X-ray grating interferometer can simultaneously retrieve attenuation, refraction and scattering signals of the imaged sample, which shows its great potential in biomedical imaging. However, fast scan of gratings and high centrifugal forces during rotating in X-ray grating-based cone-beam computed tomography (CBCT) system may lead to phase-stepping errors and grating position fluctuations, which cause reconstruction failure with phase-stepping (PS) method. Whats more, the reconstructed slices usually suffer from severe artifacts under low dose conditions. Herein, we propose a multi-frequency model to simulate the mechanical instability of the system and put forward novel iterative image reconstruction methods named MFM-TLI and MLEM-FISTA-TV to improve image quality in sparse-view trimodal CBCT. Results reveal that the model and MFM-TLI is effective to retrieve high quality absorption, differential phase contrast (DPC) and dark-field (DF) signals under mechanical instability, significantly outperforming the PS method. Image quality reconstructed by MLEM-FISTA-TV is improved compared to other iterative and analytical algorithms with sparse-view data. To the best of our knowledge, this is the first time multi-frequency method is applied in X-ray grating interferometer and iterative MLEM-TV algorithm is evaluated on experimental sparse-view dark-field CBCT data. This work might provide support for future trimodal CBCT reconstruction.
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