A simple window is often unable to ensure standard illumination to the deep parts of large office spaces, and advanced daylighting systems are necessary to ensure the level of interior illuminance. Anidolic ceiling systems are one of the less popular daylighting strategies designed to redirect and redistribute daylight deeper, which can reduce the demand for artificial lighting and energy use for lighting purposes. This study shows how a parametric approach can be applied to optimize the daylighting and energy performance of an anidolic ceiling system in a tropical climate. Multi-objective optimization (MOO) techniques were applied to combine different design variables to establish multiple design alternatives and find the optimal design by comparing their performances. A simulation study of an anidolic ceiling system was conducted with test models primarily developed by Rhinoceros and ClimateStudio, and optimization of performance metrics was conducted using Grasshopper and Octopus. Data exportation was done using the TT toolbox, while data analysis was done through mathematical and statistical analyses and cross-checked by Design Explorer. By incorporating an optimum anidolic ceiling system into the case office space, spatial daylight autonomy (sDA) increased 20.51 %∼68.18 %, annual sunlight exposure (ASE) decreased 15.83 %∼8.52 %, mean illuminance increased 221 lux–3027 lux and energy use intensity (EUI) reduced 189.3 kWh/(m2y)∼174 kWh/(m2y) for different configurations of test models. The results demonstrated a MOO methodology that successfully finds the optimum solutions for the anidolic ceiling systems in a deep plan office space to enhance daylighting and energy performance.