Background Pain lasting more than three months is termed chronic pain. Treating chronic pain is always a challenge for the therapist. Low back pain (LBP) with a high prevalence is a point of concern. Various treatment methods are available. The two treatment methods are integratedneuromuscular inhibition technique (INIT) and Mulliganmobilization with movement (MWM). In this study, we have compared INIT with MWM. Method It was an interventional study carried out at Ravi Nair Physiotherapy College and Acharya Vinoba Bhave Rural Hospital. A total of 80 participants with nonspecific LBP were included in the study. The participants were randomly divided into two groups and treated for two weeks with three weekly sessions. Statistical analysis and result Statistical analysis was done post the completion of sampling. Paired and unpaired t-tests were used. A p-value of <0.05 was consideredsignificant. The result was obtained after comparing the pre- and post-values of the numerical pain rating scale (NPRS), modified Oswestry disability index (MODI), and range of motion (ROM) of the lumbar joint. After two weeks of treatment, a reduction in functional disability and pain was seen in the INIT and MWM groups. ROM was increased after two weeks of treatment in both INIT and MWM groups. When compared, INIT showed better results than MWM. Conclusion In conclusion, we saw that the integrated neuromuscular inhibition technique might be a better technique than Mulligan mobilization with movement in terms of reducing pain and functional disability.