In 2020 the residential sector witnessed a complete transformation of the way people live and occupy the spaces. Indeed, different Countries introduced total lockdowns as a measure to contain and prevent the spread of COVID-19, forcing people to stay at home. These measures impact the indoor hygrothermal environment: higher internal thermal loads and moisture generation rate may create the perfect situation to support mould growth. This project aims to understand the impacts of increased work-from-home practices on the hygrothermal performance of residential buildings. The assessment uses a two-step methodology: firstly, whole building transient simulations (software trnsys) are used to generate the indoor temperature and humidity profiles, secondly hygrothermal transient simulations (software WUFI) are used to quantify the risk of mould growth. This research reveals the inadequacy of current design and construction practices to support flexible occupation patterns.