This paper presents a very large-scale integration (VLSI) circuit design of a micro control unit (MCU) for wireless body sensor networks (WBSNs) in cost-intention. The proposed MCU design consists of an asynchronous interface, a multisensor controller, a register bank, a hardware-shared filter, a lossless compressor, an encryption encoder, an error correct coding (ECC) circuit, a universal asynchronous receiver/transmitter interface, a power management, and a QRS complex detector. A hardware-sharing technique was added to reduce the silicon area of a hardware-shared filter and provided functions in terms of high-pass, low-pass, and band-pass filters according to the uses of various body signals. The QRS complex detector was designed for calculating QRS information of the ECG signals. In addition, the QRS information is helpful to obtain the heart beats. The lossless compressor consists of an adaptive trending predictor and an extensible hybrid entropy encoder, which provides various methods to compress the different characteristics of body signals adaptively. Furthermore, an encryption encoder based on an asymmetric cryptography technique was designed to protect the private physical information during wireless transmission. The proposed MCU design in this paper contained 7.61k gate counts and consumed 1.33 mW when operating at 200 MHz by using a 90-nm CMOS process. Compared with previous designs, this paper has the benefits of increasing the average compression rate by over 12% in ECG signal, providing body signals analysis, and enhancing security of the WBSNs.