Background: Post-surgical rehabilitation of Colle’s fracture requires manual and exercise therapy to restore normal hand function. Aim: To compare the effectiveness of Maitland mobilization and Mulligan’s mobilization with movement on hand function and pain after Colle’s fracture. Study Design: Non randomized clinical study. Methodology: Study was conducted after ethical approval, at physiotherapy department Mayo hospital Lahore in 2019-20. Sample of 60 patients estimated by epitool, was divided into three equal groups (A, B & C). Subjects were screened on the basis of predefined eligibility criteria. All three groups received the respective therapy along with baseline treatment on alternate days for 4 weeks. Pre and post treatment and follow up assessments included VAS, patient rated wrist evaluation questionnaire and wrist ranges of motion with goniometer. Results: Mean age of participants was 45.38±6.58 years. No significant measures were found in any of the outcome measure between Maitland and Mulligan mobilization (p<0.05). Statistically significant improvement was found in all groups. Conclusion: We concluded that that the Mulligan mobilization with movement was effective to reduce pain and improve hand function in management after Colle’s fracture. Keywords: Colle’s Fracture, Post Fracture Stiffness, Radius Fracture, Mobilization and Mulligan’s Mobilization