In this study, a novel interface shell element (ISE) is developed based on a variable-node element formulation to couple non-matching quadrilateral shell meshes. Shape functions for ISEs are explicitly presented in a polynomial form with the use of appropriate supports of weight functions in moving least square (MLS) approximation. Assumed natural strains in the form of the mixed interpolation of tensorial components (MITC) approach are employed to avoid the transverse shear locking when the thickness of shell tends to zero. Moreover, an assumed membrane strain field defined over quadrilateral subdomains subdividing an ISE is used to alleviate the membrane locking in curved ISEs. Numerical experiments show the effectiveness and efficiency of ISE for connecting dissimilar quadrilateral shell meshes at a common interface.