Multifunctional System Research Articles

Multifunctional Sr,Mg-Doped Mesoporous Bioactive Glass Nanoparticles for Simultaneous Bone Regeneration and Drug Delivery.

Mesoporous bioactive glass nanoparticles (MBGNs) doped with therapeutical ions present multifunctional systems that enable a synergistic outcome through the dual delivery of drugs and ions. The aim of this study was to evaluate influence of co-doping with strontium and magnesium ions (SrMg-MBGNs) on the properties of MBGNs. A modified microemulsion-assisted sol-gel synthesis was used to obtain particles, and their physicochemical properties, bioactivity, and drug-loading/release ability were evaluated. Indirect biological assays using 2D and 3D cell culture models on human bone marrow-derived mesenchymal stem cells (hBM-MSCs) and endothelial EA.hy926 cells, respectively, were used to determine biocompatibility of MBGNs, their influence on alkaline phosphatase (ALP) production, calcium deposition, and cytoskeletal organization. Results showed that Sr,Mg-doping increased pore volume and solubility, and changed the mesoporous structure from worm-like to radial-dendritic, which led to a slightly accelerated drug release compared to pristine MBGNs. Biological assays confirmed that particles are biocompatible, and have ability to slightly induce ALP production and calcium deposition of hBM-MSCs, as well as to significantly improve the proliferation of EA.hy926 compared to biochemical stimulation via vascular endothelial growth factor (VEGF) administration or regular media. Fluorescence staining revealed that SrMg-MBGNs had a similar effect on EA.hy926 cytoskeletal organization to the VEGF group. In conclusion, Sr,Mg-MBGNs might be considered promising biomaterial for biomedical applications.

From Synthesis to Functionality: Tailored Ionic Liquid-Based Electrospun Fibers with Superior Antimicrobial Properties.

Herein, we report an efficient and facile strategy for the preparation of imidazolium-based ionic liquid (IL) monomers ([CnVIm][Br], n = 2, 4, 6, 8, 10, and 12) and their corresponding polymeric ionic liquids (PILs) with potent antimicrobial activities against Gram-negative and Gram-positive bacteria and fungi. The electrospinning technique was utilized to tailor the polymers with the highest antimicrobial potency into porous membranes that can be easily implemented into diverse systems and extend their practical bactericidal application. The antimicrobial mechanism of obtained ILs, polymers, and nanomaterials is considered concerning the bearing chain length, polymerization process, and applied processing technique that provides a unique fibrous structure. The structure composition was selected due to the well-established inherent amphiphilicity that 1-alkylimidazolium ILs possess, coupled with proven antimicrobial, antiseptic, and antifungal behavior. The customizable nature of ILs and PILs complemented with electrospinning is exploited for the development of innovative antimicrobial performances born from the intrinsic polymer itself, offering solutions to the increasing challenge of bacterial resistance. This study opens up new prospects toward designer membranes providing a complete route in their designing and revolutionizing the approach of fabricating multi-functional systems with tunable physicochemical, surface properties, and interesting morphology.

Efficient Manipulation of Near‐Field Terahertz Waves: Individually Addressable Transmissive Meta‐Device

AbstractDue to the powerful capability in manipulating electromagnetic (EM) waves, digital coding and programmable metasurfaces have found vast application prospects across numerous areas such as next‐generation wireless communications and digital holography. Liquid crystals (LCs), as dielectric materials with significant birefringence effect over a wide frequency range, provide a cost‐effective solution for achieving the programmable metasurfaces and flexible EM manipulations, especially in the terahertz (THz) band. Different from the conventional 1D control and single functionality of transmissive LC‐based devices, here, a 16 × 16 addressable amplitude‐phase coding meta‐device is proposed to support for frequency multiplexing by using the film on glass (FOG) technology. Both numerical simulations and experimental results demonstrate that the meta‐atom exhibits an amplitude modulation depth over 90% and a phase tuning range ≈180° at two distinct frequencies, and hence the single meta‐device can provide multifunctional EM applications, including near‐field printing imaging, 3D THz energy convergence, and zero‐order Bessel beam generation. The proposed strategy paves a way for constructing highly integrated and high‐performance THz multifunctional information processing systems.

PVA/cellulose hydrogel with asymmetric distribution of MoS2 for highly efficient solar-driven interfacial evaporation and electricity generation

Population growth and economic globalization have exacerbated freshwater shortages and energy crises, and solar-driven interfacial evaporation (SDIE) offers a promising solution due to its environmental friendliness, accessibility, and sustainability. However, the highly efficient cogeneration of freshwater and electricity using the SDIE process is a challenge. Herein, a PVA/cellulose hydrogel with asymmetric distribution of MoS2 is proposed as a highly efficient SDIE system to overcome the bottleneck in the cogeneration of freshwater and electricity. By applying material genome engineering and microstructure regulation to improve light harvesting, energy efficiency, evaporation performance, and vapor escape. The evaporation rate of the PVA/cellulose evaporator could reach 3.23 kg m−2 h−1 when desalinating 3.5 wt% seawater under 1 sun and remained basically stable during the long-term continuous evaporation. In addition to desalination, the prepared evaporator also has a potential application in the cyclic utilization of the industrial and domestic wastewater. The synergistic effect of the electron double layer effect and the seawater battery principle produces a high output voltage of 0.714 V. Meanwhile, the optimized solar evaporator demonstrates good mechanical properties, salt resistance, environmental adaptability, and carbon emission economy. This work provides new insights into efficient seawater desalination and power generation, and inspires further research on multifunctional solar-driven interfacial evaporation systems to effectively address water scarcity and energy crises.

Antimicrobial profile and Turn-On sensing of cyanide and water traces using a dual chromophoric Dansyl-Acridine conjugate as multifunctional system

9-aminocridine derivatives bearing a dimethylmethanimidamide, L1, and the dyad conjugate dansyl-acridine, L2, were synthesized and their ability to be used as multifunctional materials using different polymer matrixes was investigated. L1 was found to modulate its emission in the presence of traces of water with a turn-on effect and to this end was used for the detection of water traces in organic solvents with a LOD and LOQ of 0.0028 and 0.0121 (V%) in acetonitrile, respectively. Due to the observed acidochromism for this compound and the different behaviour in acetonitrile and chloroform due to different stabilization of the excited state a turn-off and turn-on effect was observed for respective solvents. PMMA polymer doped films aided on the elucidation for this compound to be used as a sensor of strong acids. Furthermore, compound L2 was found fruitful for the detection of cyanide through an acid base anion sensing. Incorporation of these compounds in PVA:PVP polymer films and Irogran® microparticles were carried out to assess their antimicrobial profile.

Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats

Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by synovitis and cartilage destruction. The active compound, icariin (ICA), derived from the herb Epimedium, exhibits potent anti-inflammatory properties. However, its clinical utility is limited by its water insolubility, poor permeability, and low bioavailability. To address these challenges, we developed a multifunctional drug delivery system—adipose-derived stem cells-exosomes (ADSCs-EXO)-ICA to target active macrophages in synovial tissue and modulate macrophage polarization from M1 to M2. High-performance liquid chromatography analysis confirmed a 92.4 ± 0.008% loading efficiency for ADSCs-EXO-ICA. In vitro studies utilizing cellular immunofluorescence (IF) and flow cytometry demonstrated significant inhibition of M1 macrophage proliferation by ADSCs-EXO-ICA. Enzyme-linked immunosorbent assay, cellular transcriptomics, and real-time quantitative PCR indicated that ADSCs-EXO-ICA promotes an M1-to-M2 phenotypic transition by reducing glycolysis through the inhibition of the ERK/HIF-1α/GLUT1 pathway. In vivo, ADSCs-EXO-ICA effectively accumulated in the joints. Pharmacodynamic assessments revealed that ADSCs-EXO-ICA decreased cytokine levels and mitigated arthritis symptoms in collagen-induced arthritis (CIA) rats. Histological analysis and micro computed tomography confirmed that ADSCs-EXO-ICA markedly ameliorated synovitis and preserved cartilage. Further in vivo studies indicated that ADSCs-EXO-ICA suppresses arthritis by promoting an M1-to-M2 switch and suppressing glycolysis. Western blotting supported the therapeutic efficacy of ADSCs-EXO-ICA in RA, confirming its role in modulating macrophage function through energy metabolism regulation. Thus, this study not only introduces a drug delivery system that significantly enhances the anti-RA efficacy of ADSCs-EXO-ICA but also elucidates its mechanism of action in macrophage function inhibition.Graphical abstract

RGD-modified ZIF-8 nanoparticles as a drug carrier for MR imaging and targeted drug delivery in myocardial infarction.

Aim: A multifunctional nanoplatform has been developed to enhance the targeting capability and biosafety of drug/siRNA for better diagnosis and treatment of myocardial infarction (MI).Materials & methods: The nanoplatform's chemical properties, biodistribution, cardiac magnetic resonance imaging (MRI) capabilities, therapeutic effects and biocompatibility were investigated.Results: The nanoplatform exhibited MI-targeting properties and pH-sensitivity, allowing for effective cardiac MRI and delivery of drugs to the infarcted myocardium. The GCD/Qt@ZIF-RGD demonstrated potential as a reliable MRI probe for MI diagnosis. Moreover, the GCD/si-SHP1/Qt@ZIF-RGD effectively suppressed SHP-1 expression, increased pro-angiogenesis gene expression and reduced cell apoptosis in HUVECs exposed to hypoxia/reoxygenation.Conclusion: Our newly developed multifunctional drug delivery system shows promise as a nanoplatform for both the diagnosis and treatment of MI.

The agricultural decision process in a small tank cascade system in Sri Lanka: diagnosing options for adaptive governance

Small Tank Cascade Systems (STCS) are interconnected small reservoirs constructed in shallow valleys in the dry zone of Sri Lanka. STCS have assumed heightened significance for their potential contribution to climate adaptation of agricultural systems. Local communities managed STCS to store water by capturing seasonal rain and cultivating crops that suited local conditions over millennia. The British colonial centralisation of STCS governance led to the degradation and deterioration of STCS. Contemporary water governance literature identifies STCSs as complex multifunctional systems. Adaptive co-management (ACM) approaches can reconcile complex resource governance issues by combining co-management with co-governance. We studied Palugaswewa STCS in North Central Sri Lanka to explore farmer and government officials' views, perceptions, knowledge, and experiences about agricultural decision-making including current governance, issues, and proposed improvements seeking evidence for ACM in practice. We interviewed eleven farmers and four extension officials selected from the analysis preceding this research. Our results show that an informal decision process (pre-cultivation meeting) precedes and informs the formal decision process (cultivation meeting), farmers use their collective knowledge and experience to anticipate seasonal weather and plan cultivation, and government officials facilitate a community-led decision process with institutional limitations. We concluded that the informal process compensates for the lack of timely meteorological information, allows space for sharing and co-development of knowledge and facilitates ACM. Future governance interventions in STCS need to recognise informal processes that drive decision-making, provide timely user-centred meteorological information, and rethink legal frameworks at local and national levels to provide flexibility for local farmers.

Efficient solar utilization: Multifunctional solar absorber devices realize self-driven hydrogen production

Considered as one of the effective approaches to address the energy crisis and develop green and sustainable energy, the application of solar energy in multiple stages was investigated in this study. By designing a WS2/ZnIn2S4 heterojunction, a multifunctional coupling system based on interfacial water evaporation technology was constructed. In this system, the water evaporation rate was 1.67 kgꞏm−2ꞏh−1, and the photocatalytic degradation efficiency of rhodamine B reached 96.5 %. Moreover, the electric energy output from thermoelectric conversion was innovatively in situ applied for photocatalytic hydrogen production, which increased the photocatalytic hydrogen production efficiency by five times, with a hydrogen production rate of 40.3 μmolꞏcm−2ꞏh−1. This study successfully integrated thermoelectric power generation, photocatalytic hydrogen production, and photocatalytic degradation of dye wastewater into an advanced solar-driven interface evaporation system, enabling the simultaneous conversion of solar energy into multiple forms of energy, improving solar energy utilization efficiency, which was of great significance for promoting the practical application of solar energy.

Influence of bonding variance on electron affinity in graphene quantum dot-barium titanate nanocomposites for drug delivery system

Although chemotherapy remains a prevalent option in cancer treatment, its adverse effects on normal cells and suboptimal pharmacokinetics often limits its effectiveness. To address these challenges, this study successfully developed a new multifunctional drug delivery system comprising a covalent composite of graphene quantum dots and barium titanate nanoparticles. Notably, despite numerous reports on the surface modification of graphene quantum dots, studies focusing on cancer cell inhibition via different covalent bonds are scarce. To bridge this gap, this system was synthesized using eco-friendly esterification and amidation pathways. The anticancer drug doxorubicin was employed as a model drug, and hyaluronic acid was used to encapsulate the delivery system, enhancing its sustained release capabilities. Comprehensive material characterization confirmed the successful synthesis of the system. Its high drug loading capacity and acid-sensitive release can be attributed to the unique structure of the graphene quantum dots. Subsequent in vitro and in vivo biological evaluations not only demonstrated the system’s remarkable cancer inhibition efficacy but also accentuated the distinct impacts of the two bonding types. The underlying mechanism is believed to involve bonding affinity and electron transfer, findings that are corroborated by the experimental data. Additionally, results from animal models provide clear evidence for the potential application of this system (HA-DOX-GQD@BTNPs) in cancer therapeutics and imaging. In conclusion, this research elucidates the variances in drug carrier efficacy based on different covalent bond modifications for cancer treatment and introduces a novel drug delivery system that synergistically combines imaging and targeting capabilities.

Anticancer therapeutic potential of multimodal targeting agent- "phosphorylated galactosylated chitosan coated magnetic nanoparticles" against N-nitrosodiethylamine-induced hepatocellular carcinoma.

Superparamagnetic iron oxide nanoparticles (SPIONs) are extensively used as carriers in targeted drug delivery and has several advantages in the field of magnetic hyperthermia, chemodynamic therapy and magnet assisted radionuclide therapy. The characteristics of SPIONs can be tailored to deliver drugs into tumor via "passive targeting" and they can also be coated with tissue-specific agents to enhance tumor uptake via "active targeting". In our earlier studies, we developed HCC specific targeting agent- "phosphorylated galactosylated chitosan"(PGC) for targeting asialoglycoprotein receptors. Considering their encouraging results, in this study we developed a multifunctional targeting system- "phosphorylated galactosylated chitosan-coated magnetic nanoparticles"(PGCMNPs) for targeting HCC. PGCMNPs were synthesized by co-precipitation method and characterized by DLS, XRD, TEM, VSM, elemental analysis and FT-IR spectroscopy. PGCMNPs were evaluated for in vitro antioxidant properties, uptake in HepG2 cells, biodistribution, in vivo toxicity and were also evaluated for anticancer therapeutic potential against NDEA-induced HCC in mice model in terms of tumor status, electrical properties, antioxidant defense status and apoptosis. The characterization studies confirmed successful formation of PGCMNPs with superparamagnetic properties. The internalization studies demonstrated (99-100)% uptake of PGCMNPs in HepG2 cells. These results were also supported by biodistribution studies in which increased iron content (296%) was noted inside the hepatocytes. Further, PGCMNPs exhibited no in vivo toxicity. The anticancer therapeutic potential was evident from observation that PGCMNPs treatment decreased tumor bearing animals (41.6%) and significantly (p ≤ 0.05) lowered tumor multiplicity. Overall, this study indicated that PGCMNPs with improved properties are efficiently taken-up by hepatoma cells and has therapeutic potential against HCC. Further, this agent can be tagged with 32P and hence can offer multimodal cancer treatment options via radiation ablation as well as magnetic hyperthermia.

Effect of installation factors on the environment uniformity of multifunctional fan-coil unit system in Chinese solar greenhouse

Airflow significantly affects crop growth, and providing adequate and uniform airflow is essential to improve crop yield and quality. This paper used computational fluid dynamics software to optimize multifunctional fan-coil unit (FCU) installation factors at different crop heights. Fan pressure jump coefficient got optimized further, and the percentage of disturbance velocity was proposed as an index to evaluate the improvement of turbulence characteristics in airflow fields. The simulation results showed that the FCU system's optimal tilt angle, swing angle, and height above the ground were 20°, 45°, and 2.9 m, respectively. The optimum spacing is related to crop height. For lower tomatoes, the optimal spacing was 4.2 m and 4.5 m for higher tomatoes. The velocity coefficients of variation (Cv-v) for different height crops before optimization were 0.58 and 0.66. The Cv-v after optimization decreased to 0.37 and 0.41, and the uniformity was improved by 36.21 % and 37.88 %; the porous medium amounts percentage in the optimum air velocity range were increased to 64.70 % and 23.50 %. Simultaneously, the homogeneous airflow distribution improved the temperature field uniformity by 46.5 % and 23.95 %. This paper can provide theoretical guidance for the design and installation of FCU systems.

Designing Unconventional Molecular Ternary INHIBIT Logic Gate and Crafting Multifunctional Molecular Logic Systems.

The paper describes an improved method for building flexible interswitchable logic gates such as rare-type molecular ternary INHIBIT and combinational logic circuits using a specially designed pyridine-end oligo-p-phenylenevinylene compound featuring alkyl substituents (-C16H33) in a THF medium. The probe molecule showed distinct opto-chemical signals upon interaction with Cu(II) and Hg(II) in THF medium. It is interesting to note that the presence of certain anions (S2-, I-, and CN-) could specifically mask the interaction of either of these metal ions or both. The most exciting thing is that we used a completely new gate design technique to construct a rare-type ternary INHIBIT logic gate using Cu(II), Hg(II), and CN- ions as three chemical inputs. With the identical set of chemical inputs, two more ternary combinational logic circuits were created out of these case-specific, independent reversible and irreversible spectroscopic studies. Finally, we were able to design adaptive molecular logic systems composed of several logic gates, including NOR, AND, IMPLICATION, INHIBIT, TRANSFER, and COMPLEMENT, that in this specific situation change the sort of logic sense by effortless optical toggling.

Synthesis of bare and modified zerovalent iron nanoparticles and their use in porous polylactic acid composites for methyl orange removal

The main objective of this study was to assess the efficacy of two types of immobilised zerovalent iron nanoparticles (nZVI) incorporated into a porous biopolymer matrix of polylactic acid (PLA) as a novel multifunctional composite system for potential use in dye wastewater treatment. The study involved the preparation of unmodified and 2,6-pyridinedicarboxylic acid (PDCA) modified nZVI material using liquid phase reduction method. Zeta potential measurement and UV-Vis spectrophotometry revealed that the ligand-modified nZVI particles exhibited better dispersion stability in aqueous media than bare particles. SEM-EDS analysis showed a higher oxidation state of the ligand-modified nZVI particles and good dispersion and adhesion of nZVI particles in the mesoporous structure of PLA matrix. The removal efficiency of methyl orange was determined spectrophotometrically where a high efficiency (above 90 %) for high concentration of bare nZVI was detected. Its composites also showed an efficiency of 75 – 100 %. However, modified nZVI showed much lower efficiency, especially after embedding in the PLA matrix.

Single 5-centimeter-aperture metalens enabled intelligent lightweight mid-infrared thermographic camera.

Existing mid-infrared thermographic cameras rely on a stack of refractive lenses, resulting in bulky and heavy imaging systems that restrict their broader utility. Here, we demonstrate a lightweight metalens-based thermographic camera (MTC) enabled by a single 0.5-mm-thick, 3.7-g-weight, flat, and mass-producible metalens. The large aperture size (5 cm) of our metalens, when combined with an uncooled focal plane array, enables thermal imaging at distances of tens of meters. By computationally removing the veiling glare, our MTC realizes the temperature mapping with an inaccuracy of less than ±0.7% within the range of 35° to 700°C and shows exceptional environmental adaptability. Furthermore, by using intelligent algorithms and spectral filtering, our uncooled MTC enables visualization and quantification of the SF6 gas leakage at a long distance of 5 m, with a remarkable minimum detectable leak rate of 0.2 sccm. Our work opens the door to the lightweight and multifunctional intelligent thermal imaging systems.

Construction and synergistic anti-tumor study of a tumor microenvironment-based multifunctional nano-drug delivery system

To solve the problems existing in the clinical application of hypericin (Hyp) and tirapazamine (TPZ), a nano-drug delivery system with synergistic anti-tumor functions was constructed using mesoporous silica nanoparticles (MSN) and sodium alginate (SA). The system exhibited excellent stability, physiological compatibility and targeted drug release performance in tumor tissues. In the in vitro and in vivo experiments, Hyp released from MSN killed tumor cells through photodynamic therapy (PDT). The degree of hypoxia in the tumor tissue site was exacerbated, enabling TPZ to fully exert its anti-tumor activity. Our studies suggested that the synergistic effects between the components of the nano-drug delivery system significantly improve the anti-tumor properties of Hyp and TPZ.

Construction of an intranasal drug delivery system with hypothalamus‐targeting nanoparticles

AbstractDysfunction of the hypothalamus is associated with endocrine imbalances, growth abnormalities, and reproductive disorders. However, there is a lack of targeted treatment strategies focused on the hypothalamus. In this study, we constructed a multifunctional nanocarrier system (S@ANP) to directly target the hypothalamic neurokinin receptor 3 (NK3R) via an intranasal delivery strategy. This system could overcome the primary obstacles in drug delivery for hypothalamus‐related diseases. Under the guidance of a modified (Trp7, β‐Ala8)‐neurokinin A (4‐10) peptide with cysteine, nanoparticles encapsulated with SB222200, an NK3R inhibitor, were found to readily penetrate hypothalamic cells with substantial loading capacity, encapsulation efficiency, and sustained release in vitro. Moreover, intranasal delivery represents an optimal delivery strategy that allows for a significant reduction in oral dosage and enables nanoparticles to bypass the blood‒brain barrier and target relevant parts of the brain. The mucolytic agent N‐acetyl‐L‐cysteine (NAC) was loaded into the nanoparticles (S@ANP + NAC) to increase mucosal solubility and intranasal delivery efficiency. In vivo evaluations showed that S@ANP + NAC could effectively target the hypothalamus and modulate NK3R‐regulated hypothalamic functions in mice. Due to its high hypothalamic targeting efficiency and low toxicity, this intranasal nanoparticle drug delivery system may serve as a potential strategy for precision therapy of hypothalamic disorders.

Определение индивидуального риска травматизма горнорабочих в результате динамического проявления

The article analyses the effect of gas-dynamic manifestations on occupational injuries. It has been established that the most hazardous gas-dynamic manifestation for underground deep mines is a rock burst. As the rock burst is identified by the authors as the most hazardous effect by its manifestations, the authors offer their methodology of identification of occupational injury risk caused by a rock burst for a wider discussion. The main characteristics and causes of rock bursts and their signs and forecasting methods have been described. The statistics of accidents caused by rock bursts have been provided. The article contains statistical information on mild, severe, and lethal injuries caused by rock bursts in coal mines of the Kuznetsk coal basin. Multifunctional safety systems able to obtain information on the condition of rock mass have been analyzed. Special attention has been paid to the system of current control and forecast of rock mass conditions based on the «Mikon-GEO» system. In the majority of cases, based on the problems to solve, such a system is a part of multifunctional safety systems. The authors suggest that the forecast methodology is to be based on the data obtained by such systems operating based on the seismoacoustics principles. The mathematical model using the source data obtained from the «Mikon-GEO» system has been considered. The calculation algorithm enabling the assessment of the rock burst probability has been provided. The algorithm and the results of measurements of rock mass basic parameters are used to determine the individual risk value that is advisable to compare with the average value of occupational risk at production. The results obtained by the authors have been tested in one of the Kuznetsk Basin coal mines. The preliminary results of the forecast methodology use have shown the relevance of the studies and identified certain issues requiring specification and further research.

Study on the multifunctional spatial-temporal evolution and coupling coordination of cultivated land: A case study of Hebei Province, China.

The rational use of cultivated land can guarantee food security and thus is highly important for ensuring social stability, economic development and national security. The current study investigated the multifunctional temporal and spatial variation characteristics of cultivated land and explored the spatial and temporal characteristics of the multifunction and coupling coordination degrees of cultivated land throughout Hebei Province. Based on the administrative division data, statistical yearbook data and land use status data of the impacted areas, a multifunctional evaluation index system of cultivated land was established. The CRITIC weight method and entropy weight method were used to determine the weight of the index, the comprehensive index model was used to determine the production, social security, ecology and landscape functions of cultivated land of Hebei Province in different periods, the coupling coordination model was used to explore the multifunctional coupling coordination degree of cultivated land in each county, and spatial autocorrelation analysis was performed to determine the correlation of the multifunctional coupling coordination degrees. From 2000 to 2020, the production, social security and landscape function of cultivated land in Hebei Province trended upward; the ecological function trended slightly downward. The multifunctional coupling coordination degree of cultivated land in Hebei Province trended significantly upward and changed from limited coordination to intermediate coordination. Furthermore, it exhibited strong agglomeration and a significant positive spatial correlation, forming a 'V'-type change rule of first decreasing and then increasing. Hebei Province exhibited remarkable spatial and temporal characteristics of the multifunction and coupling coordination degrees of cultivated land. Regions could thus customize different cultivated land functions to maximize the benefits of cultivated land use. The findings of this study may provide a scientific basis and theoretical support for sustainably using and managing cultivated land resources in areas with similar human geographical environments.

Coupling bimetallic selenides with homogeneous mediators synergistically accelerating overall sulfur redox kinetics for high-performances lithium–sulfur batteries

The practical applications of lithium-sulfur batteries (LSBs) are hampered by poor electrical conductivity, severe shuttling of intermediate lithium polysulfides (LiPSs) and sluggish redox kinetics. Herein, we introduce a multifunctional catalytic system by integrating bimetallic ZnSe-CoSe2 with CoCp2 mediators, aimed at serving as redox kinetic accelerators in LSBs. In this design, the ZnSe-CoSe2 heterostructure with hierarchical pores and large surface area, is capable of immobilizing both soluble LiPSs and CoCp2 mediators, but also provides abundant active sites for catalyzing LiPSs conversions. Concurrently, the soluble CoCp2 mediators contribute to promoting the high-dimensional growth of Li2S and reducing the interface polarization. Electrochemical experiments and theoretical analyses reveal that the ZnSe-CoSe2/CoCp2 system synergistically accelerates overall sulfur redox kinetics. Consequently, the cell with the ZnSe-CoSe2/CoCp2 system under a sulfur loading of 2.3 mg cm−2 exhibits superior long-term cycling stability at 1.0C. Additionally, it achieves a remarkable areal capacity of 6.5 mAh cm−2 under a high sulfur loading of 8.0 mg cm−2 and a low electrolyte-to-sulfur ratio of 5.0 µL mg−1.