Concerns about general nutrient intake, particularly of more nutritionally vulnerable population groups such as women of child-bearing age have stimulated discussion about whether to advocate the use of modest doses of general multivitamin-mineral supplements to help meet Recommended Dietary Allowances. The purpose of this study was to determine the use of vitamin and mineral supplements in women who are employed full-time and have children under the age of six. Another component of the study was to determine whether the nutrient content of supplement users’ diets differed from that of the non-users’ diets. Subjects were 102 women recruited from area child care centers. Nutrition information was obtained using the Harvard Food Frequency Questionnaire. The women ranged in age from 22 to 47 years, with a mean age of 33 years. Fifty-eight percent reported using supplements on a regular basis with 88% consuming a multivitamin two or more times per week. Twenty-seven percent reported consuming a multivitamin 6–9 times per week and 4% consumed ten or more multivitamins per week. Paired sample t-tests were used to compare vitamin and mineral intake with and without supplementation. For the nutrients calcium, folate, iron, vitamin A, vitamin B 12, vitamin C, vitamin D, and zinc paired sample correlations of the vitamin or mineral with and without supplementation were significant (p<.05). Comparisons of the nutrient intakes of users and non-users with the Recommended Dietary Allowances revealed that only the vitamin E intake of non-users was below the recommended level. Therefore, the need for supplementation is not documented by this study. Toxicity is a concern. Fourteen of the women consumed vitamin A in amounts above 20,000 IU per day with six consuming above 30,000 IU per day.