Background: Emerging evidence highlights a concerning prevalence of accommodative and convergence anomalies in individuals with opioid use disorder. However, there remains a significant scarcity of data comparing accommodative functions of opium users and non-users. Hence, we investigated potential changes in accommodative functions of opium users compared to that of non-users. Furthermore, we evaluated changes in these parameters after administering 5% phenylephrine eye drops, both within and between the two groups. Methods: This cross-sectional case-control study recruited opium users and non-users. The binocular amplitude of accommodation (AA), monocular estimate method (MEM), negative and positive relative accommodation (NRA and PRA, respectively), and monocular and binocular accommodative facility (AF) were assessed and documented. All measurements were repeated 30 min after instillation of one drop of 5% phenylephrine hydrochloride eye drops. Results: We recruited 103 opium users and 107 non-users, with comparable mean ages (P > 0.05) but significantly different sex ratios (P < 0.05), with men outnumbering women among the opium users. All accommodative functions measured before and after the instillation of 5% phenylephrine, along with the differences in their values between the two time points, were comparable between the two groups (all P > 0.05), with the exception of the right-eye AF, which was significantly higher in non-users than in opium users after instillation (P < 0.05). Within the opium user group, all accommodative functions exhibited significant differences between pre- and post-instillation measurements (all P < 0.05), except for NRA, which did not change (P > 0.05). In contrast, the non-user group showed no significant differences between pre- and post-instillation measurements for all accommodative functions (all P > 0.05), except in the AA and the right-eye MEM (both P < 0.05). Conclusions: We observed small but significant changes in most baseline accommodative functions after the application of 5% phenylephrine eye drops in opium users. In contrast, most parameters remained unchanged in healthy non-users. When comparing the results between the two groups pre- and post-application of phenylephrine, we found similar accommodative functions overall. However, non-users had a significantly higher value for the right-eye AF following the instillation. To better understand potential binocular anomalies in opium users, further longitudinal studies that are matched for age and sex should be conducted, focusing on additional aspects of binocular vision and ocular motility.
Read full abstract