The shrinkage separation is one of the key factors restricting the development of concrete-filled steel tube (CFST) arch bridge. In this paper, its mechanism and evaluation method concerning multiple factors, including structure, environment, material and construction were investigated. Firstly, the hydration process of in-tube concrete was simulated using the hydration degree as a basic state parameter. Then with the consideration of energy and mass conservation, as well as the moisture and heat transmission effects, the temperature and relative humidity fields, early-age mechanical properties, basic creep, and total deformation of in-tube concrete were further calculated. On the basis, in accordance with the stress criterion and displacement coordination, a multi-field (hydro-thermo-hygro-constraint) coupling model was finally established, taking the ratio of normal stress to bonding strength at the steel-concrete interface as the shrinkage separation risk index. The simulation results obtained from the model were in good agreements with the full-scale CFST model test.