Mohammad Hoesin Palembang Research Articles

Risk Factor Analysis of the Incidence of Placenta Previa at RSUP Dr. Mohammad Hoesin Palembang in 2020–2021

Placenta previa is a placenta that lies at the bottom of the uterus, above or very close to the internal cervical ostium. The exact cause of placenta previa is still unknown, but several factors have been associated with an increased risk of placenta previa. This study aims to determine the relationship between maternal age, parity, distance between pregnancies, history of placenta previa, history of cesarean delivery, history of curettage, assisted reproductive technology, multiple pregnancies, and fetal gender on the incidence of placenta previa at RSUP Dr. Mohammad Hoesin Palembang in 2020-2021. This study is an observational analytic study with a case control design. This study used secondary data from medical records of obstetric patients at RSUP Dr. Mohammad Hoesin Palembang in 2020-2021 that met the inclusion criteria and exclusion criteria. The study sample amounted to 100 people consisting of 50 cases and 50 controls. The results of bivariate analysis using the chi-square test and the fisher exact alternative test showed that maternal age (p=0.010), parity (p=0.038), history of cesarean delivery (p=0.000), and history of curettage (p=0.001) had a significant relationship with the incidence of placenta previa. Distance between pregnancies (p=0.204), history of placenta previa (p=0.242), and fetal sex (p=0.162) did not have a significant relationship with the incidence of placenta previa. The results of multivariate analysis using binary logistic regression test showed that the most influential risk factors for the incidence of placenta previa were history of cesarean delivery (OR=54.751) and history of curettage (OR=20.204). It can be concluded that a history of cesarean delivery and a history of curettage are the most influential risk factors for the incidence of placenta previa.

Comparison Of Handicap Inventory Tinnitus Scores Before and After Intra Tympanic Steroid Injection In Tinnitus Patients

Introduction. Tinnitus is a symptom in the form of a conscious perception of sound that is not produced by a sound source outside the body. Patients with tinnitus often have complaints of quality of life, with some situations of extreme anxiety, depression, and life changes. The Tinnitus Handicap Inventory (THI) is a valid questionnaire to be associated with patients associated with tinnitus. The Tinnitus Research Initiative (TRI), an international academic organization founded in 2006, recommends the use of THI for the evaluation of tinnitus defects and therapeutic effects. Therefore, a THI assessment is needed at RSUP Dr. Mohammad Hoesin Palembang as a result of therapy. Methods. This research using a design that aims to determine the comparison of THI scores before and after intratympanic injection of corticosteroids in 18 samples at RSUP Dr. Mohammad Hoesin Palembang. Results. The average age of the sample was 57 (23-66) years and the number of men and women were the same, namely 9 (50%) samples. Most of the samples had problems in unilateral ears by 14 (77,8%) samples. The average THI before intratympanic steroid injection was 37 (12-72) and after injection was 20 (4-80). Wilcoxon test results showed significant changes between before and after intratympanic steroid injection. Conclusion. There was a significant improvement in THI scores after intratympanic steroid injection.

Skin Prick Test Profile: A Retrospective Study

Background: A skin prick test is one method to detect allergies. Skin prick testing in dermatology can be performed on atopic dermatitis and urticaria. Skin prick test can be done easily, it’s relatively safe, fast, and can use many allergens simultaneously in one test. Purpose: To describe the characteristics of the skin prick test results at the clinic of Dermatology and Venereology, Mohammad Hoesin Palembang General Hospital, for the period 2016-2021. Methods: Descriptive retrospective study using a cross-sectional approach. Medical record data for the period January 2016-December 2021. Result: The number of patients who underwent skin prick testing during the period January 2016 to December 2021 was 116 patients, dominated by women (59.5%) and those aged 26-35 years (40.5%). The majority of diagnoses examined were atopic dermatitis (48.3%) and chronic urticaria (31.9%). The most positive results were for allergens in the form of house dust mites, shrimp, and crabs. The positive proportion of milkfish allergen was higher in women, while the positive proportion of shrimp allergen was higher in men. Chicken feather allergen showed significant differences between the diagnoses of atopic dermatitis, chronic urticaria and acute urticaria. Conclusion: House dust mites were the dominant allergen in patients with atopic dermatitis, chronic urticaria, and acute urticaria. skin prick test is recommended to be performed in the management of atopic dermatitis, chronic urticaria, and acute urticaria in order to detect the allergen because it has significant clinical relevance.

The Correlation of IL-6 Levels With the Degree of Rheumatoid Arthritis Disease Activity at Dr. Mohammad Hoesin Palembang

Rheumatoid arthritis (RA) is an autoimmune disease that requires careful management and regular evaluation of the degree of disease activity. AR is known for its pathophysiology and is strongly influenced by the increase of proinflammatory cytokines, especially IL-6. This study was conducted to determine the correlation of IL-6 levels with the degree of disease activity in AR patients at Dr. Mohammad Hoesin Palembang. A cross-sectional study was conducted on RA patients at the Rheumatology Polyclinic, Department of Internal Medicine, Dr. Moh Hoesin Palembang, who met the inclusion criteria consecutively in October 2021. The degree of RA disease activity was assessed using the Disease Activity Score (DAS 28). Statistical analysis was performed using SPSS version 24.0. A total of 34 subjects participated in the study, with most being women and a median age of 49.5 years. The majority of subjects had a moderate-high degree of RA activity. There is no significant correlation between IL-6 levels with DAS 28 CRP (r=0.256, p=0.072) and DAS 28 LED (r= 0.056, p=0.376). There was no significant correlation between serum IL-6 levels and disease activity in Rheumatoid Arthritis patients at Dr. Mohammad Hoesin Palembang.

Level of maternal zinc serum as risk factor of preeclampsia

Objective : To know the relationship of serum zinc levels with preeclampsia (PE)
 Method: This observational research uses a type of case control research. The population of this study is all pregnant women with a single pregnancy, gestational age of 28-42 weeks who were treated at the Department of Obstetrics and Gynecology of RSUP Dr. Mohammad Hoesin Palembang from August 2020 to November 2020. The study divided into 2 group, a case group of 30 pregnant women with PE and a control group of 60 pregnant women non PE. Serum zinc level examination is performed on all samples that match the research criteria. The data is processed by using SPSS software program version 20.0 Windows.
 Result: Both case and control groups had no meaningful differences to the general characteristics of the patient. There were significant differences in average zinc levels of maternal serum in both research groups (p=0.013; 43.90 plus-minus 15.79 pg/dL). The value of serum zinc levels that have the best sensitivity and specificity is at 45.5 pg/dL.
 Conclusion: There is a meaningful relationship between serum zinc levels and PE events. Pregnant women with serum zinc levels greater than or equal to 45.5 pg /dL were significantly at 3.2 times more risk of PE than pregnant women with serum zinc levels less than or equal to 45.5 pg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia. Keywords: preeclampsia, zinc, case-control studies

Correlation of Quantitative CRP Values with Fibrinogen Levels in Covid-19 Patients at Dr. Hospital. Mohammad Hoesin Palembang

COVID-19 is a contagious acute respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In COVID-19 infection, there may be a high inflammatory response, causing thromboinflammatory processes through cytokine storm mechanisms, complement activation, and endothelial damage. Thus, the sequence of events can be seen from increased levels of CRP, fibrinogen, and other acute-phase proteins synthesized by the liver. The CRP value is useful for assessing the degree of inflammation which is widely used in predicting disease severity, prognosis, and mortality in COVID-19 patients, while fibrinogen levels are useful for assessing the severity of disease and hypercoagulation in COVID-19 patients. This study aims to determine the correlation between quantitative CRP and fibrinogen levels, as well as the correlation of fibrinogen levels with the severity of COVID-19 disease. This study was an observational correlative analytic study with a retrospective approach. The research was conducted at the Department of Internal Medicine of RSMH Palembang in May 2022 by taking medical record data of COVID-19 patients from May 2021 to September 2021. The research subjects are adult COVID-19 confirmed case patients who have not received standard therapy and anticoagulant drugs. The data taken are general characteristics, routine blood tests, blood chemistry, blood gas analysis, and hemostasis function. Data processing and analysis were done using SPSS version 25.0 for windows. There were 263 subjects, consisting of 26 subjects (26.2%) with mild degrees, 95 subjects (36.1%) with moderate degrees, 49 subjects (18.6%) with severe degrees, and 50 subjects (19%) with critical degrees. The correlation between CRP values and fibrinogen levels was obtained with a correlation coefficient of r = 0.574, while the correlation between fibrinogen levels and the severity of disease was obtained at r = 0.490. In this study, there was a strong correlation between quantitative CRP value and fibrinogen levels and a moderate correlation between fibrinogen levels and the severity of illness in COVID-19 patients at RSMH Palembang. These two parameters can be used as predictors of the severity of COVID-19 disease.

Correlation of Interleukin 6 Levels with C-Reactive Protein in Various Severity of Covid-19 Patients in Rsup Dr. Mohammad Hoesin Palembang

COVID-19 is an acute infectious respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Changes in inflammatory mediators in the laboratory can be related to the phase of the disease course and the patient's clinical course. The results help determine the degree and predict the severity of COVID-19. This study aims to determine the correlation between Interleukin 6 levels and quantitative CRP levels to the severity of COVID-19 disease. This study is an analytic observational study with a cross-sectional design. This research was conducted in the COVID-19 isolation ward of RSMH Palembang from September 2021 to February 2022, with the subjects confirmed COVID-19 with various severity. Those confirmed with COVID-19 were interviewed, checked vital signs, laboratory tests for Interleukin 6, and quantitative CRP. Statistical analysis of the correlation test used Spearman and Gamma. Sample of 39 patients, consisting of 16 patients (41%) moderate, 15 patients (38.5%) severe, 8 patients (20.5%) critical. There was a significant correlation between interleukin six levels and the degree of COVID- a disease with r = 0.719. A positive correlation with moderate strength was found between interleukin six levels and quantitative CRP levels so that these two parameters can be used as predictors of the severity of COVID-19 and have a positive correlation.

Prevalence of Extended-Spectrum Beta Lactamase-Producing Microorganisms in Dr. Mohammad Hoesin Hospital Palembang

Production of Extended-Spectrum Beta-Lactamase (ESBL) by Enterobacteriaceae continues to be a problem of infectious diseases, especially in hospitals. The main causes of ESBL-producing bacteria colonization are urinary tract infections, length of hospital stay, invasive medical equipment, and antibiotics usage. This study aims to compare the incidence of ESBL based on the type of organism in Dr. Mohammad Hoesin Hospital for the 2017 and 2018 periods. The research design used was descriptive with a cross-sectional approach, which used secondary data at the Clinical Pathology Department of Dr. RSUP. Mohammad Hoesin Palembang. The findings of this study showed a decreasing pattern in the incidence of ESBL in 2017 and 2018, but with a similar pattern which was dominated by Klebsiella pneumoniae (followed by Escherichia coli and Klebsiella ozaenae), inpatients in pediatric wards, internal medicine, and intensive care units, and on sputum specimens. This study showed the presence of high levels of ESBL-producing bacteria (>60%) in Dr. Mohammad Hoesin Hospital, which was mainly caused by Klebsiella pneumoniae.

ASSOCIATION BETWEEN METABOLIC SYNDROME AND CORONARY HEART DISEASE IN WOMEN PATIENTS AT DR. MOHAMMAD HOESIN HOSPITAL PALEMBANG

Metabolic syndrome is still a risk factor for coronary heart disease. This study aims to analyze the association between metabolic syndrome and coronary heart disease in women. This study is an observational analytic study using a cross-sectional design on 138 samples selected using consecutive sampling method and data were collected through observation of the medical records of patients at dr. Mohammad Hoesin Palembang. The results showed that the highest proportion of metabolic syndrome components in the sample of this study was hypertension (54.3%), while the lowest was hyperglycemia (26.8%). This study found a significant relationship between metabolic syndrome and coronary heart disease in female patients (p = 0.047). Female patients with metabolic syndrome had a 2.218 times greater risk of developing coronary heart disease (PR 2.218 95% CI = 1.072 - 4.587).

IDENTIFICATION OF -2849 IL-10 GENE PROMOTER POLYMORPHISM IN LEPROSY PATIENT

Leprosy is a chronic granulomatous disease. Leprosy is caused by M. leprae. However, not all exposure to M. leprae causes the disease. The condition of the host immune system determines the pathogenesis of leprosy. Interleukin-10 work as a pro- and anti-inflammatory cytokine. Polymorphism in the IL-10 gene promoter affects the amount of IL-10 secretion. The amount of IL-10 secretion determines the body’s response to M. leprae. The purpose of this study was to determine the distribution of -2849 IL-10 gene promoter polymorphism in leprosy patient at RSUP dr. Mohammad Hoesin Palembang. This research is an observational descriptive study with cross sectional design. Polymorphism identification was performed using PCR-RFLP. A total of 50 samples were identified. Most of the leprosy patients at RSUP dr. Mohammad Hoesin for the period January – February were < 50 years old (73.47%), male (66%), MB leprosy (92%), and came from Malay-South Sumatra ethnicity (53.06%). The genotype frequency distribution was GG 93.88%, AG 6.12%, and AA 0%. The frequency of allele G was 96.94% and allele A 3.06%. The majority of leprosy patients at RSUP dr. Mohammad Hoesin had wild-type genotypes.

Electronic Nutrition (e-Gizi) Application Development on RSUP Dr. Mohammad Hoesin Palembang Using the Rapid Application Development Method

Regional General Hospital Dr Mohammad Hoesin Palembang is one of the types A vertical hospitals in Palembang. Patients who come are not only from South Sumatra but also from outside the region. Dr Mohammad Hoesin Hospital has inpatient services. One of the inpatient facilities is providing food which will be divided into 3 shifts. Currently, data gathering on the patient diet is performed manually, which indicates that many patients have returned home but somehow the food has been made, and the natural ingredients at the nutrition establishment do not match what would be in it. A solution that can facilitate the distribution of food at Dr Mohammad Hoesin Hospital and make it easier to record the patient's diet is to build a website-based Electronic Nutrition (e-Gizi) application.

FACTORS RELATED UTERINE MIOMAS (UTERINE FIBROIDS) AT RSUP DR. MOHAMMAD HOESIN PALEMBANG

Background: Uterine fibroids or uterine myomas are benign tumors cell myometrial smooth muscle surrounded by a pseudocapsule. Uterine fibroids occur in reproductive age women and will slowly disappear at menopause. Uterine fibroids are the second most common reproductive problem experienced by women in Indonesia after cervical cancer. The world incidence rate of uterine myomas is 20-35%, while Indonesia ranges from 2.4% to 11.7%. The study was conducted to know related factors with incident of uterine myomas at RSUP Dr. Mohammad Hoesin Palembang. Methods: This research is an analytic observational study with a cross-sectional approach. The sample of this study were gynecological patients at RSUP Dr. Mohammad Hoesin Palembang and data collected for the period January 2020 - July 2021 that met the inclusion criteria and exclusion criteria. Results and Conclusions: From 60 patients, the proportion of patients with uterine myomas was 61.7%. The analysis using the Chi-square test showed that age ( p = 0.005) had a significant relationship with the incidence of uterine myomas. The results of the analysis using the Chi-square test showed that age at menarche ( p= 1.00), parity ( p= 0.761), body mass index ( p =0.559), infertility ( p =0.112), history of hypertension ( p =1.00 ), history of diabetes mellitus ( p = 1.00), history of using hormonal contraception ( p = 0.634) did not have a significant relationship with the incidence of uterine myoma. Conclusion of this study is the mostr related factors of uterine myomas is age factor.

Covid-19 Risk Factors and Radiographic Severity Index Description in Covid-19 Patients Dr. Mohammad Hoesin Palembang 2021

Background: COVID-19 is a pandemic disease caused by droplet infection from SARS-CoV-2. Due to its rapidtransmission and high case fatality rate, the identification of risk factors and prognostic factors is important.Obesity is a risk factor for poor outcomes in COVID-19. It is associated with chronic inflammation, disorders of theimmune system. Obesity can be determined based on BMI. Chest X-Ray is supported in establishing the diagnosisand prognosis of COVID-19 patients. Assessment of the severity index of Chest X-Ray radiographs can use theModified Chest X-Ray Scoring System of RSUP Dr. Soetomo. This study was conducted to analyze the relationshipbetween BMI and chest radiography severity index in hospitalized COVID-19 patients at dr. Mohammad HoesinPalembang in 2021.Methods: This research used a cross-sectional analytic observational design. Sampling was done using aconsecutive sampling technique with 70 samples and obtained from the patient's medical record. The data wereanalyzed by univariate and bivariate (Chi-Square) using IBM SPSS Statistics 26 software.Results: Patients with BMI Overweight-Obesity had more in Moderate-Severe (18.6%) radiographic severityindex scores (18.6%) than Normal-Mild (15.7%). Chi-Square bivariate analysis, BMI (p=0.033; p-value <0.05) hada significant relationship with the chest radiographic severity index with Odds Ratio 3,00, 95% CI (1,073–8,386).Conclusion: There is a significant relationship between body mass index and chest radiography severity index inCOVID-19 patients. Overweight-Obesity BMI patients have a 3-fold chance of having a Moderate-Severe categoryof radiographic severity index compared to Underweight-Normal BMI patients.

Association of Axial Length and Myopia Degree: A Retrospective Study

Introduction: Myopia is a clinical condition that occurs when the image of a distant object is focused in front of the retina by the non-accommodating eye. The prevalence of Myopia has been getting higher for decades. A cohort study stated continuing axial elongation in adults with high Myopia.
 Methods: This research is a retrospective study approach. Data obtained from central general hospital Dr. Mohammad Hoesin Palembang from January 2021 to February 2022. Medical record data included in this study were patients diagnosed as myopic patients. The exclusion criteria were patients with missing medical records and any other refractive disorder. The correlation between myopia degree and axial length using ANOVA or Kruskal-Wallis H test depend on its data distribution. Data processing was performed using SPSS version 25. This study aims to determine the association between axial length and myopia degree.
 Results: Female patients are found predominantly (58.5%). Through the recent surveys, either the domestic or foreign population, results have stated that the prevalence of Myopia is higher in females, and other studies found that it fluctuated with age among adolescent females. The age of patients varies from 16 years to 75 years, and the mean baseline is 30.9± 3.82 years. Mild Myopia accounts most common incidence (53.1%), with laterality, which is found to be more common in the left eye (57.1%). Mean baseline axial length 21.95± 2.85 with visual acuity in LogMar 0.89 ± 0.51. There is a statistically significant difference in axial length based on myopia degree (p=0.000).
 Conclusion: Female patients are found predominantly in myopia patients, with the age of patients varying from 16 years to 75 years and a mean baseline of 30.9± 3.82 years. There is a statistically significant difference in axial length based on myopia degree.

Microbiological Profile of Corneal Ulcer in Dr. Mohammad Hoesin General Hospital Palembang, Indonesia: July to September 2021

Introduction: Microbial agents cause infectious processes, which may result in corneal inflammation leading to corneal necrosis, ulceration, and perforation. This disorder is one of the major etiologies of monocular blindness in developing countries in Asia, Africa, and the Middle East. The etiology of corneal ulcers varies in different regions.
 Methods: This research is a descriptive study approach. Data obtained from the medical records of patients who were registered as corneal ulcer patients in Dr. Mohammad Hoesin Palembang from July 2021 to September 2021.
 Results: A total of 9 patients were diagnosed with a corneal ulcer. The number of corneal ulcer patients was more in male patients (77.8%). The age of patients varies from 16 years to 63 years, and most elderly patients are diagnosed with this condition. Predisposing factors are unknown in most patients. The most common location for ulcers is the central cornea (88.9%), with >6 mm in size. Hypopyon is found in 2 patients (22.2%), while perforation and corneal melting in 1 patient consecutively. The most common microbiological profiles of corneal ulcer patients in this study are unspecified (66.7%), while ulcers due to bacteria in the second place of the microbiological profile (33.3%) consist of Enterobacter aerogenes, Staphylococcus epidermidis, and Pantoea spp and sensitive to almost all kinds of antibiotics.
 Conclusion: The most common microbiological profiles of corneal ulcer patients in this study are unspecified, while ulcer due to bacteria in the second place of the microbiological profile consists of Enterobacter aerogenes, Staphylococcus epidermidis, and Pantoea spp and sensitive to almost all kinds of antibiotics.

Clinicopathological Characteristics of Cervical Squamous Cell Carcinoma and Correlation with Tumor-Associated Neutrophil

BackgroundCervical carcinoma is one of the most common cancers in women, according to data from World Health Organization (WHO).Cervical carcinoma ranks the fourth most deadly type of cancer. Squamous cell carcinoma is the most common type of this cervicalcancer and it is generally caused by Human Papilloma Virus (HPV) types 16 and 18. Tumor-Associated Neutrophil (TAN) are foundin various types of cancer, the density of TAN can determine the prognostic type of tumor or cancer in each individual. This studywas aimed to identify correlation between clinicopathological characteristics of cervical squamous cell carcinoma (SCC) and TAN incervical SCC patients registered at RSUP Dr. Mohammad Hoesin Palembang.MethodsThis type of research is analytic with a cross-sectional method. Data collection in this study used a 37 slides archive which werediagnosed as cervical squamous cell carcinoma in Anatomic Pathology in RSUP Dr. Mohammad Hoesin Palembang for the periodof 2017-2019.ResultsFrom 37 cervical SCC patients, the clinicopathological characteristics of the majority of cervical SCC patients occurred in the agegroup of 51 year-old (51.4%), with histopathological type of non-keratinizing SCC (75,7%) and the most frequent differentiationdegree was moderately differentiated (75,7%). The TAN density was mostly found at low TAN densities (73%). There wassignificant correlation between age and TAN density (p=0.035) and there was no significant correlation between age and TANdensity (p=0.269).ConclusionIt was explained that the higher the degree of differentiation, the lower the density value, however the neutrophils in this studycannot be ascertained whether the neutrophils of anti-tumor (N1) or pro-tumor (N2) characteristic

Psychological Well-Being of Patient with Confirmed Covid-19 at RSUP Dr. Mohammad Hoesin Palembang

Pandemic that occour at the end of 2019, Coronavirus Disease, caused respiratory tract infections with commonly till seriouslly symptoms. Patien confirmated with Covid-19 not only impact their somatic, but also their psychological and social condition. Untill now, Civil society still have negative assumed about Covid-19, which triggers social stigma and discrimination. Thats impacted to psychological well-being. Purpose of this reseach, described of psychological well being of patients with confirmed Covid-19 at RSUP Dr. Mohammad Hoesin Palembang 2021. Used quantitative descriptive design and total sample that took by purposive sampling was 45 samples. Analysis of the reseach used descriptive statistical percentage. The results describe the presentation of psychological well being was 4 respondents on high category of (8.8%), 40 respondents on moderate category 88.8%, and 1 respondent low category (2.20%). The highest score of psychological well-being in the moderate category is environment mastery dimension of 84.3%; in the high category is positive relation dimension of 26.6%; and in the low category is personal growth dimension of 15.6%. Expected of the reseach, to know overview of the psychological well-being of of patients with confirmed Covid-19 and make the optimally planning of the medical and non-medical care.

The Relationship between Age of Menarche and Body Mass Index (BMI) with Endometriosis Incidence at Dr. Mohammad Hoesin Palembang Period 2018 – 2020

Background. Endometriosis is the presence of endometrial glands and stroma outside the uterus. This study aims to analyze the relationship between age of menarche and body mass index (BMI) with the incidence of endometriosis.
 Methods. This study is an analytical observational study with a cross-sectional approach. The samples taken in this study were post-operative patients with gynecological disorders at Dr. Mohammad Hoesin General Hospital Palembang. The sample taken in this study was 62 respondents during the period 2018-2020 with a simple random sampling technique based on inclusion criteria. The research data was processed and analyzed by univariate and bivariate with Chi-square test using SPSS application.
 Results. Most of the respondents with endometriosis experienced at the age of menarche <12 years (91.3%) and had a non-obese BMI (73.3%). There was a significant relationship between the age of menarche and the endometriosis incidence (p=0.039). There was no statistically significant relationship between body mass index (BMI) and the endometriosis incidence (p=1,043).
 Conclusion. Early menarche can increase the risk of endometriosis. The majority of women with endometriosis in this study had a BMI in the non-obese category (BMI <25).

The Association Between Clinical Characteristics and Histopathology of Nasopharyngeal Carcinoma At Dr. Mohammad Hoesin General Hospital, In 2019-2020

Introduction. Nasopharyngeal carcinoma is a cancer originating from the nasopharyngeal epithelium. Clinical characteristics such as age, gender, and risk factors are believed to influence the incidence of this cancer. Patients suffering from nasopharyngeal cancer may have certain clinical symptoms and provide certain histopathological features. Methods. The method used in this research were analytic observational with a cross sectional design using secondary data in the form of medical records from the Department of Anatomical Pathology section and the Central Medical Record section of RSUP Dr. Mohammad Hoesin Palembang as the research subject. Samples obtained 64 samples, then managed using the SPSS application. Results. The highest age group was 35-55 years old, which amounted to 44 people (68.8%). According to gender, the most common were males with 53 people (82,8%). According to clinical symptom, the most common were non-epistaxis with 33 people (51.6%). According to risk factors, the most were smokers with 36 people (56.3%). According to histopathology, the most common features were differentiated non-keratinized squamous cell carcinoma with 40 people (62,5%). From the statistical test, it resulted that p > 0,05 for all variables (age, gender, clinical symptoms, and risk factors) that associated with histopathology of nasopharyngeal carcinoma. Conclusion. There was no significant association found between clinical characteristics and histopathology of nasopharyngeal carcinoma.

Correlation of Cholesteatoma Stadium with Degree of Erosion Ossicular in CSOM (Chronic Suppurative Otitis Media) Patients with Cholesteatoma in Dr. Mohammad Hoesin General Hospital Palembang

Background: Chronic suppurative otitis media (CSOM) is inflammation of the middle ear mucosa and mastoid space more than 2 months characterized by perforation of the tympanic membrane and continuous or intermittent discharge from the ear canal. CSOM with cholesteatoma is characterized by perforation that is located marginally or attic with cause destruction ossicle and often causes dangerous complications. This study was aimed to determine the correlation between cholesteatoma stadium among CSOM patients with cholesteatoma in RSUP Dr. Mohammad Hoesin Palembang.
 Methods: Observational research using a cross sectional design. The data were collected using medical record on 70 subjects with a diagnosis of CSOM with cholesteatoma who underwent mastoidectomy surgery at RSUP Dr. Mohammad Hoesin Hospital Palembang for the period of January 2018 to June 2021.
 Results: From 70 samples conducted in the study, degree of erosion ossicular in CSOM with cholesteatoma with highest group type D with MERI index score 4 in 34 patients (48,6%). There was a strong positive correlation between degree of erosion ossicular based on MERI index score and cholesteatoma stadium based on Bluestone (p<0.005, R=0.655) From the linear regression test, the most influential in causing degree of erosion ossicular in CSOM with cholesteatoma were tympanic perforation type, granulation and cholesteatoma stadium.
 Conclusions: There is a significant relationship between degree of erosion ossicular based on MERI index score and cholesteatoma stadium based on Bluestone.