It is important to determine the reasonable injection and production rates in the development of multilayer tight oil reservoir with water flooding treatment. Based on the INSIM (interconnection-based numeric simulation model), a connected network model, a new method is designed to evaluate the water injection efficiency of different layers in water flooding reservoirs and to optimize the injection-production system to produce more oil. Based on the types of sedimentary facies and corresponding injection-production data, the interwell connections are divided into four major categories (middle channel, channel edge, middle channel bar, and channel bar edge) and twelve subclasses. This classification standard of interwell connections could help to significantly improve the accuracy of judging the dominant flow path without constructing a complicated geological model. The interaction of interwells such as injection-production correlation and water injection efficiency could be revealed by simulating the production performance and computing the layer dividing coefficient and well dividing coefficient. A numerical example is used to validate this method by comparing results from FrontSim and this method, and the computational efficiency of this method is several dozen times faster than that of the traditional numerical simulation. This method is applied to quickly optimize the production schedule of a tight oil reservoir with the water flooding treatment, that is, the water injection rate of multilayer reservoirs could be optimized subtly by the injection efficiency of different layers, and the target of producing more oil with lower water cut could be achieved.