Coronary artery disease occupies a special place in cardiovascular diseases in Moroccan population because of its high frequency and mortality. In this work we propose to study the epidemiological profile, clinical; angiographic;and therapeutic characteristics of Moroccan coronary. Our study is a retrospective study that included all patients who had a coronarography from 01/01/08 to 30/12/09 in the department of cardiology of Ibn Rochd. On 846 patients with coronary artery disease male was 66.8%; their mean age was 62.3 years. The cardiovascular risk factors are hypertension in 38.89% of cases, smoking in 34.34% of cases, diabetes mellitus in 30.85% of cases, hypercholesterolemia in 16.67% of cases, age over 75 years in 9.9% of cases, the coronary heredity4.14 of cases. The coronary disease of Moroccan patient presents by angina stable angina in 35.5% of cases, unstable angina in 7% of cases, crescendo angina in 1.79% of cases, typical chest pain in 9.77% of cases, STEMI in 28.83% of cases, NSTEMI in 16.45% of cases. the silent myocardial ischemia in 0.49% of cases. The ischemia was documented on ECG changes in 42.54% of cases, on myocardial scintigraphy in 6.83% of cases, stress test in 9.94% of cases. The number of patients with acute coronary syndromes treated in the first 24 hours is 61.43%, between D7 and D21 around 4.29%, after 21 days in 5% of cases, and after one month 11.43% of patients. The ejection fraction on admission was greater than 50% in 51.31%, 41–50% in 23.86%, 30–40% in 15.3% of cases, less than 30% in 9.8% of cases. The management of coronary syndrome in our center was thrombolysis in 63.33% of cases, primary angioplasty in 13.33% with a drug-eluting stent used in 33.3% of all angioplasty. In Morocco the rate of primary angioplasty remains insufficient and does not meet the recommendations of the acute coronary syndrome. This epidemiological study is the first step of the long path to optimize the management of Moroccan coronary disease.