Stochasticity Versus Determinacy in Neurobiology: From Ion Channels to the Question of the "Free Will".

Abstract

If one accepts that decisions are made by the brain and that neuronal mechanisms obey deterministic physical laws, it is hard to deny what some brain researchers postulate, such as “We do not do what we want, but we want what we do” and “We should stop talking about freedom. Our actions are determined by physical laws.” This point of view has been substantially supported by spectacular neurophysiological experiments demonstrating action-related brain activity (readiness potentials, blood oxygen level–dependent signals) occurring up to several seconds before an individual becomes aware of his/her decision to perform the action. This report aims to counter the deterministic argument for the absence of free will by using experimental data, supplemented by computer simulations, to demonstrate that biological systems, specifically brain functions, are built on principle randomness, which is introduced already at the lowest level of neuronal information processing, the opening and closing of ion channels. Switching between open and closed states follows physiological laws but also makes use of randomness, which is apparently introduced by Brownian motion – principally unavoidable under all life-compatible conditions. Ion-channel stochasticity, manifested as noise, function is not smoothed out toward higher functional levels but can even be amplified by appropriate adjustment of the system’s non-linearities. Examples shall be given to illustrate how stochasticity can propagate from ion channels to single neuron action potentials to neuronal network dynamics to the interactions between different brain nuclei up to the control of autonomic functions. It is proposed that this intrinsic stochasticity helps to keep the brain in a flexible state to explore diverse alternatives as a prerequisite of free decision-making.