Bioclimatic design knowledge and measures, including passive techniques and natural ventilation cooling, are urgently for building renovation to mitigate global warming. The performance of indoor airflow, energy, economic, and environmental aspects has been researched separately. However, developing a comprehensive framework to investigate bioclimatic strategies under the impact of climate change is challenging. This study aims to integrate bioclimatic design strategies with a coupled simulation approach using Fluent and EnergyPlus to evaluate retrofitting techniques for a single-room office in a university building in a hot summer and cold winter climate. A bioclimatic analysis was conducted to recommend cost-effective passive cooling strategies, including natural ventilation and window shading systems. Two passive measures, changing window types and furniture layouts, were included in renovation packages. Results indicated that the empty model is not valid compared to the fully furnished model when calculating room air change per hour (ACH). Natural ventilation was the most cost-effective strategy to mitigate climate change, with a net present value (NPV) ranging from USD 135.09 to 402.81 over 30 years. However, a higher ACH did not ensure a longer natural ventilation period. By changing the top-hung window to a vertical sash and implementing a movable furniture layout, can achieve better ventilation efficiency. The installation of window vertical shadings had the highest annual emission savings by 2080, while it performed negative economic viability in both the present and the 2050 climates. This research demonstrated how combining bioclimatic measures with a co-simulation approach can offer a thorough evaluation of building energy retrofitting. The results could support architectural and engineering design by integrating bioclimate measures to identify the most effective strategies.