Readiness Potential Research Articles

Test-Retest Reliability of Event-Related Potentials Across Three Tasks

Abstract. Event-related potentials (ERPs) constitute a useful and cost-effective method to assess the neural underpinnings of multiple cognitive processes. ERPs have been used to track changes in cognitive processes in longitudinal and clinical studies. However, few studies have assessed their test-retest reliability (i.e., their consistency across time). Therefore, in the current study, we aimed to assess the test-retest reliability of ERPs (P100, N100, P200, N200, P3b, lateralized readiness potentials) across three tasks. In two assessments separated by approximately 4 months, ERPs were recorded in 26 healthy participants, during two oddball tasks (motor and counting) and a stimulus-response compatibility paradigm. Pearson’s correlations and intraclass correlations were used to assess the test-retest reliability of ERPs. Correlations between ERPs elicited by the three tasks were assessed with Pearson’s correlations. Our analyses revealed moderate to very strong test-retest reliability for most ERP components across the three tasks. Test-retest reliability did not differ between the motor and counting oddball tasks. Most ERPs were also correlated across paradigms. Therefore, these results confirm that ERPs have the potential to be reliable markers to serve as robust assessment tools in longitudinal or clinical studies.

Reduced readiness potential and post-movement beta synchronization reflect self-disorders in early course schizophrenia

Disturbances of conscious awareness, or self-disorders, are a defining feature of schizophrenia. These include symptoms such as delusions of control, i.e. the belief that one’s actions are controlled by an external agent. Models of self-disorders point at altered neural mechanisms of source monitoring, i.e. the ability of the brain to discriminate self-generated stimuli from those driven by the environment. However, evidence supporting this putative relationship is currently lacking. We performed electroencephalography (EEG) during self-paced, brisk right fist closures in ten (M = 9; F = 1) patients with Early-Course Schizophrenia (ECSCZ) and age and gender-matched healthy volunteers. We measured the Readiness Potential (RP), i.e. an EEG feature preceding self-generated movements, and movement-related EEG spectral changes. Self-disorders in ECSCZ were assessed with the Examination of Anomalous Self-Experience (EASE). Patients showed a markedly reduced RP and altered post-movement Event-Related Synchronization (ERS) in the beta frequency band (14–24 Hz) compared to healthy controls. Importantly, smaller RP and weaker ERS were associated with higher EASE scores in ECSCZ. Our data suggest that disturbances of neural correlates preceding and following self-initiated movements may reflect the severity of self-disorders in patients suffering from ECSCZ. These findings point towards deficits in basic mechanisms of sensorimotor integration as a substrate for self-disorders.

Movement-Related Potentials Associated with Motor Timing Errors as Determined by Internally Cued Movement Onset.

ObjectiveAccurate motor timing is critical for efficient motor control of behaviors; however, the effect of motor timing abilities on movement-related neural activities has rarely been investigated. The current study aimed to examine the electrophysiological correlates of motor timing errors. MethodsTwenty-two healthy volunteers performed motor timing tasks while their electroencephalographic and electromyographic (EMG) activities were simultaneously recorded. The average of intervals between consecutive EMG onsets was calculated separately for each subject. Motor timing error was calculated as an absolute discrepancy value between the subjects’ produced and given time interval. A movement-related potential (MRP) analysis was conducted using readings from Cz electrode. ResultsMotor timing errors and MRPs were significantly correlated. Our principal finding was that only Bereitschaftpotential (BP) and motor potential (MP), not movement monitoring potential, were significantly attenuated in individuals with motor timing errors. Motor timing error had a significant effect on the amplitude of the late BP and MP. ConclusionThe findings provide electrophysiological evidence that motor timing errors correlate with the neural processes involved in the generation of self-initiated voluntary movement. Alterations in MRPs reflect central motor control processes and may be indicative of motor timing deficits.

P-MU003. The impairment of excitation-contraction coupling in ICU-acquired weakness

Introduction . The aim of this study is to elucidate the impairment of excitation-contraction (E-C) coupling in ICU-acquired weakness (ICUAW) using a unique electrophysiologic method in patients received the intensive care in ICU. Methods . We examined 13 patients with ICUAW and 11 normal controls. We performed successive recordings of electrophysiological tests after ICU admission. First, CMAPs of abductor hallucis muscle (AH) and sural SNAPs were recorded using a conventional method. In addition, the tibial nerve was stimulated at the popliteal fossa using a supramaximal rectangular pulse to record CMAPs from soleus muscle (SOL). Simultaneously, movement- related potential (MRP) was recorded using an accelerometer (SV1101; NEC, Tokyo Japan) taped at the base of hallux and calculated E-C coupling time (ECCT) based on the latency differences between soleus CMAP and MRP. Results . We recorded significantly decreased CMAP amplitudes in 6 AHs and 8 SOLs and significantly longer CMAP durations in 2 SOLs. Also, we recorded significantly decreased MRPs in 9 patients and significantly prolonged ECCTs in 10 patients. These abnormal findings were detected even in very short durations of ICU stay such as 2-3 days. The durations of ICU stay seemed to be correlated with involvement of CMAP amplitudes of AH/SOL, MRPs and ECCTs. Ten patients showed decreased SOL-CMAP amplitude concomitant with decreased MRP and/or prolonged ECCT in spite of preservation of SOL-CMAP duration. In addition, CMAP amplitudes of AH/SOL and MRP were significantly smaller in patients than in controls. Furthermore, CMAP durations of AH and ECCTs were significantly longer in patients than in controls. Conclusion . The E-C coupling may be impaired in the very early stages of CIM. Noninvasive measurement of MRP and ECCT is easy to perform, and may be useful to detect the impairment of E-C coupling in the early stages of ICUAW.

SY2.3. Evaluation of dystonia

Dystonia is a syndrome characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. It can be primary or secondary and the patient can present with pure dystonia or dystonia along with other movement disorders such as tremor, myoclonus, parkinsonism, etc. Evaluation of a patient presenting primarily with dystonia includes detailed clinical evaluation, haematologic and neurometabolic work up, imaging and neurophysiological/ electrophysiological studies. This presentation will focus on the electrophysiological evaluation of dystonia, which helps in understanding the pathophysiology and better characterization of the abnormal movement. Compared to tremor and myoclonus, electrophysiological evaluation of muscle spasms and dystonia is difficult. The first step is recording surface EMG from the involved muscles for prolonged periods during abnormal movements (dystonia), rest, and with voluntary contraction. The agonists and antagonists should be included to detect co-contraction, and the unaffected muscles of the same or opposite limbs should also be studied to document overflow dystonia if present. During EMG evaluation, patients are also asked to perform various tasks which can induce dystonia, such as mental arithmetic, finger tapping and opening and closing fist of the unaffected hand, writing (in patients with writer’s cramp). EMG is analyzed to determine: (i) the pattern of EMG activity in agonists and antagonists during dystonia (spasm) (ii) duration of each EMG burst (iii) the regularity of occurrence of EMG bursts, (iv) presence of overflow activity in remote muscles while performing discrete voluntary acts, and (v) the difference in the degree of EMG activity (area of rectified EMG) between epochs with and without muscle spasms. Other investigations which are often useful to characterize dystonia or a dystonic syndrome include: (i) H-reflex recovery curve (ii) mechanically and electrically induced long-latency muscle stretch reflex (iii) reciprocal inhibition between antagonistic muscles (iv) brainstem reflexes such as blink reflex (v) cortical SEP (vi) Bereitschaftpotential (BP) and Contingent negative variation (CNV) and (viii) transcranial magnetic stimulation (TMS). TMS specifically helps to study the excitatory and inhibitory changes in the brain in patients with dystonia and may also be a useful tool to monitor therapeutic interventions.

A Comparison of Conventional and Tri-Polar EEG Electrodes for Decoding Real and Imaginary Finger Movements from One Hand.

The representations of different fingers in the sensorimotor cortex are largely overlapped, which necessitate a good signal-to-noise ratio (SNR) and high spatial resolution to classify individual finger movements from one hand. Electroencephalography (EEG) recorded with disc electrodes has low SNR and poor spatial resolution. The surface Laplacian has been applied to EEG to improve the spatial resolution and selectivity of the surface electrical activity recording. Tri-polar concentric ring electrodes (TCREs) were shown to estimate the Laplacian automatically with better spatial resolution than disc electrodes. For this work, movement-related potentials (MRPs) were recorded from four TCREs and disc electrodes while 13 subjects performed real and imaginary finger movements. The MRP signals recorded with the TCREs have significantly less mutual information and coherence between neighboring locations compared to disc electrodes. The results also show that signals from TCREs generated higher accuracy compared to disc electrodes. It further shows that TCREs using temporal EEG data as features yield an average accuracy of [Formula: see text]% and [Formula: see text]% for real and imaginary finger movements, respectively, which is significantly higher than utilizing EEG spectral power changes in [Formula: see text] and [Formula: see text] bands as features. Similarly, with the disc electrodes, it achieved highest accuracy of [Formula: see text]% and [Formula: see text]% for real and imaginary finger movements, respectively, with temporal EEG data feature.

Effect of Painful Electrical Stimuli on Readiness Potential in the Human Brain.

The readiness potential (RP), which is a slow negative electrical brain potential that occurs before voluntary movement, can be interpreted as a measure of intrinsic brain activity originating from self-regulating mechanisms. Early and late components of the RP may indicate clinical-neurophysiological features such as motivation, preparation, intention, and initiation of voluntary movements. In the present study, we hypothesized that electrical pain stimuli modulate the preparatory brain activity for movement. The grand average evoked potentials were measured at sensory motor regions with EEG during an experimental protocol consisting of painful and nonpainful stimuli. Our results demonstrated that painful stimuli were preceded by an enhanced RP when compared to non-painful stimuli at the Cz channel (p < 0.05). Furthermore, the mean amplitude of the RP at the early phase was significantly higher for the painful stimuli when compared to the non-painful stimuli (p < 0.05). Our results indicate that electrical painful stimuli, which can be considered as an unpleasant and stressful condition, modulate the motor preparation at sensory motor regions to a different extent when compared to non-painful electrical stimuli. Since early component of the RP represents cortical activation due to anticipation of the stimuli and the allocation of attentional resources, our results suggest that painful stimuli may affect the motor preparation processes and the prediction of the movement at the cortical level.

Investigating Motor Preparation in Autism Spectrum Disorder With and Without Attention Deficit/Hyperactivity Disorder.

This study investigated motor preparation and action-consequence prediction using the lateralized readiness potential (LRP). Motor impairments are common in autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which commonly co-occur. Alterations in predictive processes may impact motor planning. Whether motor planning deficits are characteristic of ASD broadly or magnified in the context of co-morbid ADHD is unclear. ASD children with (ASD + ADHD; n = 12) and without (ASD - ADHD; n = 9) comorbid ADHD and typical controls (n = 29) performed voluntary motor actions that either did or did not result in auditory consequences. ASD - ADHD children demonstrated LRP enhancement when their action produced an effect while ASD + ADHD children had attenuated responses regardless of action-effect pairings. Findings suggest influence of ADHD comorbidity on motor preparation and prediction in ASD.

The Radically Embodied Conscious Cybernetic Bayesian Brain: From Free Energy to Free Will and Back Again.

Drawing from both enactivist and cognitivist perspectives on mind, I propose that explaining teleological phenomena may require reappraising both “Cartesian theaters” and mental homunculi in terms of embodied self-models (ESMs), understood as body maps with agentic properties, functioning as predictive-memory systems and cybernetic controllers. Quasi-homuncular ESMs are suggested to constitute a major organizing principle for neural architectures due to their initial and ongoing significance for solutions to inference problems in cognitive (and affective) development. Embodied experiences provide foundational lessons in learning curriculums in which agents explore increasingly challenging problem spaces, so answering an unresolved question in Bayesian cognitive science: what are biologically plausible mechanisms for equipping learners with sufficiently powerful inductive biases to adequately constrain inference spaces? Drawing on models from neurophysiology, psychology, and developmental robotics, I describe how embodiment provides fundamental sources of empirical priors (as reliably learnable posterior expectations). If ESMs play this kind of foundational role in cognitive development, then bidirectional linkages will be found between all sensory modalities and frontal-parietal control hierarchies, so infusing all senses with somatic-motoric properties, thereby structuring all perception by relevant affordances, so solving frame problems for embodied agents. Drawing upon the Free Energy Principle and Active Inference framework, I describe a particular mechanism for intentional action selection via consciously imagined (and explicitly represented) goal realization, where contrasts between desired and present states influence ongoing policy selection via predictive coding mechanisms and backward-chained imaginings (as self-realizing predictions). This embodied developmental legacy suggests a mechanism by which imaginings can be intentionally shaped by (internalized) partially-expressed motor acts, so providing means of agentic control for attention, working memory, imagination, and behavior. I further describe the nature(s) of mental causation and self-control, and also provide an account of readiness potentials in Libet paradigms wherein conscious intentions shape causal streams leading to enaction. Finally, I provide neurophenomenological handlings of prototypical qualia including pleasure, pain, and desire in terms of self-annihilating free energy gradients via quasi-synesthetic interoceptive active inference. In brief, this manuscript is intended to illustrate how radically embodied minds may create foundations for intelligence (as capacity for learning and inference), consciousness (as somatically-grounded self-world modeling), and will (as deployment of predictive models for enacting valued goals).

Bereitschaftspotential in Multiple System Atrophy.

Objective: Multiple system atrophy (MSA) is a neurodegenerative disorder manifesting as parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is categorized into MSA with predominant parkinsonism (MSA-P) and into MSA with predominant cerebellar ataxia (MSA-C). The pathophysiology of motor control circuitry involvement in MSA subtype is unclear. Bereitschaftspotential (BP) is a feasible clinical tool to measure electroencephalographic activity prior to volitional motions. We recorded BP in patients with MSA-P and MSA-C to investigate their motor cortical preparation and activation for volitional movement.Methods: We included eight patients with MSA-P, eight patients with MSA-C, and eight age-matched healthy controls. BP was recorded during self-paced rapid wrist extension movements. The electroencephalographic epochs were time-locked to the electromyography onset of the voluntary wrist movements. The three groups were compared with respect to the mean amplitudes of early (1,500–500 ms before movement onset) and late (500–0 ms before movement onset) BP.Results: Mean early BP amplitude was non-significantly different between the three groups. Mean late BP amplitude in the two patient groups was significantly reduced in the parietal area contralateral to the movement side compared with that in the healthy control group. In addition, the late BP of the MSA-C group but not the MSA-P group was significantly reduced at the central parietal area compared with that of the healthy control group.Conclusions: Our findings suggest that patients with MSA exhibit motor cortical dysfunction in voluntary movement preparation and activation. The dysfunction can be practicably evaluated using late BP, which represents the cerebello-dentato-thalamo-cortical pathway.

Representing strangers in personal space triggers coding of defensive hand movement

Our brain codes manipulable tools as possibilities for action, particularly for those surrounding the body. Recent studies showed people would adjust their motor program when observing others around their own bodies (i.e. in the personal space). However, it remained unclear whether representing a personal space invader can automatically trigger motor coding.To address this, we devised an interaction task to measure the activation of pushing movements in facing a stranger approaching into personal space. The LRP (lateralized readiness potential) analyses revealed that observing a stranger in personal space caused an initial LRP bias associated with pushing movements, and an LRP deflection before responding of pull, suggesting representing personal space invaders activated the motor coding of push. The behavioral results showed the personal space intrusion prolonged the reaction time of participants’ subsequent instructed pulling responses. The results of experiment 2 confirmed the behavioral observation of experiment 1 and further revealed the relationship between the response bias of push and social anxiety. Together, the present study demonstrates representing a stranger in personal space activated coding of defensive hand movements and biased subsequent motor responses.

Neural correlates of implicit agency during the transition from adolescence to adulthood: An ERP study

Sense of agency (SoA), the experience of being in control of our voluntary actions and their outcomes, is a key feature of normal human experience. Frontoparietal brain circuits associated with SoA undergo a major maturational process during adolescence. To examine whether this translates to neurodevelopmental changes in agency experience, we investigated two key neural processes associated with SoA, the activity that is leading to voluntary action (Readiness Potential) and the activity that is associated with the action outcome processing (attenuation of auditory N1 and P2 event related potentials, ERPs) in mid-adolescents (13–14), late-adolescents (18–20) and adults (25–28) while they perform an intentional binding task. In this task, participants pressed a button (action) that delivered a tone (outcome) after a small delay and reported the time of the tone using the Libet clock. This action-outcome condition alternated with a no-action condition where an identical tone was triggered by a computer. Mid-adolescents showed greater outcome binding, such that they perceived self-triggered tones as being temporally closer to their actions compared to adults. Suggesting greater agency experience over the outcomes of their voluntary actions during mid-adolescence. Consistent with this, greater levels of attenuated neural response to self-triggered auditory tones (specifically P2 attenuation) were found during mid-adolescence compared to older age groups. This enhanced attenuation decreased with age as observed in outcome binding. However, there were no age-related differences in the readiness potential leading to the voluntary action (button press) as well as in the N1 attenuation to the self-triggered tones. Notably, in mid-adolescents greater outcome binding scores were positively associated with greater P2 attenuation, and smaller negativity in the late readiness potential. These findings suggest that the greater experience of implicit agency observed during mid-adolescence may be mediated by a neural over-suppression of action outcomes (auditory P2 attenuation), and over-reliance on motor preparation (late readiness potential), which we found to become adult-like during late-adolescence. Implications for adolescent development and SoA related neurodevelopmental disorders are discussed.

Stochasticity Versus Determinacy in Neurobiology: From Ion Channels to the Question of the "Free Will".

If one accepts that decisions are made by the brain and that neuronal mechanisms obey deterministic physical laws, it is hard to deny what some brain researchers postulate, such as “We do not do what we want, but we want what we do” and “We should stop talking about freedom. Our actions are determined by physical laws.” This point of view has been substantially supported by spectacular neurophysiological experiments demonstrating action-related brain activity (readiness potentials, blood oxygen level–dependent signals) occurring up to several seconds before an individual becomes aware of his/her decision to perform the action. This report aims to counter the deterministic argument for the absence of free will by using experimental data, supplemented by computer simulations, to demonstrate that biological systems, specifically brain functions, are built on principle randomness, which is introduced already at the lowest level of neuronal information processing, the opening and closing of ion channels. Switching between open and closed states follows physiological laws but also makes use of randomness, which is apparently introduced by Brownian motion – principally unavoidable under all life-compatible conditions. Ion-channel stochasticity, manifested as noise, function is not smoothed out toward higher functional levels but can even be amplified by appropriate adjustment of the system’s non-linearities. Examples shall be given to illustrate how stochasticity can propagate from ion channels to single neuron action potentials to neuronal network dynamics to the interactions between different brain nuclei up to the control of autonomic functions. It is proposed that this intrinsic stochasticity helps to keep the brain in a flexible state to explore diverse alternatives as a prerequisite of free decision-making.

Fear of movement-related pain disturbs cortical preparatory activity after becoming aware of motor intention

Fear of movement-related pain is known to disturb the process of motor preparation in patients with chronic pain. In the present study, we aimed to clarify the neural mechanisms underlying the influence of fear movement-related pain on motor preparatory brain activity using Libet’s clock and electroencephalography (EEG). Healthy participants were asked to press a button while watching a rotating Libet’s clock-hand, and report the number on the clock (“W time”) when they made the “decision” to press the button with their right index finger. Immediately after pressing the button, a painful electrical stimulus was delivered to the dorsum of the left hand, causing participants to feel fear of movement (button press-related pain). We found that fear of movement-related pain caused the W time to be early, and that the amplitudes of readiness potentials (RPs) increased after awareness of motor intention emerged. In addition, fear of movement-related pain caused over-activation of the medial frontal cortex, supplementary motor area, cingulate motor area, and primary motor cortex after participants became aware of their motor intention. Such over-activation might result from conflict between the unrealized desire to escape from a painful experience and motivation to perform a required motor task.

The limits of the neuroscience of moral responsibility

The findings of the neuroscientist Benjamin Libet are among the most discussed in moral philosophy. They present a clear challenge to the notion of intentional action as a consciously chosen action. According to them, the awareness of the decision to act by the subjects of his studies came only after the moment of preparedness of the action in our brains, called “readiness potential”. Many, including Libet, saw these results as an evidence that we do not have free will nor moral responsibility. The aim of this article is to criticize the claim that moral responsibility would be in danger because of the Libet’s findings. First, the concept of free will as intentional action will be explained in order to understand how the notion of being conscious in deciding when and how to act is relevant. Then, the findings from Libet’s experiments and the argument of how they could be a challenge to the notions of free will and of moral responsibility are presented. At the end, it will be argued that the notion of moral responsibility involves more than psychological capacities, but, foremost, the attribution of social roles in a moral community.

Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing

In the preclinical stage of the Alzheimer’s disease (AD) continuum, subjects report subjective memory complaints (SMCs), although with the absence of any objective decline, and have a higher risk of progressing to dementia than the general population. Early identification of this stage therefore constitutes a major focus of current AD research, to enable early intervention. In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results seem to be influenced by a negative tendency overlapping stimulus-related waveforms. The declines observed in this study are mostly consistent with those observed in aMCI participants, supporting the notion of the AD continuum regarding SMC state.

What Is the Readiness Potential?

The readiness potential (RP), a slow buildup of electrical potential recorded at the scalp using electroencephalography, has been associated with neural activity involved in movement preparation. It became famous thanks to Benjamin Libet (Brain 1983;106:623–642), who used the time difference between the RP and self-reported time of conscious intention to move to argue that we lack free will. The RP’s informativeness about self-generated action and derivatively about free will has prompted continued research on this neural phenomenon. Here, we argue that recent advances in our understanding of the RP, including computational modeling of the phenomenon, call for a reassessment of its relevance for understanding volition and the philosophical problem of free will.

High-Frequency Oscillations in the Pallidum: A Pathophysiological Biomarker in Parkinson's Disease?

Abnormal oscillatory neural activity in the beta-frequency band (13-35 Hz) is thought to play a role in Parkinson's disease (PD); however, increasing evidence points to alterations in high-frequency ranges (>100 Hz) also having pathophysiological relevance. Studies have found that power in subthalamic nucleus (STN) high-frequency oscillations is increased with dopaminergic medication and during voluntary movements, implicating these brain rhythms in normal basal ganglia function. The objective of this study was to investigate whether similar signaling occurs in the internal globus pallidus (GPi), a nucleus increasingly used as a target for deep brain stimulation (DBS) for PD. Spontaneous and movement-related GPi field potentials were recorded from DBS leads in 5 externalized PD patients on and off dopaminergic medication, as well as from 3 rhesus monkeys before and after the induction of parkinsonism with the neurotoxin 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine. In the parkinsonian condition, we identified a prominent oscillatory peak centered at 200-300 Hz that increased during movement. In patients the magnitude of high-frequency oscillation modulation was negatively correlated with bradykinesia. In monkeys, high-frequency oscillations were mostly absent in the naive condition but emerged after the neurotoxin 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine. In patients, spontaneous high-frequency oscillations were significantly attenuated on-medication. Our findings provide evidence in support of the hypothesis that exaggerated, movement-modulated high-frequency oscillations in the GPi are pathophysiological features of PD. These findings suggest that the functional role(s) of high-frequency oscillations may differ between the STN and GPi and motivate additional investigations into their relationship to motor control in normal and diseased states.

The role of cognitive control and top-down processes in object affordances.

A widely held though debatable claim is that the picture of an object like a frying pan automatically elicits features of a left/right-handed grasp action even in perceptual tasks that make no demands on the observer to consider the graspable properties of the depicted object. Here, we sought to further elucidate this claim by relying on a methodology that allowed us to distinguish between the influence of motor versus spatial codes on the selection of a left/right-handed response while electroencephalographic data were recorded. In our experiment, participants classified images of frying pans as upright or inverted using a left/right key press or by making a left/right-handed reach-and-grasp action towards a centrally located response element while we recorded electroencephalographic (EEG) data. In line with previous evidence (Bub, Masson, & van Noordenne, Journal of Experiment Psychology: Human Perception and Performance, 47(1), 53-80, 2021), these two modes of responding generated distinct correspondence effects on performance induced by the same set of images. In terms of our EEG data, we found that neither motor (the lateralized readiness potential) nor visual (N100 and P100) potentials were sensitive to handle-response hand correspondence. However, an exploratory theta analysis revealed that changes in frontal theta power mirrored the different correspondence effects evoked by the image on key press responses versus reach and grasp actions. Importantly, our results provide a link between these disparate effects and the engagement of cognitive control, highlighting a possible role of top-down control processes in separating motor features from the task-irrelevant features of an object, and thus in claims regarding object affordances more generally.

Evidence accumulation under uncertainty - a neural marker of emerging choice and urgency

To interact meaningfully with its environment, an agent must integrate external information with its own internal states. However, information about the environment is often noisy. In this study, we identify a neural correlate that tracks how asymmetries between competing alternatives evolve over the course of a decision. In our task participants had to monitor a stream of discrete visual stimuli over time and decide whether or not to act, on the basis of either strong or ambiguous evidence. We found that the classic P3 event-related potential evoked by sequential evidence items tracked decision-making processes and predicted participants’ categorical choices on a single trial level, both when evidence was strong and when it was ambiguous. The P3 amplitudes in response to evidence supporting the eventually selected option increased over trial time as decisions evolved, being maximally different from the P3 amplitudes evoked by competing evidence at the time of decision. Computational modelling showed that both the neural dynamics and behavioural primacy and recency effects can be explained by a combination of (a) competition between mutually inhibiting accumulators for the two categorical choice outcomes, and (b) a context-dependant urgency signal. In conditions where evidence was presented at a low rate, urgency increased faster than in conditions when evidence was very frequent. We also found that the readiness potential, a classic marker of endogenously initiated actions, was observed preceding movements in all conditions - even when those were strongly driven by external evidence.