Multidisciplinary Prevention Research Articles

Development of an mHealth Platform for Adolescent Obesity Prevention: User-Centered Design Approach.

Obesity is a chronic condition that influences the quality of life of patients and families while increasing the economic burden for the world population. Multidisciplinary prevention programs are crucial to address it, allowing an early introduction of healthy behaviors into daily habits. Mobile health interventions provide adequate support for these programs, especially considering the gamification techniques used to promote users’ engagement. TeenPower is a multidisciplinary mHealth intervention program conducted in Portugal during 2018 to empower adolescents, promoting healthy behaviors while preventing obesity. An agile software development process was applied to the development of the digital platform that holds a web-based application and a mobile application. We also propose a model for future developments based on the user-centered design approach adopted for this development and the assessment conducted in each phase. The user-centered design approach model proposed has three distinct phases: (1) design study; (2) pre-production usability tests; and (3) post-production data. Phase 1 allowed us to obtain the high-fidelity version of the graphical user interfaces (n = 5). Phase 2 showed a task completion success rate of 100% (n = 5). Phase 3 was derived from statistical analysis of the usage of the platform by real end users (n = 90). We achieved an average retention rate of 35% (31 out of 90 participants). Each technique has provided input for the continuous design and improvement of the platform. This allowed the creation of a tailored platform that could meet users’ expectations. Nevertheless, the retention rate decreased significantly over a short period of time, revealing the need for further work in the improvement of the gamification experience.

Reducing duration of invasive mechanical ventilation for preterm infants

Mechanical ventilation contributes to bronchopulmonary dysplasia in preterm infants. We aimed to reduce the duration of ventilation by weaning ventilator settings within 1 h of “weanable” blood gases and extubating within 1 h of a “weanable” blood gas on “extubatable” ventilator settings. Infants born at < 32 weeks/< 1500 g were included. “Weanable” blood gases and “extubatable” ventilator settings were defined. Interventions included: a multidisciplinary BPD prevention team, extubation criteria, NICU education, a process for rapid notification of medical staff about all blood gas results, and monthly data dissemination. Extubations within 1 h of criteria increased from 64% to 88% after the dissemination of guidelines and education. The time to extubation decreased from 325 to 49 min, and the duration of intubation decreased from 8 to 3 days. However, the time for ventilator weaning did not change. Re-intubation rates did not change. Standardization of extubation led to decreased duration of mechanical ventilation.

Multidisciplinary preventive intervention for breast cancer-related lymphedema: An international consensus.

To establish a consensus regarding the multidisciplinary prevention of breast cancer-related lymphedema (BCRL), taking into account the expert opinion of professional groups from across the world involved in the identification and treatment of breast cancers. International consensus study involving a modified nominal group and Delphi process. A total of 50 preventive strategies representing those used by a range of health disciplines involved in breast cancer care were identified by the nominal group. These strategies were categorised into four subgroups (general recommendations, therapeutic approach, rehabilitation medicine and physiotherapy and dietary recommendations) and presented in survey format to a multidisciplinary panel of experts in a two-round Delphi process. Eleven specialist areas and 15 countries were represented on the panel. Twenty-seven experts responded to both Delphi rounds, and the mean overall agreement after Round 2 was 85.7%. Of the 50 proposed strategies for preventing BCRL, 48 yielded consensus among experts. We report an international consensus for the multidisciplinary prevention of BCRL, setting out recommendations aimed at systematising the care of women with breast cancer. The consensus could provide a platform for the development of standardised clinical guidelines.

Qualitative Analysis of Operational Deliverables of the PGH-Child Protection Unit and Child Protection Network in Advancing the Care Continuum for Child Maltreatment: A Roadmap for Setup and Evaluation

Objective. Our goal is to identify an operational roadmap of core elements in the set-up of the Philippines General Hospital Child Protection Unit (PGH-CPU) established in 1997, and Child Protection Network (CPN) established in 2002. This roadmap will guide future improvement needs for PGH-CPU and CPN and could help accelerate the set-up of future child protection units or networks.&#x0D; Methods. Using the 5 pillars of the Care Continuum for Child Maltreatment for categorization of deliverables — multidisciplinary intervention, training, governance, research/publication, and prevention — we identified operational deliverables (excluding patient numbers and outcomes) of the PGH-CPU and CPN. These were qualitatively analyzed to identify trends across the past 20-years and along 5 pillars of the Care Continuum.&#x0D; Results. Identification and qualitative analyses of documented deliverables reveal pillar-specific and time-dependent trends across 5-year periods. This trend analysis identified the core elements central to the set-up of a CPU and reveal an operational roadmap in the set-up of CPUs in resource-constrained settings.&#x0D; Conclusions. Case study review and qualitative analyses identify core elements that comprise a roadmap for need based prioritization in the set-up of CPUs/CPNs towards a comprehensive care continuum for child maltreatment. The 20-year experience in a developing nation context validates the roadmap

Ibuprofen-Induced Toxic Epidermal Necrolysis: A Case Report

Introduction: Toxic epidermal necrolysis (TEN) is a medical emergency that most commonly occurs as an adverse effect of certain drugs. Here, we describe a case of a 41-year-old man with no comorbid illness who developed TEN. Case Presentation: The patient had been prescribed ibuprofen for myalgia and developed skin lesions after the single dose. The lesions were erythematous papules and macules distributed all over the body after ibuprofen intake. TEN was diagnosed based on the patient’s clinical presentation and laboratory findings. He was treated with intravenous dexamethasone, intravenous immunoglobulin, and cyclosporine. Daily dressing changes and skin care was done with saline, chlorhexidine, and liquid paraffin. The patient was intubated and tracheostomized, and he gradually improved and survived. Later, he developed septicemia in the intensive care unit and was treated successfully. Discussion: The management of TEN includes cessation of the causative cause, multidisciplinary ICU care, prevention and early detection of sepsis, fluid and electrolyte balance, adequate analgesia and temperature control, proper organ support, aggressive nutritional management, and good psychological support. The pharmacological therapy for TEN includes corticosteroids, intravenous immunoglobulin, and cyclosporine. The key elements of management are aseptic care and proper dressing of the skin. Conclusion: TEN is associated with high mortality if not managed in a systemic and protocolized way.

Feasibility of a new multifactorial fall prevention assessment and personalized intervention among older people recently discharged from the emergency department

Falls among older people occur frequently and are a leading cause of Emergency department (ED) admissions, disability, death and rising health care costs. Multifactorial fall prevention programs that are aimed to target the population at risk have shown to effectively reduce the rate of falling and fall-related injuries in community-dwelling older people. However, the participation of and adherence to these programs in real life situation is generally low. To test the feasibility of a transitionally organized fall prevention assessment with accompanying personalized intervention initiated at the ED. A process evaluation, of a non-randomized controlled pilot trial for implementing a transitionally organized multifactorial fall prevention intervention, was performed using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework to gain insight into the barriers and facilitators of implementation. Older fallers (>70yrs) presenting at the ED were selected based on ZIP-code and after obtaining informed consent, data for the evaluation was collected through questionnaires and interviews. Furthermore, feedback was collected from the healthcare providers. The consent was obtained by 24 (70%) of the patients approached directly at the ED and 17 (26%) of the patients approached later by phone. Adherence to the protocol by the participants, clinical assessors and family practice were all more than 90%. After three months, nine (26%) of the participants had at least one recurrent fall: three (20%) patients in the intervention group and six (32%) in the control group. ED presentation due to a fall in older persons provides a window of opportunity for optimizing adherence to a multifactorial fall prevention program as willingness to participate was higher when the patients were approached at the ED during their stay. Implementing a transitionally organized multidisciplinary fall prevention program was successful with a high protocol adherence. NTR NL8142, November 8, 2019.

Interaction of Gut Microbiota with Endocrine Homeostasis and Thyroid Cancer.

Simple SummaryAs the interaction between gut microbiota and thyroid cancer is gradually being revealed, the thyroid gland, as an important endocrine organ, constitutes the gut-thyroid axis. Dysbiosis of the gut microbiota leads to the accumulation of metabolites that, through specific mechanisms, lead to genetic instability in the thyroid, ultimately leading to tumorigenesis and progression. In addition, these metabolites can lead to autoimmune responses, resulting in imbalance of endocrine homeostasis and the development of autoimmune diseases. In this review, we discuss the interaction of gut microbiota with thyroid disease and thyroid cancer. We hope to provide some potential new strategies for the prevention and treatment of thyroid disease or thyroid cancer.The gut microbiota plays a crucial role in healthy individuals as well as in patients with thyroid diseases, including thyroid cancer. Although the prognosis of differentiated thyroid cancer is predictable, that of some poorly differentiated, medullary, and anaplastic thyroid cancers remains unpromising. As the interaction between the gut microbiota and thyroid cancer has been gradually revealed in recent years, the thyroid gland, a crucial endocrine organ, is shown to have a complex connection with the body’s metabolism and is involved in inflammation, autoimmunity, or cancer progression. Dysbiosis of the gut microbiota and its metabolites can influence changes in hormone levels and susceptibility to thyroid cancer through multiple pathways. In this review, we focus on the interactions of the gut microbiota with thyroid function diseases and thyroid cancer. In addition, we also discuss some potential new strategies for the prevention and treatment of thyroid disease and thyroid cancer. Our aim is to provide some possible clinical applications of gut microbiota markers for early diagnosis, treatment, and postoperative management of thyroid cancer. These findings were used to establish a better multi-disciplinary treatment and prevention management strategy and to individualize the treatment of patients in relation to their gut microbiota composition and pathological characteristics.

Optimizing Post-Acute Care Patient Safety: A Scoping Review of Multifactorial Fall Prevention Interventions for Older Adults.

Accidental falls are preventable adverse events for older post-acute care (PAC) patients. Yet, due to the functional and medical care needs of this population, there is little guidance to inform multidisciplinary prevention efforts. This scoping review aims to characterize the evidence for multifactorial PAC fall prevention interventions. Of the 33 included studies, common PAC intervention domains included implementing facility-based strategies (e.g., staff education), evaluating patient-specific fall risk factors (e.g., function), and developing an individualized risk profile and treatment plan that targets the patient's constellation of fall risk factors. However, there was variability across studies in how and to what extent the domains were addressed. While further research is warranted, health system efforts to prevent accidental falls in PAC should consider a patient-centered multifactorial approach that fosters a culture of safety, addresses individuals' fall risk, and champions a multidisciplinary team.

Early multidisciplinary prevention program of post-stroke shoulder pain: A randomized clinical trial

Objective To evaluate if positioning the upper-limb promoting abduction, external rotation and flexion of the shoulder reduces the intensity of post-stroke shoulder pain at day-7 compared to usual clinical practice. Design & setting Prospective single-center randomized clinical trial using a superiority design comparing two preventive strategies of post-stroke shoulder pain in a stroke unit. Subjects Patients were included within 2 days from a first symptomatic ischemic stroke affecting shoulder motor function. Interventions Intervention group included specific positioning of the shoulder in abduction, external rotation and flexion in bed, chair and during mobilization. Control group referred to usual practice i.e. positioning using a standard support scarf. Main measures Primary outcome was the intensity of shoulder pain assessed by the visual analog scale (VAS) (0–100) at day-7 post-stroke. Other outcomes measured at day-7 and 2 months post-stroke were the VAS, motor function, spasticity, depression, functional independence and rates of complex regional Pain syndrome (CRPS). Results 76 patients (49 males; mean age = 68.3) were randomized. The shoulder pain at day-7 was not different between the control group (16.1, SD = 27.4) and the intervention group (10.3, SD = 21.5, p = 0.18) as well as at 2 months (p = 0.12). A lower rate of depression was observed in the intervention group at 2 months 36.7% (CI95% 19.9;56.1) vs 52.9% (CI95% 35.1;70.2). No between-group difference in other outcomes was observed at 2 months. Conclusions This study failed to demonstrate the benefit of a specific positioning tool in reducing the intensity of post-stroke shoulder pain which was lower than previously reported in the literature.

Nurses' perceptions of fall risk factors and fall prevention strategies in acute care settings in Saudi Arabia.

AimThis study aimed to explore nurses’ perceptions of the factors associated with falls and of fall prevention strategies in acute care settings in Saudi Arabia.DesignThis is a cross‐sectional, correlational, descriptive study.MethodsData were collected from 102 nurses using a survey on the risk factors and prevention strategies of injurious falls.ResultsWe found that impaired balance and muscle strength, limited mobility, and an inability to follow safety instructions were reported as the top factors in falls. Multidisciplinary fall prevention strategies are effective in reducing the prevalence of falls. Nurses with higher levels of education had higher perceptions towards the risk factors of falls. Formal patient safety training, including fall prevention education programmes, were shown to reduce falls by making nurses more aware of fall risk factors and prevention strategies. The findings of this study can be used to inform managers about factors that may contribute to falls in acute care settings.

Poisoning-related emergency department visits: the experience of a Saudi high-volume toxicology center.

BACKGROUND: Acute poisoning is a major contributing factor to mortality and morbidity. There is a lack of research on the epidemiology of acute poisoning risk factors in Saudi Arabia.OBJECTIVES: Descriptive overview of poisoning cases at a tertiary care center.DESIGN: Descriptive, medical record review.SETTINGS: Tertiary care center in Riyadh.PATIENTS AND METHODS: From the electronic medical record system, we collected demographic information, medical history, and the poisoning history on all emergency department visits diagnosed as acute poisoning from January 2016 to January 2021. Patients were classed as children (<18 years old) or adults, and further classified by body mass index.MAIN OUTCOME MEASURES: Intensive care unit (ICU) admission, organ transplantation, and mortality were classified as poor outcomes.SAMPLE SIZE: 492 adults and 1013 children (<18 years old) were identified.RESULTS: The most frequent agent in poisoning for both groups was acetaminophen (n=52, 10.57% and n=100, 9.87%, respectively). The ICU admission rate was 6.7% and 4.8%, and the mortality rate 0.8% and 0.3%, respectively. The accidental poisoning rate was 57.7% among adults (n=284) and 67.6% among children (n=658). The suicide intention rate was 11.2% (n=55) and 7.4% (n=75) among adults and children, respectively. The management for both populations was nonspecific, involving observation, supportive measures, and symptomatic treatment.CONCLUSION: Although the ICU admission rates were consistent with reported data, the mortality rate was marginally lower. The pediatric predominance in the population implies a lack of caregiver education in the region regarding the safe storage of drugs and household products, as well as the use of child-resistant packaging. The high rate of accidental poisoning in both age groups should prompt further investment to promote public health education on the rational use and safe storage of toxic agents and self-protection. The high suicide intention rate needs to be investigated to develop multidisciplinary risk prevention strategies.LIMITATIONS: Single center, retrospective, small population size.CONFLICT OF INTEREST: None.

Analýza výsledkov aplikácie koncepcie CPTED v zahraničí

The process of designing security into architecture is known as "Crime Prevention Through Environmental Design." It includes a design built environment to reduce opportunities and fear of crime. Crime prevention through environmental design can help with reducing the chances of committing crimes and also can provide guidance to property owners on how to protect their property. There is not enough information about the concept in the territory of the Slovak Republic, so the objective of this article is to point out its effectiveness. The effectiveness of the CPTED concept will be demonstrated through an analysis of implemented projects abroad, which have confirmed that the concept is an effective, successful and feasible multidisciplinary prevention strategy.

Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery

Delirium significantly worsens elective surgery outcomes and costs. Delirium risk is highest in elderly populations, whose surgical health care resource consumption (50%) exceeds their demographic proportion (15% to 18%) in high-resource countries. Effective nonpharmacologic delirium prevention could safely improve care in these vulnerable patients, but data from procedure-specific studies are insufficiently compelling to drive changes in practice. Delirium prevention approaches applicable to different surgical settings remain unexplored. To examine whether a multifaceted prevention intervention is effective in reducing postoperative delirium incidence and prevalence after various major surgical procedures. This stepped-wedge cluster randomized trial recruited 1470 patients 70 years and older undergoing elective orthopedic, general, or cardiac surgery from November 2017 to April 2019 from 5 German tertiary medical centers. Data were analyzed from December 2019 to July 2021. First, structured delirium education was provided to clinical caregivers at each site. Then, the study delirium prevention team assessed patient delirium risk factors and symptoms daily. Prevention was tailored to individual patient needs and could include: cognitive, motor, and sensory stimulation; meal companionship; accompaniment during diagnostic procedures; stress relaxation; and sleep promotion. Postoperative delirium incidence and duration. Of 1470 included patients, 763 (51.9%) were male, and the median (IQR) age was 77 (74-81) years. Overall, the intervention reduced postoperative delirium incidence (odds ratio, 0.87; 95% CI, 0.77-0.98; P = .02) and percentage of days with delirium (intervention, 5.3%; control, 6.9%; P = .03). The effect was significant in patients undergoing orthopedic or abdominal surgery (odds ratio, 0.59; 95% CI, 0.35-0.99; P = .047) but not cardiac surgery (odds ratio, 1.18; 95% CI, 0.70-1.99; P = .54). This multifaceted multidisciplinary prevention intervention reduced postoperative delirium occurrence and days with delirium in older patients undergoing different elective surgical procedures but not cardiac procedures. These results suggest implementing this delirium prevention program will improve care and outcomes in older patients undergoing elective general and orthopedic procedures.

Data processing algorithms for the in silico SARS-CoV-2 epitope prediction and vaccine development

Based on literature analysis and own bioinformatics and virology research experience, authors propose multistep data processing algorithms, designed for the objectives of assisting the SARS-CoV-2 epitope vaccine production. Epitope vaccines are expected to provoke a weaker but safer response of the vaccinated person. Methodologies of reverse bioengineering, vaccinology and synthetic peptide manufacturing have a promising future to combat COVID-19 brutal disease. The significant mutational variability and evolution of the SARS-CoV-2, which is more typical for natural animal-borne viruses, are the hurdle for the effective and robust vaccine application and therefore require multidisciplinary research and prevention measures on the international level of cooperation. However, we can expect that other viruses with different nature and content may be labelled as SARS-CoV-2. In this case metagenomics is an important discipline for COVID-19 discovery. High quality reliable virus detection is still an unresolved question for improvement and optimization. It is of upmost importance to develop the in silico and in vitro methods for the vaccine recipient reaction prediction and monitoring as techniques of the so-called modern personalized medicine. Many questions can`t be solved applying exclusively in silico techniques and only can be discovered in vitro and in vivo, demanding significant time and money investments. Future experiments also should be directed at the discovery of optimal vaccine adjuvants, vectors and epitope ensembles, as well as the personal characteristics of citizens of a certain region. This research would require several more years of meticulous large-scale laboratory and clinical work in various centers of biomedical institutions worldwide

Review new concepts in pharmacotherapy for peripheral arterial disease

To provide an overview of new concepts in the pharmacotherapy of patients with peripheral artery disease (PAD). Modern therapeutic strategies for patients with PAD include specific symptom management and multidisciplinary prevention of cardiovascular events. Low-dose rivaroxaban in combination with aspirin improves outcomes compared with aspirin monotherapy among patients with PAD. Other novel concepts include the use of bosentan, vorapaxar or sildenafil among symptomatic patients with PAD. Likewise, lipid-lowering therapy reduces the risk of major cardiovascular and limb events. Personalized management, identification of risk factors and shared-decision making are crucial in improving the best medical therapy for patients with PAD. Further studies are needed to assess the long-term safety and efficacy of novel strategies in real-world patients.

A single center’s 15-year experience with palliative limb care for chronic limb threatening ischemia in frail patients

ObjectiveOur institution’s multidisciplinary Prevention of Amputation in Veterans Everywhere (PAVE) program allocates veterans with critical limb threatening ischemia (CLTI) to immediate revascularization, conservative care, primary amputation, or palliative limb care according to previously reported criteria. These four groups align with the approaches outlined by the global guidelines for the management of CLTI. In the present study, we have delineated the natural history of the palliative limb care group of patients and quantified the procedural risks and outcomes. MethodsVeterans prospectively enrolled into the palliative limb cohort of our PAVE program from January 2005 to January 2020 were analyzed. The primary outcome was mortality. The secondary outcomes included overall and limb-related readmissions, limb loss, and wound healing. The clinical frailty scale (CFS) score was calculated, and the 5-year expected mortality was estimated using the Veterans Affairs Quality Enhancement Research Initiative tool. Regression analysis was performed to establish associations among the following variables: mortality, wound, ischemia, and foot infection (WIfI) score, CFS score, overall admissions, and limb-related admissions. ResultsThe PAVE program enrolled 1158 limbs during 15 years. Of the 1158 limbs, 157 (13.5%) in 145 patients were allocated to the palliative limb care group. The overall mortality of the group was 88.2% (median interval, 3.5 months; range, 0-91 months). Of the 128 patients who had died, 64 (50%) had died within 3 months of enrollment. The predicted 5-year mortality for the group was 66%. The average CFS score for the group was 6.2, denoting persons moderately to severely frail. Using the CFS score, 106 patients were considered frail and 39 were considered not frail. No differences were found in mortality between the frail and nonfrail patients. However, a statistically significant difference was found in early (<3 months) mortality (56.2% vs 37.5%; P = .032). The 30-day limb-related readmission rate was 4.7%. Eventual major amputation was necessary for 18 limbs (11.5%). Wound healing occurred in 30 patients (20.6%). Regression analysis demonstrated no association between the CFS score and mortality (r = 0.55; P = .159) or between the WIfI score and mortality (r = 0.0165; P = .98). However, a significant association was found between the WIfI score and limb-related admissions (r = 0.97; P < .001). ConclusionsFrail patients with CLTI had high early mortality and a low risk of limb-related complications. They also had a low incidence of deferred primary amputation or limb-related readmissions. In our cohort, the vast majority of patients had died within a few months of enrollment without requiring an amputation. A comprehensive approach to the treatment of CLTI patients should include a palliative limb care option because a significant proportion of these patients will have limited survival and can potentially avoid unnecessary surgery and major amputation.

Arterial Thrombosis in Cancer Patients: An Update.

Cancer is associated with an increased incidence of both venous thromboembolism (VTE) and arterial thrombosis (cardiovascular events and ischemic stroke). Cancer-associated arterial thrombotic events are less well studied than VTE, but increasingly recognized, particularly in specific malignancies and in association with specific anticancer therapies. The pathogenesis of arterial thrombotic events in cancer is complex and involves generation of tumor-associated procoagulant factors and a variety of alterations in platelet function as well as in the coagulation and fibrinolytic systems, and endothelial injury and dysfunction, that combine to produce hypercoagulability. The multifactorial interaction between this prothrombotic state, the individual cardiovascular risk, advanced age and presence of comorbidities, and the specific neoplasm characteristics and therapy, may induce the vascular events. Recent studies based on population databases and prospective or retrospective analyses with prolonged follow-up highlight that cancer patients experience an increased (approximately 1.5-2-fold) risk of both cerebrovascular and cardiovascular events compared with noncancer individuals, which peaks in the time period of the diagnosis of cancer but may persist for years. Beyond the type of cancer, the risk reflects the tumor burden, being higher in advanced stages and metastatic cancers. The occurrence of arterial thromboembolic events is also associated with increased overall mortality. We here present an update of the pathophysiology, risk factors, clinical evidence, and treatment considerations on cancer-associated arterial thrombosis, in the light of the need for specific multidisciplinary prevention and surveillance strategies in this setting, in the frame of cardio-oncology approaches.

Multimodal Interventions to Improve the Management of Chronic Non-Malignant Pain in Primary Care Using Participatory Research.

Background: The use of diverse therapies combined with a multidisciplinary approach and prevention initiatives for patients with chronic non-malignant pain (CNMP) can improve health and have a positive impact on psychotropic drug use and the self-management of pain. Purpose: This purpose of this study has been two-fold: to conduct a literature review with a view to selecting best evidence recommendations for CNMP and to prioritize self-care recommendations using a participatory methodology for the analysis and selection of interventions. Methods: A qualitative, descriptive, and documentary method based on participatory action research was used. Findings: Based on the study results, a multimodal psychosocial intervention program has been designed for CNMP that includes psychoeducational therapy, pharmacological therapy, physical exercise, and health assets. Discussion: The findings are consistent with previous studies underlining the need to invest in resources for the management of CNMP, including strategies for good differential diagnoses and pharmacological treatments combined with non-pharmacological treatments to confer greater well-being for people living with pain who want to participate in their own recovery.

Deep Vein Thrombosis (DVT) Prophylactic Team Activity to Support DVT Prevention Protocol for the Purpose of the Prophylaxis of Pulmonary Thromboembolism (PTE) and Operation.

Objective: In 2017, the Medical Accident Investigation and Support center in Japan released an analysis of acute pulmonary thromboembolism (PTE) related mortality. This recommendation called for maintaining a “team in charge of PTE’s risk assessment, prevention, diagnosis and treatment” and preventing PTE through team activities. Therefore, we recommended establishing a deep vein thrombosis (DVT) prevention team. Before this recommendation, a multidisciplinary DVT prevention team was established in our hospital, with excellent outcomes. In the current study, we report the results of the DVT prevention team.Methods: Our multidisciplinary team consisted of several departments: Cardiovascular Surgery, ward nurses, medical safety managers, and clerks. The following themes were launched: 1) preparation of DVT prevention protocol; 2) preparation of DVT preventive manual; 3) regular round for evaluating DVT preventive measures; 4) staff education. The protocol’s strong point was that nurses evaluated patients over 16-year-old with Wells’ score for DVT on admission. We retrospectively investigated the diagnosis rate of DVT and PTE for 9 months before and after protocol operation.Results: The diagnosis rate of DVT was significantly improved after protocol implementation (before: 0.06% vs. after: 0.56%, p=0.0017). However, no significant difference was observed in the diagnosis rate of PTE before and after the protocol execution (before: 0.03% vs. after: 0.07%, p=0.98).Conclusion: Our DVT prophylactic protocol improved the diagnostic rate of DVT resulting in a decrease of PTE in our hospital. (This is a translation of Jpn J Phlebol 2019; 30(3): 285–293.)

PrEP University: A Multi-Disciplinary University-Based HIV Prevention Education Program

The introduction of emtricitabine/tenofovir diphosphate (FTC/TDF) as pre-exposure prophylaxis (PrEP) for HIV prevention has raised questions regarding which clinicians will serve as prescribers and how providers will be educated about this HIV prevention strategy. We piloted an HIV Prevention Education Program called PrEP University (PrEP U) to address knowledge gaps in HIV prevention among medical trainees. We examined PrEP awareness and assessed learning as a result of the program, measuring knowledge before and after the lectures with an anonymous 5-question multiple choice test. A total of 198 learners participated in PrEP University, which included 127 first year medical students, and post-graduate trainees in internal medicine (n = 23), family medicine (n = 16), OBGYN (n = 13) and pharmacy (n = 19). Prior to PrEP U, 27% of all participants were not aware of PrEP and an additional 8% were unsure if they had heard of it. Knowledge increased significantly after the education program among trainees in OBGYN (2.3 vs 3.8, p < 0.001), pharmacy (1.4 vs 2.5, p = 0.012) and school of medicine (3.3 vs 4.4, p < 0.001), with a trend seen in family medicine (2.7 vs. 3.7, p = 0.067) and internal medicine (2.7 vs 3.4, p = 0.068). Overall, an HIV Prevention Education Program was successfully administered to nearly 200 participants and resulted in improved knowledge of HIV prevention and PrEP across. Pharmacists and OBGYN physicians are two groups with an expanding role in the use of PrEP. Similar programs at other medical schools should be implemented to ensure that future physicians and pharmacists are comfortable with PrEP prescription.