Abstract The article examines the evolving role of regions in the EU integration process, particularly in light of recent crises, such as the euro and COVID-19 crises. Historically, EU regional studies have emphasized the importance of regions in EU identity and integration, highlighting their role in regional and cohesion policies as key to a multilevel governance system. However, the euro crisis marked a significant shift, as the European Union’s response—focusing on fiscal discipline—curtailed regions’ budgetary autonomy, especially in Southern Europe. In contrast, the COVID-19 crisis prompted a different approach, with the EU relaxing fiscal controls and increasing public expenditure through initiatives like the Recovery Plan for Europe. Despite these measures, the article argues that state interests continue to dominate, sidelining regional voices in the new institutional structures. The article focuses on two critical aspects: the formal participation of regions in EU governance, particularly in the Economic and Monetary Union and the new pandemic-related frameworks, and the impact of these crises on EU regional policy. The findings suggest a decline in regional influence both in institutional participation and in regional policy resources, marking a regression from pre-crisis trends. While the article does not cover a broader multipolicy analysis or the national-level role of regions, it indicates that the post-crisis era has been challenging for regions in maintaining their relevance and influence within the EU framework. The article thus contributes to the discourse on whether the European Union’s interest in regions has diminished, signaling a potential shift in the balance of power within the EU integration process.