mechanically tough, highly stretchable, and recyclable composite conductive materials for application in multifunctional sensors remained great challenges. In this work, a mechanically tough, highly stretchable, and recyclable composite conductive elastomer with the dynamic physical-chemical dual-crosslinking network was fabricated by the combination of multiple hydrogen bonds and dynamic ester bonds. To prepare the proposed composite elastomers, the polyaniline-modified carboxylate cellulose nanocrystals (C-CNC@PANI) were used as both conductive filler to yield high conductivity of 15.08 mS/m, and mechanical reinforcement to construct the dynamic dual-crosslinking network with epoxidized natural rubber latex to realize the high mechanical strength (8.65 MPa) and toughness (29.57 MJ/m3). Meanwhile, the construction of dynamic dual-crosslinking network endowed the elastomer with satisfactory recyclability. Based on these features, the composite conductive elastomers were used as strain sensors, and electrode material for assembling flexible and recyclable self-powered sensors for monitoring human motions. Importantly, the composite conductive elastomers maintained reliable sensing and energy harvesting performance even after multiple recycling process. This study provides a new strategy for the preparation of recyclable, mechanically tough composite conductive materials for wearable sensors.

Superior strength, highly stretchable, bionic self-healing polyurethane and its composites for flexible conductivity and self-cleaning applications

Balancing the exceptional mechanical strength and repair efficiency of self-healing materials presents a significant challenge to unlocking their full potential in practical applications. Inspired by natural spider silk and cartilage, multiple dynamic hydrogen bonds were introduced into the pre-prepared polyurethane (PU). Then modifided graphene oxide (GO) nanosheets with dynamic hydrogen bonds were added into the prepared PU to form composites (AU-PU/GDU) to establish a dense hydrogen bond network structure, providing strong interfacial interactions. The AU-PU/GDU film exhibits excellent tensile strength (39.6 MPa), high elongation at break (1155.6 %), and outstanding repair efficiency (90.3 %). Using AU-PU/GDU as the flexible base, a superhydrophobic conductive composite coating (F-AU-PU/GDU) with a contact angle greater than 150° was prepared by incorporating superhydrophobic nanomaterials. This work lays the foundation for the development of multifunctional materials through the creation of self-healing superhydrophobic conductive composite coatings, which have a wide range of potential applications.

Multiple hydrogen-bonding induced nonconventional red fluorescence emission in hydrogels

The development of unconventional long-wavelength fluorescent polymer hydrogels without using polycyclic aromatic hydrocarbons or extended π-conjugation is a fundamental challenge in luminescent materials owing to a lack of understanding regarding the spatial interactions induced inherent clustering-triggered emission under water-rich conditions. Inspired by the color change of protein astaxanthin as a result of heat-induced denaturation, we propose a thermodynamically driven strategy to develop red fluorescence (~610 nm) by boiling multiple hydrogen-bonded poly(N-acryloylsemicarbazide) hydrogels in a water bath. We reveal that thermodynamically driven conformational changes of polymer chains from isolated hydrogen bonding donor-acceptor structures to through-space interaction structures induce intrinsic fluorescence shifts from blue to red during clustering-triggered emission. The proposed multiple hydrogen-bonding supramolecular hydrogel shows good fluorescence stability, mechanical robustness, and 3D printability for customizable shaping. We provide a viable method to prepare nonconventional long-wavelength fluorescent hydrogels towards soft fluorescent devices without initially introducing any fluorescent components.

Pearl-Inspired Intelligent Marine Hetero Nanocomposite Coating Based on "Brick&Mortar" Strategy: Anticorrosion Durability and Switchable Antifouling.

Corrosion activities and biofouling pose significant challenges for marine facilities, resulting in substantial economic losses. Inspired by the "brick&mortar" structure of pearls, a novel nanocomposite coating (Pun-HJTx) with long-lasting anticorrosion and intelligent antifouling modes is fabricated by integrating a compatible MoS2/MXene heterostructure as the "brick" into a polyurea-modified PDMS (Pun) acting as "mortar." Notably, the presence of multiple hydrogen bonds within the coating effectively reduces the pinholes resulted from solution volatilizing. In the dark, where fouling adhesion and microbial corrosion activities are weakened, the MoS2/MXene plays a role in contact bactericidal action. Conversely, during daylight when fouling adhesion and microbial corrosion activities intensify, the coating releases reactive oxygen species (such as hydroxyl radicals and superoxide ions) to counteract fouling adhesion. Additionally, the coating exhibits multisource self-healing performance under heated or exposed to light (maximum self-healing rate can reach 99.46%) and proves efficient self-cleaning performance and adhesion strength (>2.0 Mpa), making it highly suitable for various practical marine applications. Furthermore, the outstanding performance of the Pun-HJT1 is maintained for ≈180 days in real-world marine conditions, which proving its practicality and feasibility in real shallow sea environments.

Preparation of high color fastness structural colored cotton fabric via SiO2@PDA photonic crystal

Structural color is an important way to achieve the ecological coloring of textiles. SiO2 microspheres with sizes in the range of 200–337 nm were synthesized by the Stober method and then covered with highly light-absorbing melanin PDA to form SiO2@PDA photonic crystals. The SiO2@PDA photonic crystals were assembled onto the surface of white cotton fabrics by gravity deposition to achieve structural color. The addition of polyvinylpyrrolidone (PVP) enhances interfacial bonding by forming multiple hydrogen bonds between its lactam group and the phenolic hydroxyl group of PDA, resulting in a structured color cotton fabric with high color fastness. Scanning electron microscopy (SEM) was used to study the structure and morphology of SiO2@PDA microspheres. The chemical compositions of PDA and PVP were surveyed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The surface structural color of cotton fabrics was investigated by UV–Vis reflectance spectroscopy.

Thermally and mechanically robust self-healing supramolecular polyurethanes featuring aliphatic amide end caps

A series of supramolecular polyurethanes (SPUs) were designed and synthesised with synergetic multifunctional hydrogen bonding aliphatic amide end-caps. Hydrogen bonding between the urethane, urea, and amide motifs in the polymers afford strong dynamic association between polymer chains in the solid state. Phase separation of the apolar and polar components of the polyurethanes also serves to reinforce their thermal and mechanical properties. The supramolecular polyurethane with bisamide-morpholine end caps associates via multiple hydrogen bonds and exhibits enhanced tensile and thermal properties when compared to the other materials. Variable-temperature infrared spectroscopy (VT-IR) and atomic force microscopy (AFM), were carried out to study the phase morphology of the polymers and revealed a correlation between increased phase separation and the introduction of amide motifs in the end-caps. These SPUs also exhibit excellent healing abilities, requiring temperatures >200 °C to recover their physical properties.

Asymmetric Synthesis of Hydroindoles via Desymmetrizing [3+2] Annulation of p-Quinamines and Arylalkylketenes.

The asymmetric desymmetrizing [3+2] annulation reaction of p-quinamines and arylalkylketenes to synthesize hydroindoles was realized. Catalyzed by chiral bisguanidinium hemisalt via multiple hydrogen bond interactions, enantiomerically enriched products with reversal of diastereoselectivity in comparison with the racemic version were afforded in good yields under mild reaction conditions. Diaryl-substituted hydroindoles could also perform the Friedel-Crafts type of addition to give more complicated multicycles. Density functional theory calculations revealed that the enantio- and diastereoselectivity stem from varied hydrogen-bonding manners.

Regulation of Hard Segment Cluster Structures for High-performance Poly(urethane-urea) Elastomers.

Elastomers are widely used in daily life; however, the preparation of degradable and recyclable elastomers with high strength, high toughness, and excellent crack resistance remains a challenging task. In this report, a polycaprolactone-based poly(urethane-urea) elastomer is presented with excellent mechanical properties by optimizing the arrangement of hard segment clusters. It is found that long alkyl chains of the chain extenders lead to small and evenly distributed hard segment clusters, which is beneficial for improving mechanical properties. Together with the multiple hydrogen bond structure and stress-induced crystallization, the obtained elastomer exhibits a high strength of 63.3MPa, an excellent toughness of 431MJm-3 and an outstanding fracture energy of 489kJm-2, while maintaining good recyclability and degradability. It is believed that the obtained elastomer holds great promise in various application fields and it contributes to the development of a sustainable society.

Hydrogen-bonding induced assembly of polymer-grafted nanoparticles towards photothermal antibacterial activities

The multiple hydrogen-bond has been introduced as a reversible driving force for directing the assembly of polymer-grafted nanoparticles (PGNPs). The complementary hydrogen-bonds among the polymer ligands lead to the spontaneous aggregation of PGNPs. However, it may also induce the uncontrollable aggregation of PGNPs into assemblies with non-uniform size, even irregular precipitates, due to the immoderate agglomeration associated with the strong interactions of multiple hydrogen-bonds. This severely limits the stable dispersion of PGNP aggregates in a solvent and their applications. In this work, the gold nanoparticles (AuNPs) grafted with thymine-terminated polystyrene (AuNP@PS-Thy) and diaminopyridine-terminated polystyrene (AuNP@PS-Dap) were synthesized, respectively. Their thermal-responsive assembly behavior in an organic solvent was systematically studied. By optimizing the assembly conditions, i.e., the concentration of PGNPs and the incubation time, the assemblies of AuNP@PS-Thy/AuNP@PS-Dap with controllable size were obtained. Interestingly, the assemblies deposited on a solid substrate showed excellent photothermal antimicrobial activities under irradiation of 808 nm and 655 nm lasers. The killing percentage of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) could reach 99 % after irradiating for 10 min. This work establishes an approach for controlling the hydrogen-bonding-induced assembly behavior of PGNPs, which may be extended to construct functional metamaterials with controllable structures.

Hysteresis-free, fatigue-resistant and self-adhesive conductive hydrogel electronics towards multimodal wearable application

Conductive hydrogel-based electronic skins (e-skins) have attracted great attentions in health monitoring, human-machine interactions, and soft devices. Yet, broad challenges still remain in manufacturing of high-performance units, ingenious assembly of devices and developing of multimodal applications. Here, a typical strategy of combined covalent crosslinking and dynamic non-covalent interaction (multiple hydrogen bonds and electrostatic complexation) is used to prepare the ultra-durable polyacrylic acid (PAA)/ chitosan (CS)/ Ti3C2Tx (MXene) conductive hydrogel. It exhibits matched modulus for human skin, subtle mechanical hysteresis behavior (η=0.27% of 200% stretch, energy loss coefficient), great fatigue-resistant stability (>99%, 400% strain), robust interface adhesion (∼30 kPa) and essential biocompatibility. Benefited of such high performance, a series of hydrogel-based devices are further assembled to demonstrate the multi-mode and multi-scenario applications, including the strain and temperature sensors, triboelectric nanogenerator. Clearly, thereby this work provides a new toolbox for the rational design of high-performance hybrid hydrogel, and points out a general route for further hydrogel-based device assembly and multimodal applications.

Morphological Transformation and Surface Engineering of Glycovesicles Driven by Bioinspired Hydrogen Bonds of Nucleobases.

Glycopolymer-based supramolecular glycoassemblies with signal-driven cascade morphological deformation and accessible surface engineering toward bioinspired functional glycomaterials have attracted much attention due to their diverse applications in fundamental and practical scenarios. Herein, we achieved the cascade morphological transformation and surface engineering of a nucleobase-containing polymeric glycovesicle through exploiting the bioinspired complementary multiple hydrogen bonds of complementary nucleobases. First, the synthesized thymine-containing glycopolymers (PGal30-b-PTAm249) are capable of self-assembling into well-defined glycovesicles. Several kinds of amphiphilic adenine-containing block copolymers with neutral, positive, and negative charges were synthesized to engineer the glycovesicles through the multiple hydrogen bonds between adenine and thymine. A cascade of morphological transformations from vesicles to ruptured vesicles with tails, to worm-like micelles, and finally to spherical micelles were observed via continuously adding the adenine-containing polymer into the thymine-containing glycovesicles. Furthermore, the surface charge properties of these glyconano-objects can be facilely regulated through incorporating various adenine-containing polymers. This work demonstrates the potential application of a unique bioinspired approach to precisely engineer the morphology and surface properties of glycovesicles for boosting their biological applications.

Spacer Conformation Induced Multiple Hydrogen Bonds in 2D Perovskite toward Highly Efficient Optoelectronic Devices.

Two-dimensional (2D) Dion-Jacobson (DJ) perovskites typically outperform Ruddlesden-Popper (RP) analogs in terms of photodetection (PD). However, the mechanism behind this enhanced performance remains elusive. Theoretical calculations for elucidating interlayer spacer conformation-induced multiple hydrogen bonds in 2D perovskite are presented, along with the synthesis of DPAPbBr4 (DPB) single crystals (SCs) and their PD properties under X-ray/ultraviolet (UV) excitation. The high-quality DPB SC enhances PD with exceptional photoresponse attributes, including a high on/off ratio (4.89×104), high responsivity (2.44 AW⁻1), along with large dynamic linear range (154 dB) and low detection limit (7.1 nWcm⁻2), which are currently the best results among 2D perovskite SC detectors, respectively. Importantly, high-resolution images are obtained under UV illumination with weak light levels. The SC X-ray detector exhibits a high sensitivity of 663 µC Gyair⁻1 cm-2 at 10 V and a detection limit of 1.44 µGyair s⁻1. This study explores 2D DJ perovskites for efficient and innovative optoelectronic applications.

N-Triflyl Phosphoric Triamide (N-TPT) as an Efficient Activator for ‘On-Water’ Accelerated Aquacatalytic Polar Substrate Allylation

AbstractThe development of sustainable, functional-group-tolerant catalysis is highly significant from the perspectives of safety, user-friendliness, and cost-effectiveness. We report herein the triple hydrogen-bonding donor activator N-triflyl phosphoric triamide ( N-TPT) for the synergistic Brønsted acid aquacatalysis of multicomponent allylation ‘on-water’. The reaction demonstrated remarkable efficiency in converting polar diol substrate, such as 1,3-dihydroxyacetone, into α-tertiary amine derivative incorporating homoallylic amine functionalities using bulk water as the reaction medium. The single crystal X-ray structure and control experiments highlighted the crucial role of multiple hydrogen bonds in enabling this aqueous reaction.

Peptidic Compound as DNA Binding Agent: In Silico Fragment-based Design, Machine Learning, Molecular Modeling, Synthesis, and DNA Binding Evaluation.

Cancer remains a global burden, with increasing mortality rates. Current cancer treatments involve controlling the transcription of malignant DNA genes, either directly or indirectly. DNA exhibits various structural forms, including the G-quadruplex (G4), a secondary structure in guanine-rich regions. G4 plays a crucial role in cellular processes by regulating gene expression and telomerase function. Researchers have recently identified G4-stabilizing binding agents as promising anti-cancer compounds. Additionally, peptides have emerged as effective anticancer pharmaceuticals due to their ability to form multiple hydrogen bonds, electrostatic interactions, and van der Waals forces. These properties enable peptides to bind to specific areas of DNA chains selectively. However, despite these advancements, designing G4-binding peptides remains challenging due to a lack of comprehensive information. In our present study, we employed an in silico fragment-based approach to design G4- binding peptides. This innovative method combines machine learning classification, molecular docking, and dynamics simulation. AutoDock Vina and Gromacs performed molecular docking and MD simulation, respectively. The machine learning algorithm was implemented by Scikit-learn. Peptide synthesis was performed using the SPPS method. The DNA binding affinity was measured by applying spectrophotometric titration. As a result of this approach, we identified a high-scoring peptide (p10; sequence: YWRWR). The association constant (Ka) between p10 and the ctDNA double helix chain was 4.45 × 105 M-1. Molecular modeling studies revealed that p10 could form a stable complex with the G4 surface. The obtained Ka value of 4.45 × 105 M-1 indicates favorable interactions. Our findings highlight the role of machine learning and molecular modeling approaches in designing new G4-binding peptides. Further research in this field could lead to targeted treatments that exploit the unique properties of G4 structures.

A Lignin Silver Nanoparticles/Polyvinyl Alcohol/Sodium Alginate Hybrid Hydrogel with Potent Mechanical Properties and Antibacterial Activity.

Antibacterial hydrogels have attracted significant attention due to their diverse applications, efficient antimicrobial properties, and adaptability to various environments and requirements. However, their relatively fragile structure, coupled with the potential for environmental toxicity when exposed to their surroundings for extended periods, may significantly limit their practical application potential. In this work, a composite hydrogel was synthesized with outstanding mechanical features and antibacterial capability. The hydrogel was developed through the combination of the eco-friendly and enduring antibacterial agent, lignin silver nanoparticles (Lig-Ag NPs), with polyvinyl alcohol (PVA) and sodium alginate (SA), in varying proportions. The successful synthesis of the hydrogel and the dispersed distribution of Lig-Ag NPs within the hydrogel were confirmed by various analytical techniques, including field emission scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), mercury intrusion porosimetry (MIP), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The formation of multiple hydrogen bonds between Lig-Ag NPs and the composites contributed to a more stable and dense network structure of the hydrogel, consequently enhancing its mechanical properties. Rheological tests revealed that the hydrogel exhibited an elastic response and demonstrated outstanding self-recovery properties. Significantly, the antibacterial hydrogel demonstrated effectiveness against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), achieving a <5% survival of bacteria within 12 h. This study presented a green and straightforward synthetic strategy for the application of antibacterial composite hydrogels in various fields.

Poly(2-hydroxyethyl methacrylate)/BN nanohybride: Enhanced adsorption of antibiotic pollutant removal from wastewater

Increasing wastewater pollution by pharmaceutical waste poses a serious threat to environmental safety and public health, so sorbents with high adsorption capacity and removal efficiency are in high demand. To address this important problem, a novel pellet sorbent containing (2-hydroxyethylmethacrylate)-modified BN nanoparticles (pHEMA/BN) was produced by a combination of CVD synthesis (BN), solution method (pHEMA/BN nanoparticles) and uniaxial pressing (pHEMA/BN pellets) and studied for the adsorption of tetracycline (TC) and linezolid (LNZ) from aqueous solutions. Characterization techniques, including scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy, have provided insight into adsorbent microstructure and specific surface area. At an initial antibiotic concentration of 100 mg/L, pHEMA/BN adsorbent demonstrated an 84–88 % increase in equilibrium adsorption capacity after 24 h and an 86–89 % increase in antibiotic removal efficiency compared to unmodified BN. Molecular dynamics calculations revealed robust interactions between the polymer and BN, accompanied by an electron density redistribution. And density functional theory calculations showed the formation of multiple hydrogen bonds between the polymer hydroxyl groups and the antibiotic functional groups. Adsorption kinetics analysis suggested that pHEMA/BN adsorption involves both physical interaction and chemisorption. The pHEMA/BN material demonstrates good reusability with an adsorption efficiency >90 % after three sorption cycles with sorbent regeneration between cycles. These results highlight the high potential of pHEMA/BN adsorbents for practical applications in drinking water and wastewater treatment, offering versatility and efficiency in the pharmaceutical contaminant adsorption, thereby facilitating the development of more cost-effective and sustainable wastewater treatment methods compared to conventional adsorbents.