Creep rupture properties for Alloy 617 were investigated by a series of creep tests under different applied stresses in air and He environments at 800°C. The creep rupture time in air and He environments exhibited almost similar life in a short rupture time. However, when the creep rupture time reaches above 3000h, the creep life in the He environment reduced compared with those of the air environment. The creep strain rate in the He environment was a little faster than that in the air environment above 3000h. The reduction of creep life in the He environment was due to the difference of various microstructure features such as the carbide depleted zone, oxidation structures, surface cracking, voids below the surface, and voids in the matrix in air and He environments. Alloy 617 followed Norton’s power law and the Monkman–Grant relationship well. As the stress decreased, the creep ductility decreased slightly. The thickness of the outer and internal oxide layers presented the trend of a parabolic increase with an increase in creep rupture time in both the air and He environments. The thickness in the He environment was found to be thicker than in the air environment, although pure helium gas of 99.999% was used in the present investigation. The differences in the oxide-layer thickness caused detrimental effects on the creep resistance, even in a low oxygen-containing He agent.