GFRG (Glass Fibre Reinforced Gypsum) panels present a viable alternative to conventional masonry infills in masonry infilled RC frames. Based on the experimental study on the lateral load behaviour of GFRG infilled RC frames, it was understood that the GFRG panels enhance the structural performance of the RC framed structure. To delve further into this, numerical modelling of GFRG infilled RC frames with different fillings inside the cavities of the panel was performed using SAP2000. The GFRG panels were modelled using nonlinear layered shell elements, while the interface between the GFRG web and the infill material was represented using multilinear plastic link elements. The monotonic lateral load–deflection behaviour and the in-plane hysteresis response were simulated by performing monotonic and cyclic pushover analyses. The cyclic pushover analysis incorporated pivot hysteretic models for the materials, hinges and links. Validation of the proposed numerical models was carried out by comparing the results with those obtained from the experimental study. Key parameters such as peak load, initial stiffness, stiffness degradation, and energy dissipation were carefully compared to ensure the accuracy and reliability of the proposed model. It was observed that the proposed numerical model was able to capture the monotonic and cyclic load–deflection behaviour and other performance parameters. The numerical model accurately predicted the peak load in the positive direction but overestimated the corresponding value in the negative direction. Moreover, the overestimation observed in the cumulative energy dissipated for all the specimens is relatively minor and does not significantly affect the overall accuracy of the model.