Motherwort Research Articles

Clinical study of carboprost tromethamine combined with motherwort injection in prevention of high-risk ce-sarean section hemorrhage

Objective To investigate the carboprost ammonia butyl alcohol three plus motherwort injection on prevention of high risk maternal postpartum hemorrhage effect .Methods 120 cases of cesarean section operation and potential bleeding symptom of women were selected as the research object ,and randomly divided into two groups , the observation group of 60 cases using carboprost ammonia butyl alcohol three joint of leonurus heterophyllus injec -tion for prevention and treatment ,the control group of 60 cases used oxytocin for prevention and treatment ,prevention and treatment effects were compared between the two groups .Results After treatment,the observation group 2h,24h postpartum hemorrhage were （422.41 ±213.49）mL,（35.29 ±16.44）mL,were significantly less than those in the control group （589.64 ±345.21）mL,（69.31 ±29.47）mL（t=6.732,8.915,all P<0.05）;the observation group 1 cases without production after bleeding ,control group 5 cases of postpartum hemorrhage ,statistically significant differ-ences between the two groups （χ2 =4.973,P<0.05）.Conclusion Carboprost ammonia butyl alcohol three plus motherwort injection on prevention of high risk maternal postpartum hemorrhage has a significant effect ,which can re-duce the cesarean section uterine bleeding and reduce the amount of bleeding ,promote uterine involution ,conducive to maternal rehabilitation . Key words: Carboprost tromethamine; motherwort injection; cesarean section; postpartum hemorrhage

Analysis to the impact of combined use of motherwort injection with oxytocin on hemorrhage in cesarean section and postoperative stage

Objective To analyze the impact of combined use of motherwort injection with oxytocin on hemorrhage in cesarean section and postoperative stage.Methods 512 pregnant women after processing cesarean section were randomly divided into an experimental group (n=256) and a control group (n=256).The experimental group used motherwort injection and oxytocin,and the other group only used oxytocin.Intraoperative and postoperative bleeding and adverse drug reactions were observed.Results Bleeding volume in the experimental group was less than the control group [ (210.43 ± 50.38)ml,(35.84 ±29.24)ml,(61.62 ±35.32) ml vs (234.14 ±16.91) ml,(52.37 ± 32.15) ml,(86.18 ± 36.67) ml],P＜0.05).There were no significant adverse reactions.Conclusion Motherwort injection and oxytocin used together can be more effective in reducing bleeding in cesarean section and postoperative stage. Key words: Motherwort injection; Cesarean section; Oxytocin

Analysis of modern literature of maternal-fetal blood group incompatibility

Objective By selecting the prescriptions of treating blood group incompatibility in modern literature, and exploring their regularity, to establish the overall thought of traditional Chinese medicine in treatment.Methods 90 articles on maternal-fetal blood group incompatibility were found.Statistical methods were adopted to summarize high frequently used medicines and formula. Results High frequently used medicines were Virgate Wormwood Herb, Baical Skullcap Root, Rhubarb, Cape Jasmine Fruit, White peony Alba, Chinese Angelica,Largehead Atractylodes Rhizome,Motherwort Herb,and Milkvetch Root, which were mentioned for 238 times in the literatures, occupying 72.79% of the total frequency. Conclusion Based on this result,heat-clearing and dampness-removing, activating blood circulation to eliminate blood stasis was setup as the principle for treating this disease. Key words: Maternofetal blood group incompatibility; Modern literature; Traditional Chinese medicine

Motherwort combined with oxytocin in the prevention of postpartum hemorrhage and the acceleration of uterine restoration

Objective To explore the effective methods for the prevention of postpartum hemorrhage and the acceleration of uterine restoration.Methods 126 women at high-risks of postpartum hemorrhage after Cesarean section were randomly assigned to receive motherwort combined with oxytocin (63 women,study group)or oxytocin alone(63 women,control group ). The intraoperative and postoperative vaginal bleeding volumes were compared between the two groups,so was the average decreased height of the fundus to determine uterine restoration.Results The bleeding volumes were significantly less in the study group than in the control group intraoperatively,and at hours 2,12,24,and 48(P＜0.05). 5 days after treatment,the daily decreased height of fundus was greater in the study group than in the control group(P＜0.05).The speed of the decrease in fundus was quicker in the study group(P＜0.05).Conclusions Oxytocin has a rapid onset of action and a shorter half-life while motherwort has a longer half-life and a slow action.The combination therapy has a synergistic action.It Can strengthen uterine contraction,accelerate uterine restoration,and revent postpartum hemorrhage,and is safe. Key words: Cesarean section; Postpartum hemorrhage; Motherwort injection; Oxytocin; Uterine restoration

Curative effect observation on the treatment of vaginal bleeding after drug-induced abortion with self-made biochemical mixture

Objective To explore the curative effects of treating vaginal bleeding after drug-induced abortion with self-made biochemical mixture. Methods A total of 100 pregnant patients were randomly recruited into a control group and a treatment group. Both groups were treated with mifepristone and misoprostol. On this basis, the control group was administrated with Motherwort herb preparation orally, and the treatment group was treated with self-made biochemical mixture orally. Both groups were treated for 7 days. Therapeutic effects were observed after the treatment. Results The total effective rate was 76% and 94% in the control group and the treatment group respectively, showing statistical difference (χ2=8.663, P＜0.05).Conclusion It is effective to treat vaginal bleeding after drug-induced abortion with self-made biochemical mixture. Key words: Drug-induced abortion; Vagina bleeding; Biochemical mixture; Motherwort herb preparation

Therapeutic observation on 23 cases of treatment of cerebral hemorrhage with Huoxuetongfulishui decoction

Objective To observe the clinical effects of treating acute cerebral hemorrhage with Huoxuetongfulishui decoction. Methods A total of 46 patients with acute cerebral hemorrhage were randomly recruited into a control group and a treatment group, with 23 patients in each group. The control group was treated with conventional western medicine; the treatment group was treated with Huoxuetongfulishui decoction (which is composed of rhubarb, motherwort herb, giant knotweed rhizome, sanchi, leech, and earth worm) on the basis of the control group. Results The total effective rate was 91.31% and 75% in the treatment group and the control group respectively, showing statistical significance (χ2=5.78, P＜0.05＝. CT scan showed that fully hematoma absorption happened in 15 patients, absorption range ＞51% happened in 7patients, and zero hematoma absorption in 1 patient in the treatment group, contrasting to the number of 6, 9 and 3 in the control group respectively. There was statistical difference between the two groups (χ2=5.66, P＜0.05＝. Conclusion It was effective to treat cerebral hemorrhage with Huoxuetongfulishui decoction. Key words: Acute stage of cerebral hemorrhage; TCM therapy; Huoxuetongfulishui decoction

Motherwort injection with oxytocin in the prevention of postpartum hemorrhage

Objective To investigate the Leonuri injection of oxytocin on the preventive effect of postpartum hemorrhage.Methods In our hospital from June 2008 to June 2009,216 cases of vaginal delivery by maternal and randomly divided into two groups,the observation group (injection motherwort with oxytoein group) for 108 eases,post-grant motherwort Injection for 1ml (40mg)+oxytoein for 20U,108 cases of the control group given oxytocin 20U.And to be observed for 2 hours post-partum haemorrhage volume and the number of bleeding patients,and compared the two groups.Results 2 hours post-partum hemorrhage volume (166±41.2) ml,post-partum hemorrhage 24-hour volume (185±45.3) ml,post-partum hacmorrhage in 2 cases;the control group 2 hours post-partum hemorrhage volume (208±34.8) ml,post-partum hemorrhage within 24 hours of (275±42.8) ml,postpartum hemorrhage in 8 cases.Observation group and control group at 2 hours post-partum haemorrhage,a 24-hour comparison of the difference was significant (P＜0.05),the two groups had no significant adverse reactions(P＞0.05).Conclusion Injection motherwort oxytocin to prevent postpartum hemorrhage very good and convenient administration,security,and no significant adverse events. Key words: Motherwort injection; Vaginal delivery; Postpartum hemorrhage

Multi-center study of motherwort injection to prevent postpartum hemorrhage after caesarian section

To evaluate the efficacy and safety of motherwort (herba leonuri/leonurus heterophyllus sweet) injection for preventing postpartum hemorrhage after caesarian section. The prospective study was designed as a randomized and single blind multi-center research matched with positive agent as controls from Apr 2007 to Aug 2007. 440 women underwent caesarian section (CS) indicated by obstetric factors were enrolled from 15 teaching hospitals in China and assigned into three groups: group of motherwort: 147 cases were administered by motherwort 40 mg uterine injection during CS and 20 mg intramuscular injection per 12 hours 3 times after CS; group of motherwort+oxytocin: 144 cases were administered by motherwort 40 mg and oxytocin 10 U uterine injection during CS and motherwort 20 mg intramuscular injection per 12 hours 3 times after CS and group of oxytocin: 149 cases were administered by oxytocin 10 U uterine injection and oxytocin 10 U+5% glucose 500 ml intravenously injection during operation and oxytocin 10 U intramuscular injection per 12 hours 3 times after CS. The following clinical parameter were collected and analyzed: (1) The amount of blood loss during operation, at 2, 6, 12, 24, 48 hours after operation. (2) The total amount of blood loss in 24 hours after CS and the incidence of postpartum hemorrhage. (3) The change of level of hemoglobin (Hb) and counting of red blood cell (RBC) from prepartum to postpartum. (4) Adverse reaction. (1) The mean amount of blood loss during operation were (368+/-258) ml in group of motherwort, (255+/-114) ml in group of motherwort+oxytocin and (269+/-141) ml in group of oxytocin, which exhibited significant difference among three groups (P<0.01). Meanwhile, no statistical different amount of blood loss among three groups were observed at 2, 6, 12, 24, 48 hours after CS. (2) The amount of blood loss of postpartum at 24 hours were (480+/-276) ml in group of motherwort, (361+/-179) ml in group of motherwort+oxytocin, (381+/-179) ml in group of oxytocin, which showed significant difference among 3 groups (P<0.01). (3) The incidence of postpartum hemorrhage were 32.0% (47/147) in group of motherwort, 11.1% (16/144) in group of motherwort+oxytocin, and 18.8% in (28/149) in group of oxytocin. When comparing the lowest rate of postpartum blood loss in group of motherwort+oxytocin and the highest rate in group of motherwort, it displayed statistical difference (P<0.01). (4) The decreased level of RBC and Hb were shown that RBC (0.3+/-0.5)x10(12)/L and Hb (9+/-13) g/L in group of motherwort, RBC (0.2+/-0.4)x10(12)/L and Hb (6+/-10) g/L in group of motherwort+oxytocin and RBC (0.2+/-0.4)x10(12)/L and Hb (7+/-30) g/L in group of oxytocin respectively. However, the comparison of different value of RBC and Hb in group of oxytocin and motherwort+oxytocin showed significant difference (P<0.05). (5) Two cases with allery reaction was observed. It is safe and efficacious that combined use of motherwort injection and oxytocin was to prevent postpartum hemorrhage during or after caesarian section.

Anti-inflammatory activity of Motherwort (Leonurus sibiricus L.)

Motherwort (MW), a Korean folk medicine, has been applied to treat inflammatory disease. However, its effect on inflammatory cytokine release from mast cells is not well known. We investigated the anti- inflammatory effect of MW on the secretion of inflammatory cytokine such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 and IL-8 in human mast cell line (HMC-1). MW was treated in vitro before activation of HMC-1 cells with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. MW had no cytotoxic effects on HMC-1 cell viability. MW (1 mg/ml) inhibited PMA plus A23187-stimulated gene expression and production of TNF-α, IL-6, and IL-8. Stimulation with PMA plus A23187 induced NF-κB activation in HMC-1 cells, which was inhibited by MW (1 mg/ml). MW inhibited secretion of TNF-α, IL-6, and IL-8 possibly by inhibiting NF-κB activation. These results indicate that MW may be helpful in regulating inflammatory diseases.