Frequency Of Movements Research Articles

Surface Electromyography for the Diagnosis of Tremor Syndrome: A Study of 97 Patients.

Tremor is one of the most frequent movement disorders encountered in clinical practice with heterogeneous phenomenology and etiology. Surface electromyography (SEMG) is a noninvasive and reproducible test that can diagnose tremor syndromes. In this retrospective study, the clinical and electrophysiologic records of 97 consecutive patients with tremor syndromes who visited our movement disorder clinic between January 2023 and March 2024 were examined. In our study, 28.8% (n = 28) of patients were of essential tremor (ET) syndrome. SEMG of ET syndrome patients showed synchronous bursts in 71.4% (n = 20), alternating bursts in 10.7% (n = 3), synchronous bursts with co-contraction of agonist and antagonist muscles in 10.7% (n = 3), and both synchronous and alternating bursts in 3.6% (n = 1) of patients. Tremor-ataxia syndrome formed 21.6% (n = 21) of our study population, with 71.4% (n = 15) of patients showing synchronous bursts and co-contraction and 28.6% (n = 6) patients having alternating bursts. Moreover, 12.3% (n = 12) patients were of parkinsonian tremor, of whom alternating bursts were present in 75% (n = 9) and synchronous bursts with co-contraction were present in 25% (n = 3) of patients. In addition, 11.3% (n = 11) of patients had dystonic tremor (DT), of whom 81.8% (n = 9) had synchronous bursts and co-contraction and 18.2% (n = 2) had alternating bursts. Synchronous bursts with co-contraction suggestive of DT were observed in most patients with tremor-ataxia syndrome and a small number of patients with ET syndrome. Our data suggests that SEMG helps differentiate these two clinical syndromes, which is difficult in a clinical setting.

Questioning the Correlation Between Incidence of Hirschsprung Disease and Indications for Rectal Biopsy.

Aim: To review the indications for rectal mucosal/submucosal biopsy (RMSBx) used for diagnosing Hirschsprung's disease (HD) in pediatric patients. Methods: The medical records of all children between 1 and 15 years old assessed for chronic constipation between 2012 and 2022 were reviewed. Until the end of 2018, enema usage (E+) was a major indication for RMSBx. In 2019, laxative use for 3 months irrespective of enema use was added as an indication (L+). To determine the relevance of enema usage, L+ was subdivided by enema usage into (L+E+) and (L+E-) groups. The effect of changing the indications for RMSBx on the incidence of HD was investigated. Results: Of 562 eligible subjects, E+ = 410, L+ = 152; demographics are similar. RMSBx rate in E+ (E+RMSBx) was 36/410 (8.8%) and in L+ (L+RMSBx) was 42/152 (27.6%;) (P < .05). For L+RMSBx, 15/42 were L+E+ and 27/42 were L+E-. HD incidence in E+RMSBx was 8/36 (22.2%; E+HD) and in L+RMSBx was 13/42 (31.0%; L+HD) (p = ns). In L+RMSBx, HD incidence in L+E+ was 5/15 (33.3%; L+E+HD) and in L+E- was 8/27 (29.6%; L+E-HD) (P = ns). Differences in daily bowel motion frequency 6 months postoperatively were not statistically significant; E+HD (1.75/d) versus L+HD (2.03/d) and L+E+HD (1.60/day) versus L+E-HD (2.31/day). Unassisted voluntary defecation was confirmed 12 months postoperatively in 7/8 (87.5%) E+HD, 11/13 (84.6%) L+HD, 4/5 (80.0%) L+E+HD, and 7/8 (87.5%) L-E-HD; differences were not significant. Laxatives were still required in 2/8 (25.0%) E+HD, 3/13 (23.1%) L+HD, in 1/5 (20.0%) in L+E+HD, and 2/8 (25.0%) L+E-HD; differences were not significant. Conclusion: Incidence of HD was higher in L+HD, but not significantly different suggesting that indications for RMSBx have potential to influence incidence of HD and hint that the incidence of HD could actually be higher. Further assessment of additional indications is warranted to diagnose HD with greater accuracy.

Association between dietary calcium intake and constipation in a metabolic syndrome population: evidence from NHANES 2005-2010.

The global prevalence of Metabolic Syndrome (MetS) is increasing, primarily characterized by abdominal obesity, which significantly heightens the risk of cardiovascular diseases, gastrointestinal disorders, and cancers. Constipation is a common gastrointestinal issue that impacts both physiological and psychological health and worsens with age. Calcium, an essential mineral vital for human health, has been proven to be crucial not only for bone health but also beneficial for gastrointestinal health. However, the results regarding its impact on constipation are inconsistent. This study aimed to investigate the relationship between dietary calcium intake and constipation in individuals with MetS. This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2010. Participants were assessed for MetS based on the International Diabetes Federation (IDF) criteria. Dietary calcium intake was evaluated through 24-h dietary recalls, and constipation was defined based on the frequency of bowel movements recorded in the bowel health questionnaire. The relationship between calcium intake and constipation was explored using logistic regression models with adjustment for covariates, and restricted cubic spline analyses were also used to investigate nonlinear relationships. The study included 4,838 adult participants with MetS. Adjusted logistic regression revealed that an increase in dietary calcium intake was significantly associated with a reduced risk of constipation (OR: 0.562, 95% CI: 0.379 to 0.835, p = 0.006). Compared to the lowest quartile, the highest quartile of dietary calcium intake significantly decreased the risk of constipation (OR: 0.282, 95% CI: 0.115 to 0.691, p = 0.008). Results from the restrictive cubic spline analysis indicated a negative linear association between dietary calcium intake and constipation risk (non-linearity p = 0.704). The findings suggested that increased dietary calcium intake is associated with a decreased risk of constipation among MetS patients, emphasizing dietary calcium as a potentially modifiable factor for managing gastrointestinal symptoms in this population.

Seismic mitigation of porcelain cylindrical electrical equipment using synergistic concept with base isolation and tuned mass damper

Porcelain cylindrical electrical equipment (PCEEs), such as potential and current transformers, are critical components of electrical substations and essential to power supply networks. Nevertheless, previous strong earthquakes have rendered high vulnerability and poor performance of PCEE during seismic occurrences. To improve seismic performance of PCEE and alleviate adverse seismic impacts, an innovative synergistic mitigation method based on base isolation (BI) and tuned mass damper (TMD) was proposed and subsequently employed to PCEE. Combining BI with TMD allows for a greater utilization of each technology’s capabilities while also circumventing some of the limits of each. While TMD effectiveness is sensitive to input ground motion frequencies, BI could act as a filter to tune input frequency and help TMD fulfill better damping effectiveness. TMD could in return help BI achieve better stability under long-period dominant or pulse-like ground motions. The BI-TMD effectiveness and robustness were investigated using finite element modeling and nonlinear time history analysis. A comprehensive parametric study that considers variable PCEE frequencies, BI periods, TMD mass ratios, and TMD control frequencies was conducted. Results show that the proposed BI-TMD method can significantly enhance the effectiveness and robustness beyond BI single control in mitigating seismic responses of PCEE.

Appropriate Selection of Frequency Range and Damping Ratio to Reduce the Resonance Effect, Lower Power Consumption, and Improve the Accuracy of the Capacitive Accelerometer

Introduction: In this work, we explored the capacitive accelerometer in depth by highlighting its advantages over other accelerometers. However, a major challenge associated with using capacitive accelerometers lies in choosing the appropriate frequency range. Method: Incorrect selection of the frequency range can cause several problems. It can decrease the accuracy of the accelerometer, increase the measurement error, and increase power consumption. To overcome these challenges, we undertook detailed modeling of the physical behaviour of the capacitive accelerometer. This modeling takes into account the mechanical and electrical properties of the sensor, including its mass, its rigidity, and the characteristics of its capacitive circuit. By simulating the developed model, we analyzed how the accelerometer reacts to different frequencies of vibratory movements. Result: This analysis led to the extraction of an important mathematical relationship that links the natural frequency of the accelerometer to the frequency of the vibratory movements to which it is subjected. Using this mathematical relationship, we determined the optimal frequency range for capacitive accelerometer operation. This precise determination of the frequency range makes it possible to significantly reduce the measurement error by avoiding resonance regimes and ensuring that the sensor operates in its maximum precision zone. Conclusion: Additionally, this approach helps improve overall measurement accuracy and minimize sensor power consumption by avoiding inefficient operating conditions.

Effectiveness and safety study of formula containing probiotics, prebiotics, synbiotics on fullterm infants' growth - a systematic review and meta-analysis of randomized controlled study.

Probiotics, prebiotics, and synbiotics, are hot topics of research and have been shown to improve the body's disease state and promote health. Analysis of whether infant formula containing probiotcs, prebiotics, synbiotics is beneficial to infant and child growth. We systematically searched multiple electronic databases (PubMed, Web of Science, The Cochrane Library, Embase) to identify eligible studies published from 1966 to December 25, 2022. Included studies were randomized controlled trials (RCTs) studying the influence of milk powder containing probiotcs, prebiotics, synbiotics on infants and children's growth. RevMan 5.4 was used to analyze the data. A total of 55 RCTs with a total sample size of 8868 participants met the inclusion criteria. Milk powder with probiotics, prebiotics, synbiotics does not significantly improve the growth of infants and children (Weight, height, BMI, and Head Circumference); The incidence of minor adverse events (OR 0.88, 95% CI 0.70-1.11 P = 0.28) and serious adverse events (OR 0.92, 95% CI 0.62-1.36 P = 0.67) was also comparable to the control group; The intestinal microbial diversity of infants consuming probiotcs, prebiotics, synbiotics supplemented formula was lower than that of infants consuming formula without probiotcs, prebiotics, synbiotics (SMD -0.88, 95% CI -1.66- -0.1 P = 0.03), but the abundance of individual beneficial flora was increased. (SMD 1.62, 95%CI 0.61-2.62 P = 0.002). In particular, the abundance of Lactobacillus (SMD 1.62, 95% CI 0.61-2.62 P = 0.002). For metabolites, synbiotics increased fecal antibody concentrations (SMD 0.47, 95% CI 0.08-0.86 P = 0.02), but fecal short-chain fatty acid concentrations remained balanced in both groups (SMD 0.05 95% CI -0.17-0.28 P = 0.64). Compared to the control group, infants who consumed formula with prebiotics had softer stools (SMD -1.47, 95% CI -2.23 to -0.7 P = 0.002) and lower stool pH (SMD -0.82, 95% CI -1.15- -0.5 P < 0.00001), there is also more frequency of bowel movements (SMD 0.27, 95% CI 0.09-0.44 P = 0.002). Probiotcs, prebiotics, synbiotics supplemented formulas significantly increased abundance of individual probiotics, alter intestinal antibody secretion, and improve bowel movements. Incidence of adverse reactions did not differ between the two groups. So we can choose formula-supplemented probiotcs, prebiotics, synbiotics to maintain the intestinal health of infants.

Oral rehydration in diarrhea: from history to current guidelines. A review

Acute gastroenteritis (AGE) is usually defined as a change in stool consistency (liquid or unformed) and/or an increase in the frequency of bowel movements, which can also be accompanied by vomiting and fever. Fever increases the metabolic rate by more than 1.5 times; for every 1°C increase in body temperature, fluid loss increases by 10%. AGE is a common cause of morbidity and mortality among infants and children. The prognosis is favorable if the condition is recognized promptly and appropriate treatment is started. The main goal of AGE therapy is to restore water balance and prevent dehydration, which can be achieved with an oral rehydration solution. The composition and proportion of the components of rehydration agents are described in the guidelines of the European Society for Paediatric Gastroenterology Hepatology and Nutrition, of which the Russian Society of Pediatric Gastroenterologists is a collective member, and such agents are fully consistent with the balanced formulations of RehydroStandard and Rehydron Bio rehydration agents. The latter includes the probiotic strain Lactobacillus rhamnosus GG, well studied and recommended by the European Society for Paediatric Gastroenterology Hepatology and Nutrition for acute intestinal infections since this strain reduces the duration and severity of diarrhea according to the results of studies. Rehydron Bio and RehydroStandard can be recommended for use in clinical pediatric practice.

Investigation of discharge valve in ultra-high-speed rotary compressors: An experimental and FSI simulation-based study

The rotary compressors are currently witnessing a trend towards high-speed operation, resulting in an increased frequency of valve motion and a higher mass flow rate through the discharge valve. Consequently, high-speed operation leads to intensified impact between the valve and both the valve stopper and valve seat, thereby posing challenges to the reliability of the valve. Simultaneously, the dynamic characteristics of the valve at high operating speeds exert a significant influence on the compressor's performance. This paper develops a three-dimensional fluid-structure interaction (FSI) model to investigate the dynamic characteristics and reliability of the valve in a high-speed rotary compressor while considering heat transfer during the flow process within the cylinder. The proposed model shows better agreement with the experiment. The study revealed that as the rotational speed increases, there is an obvious rise in over-compression loss and a pronounced valve closure delay, which increases the impact velocity of the valve. The valve experiences two peaks of equivalent stress within one cycle, rendering it susceptible to fail at high speeds. The adoption of a double-valve structure at a rotational speed of 12,000 rpm leads to a significant reduction in over-compression loss by 62.9 %, an increase in volumetric efficiency by 6.7 %, a maximum decrease in impact velocity by 54.5 %, and a maximum decrease in equivalent stress by 25.6 %. The reliability of the double-valve structure under 12,000 rpm was proved by an endurance experiment. Besides, the asymmetry in the opening process of the two valves has been unveiled for the first time.

Efficiency of the method of forming special knowledge and skills in the process of physical training of cadets

The article theoretically substantiates, develops and experimentally tests the method of formation of special knowledge and skills of future officers in the process of physical education. It is determined that Military specialization has a different content of combat activity and, thus, different requirements for the training of future specialists, according to the specifics of the activity, the structure of work movements, and the involvement of the body's systems and functions.Analysis of the dynamics of psychophysiological preparation of future officers in the conditions of a pedagogical experiment showed the presence of reliable positive changes in the development of movement frequency, accuracy of reproduction of half and a quarter of muscle effort, accuracy of reproduction of short and long time intervals, accuracy of distance reproduction, speed of reaction to a moving object, speed of perception and processing of visual information, efficiency of psychomotor activity, mental stability, volume, distribution and switching of attention in young cadets. In female cadets, a significant increase is observed in the indicators of the frequency of movements, the accuracy of reproduction of half and a quarter of muscle efforts, the accuracy of reproduction of short and long time intervals, the strength of nervous processes, the speed of perception and processing of visual information, the efficiency of mental activity, mental stability, volume, distribution and switching of attention. In addition, it has been proven that the implementation of the method of formation of special knowledge and skills of future officers in the process of physical education significantly increased the effectiveness of professional training of cadets of military higher educational institutions.

The magnitude of chronic constipation and associated factors among type 2 diabetic patients in Harar, Eastern Ethiopia

BackgroundConstipation, which affects 16% of adults worldwide, is a chronic health problem characterized by unsatisfactory frequency of bowel movements, causing pain, bloating or incomplete bowel movements. The study aims to assess the magnitude of chronic constipation and associated factors among T2DM patients attending the endocrinology outpatient clinic at Hiwot Fana Comprehensive Specialized University Hospital from January 1 to May 30, 2023.MethodsHospital-based cross-sectional study design was carried out to assess the magnitude and associated factors of chronic constipation among T2DM patients at Hiwot Fana Comprehensive Specialized University Hospital. Using a single population formula 300 T2DM patients were enrolled in this study. The data was analyzed by using the Epi-Data 4.6 and SPSS version 25. Descriptive, bivariate, multivariate, and logistic regression were used. P < 0.05 was used to declare association.Results300 T2DM patients participated in this survey. Of these 137 (45.7%) were male and 163 (54.3%) were female and the mean age was 58.57 ± 11.09 SD years, the range from 35 to 85 years. The prevalence of constipation was 73 (24.3%) (95% CI: 0.196–0.296). Education status above high school (AOR: 0.151.95% CI: 0.032–0.718), less than 7 h of sleep per day (AOR: 12.39.95% CI: 2.712–56.69), frequent depression (AOR: 6, 84, 95% CI: 2.639–17.743), parents with constipation (AOR: 6.843.95% CI: 2.639–17.743), daily water intake < 1300 ml (AOR: 4.760.95% CI: 1.146–19.773), TAG levels below 150 mg/dl (AOR: 0.050, 95% CI: 0.015–0.166), HbAlc between 6 and 7% (AOR: 0.013.95% CI: 0.001–0.132) ,HbAlc between 7.1 and 8% (AOR: 0.006, 95% CI: 0.001–0.067), and LDL levels were significantly associated with chronic constipation in T2DM patients.ConclusionsThe prevalence of chronic constipation was considerable in T2DM patients. Education level above high school, less than 7 h of sleep per day, frequent depression, parents with constipation, daily water intake < 1300 ml, TAG and HbAlc play a significant role in the development of chronic constipation in T2DM patients. T2DM patients can reduce the extent of constipation by treating the above problem in a timely and timely manner.

Cross border population movements across three East African states: Implications for disease surveillance and response.

The frequent population movement across the five East African Countries poses risk of disease spread in the region. A clear understanding of population movement patterns is critical for informing cross-border disease control interventions. We assessed population mobility patterns across the borders of the East African states of Kenya, Uganda, and Rwanda. In November 2022, we conducted Focus Group Discussions (FGDs), Key Informant Interviews (KIIs), and participatory mapping. Participants were selected using purposive sampling and a topic guide used during interviews. Key informants included border districts (Uganda and Rwanda) and county health officials (Kenya). FGD participants were identified from border communities and travellers and these included truck drivers, commercial motorcyclists, and businesspersons. During KIIs and FGDs, we conducted participatory mapping using Population Connectivity Across Borders toolkits. Data were analysed using thematic analysis approach using Atlas ti 7 software. Different age groups travelled across borders for various reasons. Younger age groups travelled across the border for education, trade, social reasons, employment opportunities, agriculture and mining. While older age groups mainly travelled for healthcare and social reasons. Other common reasons for crossing the borders included religious and cultural matters. Respondents reported seasonal variations in the volume of travellers. Respondents reported using both official (4 Kenya-Uganda, 5 Rwanda-Uganda borders) and unofficial Points of Entry (PoEs) (14 Kenya-Uganda, 20 Uganda-Rwanda) for exit and entry movements on borders. Unofficial PoEs were preferred because they had fewer restrictions like the absence of health screening, and immigration and customs checks. Key destination points (points of interest) included: markets, health facilities, places of worship, education institutions, recreational facilities and business towns. Twenty-eight health facilities (10- Lwakhakha, Uganda, 10- Lwakhakha, Kenya, and 8- Cyanika, Uganda) along the borders were the most commonly visited by the travellers and border communities. Complex population movement and connectivity patterns were identified along the borders. These were used to guide cross-border disease surveillance and other border health strategies in the three countries. Findings were used to revise district response and preparedness plans by strengthening community-based surveillance in border communities.

A Study of Sliding Base Isolation System: A Review

Seismic isolation systems are crucial for protecting structures by minimizing the transmission of acceleration during seismic events, and among the various types, the resilient sliding system, which combines restoring springs and sliders, is highly effective in mitigating seismic impacts. This system controls structural responses by balancing stiffness and friction, ensuring safety while maintaining the functionality of buildings. However, optimizing the design of this system requires carefully selecting combinations of stiffness and the coefficient of friction to achieve low acceleration levels, while simultaneously managing the relative displacement within the isolation system to protect both the structure and its occupants. Excessive displacement may compromise the integrity of the isolation system or cause damage to the structure it is meant to protect. The challenge lies in finding the optimal friction and stiffness levels that provide sufficient energy dissipation and restore forces without allowing displacement to exceed acceptable thresholds. Studies show that restoring forces generated by springs help limit excessive displacements, while sliders dissipate seismic energy, and adjustments in these parameters must account for variations in ground motion intensity and frequency. Thus, a balance between flexibility and resistance is essential in sliding systems to ensure maximum structural safety and occupant protection during earthquakes. This paper reviews different sliding isolation systems which fulfils the requirements of controlling the earthquake and functioning accordingly. It include systems such as PF, FPS, VFPI , CFPI,VFPS,PFPE, VCFPS,VFFPI etc.

Simultaneous EEG recording of cortical tracking of speech and movement kinematics

Rationale: Cortical activity is coupled with streams of sensory stimulation. The coupling with the temporal envelope of heard speech is known as the cortical tracking of speech (CTS), and that with movement kinematics is known as the corticokinematic coupling (CKC). Simultaneous measurement of both couplings is desirable in clinical settings, but it is unknown whether the inherent dual-tasking condition has an impact on CTS or CKC. AimWe aim to determine whether and how CTS and CKC levels are affected when recorded simultaneously. MethodsTwenty-three healthy young adults underwent 64-channel EEG recordings while listening to stories and while performing repetitive finger-tapping movements in 3 conditions: separately (audio- or tapping-only) or simultaneously (audio-tapping). CTS and CKC values were estimated using coherence analysis between each EEG signal and speech temporal envelope (CTS) or finger acceleration (CKC). CTS was also estimated as the reconstruction accuracy of a decoding model. ResultsAcross recordings, CTS assessed with reconstruction accuracy was significant in 85 % of the subjects at phrasal frequency (0.5 Hz) and in 68 % at syllabic frequencies (4–8 Hz), and CKC was significant in over 85 % of the subjects at movement frequency and its first harmonic. Comparing CTS and CKC values evaluated in separate recordings to those in simultaneous recordings revealed no significant difference and moderate-to-high levels of correlation.Conclusion.Despite the subtle behavioral effects, CTS and CKC are not evidently altered by the dual-task setting inherent to recording them simultaneously and can be evaluated simultaneously using EEG in clinical settings.

Effect of Cognitive Decline on Mandibular Movement during Mastication in Nursing Home Residents.

Background: Many studies have reported on the relationship between cognitive and masticatory functions. However, it remains unclear how the mandibular movements change during chewing in facility residents as dementia progresses. This study aimed to investigate the relationship between a kinematic analysis of mandibular movement during mastication and cognitive function in facility residents. Methods: Sixty-three participants were included from two long-term care facilities. The primary outcome variable was the kinematic data of mandibular movement during mastication. The participants chewed rice crackers, and their faces were recorded during this motion. The partial correlation coefficient between kinematic data and cognitive function was calculated. Furthermore, group comparisons were performed after dividing the participants into three groups based on their cognitive function. Results: Circular motion frequency was significantly correlated with the ABC dementia scale, even after adjusting for the appendicular skeletal muscle index, Eichner index, and short-form mini-nutritional assessment. The cycle and circular motion frequencies were markedly lower in the severe dementia group than in the mild dementia group. Conclusions: With declining cognitive function, mandibular movements during mastication decrease in circular motion and increase in linear motion. Additionally, our results suggested that residents with severe cognitive impairment had more linear mandibular motions during mastication than those with mild cognitive impairment. This may make it more difficult for residents with cognitive decline to ingest normal solid foods.

Literature Review: Guava Leaves (Psidium Guajava) for Treating Diarrhea

Diarrhea is a significant health problem, especially in developing countries. Guava leaves (Psidium guajava) have long been used in traditional medicine to treat diarrhea. This study aims to review the literature on the effectiveness of guava leaves in treating diarrhea by focusing on ten aspects: raw material name, raw material content, raw material composition, active substance content, efficacy claims, empirical data, raw material standardization, preclinical test, toxicity test, and clinical trial. The results of several studies show that guava leaves contain tannins, flavonoids, saponins, and essential oils that play a role in the antidiarrheal effect. Preclinical research shows a reduction in the frequency of bowel movements and an increase in stool consistency in animal models. Although empirical claims and preclinical trials support the use of guava leaves as a treatment for diarrhea, more research is still needed regarding the standardization of raw materials, toxicity tests, and clinical trials to ensure its overall efficacy and safety.

Characteristics of the Reciprocal Movement of Radiographers’ Gaze Based on a Comparison of Entry-Level and Experienced Radiographers

With the development of AI, AI may substitute for physicians in radiological interpretations in the future. The purpose of this paper is to identify factors that could form the foundation for algorithms enabling AI to explore pathological findings. This study focuses on the "angles of gaze trajectory" and "average speeds of gaze movement," and conducts a comparative analysis between entry-level and experienced radiographers. Firstly, based on the results of angles of gaze movement, experienced radiographers exhibited frequent movements around the 180-degree mark compared to entry-level radiographer. Both entrylevel and experienced radiographers commonly displayed frequent movements around 0 degrees and near 350 degrees. Secondly, according to the results of average speeds of gaze movement, entry-level radiographers were found to have faster movement speeds compared to experienced radiographers.

Efficacy and safety of linaclotide in treatment-resistant chronic constipation: A multicenter, open-label study.

This study aimed to evaluate the efficacy and safety of linaclotide in patients with chronic constipation (CC) or irritable bowel syndrome with constipation (IBS-C) who did not respond to treatment with magnesium oxide (MgO). This study was designed as a multicenter, open-label, single-arm, exploratory study. Patients with CC or IBS-C who took MgO and those meeting the medication initiation criteria were administered linaclotide at a daily dosage of 500 μg for 12 weeks. The primary endpoint was a change in the Japanese version of the Patient Assessment of Constipation Quality of Life (JPAC-QOL) score from baseline, which was evaluated by using a paired t-test. The patients' mean age (± standard deviation) was 67.6 ± 13.82 years. The full analysis set included 61 patients. The JPAC-QOL total score was 1.60 at baseline and 0.70 at 12 weeks, with a significant mean change of -0.89 ± 0.721 (p < 0.001). Several secondary endpoints also showed improvement. The frequency of spontaneous bowel movement (SBM) and complete SBM increased by 2.70 ± 7.254 (p < 0.01) and 2.81 ± 5.254 times, respectively (p < 0.001). The Bristol Stool Form Scale, abdominal bloating severity, and straining severity scores improved by 1.33 ± 1.274 (p < 0.001), -0.16 ± 0.563 (p < 0.05), and -0.46 ± 0.795 (p < 0.001) points, respectively. The safety analysis set included 65 patients, 7 of whom had diarrhea, which improved with dose reduction and drug withdrawal. The study was conducted in an older adult population, similar to real clinical practice. Linaclotide may be an option for treating CC that shows an inadequate response to conventional therapy.

7087 An Unusual Movement Disorder, Case of Diabetic Striatopathy!

Abstract Disclosure: S. Azmat: None. O. Lodhi: None. R. Safi: None. H. harb: None. H. Ashok: None. M.F. Siddiqui: None. J.L. Gilden: None. Background: Non-ketotic Hyperglycemia Hemichorea-Hemiballismus Syndrome (NKH-CB) is rare complication of poorly controlled diabetes mellitus (DM) characterized by continuous, irregular jerky movements localized to one side of the body. It is commonly seen in type 2 DM and is often presented in females of East Asian descent. NKH-CB is often misdiagnosed due to its rarity and radiographic features easily mistaken for intracerebral hemorrhage.Case: A 70-year-old Latino male with type 2 diabetes mellitus, hypertension, bipolar disorder and past history of two cerebrovascular accidents presented to ED with non-radiating, midsternal chest pain. ACS was ruled out with negative serial troponins and normal EKG. Vital signs were significant for elevated blood pressure 151/64 mmHg. Labs showed blood glucose=447 mg/dL. Physical examination revealed large amplitude involuntary movements in left upper and lower extremities and facial region. He also veered to the left when ambulating. The patient reported that these abnormal movements were occurring for last three weeks although sensation was preserved bilaterally. Code stroke was called; non-contrast CT showed unilateral hyper density of the right caudate and putamen with no evidence of acute intracranial hemorrhage or large arterial territory infarction. CT Angiogram did not show any signs of stenosis or occlusion. He received intravenous fluids and 8 units lispro insulin in ED. Was admitted for further evaluation and received basal/bolus insulin therapy with target blood glucose of 140-160 mg%. He also received risperidone for his mental condition. Subsequent testing revealed hemoglobin A1C of 16.9% (reference range: &amp;lt; 5.7%). MRI Brian showed unilateral T1 hyperintensity involving right caudate and putamen corresponding to the hypodensity seen on CT. Neurology service was consulted. Based on clinical signs/symptoms coupled with neuroimaging, he was diagnosed with non-ketotic Hyperglycemia Hemichorea-Hemiballismus Syndrome. On day 2 with resolution of hyperglycemia, amplitude and frequency of involuntary arm movements were minimal. The patient was discharged with Lantus 7 and metformin 1000 mg for DM and risperidone for symptoms management. Conclusion: Diabetic neuropathy is commonly known to result in small and/or large fiber sensorimotor polyneuropathy, proximal motor, and acute mononeuropathies as well as entrapments, radiculopathies, autonomic neuropathies, and even cognitive disorders. This case describes rare case of simultaneous NKH-CB with history of CVA and antipsychotic medication use in a patient with poorly controlled DM which resolved with treatment of hyperglycemia. Thus offers valuable insights into the diagnostic challenges associated with this condition as well as potential links to other neurological complications. One should also remain vigilant of potential onset of seizures commonly seen with NKH. Presentation: 6/3/2024

Development of automatic audio panning system for immersive sound through stage size-aware model and object-tracking

We investigated a novel AI-assisted automated 'immersive' audio panning system designed to track audio-related objects within a video clip. This system comprises four sequential steps: Object-Tracking, Stage dimension Estimation, XY-Coordinate Calculation, and Object Audio Rendering. The system is designed to overcome existing challenges arising from the rapid and frequent movement of target objects by employing a pre-trained object-tracking model and integrating depth information to ensure stability in subsequent tasks. Additionally, we introduce a stage size-aware model to extrapolate stage dimension using our manually collected dataset, formatted as (Image, Width, Depth), which facilitates model training. Consequently, the system calculates XY-Coordinate pairs, serving as panning values for conventional audio mixers or decoders to enable immersive audio reproduction. We anticipate that this video- and space-aware automatic panning system will be valuable for the rapid production of new media.

Video Analysis Comparing Pickleball and Tennis Gameplay: Is the Achilles Tendon At Risk?

Category: Sports; Ankle Introduction/Purpose: Pickleball is one of the fastest growing sports. In 2018, there were 3.1 million pickleball players in the U.S, a 12 percent increase from 2017. Individuals greater than the age of 50 or older accounted for 90.9% of pickleball injuries. Pickleball injuries were projected to cost the US healthcare system up to $500 million in 2023. Anecdotally, orthopaedic surgeons are noticing rising pickleball-related Achilles Tendon (AT) ruptures. However, there is a paucity of literature examining the incidence of Pickleball AT ruptures. Given the biomechanical similarities between pickleball and tennis, we compared the frequency of such at-risk movements for AT ruptures in these sports, hypothesizing that such movements would be greater in pickleball than in tennis match play. Methods: Publicly available footage of professional men’s and women’s singles matches from US Open Tennis and Pickleball Championships were collected and edited to display the first 5 minutes of active gameplay. Videos were then reviewed by 3 fellowship trained orthopaedic surgeons and 1 orthopaedic resident. Previous literature identified AT eccentric contractions, hip extension, knee flexion, and foot dorsiflexion leading to such ruptures. The authors determined at-risk movements (running takeoff/accelerating, pivot/cut) and body part positions, such as foot position (abduction, adduction, neutral, pronation, supination, dorsiflexion, plantarflexion), knee position in the sagittal plane, and hip position (extension, flexion). The number of at-risk AT movements was quantified and averaged among reviewers. Two-sided T-tests were used to evaluate for evidence of a statistically significant difference in the total number of at-risk ankle movements between the two sports. Results: After averaging across observations made by 3 orthopaedic surgeons and 1 orthopaedic surgeon resident, Pickleball players executed an average 97.59 (SD 8.08) at-risk movements and tennis players executed an average 68.39 (SD 10.75) at-risk movements per ankle with a significance value of 2.61E-07. When subdivided into individual ankles, there was still a statistically significant difference between the two sports (p&lt; 0.001) with Pickleball having markedly more at-risk movements. This makes sense given that there was not a significant difference between Left and Right movements in either sport. Similarly, comparing ankle movements of each sport across and within each gender demonstrated a statistically significant difference as well (p&lt; 0.05). Conclusion: In a small sample of professional athletes, there exists a significant increase in at-risk Achilles tendon movements of both ankles in Pickleball compared to Tennis independent of demographics. AT ruptures sustained during pickleball are multifactorial and the fraction of Achilles tendons that rupture during at-risk movements performed is exceedingly small. However, the higher frequency of at-risk movements during pickleball may influence pickleball-related AT ruptures. Being that pickleball has and will continue to grow in popularity, particularly with older age groups, evaluating the physical risks that this sport poses will help better inform athletic training and rehab programs for injury prevention.