Multifunctional Activities Research Articles

Myco-synthesized copper oxide nanoparticles using harnessing metabolites of endophytic fungal strain Aspergillus terreus: an insight into antibacterial, anti-Candida, biocompatibility, anticancer, and antioxidant activities

BackgroundThe overuse of antibiotics leads to the emergence of antibiotic-resistant microbes which causes high mortality worldwide. Therefore, the synthesis of new active compounds has multifunctional activities are the main challenge. Nanotechnology provides a solution for this issue.MethodThe endophytic fungal strain Aspergillus terreus BR.1 was isolated from the healthy root of Allium sativum and identified using internal transcribed spacer (ITS) sequence analysis. The copper oxide nanoparticles (CuO-NPs) were synthesized by harnessing the metabolites of the endophytic fungal strain. The UV-Visble spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), Transmission electron micrscopy (TEM), Energy dispersive X-ray (EDX), X-ray diffraction (XRD), Dynamic light scattering (DLS), and zeta potential (ζ) were used for the characterization of synthesized CuO-NPs. The activity against different pathogenic bacteria and Candida species were investigated by agar well-diffusion method. The biocombatibility and anticancer activity were assessed by MTT assay method. The scavenging of DPPH was used to investigate the antioxidant activity of synthesized CuO-NPs.ResultsData showed the successful formation of crystalline nature and spherical shape CuO-NPs with sizes in the ranges of 15–55 nm. The EDX reveals that the as-formed sample contains ions of C, O, Cl, and Cu with weight percentages of 18.7, 23.82, 11.31, and 46.17%, respectively. The DLS and ζ-potential showed high homogeneity and high stability of synthesized CuO-NPs with a polydispersity index (PDI) of 0.362 and ζ-value of − 26.6 mV. The synthesized CuO-NPs exhibited promising antibacterial and anti-Candida activity (concentration-dependent) with minimum inhibitory concentration (MIC) values in the ranges of 25–50 µg mL–1. Moreover, the fungal mediated-CuO-NPs targeted cancer cells of MCF7 and PC3 at low IC50 concentrations of 159.2 ± 4.5 and 116.2 ± 3.6 µg mL–1, respectively as compared to normal cells (Vero and Wi38 with IC50 value of 220.6 ± 3.7 and 229.5 ± 2.1 µg mL–1, respectively). The biosynthesized CuO-NPs showed antioxidant activity as detected by the DPPH method with scavenging percentages of 80.5 ± 1.2% at a concentration of 1000 µg mL–1 and decreased to 20.4 ± 4.2% at 1.9 µg mL–1 as compared to ascorbic acid (control) with scavenging activity of 97.3 ± 0.2 and 37.5 ± 1.3% at the same concentrations, respectively.ConclusionThe fungal mediated-CuO-NPs exhibited promising activity and can be integrated into various biomedical and theraputic applications.

The Evolution of Multifunctional Agriculture in Italy

This study dealt with multifunctional farming, which is meant as a dynamic strategy that is carried out by Italian farms. The path alongside the multifunctional paradigm is carried out through both supply chain and territorial strategies, which deserve more attention. These strategies reinforce sustainable business models characterized by the presence of both deepening and broadening strategies. The first ones are centered around product differentiation and valorization through geographical indications, organic farming, etc. Broadening strategies are implemented through new on-farm activities, such as agritourism, and other gainful activities carried out at the farm level. Set against this background, the article discusses the evolution of farms according to the Farm Accountancy Data Network (FADN) database by putting forward an empirical analysis, which considered the evolution of farm typologies oriented toward multifunctionality in the last decade. The analysis underlined the positive dynamics and the evolution of farms adhering to the multifunctional paradigm. Moreover, as evidenced in the econometric analysis, the adoption of multifunctional farming activities provided a sound contribution to income formation. This addressed some policy issues that were identified at the beginning of the new programming period for rural development of the EU and their resolution aims to reinforce the virtuous trajectory toward multifunctional farming.

Multifunctional catalytic activity of Cu3N (001) surface: A first-principles study

Multifunctional catalysts that exhibit high catalytic performance for the hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and oxygen reduction reaction (ORR) in a single material hold great promise for broad-spectrum applications, including overall water splitting, fuel cells, and metal–air batteries. In this first-principles study, Cu 3 N is computationally demonstrated as a multifunctional electrocatalyst for the HER, OER, and ORR owing to the unique coordination of N and Cu atoms on the (001) surface. Cu 3 N exhibits better HER catalytic activity than noble Pt-based catalysts. Furthermore, its OER and ORR catalytic activity is comparable to that of commercialized unifunctional catalysts, and its 4e – pathway selectivity is high during the ORR. The catalytic performance of the ORR is significantly improved by the introduction of vacancy defects. The integration of highly efficient HER, OER, and ORR catalytic performance in earth-abundant Cu 3 N not only opens an avenue for developing cost-efficient omnipotent catalysts but also facilitates advances in clean and renewable energy.

Understanding Chromosome Replication and Segregation Unit of Mycobacterium and Its Comparative Analysis with Model Organisms: From Drug Targets to Drug Identification

Bacterium maintains its pathogenicity in the host by continuing replication and adopting temporal and spatial coordination of cell division steps such as cell wall synthesis, DNA replication, chromosome segregation, Z ring assembly, septum formation and finally cytokinesis. This multistep process requires spatiotemporal assembly of macromolecular complexes and is probably regulated by redundant and multifunctional activities of cell replication and division proteins. Two macromolecular assemblies of peptidoglycan biosynthesis, known as elongasome and divisome are known to drive the division of mother cell into two daughter cells and are characterized by the presence of signature protein complexes. Though the exact composition of macromolecular complexes is yet to be defined in Mycobacterium, the presence of some conserved proteins demonstrates the preservation of elementary units. Along with elongasome and divisome complexes, chromosome replication and segregation proteins are very important to understand as these proteins are very essential for bacilli survival, sustenance, and pathogenesis. In this review, along with presenting the differential features of Mycobacterium cell division process, we are comparing chromosome replication and segregation proteins of Mycobacterium with other bacterial species as we aim to identify structural and functional differences between these proteins in different species. In this review, we have also listed the potential drugs that can be tested to target Mycobacterium chromosome replication and segregation proteins. We expect that based on these differences identified, researchers would be able to direct their research in the characterization of Mycobacterium specific drug.

Transforming Growth Factor-β1 and Tumor Development

Transforming growth factor-β (transforming growth factor-β, TGF-β) is a cytokine with multifunctional biological activities. It is highly expressed in a variety of tumors and is closely related to the occurrence, development, and prognosis of tumors. In most cells, TGF-β1 can conduct signal transduction through the classical pathway (depending on Smad) and the non-canonical pathway (independent of Smad), exerting its biological effects. Studies have shown that TGF-β1 mainly affects the development of tumors through epithelial-mesenchymal transition, immune cells in the tumor microenvironment, and carcinoembryonic antigen receptors. Elucidating the molecular mechanism of TGF-β1 carcinogenesis will provide new therapeutic methods to prevent tumor recurrence and delay its metastasis.

Discovery of Lactomodulin, a Unique Microbiome-Derived Peptide That Exhibits Dual Anti-Inflammatory and Antimicrobial Activity against Multidrug-Resistant Pathogens.

The human body is a superorganism that harbors trillions of microbes, most of which inhabit the gut. To colonize our bodies, these microbes have evolved strategies to regulate the immune system and maintain intestinal immune homeostasis by secreting chemical mediators. There is much interest in deciphering these chemicals and furthering their development as novel therapeutics. In this work, we present a combined experimental and computational approach to identifying functional immunomodulatory molecules from the gut microbiome. Based on this approach, we report the discovery of lactomodulin, a unique peptide from Lactobacillus rhamnosus that exhibits dual anti-inflammatory and antibiotic activities and minimal cytotoxicity in human cell lines. Lactomodulin reduces several secreted proinflammatory cytokines, including IL-8, IL-6, IL-1β, and TNF-α. As an antibiotic, lactomodulin is effective against a range of human pathogens, and is most potent against antibiotic-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE). The multifunctional activity of lactomodulin affirms that the microbiome encodes evolved functional molecules with promising therapeutic potential.

Multifunctional Biological Activities and Cytotoxic Evaluation of Bouea macrophylla for Cosmetic Applications

This study aimed to investigate the biological activities, cytotoxicity, phytochemical constituents and stability profile of Bouea macrophylla Griff. peel extracts for cosmeceutical applications. Extraction using maceration or fractionation was optimized using various solvents; ethyl acetate, ethanol, 50%v/v ethanol. The antioxidant activities were determined using DPPH and ABTS radical scavenging, lipid peroxidation inhibition and FRAP assays. Anti-tyrosinase activity was also performed for implying skin depigmentation effects. Total phenolics content, total flavonoids content and total anthocyanin content were also investigated. In addition, ex vivo cytotoxicity and anti-inflammatory effects of the selected extract were studied. Moreover, high performance liquid chromatography (HPLC) technique was used to analyze and quantify phytochemical components of the extract to study the stability profile. The results revealed that the highest percentage yield was shown in hydroethanolic extract (BPHE). Regarding phytochemical contents, BPHE contained 83.91 ± 0.00 mg gallic acid equivalent (GAE)/g extract, 12.98 ± 0.01 mg quercetin equivalent (QE)/g extract. Additionally, BPHE exhibited the strongest antioxidant and anti-tyrosinase properties along with good anti-inflammatory effects. Furthermore, BPHE had no cytotoxicity to human fibroblast cells. The HPLC results showed two major peaks in BPHE, i.e., gallic and ellagic acids. Accordingly, B. macrophylla peel extract could be a promising bioactive ingredient to develop further as anti-aging cosmetic and cosmeceutical products. Keywords: Bouea macrophylla Griff. peel extract, Antioxidant, Anti-tyrosinase, Anti-inflammatory, Cytotoxicity

Settlement layout and social organisation in the mid-6th Millennium BC at Uğurlu on the island of Gökçeada, North-eastern Aegean

Abstract This article examines the complex social organization that emerged in the mid-6th Millennium BC from the perspective of new research conducted in Uğurlu (Phase III), on the island of Gökçeada (Imbros). The mid-6th Millennium BC witnessed major cultural transformations and abrupt changes in virtually all regions from Anatolia to Central Europe, as new settlements brought new forms of social organization. Our aim here is to stimulate further debate about the early complex social organization in the mid-6th Millennium BC. The results of this study reveal a well-organized rural community on the island, reflected in the complex settlement layout, with ritual areas, multifunctional central buildings and activity areas.

Bactericidal Properties of Natural Fibers Hybrid Functionalized with ZnO/Cu2+ and ZnO/Cu0

Multifunctional natural fibers with antimicrobial properties have been applied as a viable strategy to prevent microorganism contamination and proliferation on the surface of clothes and personal protection equipment marketed and used by health professionals, patients, and the general population. They present intrinsic antimicrobial capacity, providing effective protection preventing the transmission and contagion of diseases caused by pathogenic microorganisms. Herein, we successfully functionalized cotton fibers with ZnO/Cu2+ and ZnO/Cu0 hybrid systems via a hydrothermal routine. Rietveld refinement from X-ray Diffractometry (XRD) data and Fourier-Transform Raman Spectroscopy (FT-Raman) indicate alterations on the cellulose crystallinity index in the cotton fibers after functionalization, mainly on the proportion of cellulose Iβ polymorph crystal. Scanning Electron Microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) indicate adequate ZnO nanoparticles fixation and in-situ reduction of copper ions. Antimicrobial tests confirm that the multifunctional fibers present bactericidal activity against Gram-negative and Gram-positive bacteria under electromagnetic irradiation (440–480 nm). Self-disinfection capability and UV blocking properties of wipes with fibers after ZnO/Cu2+ and ZnO/Cu0 functionalization were improved.

Nobiletin Prevents Obesity-Related Complications and Neurological Disorders: An Overview of Preclinical and Clinical Studies

Nobiletin (NOB) chemically known as 5, 6, 7, 8, 3, 4-hexamethoxyflavone is a polymethoxylated flavonoid that is predominantly found in the peel of citrus fruits. Animal studies and a limited number of clinical trials suggest that NOB has multifunctional biological activities such as protection against obesity and obesity related cardiometabolic disorders, neuroprotection, antidiabetic, anticancer, anti-allergy, antioxidant, anti-inflammatory, and free radical scavenging abilities. NOB and its metabolites have also displayed antibacterial and antiviral properties and inhibition of hepatic lipogenesis. This review is intended to discuss the pharmacological actions and therapeutic potential of NOB and its metabolites in the prevention of obesity and obesity associated health complications. Evidence obtained from animal studies and a limited number of clinical trials suggest that NOB may be a promising candidate for the prevention of obesity and obesity related disorders as well as non-communicable diseases. Further studies are needed to understand the mechanism of action of NOB at the cellular, genetic, and molecular levels. Keywords: Nobiletin, obesity, cardiometabolic disorders, inhibition of hepatic lipogenesis, antiatherogenesis.

A 3D-printed vanperio educative dental model - A review report of its chairside evaluation.

Patient education and demonstration of osseous defects by teachers and clinicians are difficult even though there are different models made up of metal, plastic, plaster, stone, and acrylic. To overcome such difficulty, 3D printed Vanperio model was printed for multifunctional activity. The aim of this article was to provide information on the 3D printed VANPERIO model and its implications in the field of periodontics and general dentistry. Vanperio model proves to be a promising model for teachers, students, and clinicians in the field of periodontics and general dentistry as it helps in patient education, student learning and also for various demonstrations which is not possible to achieve in other available expensive models.

Reshuffling city life: spatial and functional dynamics of urban activity in Tokyo during COVID-19

ABSTRACT The COVID-19 pandemic, and the measures to curb it have profoundly affected the geography of urban activities in the past years. In this paper, we discuss its effects on urban activity in Tokyo during the first wave of COVID between February and July 2020. Different from other papers, which have analysed general changes in urban activity levels or changes in specific activities, we have focused on changes in activity levels in different types of multifunctional urban activity centres (UAC), allowing us to reveal interactions between UAC types, (combinations of) activities and location within a wider urban system. Our results show how the distribution of urban activity across UAC changed in space and time in reaction to pandemic measures, and relate these dynamics to the spatial patterns of functional specialization of UAC. The existing spatial pattern of UAC allowed urban activities to redistribute spatially, but continue without too much inhibition. Moreover, these changes appeared to be temporary, rather than resulting in irreversible urban transformations. Our analysis thus suggests that Tokyo’s multilayered polynuclear structure appeared to contribute to the city’s pandemic resilience, allowing urban activities to spatially reorganize, without needing to resort to a total lockdown and collapse of urban life.

Conferring Antioxidant Activity to an Antibacterial and Bioactive Titanium Surface through the Grafting of a Natural Extract.

The main unmet medical need of bone implants is multifunctional activity, including their ability to induce rapid and physiological osseointegration, counteract bacterial biofilm formation, and prevent in situ chronic inflammation at the same time. This research starts from an already developed c.p. titanium surface with proven bioactive (in vitro hydroxyl apatite precipitation) and antibacterial activities, due to a calcium titanate layer with nano- and micro-scale roughness and loaded with iodine ions. Here, antioxidant ability was added to prevent chronic inflammation by grafting polyphenols of a green tea extract onto the surface, without compromising the other functionalities of the surface. The surface was characterized before and after functionalization through XPS analysis, zeta potential titrations, ion release measurements, in vitro bioactivity tests, SEM and fluorescence microscopy, and Folin-Ciocalteu and biological tests. The presence of grafted polyphenols as a homogeneous layer was proven. The grafted polyphenols maintained their antioxidant ability and were anchored to the surface through the linking action of Ca2+ ions added to the functionalizing solution. Iodine ion release, cytocompatibility towards human mesenchymal stem cells (hMSC), and antibacterial activity were maintained even after functionalization. The antioxidant ability of the functionalized surface was effective in preserving hMSC viability in a chemically induced pro-inflammatory environment, thus showing a scavenger activity towards toxic active species responsible for inflammation.

Sustainable approach to natural makeup cosmetics containing microencapsulated butterfly pea anthocyanins

Sustainable development is regarded as the global goal for consumer products including cosmetics. Colorants are important cosmetic ingredients gaining high attention in sustainable cosmetics in accordance with the multifunctional activity surplus with their conceivable safety and sustainability. A sustainable approach to makeup cosmetics that uses a large proportion of colorants, i.e., rouge, is therefore challenged in this study. Natural makeup cosmetics containing the microencapsulated butterfly pea anthocyanins, a natural colorant, corn starch as a substitute for talc, and additional natural substances have been developed. Decorative cosmetics imparting a red shade are more dependent upon their performance than the other shades. The quality of the preparations was examined spreadability, adhesion, pH, compressibility and color. The selected base formula was developed with natural colorant. The developed red shade rouges containing 2–8% of microencapsulated butterfly pea anthocyanins with 6% corn starch were stable following an accelerated stability test. The natural colorant was compatible with the available cosmetic ingredients. In addition, it could be accounted as Microencapsulated butterfly pea anthocyanins could be considered a slip modifying and neutralizing agent in addition to its main action as a colorant. This natural colorant is a multifunctional ingredient. A sustainable approach to cosmetics is therefore achieved on the basis of the natural/biobased ingredients utilization as presented in this context.

2-Hydroxy-4-benzyloxylimine Resveratrol Derivatives as Potential Multifunctional Agents for the Treatment of Parkinson's Disease.

A series of 2-hydroxy-4-benzyloxylimine resveratrol derivatives was designed, synthesized and evaluated as multifunctional agents for the treatment of Parkinson's disease. The results revealed that most derivatives possessed good multifunctional activities. Among them, representative compound (E)-5-[(4-fluorobenzyl)oxy]-2-{[(4-hydroxyphenyl)imino]methyl}phenol (7 h) exhibited excellent MAO-B inhibition (IC50 =8.43×10-3 μM) and high antioxidant activity (ORAC=3.45 Trolox equivalent). Additionally, 7 h displayed good metal chelating ability, appropriate blood-brain barrier (BBB) permeability, significant neuroprotective effect, and great anti-neuroinflammatory activity. Furthermore, 7 h can also ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease symptoms in mice. Therefore, compound 7 h was found to be a promising candidate for further development against PD.

Tenofovir-tethered gold nanoparticles as a novel multifunctional long-acting anti-HIV therapy to overcome deficient drug delivery-: an in vivo proof of concept

BackgroundThe adoption of Antiretroviral Therapy (ART) substantially extends the life expectancy and quality of HIV-infected patients. Yet, eliminating the latent reservoirs of HIV to achieve a cure remains an unmet need. The advent of nanomedicine has revolutionized the treatment of HIV/AIDS. The present study explores a unique combination of Tenofovir (TNF) with gold nanoparticles (AuNPs) as a potential therapeutic approach to overcome several limitations of the current ART.ResultsTNF-tethered AuNPs were successfully synthesized. Cell viability, genotoxicity, haemolysis, and histopathological studies confirmed the complete safety of the preparation. Most importantly, its anti-HIV1 reverse transcriptase activity was ~ 15 folds higher than the native TNF. In addition, it exhibited potent anti-HIV1 protease activity, a much sought-after target in anti-HIV1 therapeutics. Finally, the in vivo biodistribution studies validated that the AuNPs could reach many tissues/organs, serving as a secure nest for HIV and overcoming the problem of deficient drug delivery to HIV reservoirs.ConclusionsWe show that the combination of TNF and AuNPs exhibits multifunctional activity, viz. anti-HIV1 and anti-HIV1 protease. These findings are being reported for the first time and highlight the prospects of developing AuNP-TNF as a novel next-generation platform to treat HIV/AIDS.Graphical

Back to the origin: A spick‐and‐span sustainable approach for the devulcanization of ground tire rubber

AbstractA new sustainable approach for the development of value added devulcanized rubber will augment its application in tire industry and play a significant role toward the product quality, production economy and market completion. The right choice of devulcanizing agent is carried out to keep in mind that the chemical will act as superior devulcanizing agent, easily available, low cost, smoothly penetrate into the crosslinked network in presence of carrier, multifunctional activity and eco‐friendly in nature. Consequently, the current research work is focused on the devulcanization of ground tire rubber (GTR) by way of a multifunctional devulcanizing agent, bis(3‐triethoxysilylpropyl)tetrasulfide. The uniqueness of the chemical agent is that it will devulcanize GTR mechanochemically and subsequently the so‐grown devulcanized rubber can facilitate the homogeneous silica dispersion into the revulcanized rubber compound. The degree of devulcanization and the devulcanized rubber quality is measured by the swelling experiment and Horikx theory. The experimental results clearly specified that the optimal devulcanization time is 40 min to obtain better‐quality of devulcanized rubber and enhanced mechanical and thermal performance of revulcanized rubber. The homogeneous silica dispersion in the rubber matrix is further supported by the scanning electron microscopy images. Ultimately, it was established that the as‐grown technology is suitable for rubber reclaiming, which provides to the advancement in the ecological sustainability.

Novel N1 or N9 modified α-carboline analogues as potential ligands in Alzheimer's disease therapy: Synthesis and neurobiological activity evaluation

A series of new α-carboline analogues modified at N1 or N9 positions by alkyl, benzyl and phenyl were synthesized and characterized as potential ligands for AD therapy. These compounds exhibited multifunctional neurobiological activities including anti-neuroinflammatory, neuroprotective and cholinesterase inhibition. Among them, compound 5d with good drug-like properties and no cytotoxicity, showed potent inhibitory activity against NO production (IC50 = 1.45 μM), which could suppress the expression levels of iNOS and COX-2 in a dose-dependent manner. Further mechanism exploration indicated that compound 5d could regulate the NF-κB signaling pathway by decreasing the phosphorylation of IκB-α and p65. Notably, compound 5d could effectively decrease the LPS-induced aberrations in zebrafish. Compounds 3b, 4f, 5c, 5g, 5m and 6i exhibited potential neuroprotective activity (cell viability > 70 %) in the H2O2-induced PC-12 neuronal death model and rescued the SOD activity. In particular, compounds 3b, 4f, and 5g activated the Nrf2 signaling pathway, and improved the expressions of antioxidant proteins NQO-1 and HO-1, which alleviated the head cell apoptosis in zebrafish. Additionally, compound 6i exhibited potential inhibitory activity against BuChE with IC50 of 0.77 μM. Overall, this work provided some lead compounds based on α-carboline used for AD therapy.

Compounds from the Petroleum Ether Extract of Wedelia chinensis with Cytotoxic, Anticholinesterase, Antioxidant, and Antimicrobial Activities.

Wedelia chinensis is a folk medicine used in many Asian countries to treat various ailments. Earlier investigations reported that the petroleum ether extract of the plant has potential biological activity, but the compounds responsible for activity are not yet completely known. Therefore, the current work was designed to isolate and characterize the compounds from the petroleum ether extract and to study their bioactivities. Four compounds including two diterepenes (-) kaur-16α-hydroxy-19-oic acid (1) and (-) kaur-16-en-19-oic acid (2), and two steroids β-sitosterol (3), and cholesta-5,23-dien-3-ol (4) were isolated and characterized. Among the compounds, the diterpenes were found to have more biological activities than the steroidal compounds. Compound 1 showed the highest cytotoxicity with LC50 of 12.42 ± 0.87 μg/mL. Likewise, it possesses good antioxidant activity in terms of reducing power. On the contrary, compound 2 exerted the highest antiacetylcholinesterase and antibutyrylcholinesterase activity. Both the diterpenes showed almost similar antibacterial and antifungal activity. The identification of diterpenoid and steroid compounds with multifunctional activities suggests that W. chinensis may serve as an important source of bioactive compounds which should be further investigated in animal model for therapeutic potential in the treatment of different chronic diseases.

Laser-Induced Combinatorial Chemotherapeutic, Chemodynamic, and Photothermal Therapy for Hepatocellular Carcinoma Based on Oxaliplatin-Loaded Metal-Organic Frameworks.

The activation of nanoparticles (NPs) in the tumor microenvironment exerts synergistic therapeutic effects with chemotherapy against multiple cancers. In this study, an NP system prepared using biocompatible MIL-100 NPs was studied as an effective vehicle to deliver oxaliplatin for hepatocellular carcinoma treatment. The NPs were coated with polydopamine (PDA) and NH2-PEGTK-COOH and then loaded with oxaliplatin to create the multi-functional NP Oxa@MIL-PDA-PEGTK. Oxa@MIL-PDA-PEGTK is activated in the tumor microenvironment, causing the generation of cytotoxic reactive oxygen species (ROS) via the Fenton reaction and the release of the loaded oxaliplatin. In addition, under near-infrared (NIR) irradiation, Oxa@MIL-PDA-PEGTK can generate hyperthermia at tumor sites. Moreover, owing to the light-induced activation of the Oxa@MIL-PDA-PEGTK NPs, higher drug delivery efficiency, more precise targeted activation, and reduced off-target toxicity were observed in in vitro and in vivo experiments. Taken together, owing to its improved drug delivery efficiency and multi-functional activities, including the ability for targeted chemotherapy coupled with photothermal and chemodynamic therapy, Oxa@MIL-PDA-PEGTK may serve as a new approach for treating hepatocellular carcinoma.