Mohammad Hoesin General Hospital Research Articles

The Relationship Between High-Sensitivity C-Reactive Protein (hs-CRP) and Diastolic Dysfunction in Geriatrics Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Background: Systemic inflammation associated with high hs-CRP levels constitutes one pathway through which diastolic dysfunction develops in older adults. This study aims to determine the relationship between high-sensitivity c-reactive protein (hs-CRP) and diastolic dysfunction in older adults at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.
 Methods: This research is an observational analytical study using a cross sectional design. The research was conducted at the geriatrics polyclinic at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia from June to August 2023. A total of 65 people took part in this study. The relationship between hs-CRP and diastolic dysfunction was analyzed using SPSS version 25, univariate and bivariate.
 Results: Hs-CRP had a significant relationship with diastolic dysfunction on a numerical scale (p=0.012), with a median value of 1.6 mg/dL in subjects with diastolic dysfunction and 0.9 mg/dL in subjects without diastolic dysfunction. On the categorical scale, the hsCRP less than 1 mg/dL group found nine subjects (23.7%) with diastolic dysfunction and 14 subjects (51.9%) without diastolic dysfunction, the hsCRP 1-3 mg/dL group found 21 subjects (55.3%) with diastolic dysfunction and 12 subjects (44.9%) without diastolic dysfunction, in the hsCRP more than 3 mg/dL group (p=0.026) there were eight subjects (21.1%) with diastolic dysfunction and one subject (3.7%) without dysfunction diastolic.
 Conclusion: There is a significant relationship between hsCRP and left ventricular diastolic dysfunction in geriatrics patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

Accuracy of Bleeding Volume as a Predictor of Mortality in Epidural Hemorrhage Patients Undergoing Surgery at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction: EDH is a collection of blood clots between the dura layer and the cranium. This is usually caused by rupture of the middle meningeal artery but can also be caused by rupture of the dural venous sinus, diploic vein, meningeal vein, or bleeding from the fracture line. CT scan is the investigation of choice to detect intracranial injury after trauma. CT scans can also identify additional features that influence the results, namely, midline shifting, blood clot thickness and hematoma volume, cerebral edema, and cranium fractures. This study aimed to determine the accuracy of bleeding volume as a predictor of mortality in epidural hemorrhage patients undergoing surgery at Dr. Mohammad Hoesin General Hospital, Palembang Indonesia.
 Methods: This study is a retrospective study of prognostic tests to determine the accuracy of bleeding volume as a predictor of mortality in patients with EDH who underwent surgery at Dr. Mohammad Hoesin General Hospital. This study uses secondary data obtained from medical record data at the medical records installation of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 106 research subjects participated in this study. 
 Results: The sensitivity value of bleeding volume was 77.7%, and specificity was 78.3%, and also obtained a positive predictive value of 7.21% and a negative predictive value of 97.4%, it can be concluded that bleeding volume is not accurate as a predictor of mortality.
 Conclusion: Bleeding volume is not an accurate predictor of mortality in epidural hemorrhage patients undergoing surgery at Dr. Mohammad Hoesin General Hospital, Palembang Indonesia.

Determinant of Abdominal Wound Dehiscence (AWD) in Post-Laparotomy Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction. Abdominal wound dehiscence (AWD) is a significant risk factor for mortality during the perioperative period. The high mortality rate, prolonged hospitalization, and increased incidence of repeat operations increase in hospital costs result in worsening the AWD problem itself. This study aims to determine the determinants of abdominal wound dehiscence in post-laparotomy patients at the Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.
 Methods. This study is quantitative analytical research with a cross-sectional design to determine the determinants of abdominal wound dehiscence (AWD) in post-laparotomy patients based on secondary data from medical records at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 161 research subjects participated in this study.
 Results. Emergency surgery patients are 0.4 times more likely to experience AWD than elective patients. Then, patients who experience hypoalbuminemia have 1.8 times the risk, those aged more than 60 years have 0.5 times the risk, sepsis has 1.5 times the risk, and trauma patients have 0.8 times the risk of experiencing AWD.
 Conclusion. Emergency surgery is the most influential determinant in the incidence of AWD at Dr. Mohammad Hoesin Palembang, Indonesia.

The Relationship between Skeletal Muscle Strength and Cardiac Senescence Performance in the Elderly at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

The Relationship between Skeletal Muscle Strength and Cardiac Senescence Performance in the Elderly at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

The Effect of Giving Vitamin D Supplements on Improving Ejection Fraction in Heart Failure Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Background: The role of vitamin D as an inflammation modulator, regulation system renin-angiotensin-aldosterone (RAAS), inhibits the production of parathyroid hormone (PTH), thereby causing left ventricular hypertrophy, causing hypocalcemia which induces hypertrophy in cardiac myocytes and can reduce cardiac contractility. This study aimed to determine the effect of giving vitamin D supplements on improving ejection fraction in heart failure patients at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang, Indonesia.
 Methods: This study is an experimental study with a double-blind, randomized clinical trial design and uses primary data obtained from clinical examinations and supporting examinations of research subjects. A total of 40 research subjects participated in this study.
 Results: In this study, the median vitamin D level in the vitamin D supplementation group before treatment was 19.92 ng/dl (18.65-20.22), and in the placebo group was 19.74 ng/dl (18.14 - 20.13). After treatment with 1000 iu of vitamin D given for 3 months, the results showed that in the vitamin D supplementation group, there was an increase in vitamin D levels to 33.06 ng/dl (an increase of 13.14) with statistically significant results (p < 0 .05). In the vitamin D supplementation group, there was an increase in ejection fraction to 37.9% (an increase of 3.65%) with statistically significant results (p<0.05). Contrasting results were shown in the group that received a placebo, where there was a decrease in ejection fraction to 33.15% (2.25% decrease).
 Conclusion: There is an improving effect of giving vitamin D supplements on increasing ejection fraction in heart failure patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

The Relationship between Maxillofacial Injury Severity Score (MFISS) and Outcomes of Maxillofacial Trauma Patients at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang, Indonesia

Introduction: Maxillofacial trauma is an important public health problem, and understanding the relationship between injury severity and patient outcomes is critical for effective management. This study aimed to determine the relationship between the maxillofacial injury severity score (MFISS) and the outcomes of maxillofacial trauma patients at Dr. Mohammad Hoesin General Hospital, Palembang.
 Methods: An analytical observational study was conducted involving 121 maxillofacial trauma patients from April to May 2023. Data regarding patient characteristics, MFISS scores, type of management, length of stay, and mortality were collected and analyzed using statistical tests.
 Results: The majority of maxillofacial trauma patients were male (74.4%) and aged over 18 years (63.6%). Traffic accidents are the main cause of trauma (84.3%). The distribution of MFISS scores showed that 75% of patients had mild scores, 18.2% had moderate scores, and 5.8% had severe scores. Most patients underwent surgical management, with the majority having a length of stay of ≤7 days. The mortality rate was 2.5%. There was no significant relationship between the MFISS score and type of management (p > 0.05). However, there was a significant difference in the length of stay based on the MFISS score (p = 0.000). Patients with severe MFISS scores had significantly longer lengths of stay compared with patients with mild or moderate scores. In addition, there was a significant relationship between MFISS score and mortality (p = 0.000). Patients with severe MFISS scores had a higher risk of death compared with patients with mild to moderate scores.
 Conclusion: The MFISS score is associated with length of stay and mortality in maxillofacial trauma patients. However, there was no significant relationship between the MFISS score and the type of management.

Association Between Sebum, Total Cholesterol, and Low-Density Lipoprotein (LDL) Cholesterol Levels With Post-acne Keloids.

Background Prolonged acne inflammation causes scar formation, one of which is post-acne keloids. Sebum, total cholesterol, and low-density lipoprotein (LDL) level can influence post-acne keloids. This study aims to determine the association between sebum, total cholesterol, and LDL levels with post-acne keloids to better define the predisposing factors for this condition. Methods This study used primary data involving sociodemographics, clinical features, keloid classification, sebum levels, total cholesterol levels, and LDL levels in post-acne keloid patients at the Dermatology, Venereology, and Aesthetics Outpatient Clinics of Dr. Mohammad Hoesin General Hospital Palembang, Indonesia. Study samples were patients who fulfilled the inclusion and exclusion criteria by consecutive sampling. The data then underwent univariate and bivariate analyses to show the association between variables. Result A total of 22 patients with post-acne keloids participated. The subjects presented mostly with major keloids based on the classification (59.1%). The patients were predominantly 21-30 years old (50%) and male (90.9%). The keloids had onsets >six months to one year (45.5%), durations of one to five years (77.3%), and multiple presentations (68.2%). Vancouver Scar Scale (VSS) assessment showed mainly red vascularity (40.9%), mixed pigmentation (68.2%), >5 mm keloid height (59.1%), and firm pliability (40.9%). Most patients presented with pruritus (86.4%) but without pain (54.5%). Most had low levels of sebum (50%), normal total cholesterol (90.9%), and near-optimal LDL level (40.9%). There were no significant association between sebum (p = 1.000), total cholesterol (p = 1.000), and LDL (p = 0.376) levels with post-acne keloids. However, LDL levels above normal were most found in this study (68.2%). Conclusions There is no association between sebum, total cholesterol, and LDL levels with post-acne keloids. Despite the fact that LDL level was not statistically significant, there has been a rise in LDL level in the research subjects. Further research with a larger number of subjects and consideration of multicenter study through retrospective/prospective methods and complete lipid profile examinations is still required to provide a more representative study.

The Relationship between Thoracic Trauma Scoring and Mortality in Blunt Thoracic Trauma Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction: Closed thoracic trauma is frequently associated with rib fractures and pulmonary contusions. Thoracic trauma can be life-threatening if it is not treated immediately and properly. This study aimed to determine the relationship between thoracic trauma scoring and mortality in blunt thoracic trauma patients in sub-population Indonesia, especially at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.
 Methods: This study is a cross-sectional observational study. A total of 70 research subjects participated in this study. Data analysis was carried out using SPSS in univariate and bivariate to determine the relationship between thoracic trauma scoring and mortality.
 Results: There is a significant relationship between CTS scores and mortality (p = 0.000). Patients with a CTS score ≥ 5 were significantly more at risk of dying than patients with a CTS score < 5 (p = 0.000).
 Conclusion: There is a relationship between CTS score and blunt trauma patient mortality thorax at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

Gene Expression of Human Beta-Defensin-3 and Cathelicidin in the Skin of Leprosy Patients, Household Contacts, and Healthy Individuals from Indonesia.

Leprosy, a chronic infectious peripheral neuropathy, is caused by Mycobacterium leprae. This bacterium produces triacylated lipopeptides that can induce the immune system via the Toll-like receptor 2/1 (TLR 2/1) complex. Activation of TLR 2/1 produces proinflammatory cytokines and antimicrobial peptides (AMPs), including human beta-defensin-3 (HBD-3) and cathelicidin. To analyze differences in gene expression of HBD-3 and cathelicidin in the skin of leprosy patients, household contacts, and healthy individuals. An analytic observational study was conducted at the Outpatient Clinic of Dermatology and Venereology of Dr Mohammad Hoesin General Hospital, Palembang, Indonesia, from January 2021 to June 2022. In each group of 18 subjects, 72 samples were collected, including skin lesion in leprosy patients, normal skin in leprosy patients, household contacts, and healthy individuals. A comparison of HBD-3 and cathelicidin gene expression between the four groups was analyzed using Pearson Chi Square, Kruskal-Wallis, and Mann-Whitney Test. The median value of HBD-3 gene expression on skin lesion in leprosy patients was 260.61 (0.19-3734.10); normal skin in leprosy patients was 1.91 (0.01-151.17); household contacts skin was 7.93 (0.27-121.10); and healthy individuals' skin was 1.00 (1.00-1.00) is highly significant difference (p < 0.0001). The median value of cathelicidin gene expression on skin lesion in leprosy patients was 38.72 (0.28-1852.17); normal skin in leprosy patients was 0.48 (0.01-15.83); household contacts skin was 9.8 (0.04-128.0); and healthy individual skin was 1.00 (1.00-1.00), also highly significant difference (p < 0.0001). Gene expression of HBD-3 and cathelicidin increased in skin lesions of leprosy patients and household contacts.

Factors Associated with Free Flap Viability at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction: A free flap is part of reconstructive surgery. This technique takes tissue or bone flaps along with their original vascular supply and performs microvascular anastomosis of the pedicle arteries and veins at the recipient site. Several risk factors that influence the occurrence of flap failure are still a major concern, such as age, gender, defect size, duration of surgery, length of tissue ischemic time, nutritional status, etc. This is further associated with higher morbidity, the potential for flap failure, higher costs, and increased length of stay in the hospital. This study aimed to determine the factors associated with free flap viability at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.&#x0D; Methods: Cross-sectional analytic observational study. A total of 33 research subjects participated in this study. Observation of risk factors was carried out using SPSS univariate and bivariate.&#x0D; Results: Gender and ischemic time factors are related to free flap viability. Male gender and ischemic time &lt; 60 minutes increase the success of free flap viability.&#x0D; Conclusion: Gender and length of ischemic time are associated with free flap viability at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

Evaluation of Upper Extremity Function after Operative and Non-Operative Management of Proximal Humeral Fracture Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction: Proximal humeral fractures are one of the most common long bone fractures due to osteoporosis. The need for operative action can provide greater benefits than non-operative measures. However, the difference between the need for operative and non-operative measures in proximal fractures is still controversial. This study aimed to determine differences in DASH (disability of the arm, shoulder, and hand) scores as a function of assessing upper extremity patients with proximal humeral fractures after operative and non-operative management at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.&#x0D; Methods: Cross-sectional analytic observational study, in which 37 research subjects participated in this study. Univariate and bivariate analyses were carried out using SPSS software on the patient's sociodemographic data as well as the clinical data of the study subjects.&#x0D; Results: There was no statistically significant difference in upper extremity function (DASH score) between operative and non-operative procedures in patients with proximal humeral fractures, p&gt; 0.05.&#x0D; Conclusion: There was no difference in upper extremity function as assessed by the DASH score in operative and non-operative procedures in patients with proximal humeral fractures at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

Overview of Sensorineural Deafness Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction: Sensorineural deafness is deafness that occurs due to disturbances in the inner ear or in the nerve pathways from the inner ear to the brain. This study aimed to provide an overview of sensorineural deaf patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.&#x0D; Methods: This study was a descriptive observational study and used secondary data obtained from medical record data at the medical records installation of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 50 research subjects participated in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients aged &gt; 18 years who were diagnosed with sensorineural hearing loss at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, for the January-December 2022 period and had complete medical record data.&#x0D; Results: The majority of research subjects have an age range of &gt; 50 years. Subject the majority of studies have male gender. The majority of research subjects complained of deafness in both ears. The majority of research subjects have a profound hearing threshold.&#x0D; Conclusion: Characteristics of sensorineural deafness at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, generally occur at the age of &gt; 50 years, male gender, occurs bilaterally, and has a very poor hearing threshold.

Characteristics of Acute Pharyngitis at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction: Pharyngitis presents with a variety of symptoms, including sudden sore throat, fever, headache, lymphadenitis, and sometimes abdominal pain, nausea, fatigue, and/or rash. This study aimed to provide data on the basic characteristics of acute pharyngitis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.&#x0D; Methods: This study was a descriptive observational study. This study uses secondary data obtained from medical record data at the medical records installation of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 100 research subjects participated in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients diagnosed with acute pharyngitis at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, for the period January – December 2022 and who have complete medical record data. Observations on sociodemographic data as well as observations on clinical data, were carried out in this study. Univariate data analysis was performed to present the distribution of frequencies and percentages of each variable. Data analysis was carried out using SPSS version 25.&#x0D; Results: The majority of research subjects are in the age range of 0-14 years. The majority of research subjects are female. The majority of research subjects had clinical symptoms of sore throat and difficulty swallowing. The symptoms that arise in acute pharyngitis depend on the microorganisms that accompany it. Acute pharyngitis caused by bacteria is characterized by severe headache, fever or chills, malaise, painful swallowing, vomiting, and possibly coughing but rarely.&#x0D; Conclusion: The characteristics of pharyngitis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, are aged 0-14 years with prominent clinical symptoms of sore throat and difficulty swallowing.

The Relationship between Neutrophil Lymphocyte Ratio in Head Injured Patients and Patient Outcomes at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction: Head injury causes microglial activation and release of proinflammatory cytokines. One of the inflammatory markers that can be used is the neutrophils to lymphocytes ratio (NLR). Within 24 hours after brain injury, the number of circulating neutrophils was markedly increased compared to the uninjured control group. This study aimed to determine the relationship between ratios of neutrophil-lymphocyte head injury patients with patient outcomes at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.&#x0D; Methods: This study was a cross-sectional analytic observational study. A total of 36 research subjects participated in this study. Observations on sociodemographic, clinical, and laboratory data were carried out in this study. Data analysis was carried out using SPSS using univariate and bivariate.&#x0D; Results: The majority of study subjects with a good Glasgow outcome scale had a neutrophil-lymphocyte ratio &lt;7.35. Meanwhile, research subjects with Glasgow the poor outcome scale had a neutrophil-lymphocyte ratio ≥7.35, p&lt;0.05.&#x0D; Conclusion: There is a relationship between the neutrophil-lymphocyte ratio and the outcome of head injury patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

The Relationship between Hba1c Levels and Body Mass Index with Severity of Diabetic Neuropathy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction: Diabetic neuropathy is the most common microvascular complication in diabetes mellitus patients. Diabetic neuropathy is known to be associated with conditions of hyperglycemia and obesity that occur in diabetic patients. Hyperglycemia in diabetic patients can be monitored through HbA1c levels. This study aimed to assess the relationship between HbA1C values and body mass index with the severity of diabetic neuropathy based on nerve conduction velocity examination.&#x0D; Methods: A study with a cross-sectional design with a total of 25 subjects with diabetes mellitus. The severity of diabetic neuropathy was determined based on Baba's diabetic neuropathy classification (BDC), degrees 0 to 4. In all study subjects, plasma HbA1c levels were examined, and body mass index was assessed. The relationship between categorical variables was tested with the chi-square test, and the relationship between numerical and categorical variables with a one-way ANOVA test, the value was considered statistically significant if the p-value &lt;0.05.&#x0D; Results: The 25 subjects with diabetes found a mean age of 54.88 (±SD 8.918) years, with a gender distribution of 46.4% for women and 42.9% for men. The average HbA1c level was 8.9560 (± 2.21850), and the highest body mass index was obese (50%). There was a significant relationship between HbA1c levels and the severity of diabetic neuropathy based on electrophysiological examination (p&lt;0.05), but there was no significant relationship between the value of body mass index and the severity of diabetic neuropathy.&#x0D; Conclusion: Increased HbA1c levels are associated with increased severity of peripheral neuropathy in patients with diabetes mellitus.

Overview of Risk Factors for Ectopic Pregnancy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction: Ectopic pregnancy is an emergency condition that is the cause of maternal death during the first trimester of pregnancy. Most extrauterine implantations occur in the fallopian tubes. This study aimed to find an overview factor risk of ectopic pregnancy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.&#x0D; Methods: This study was a descriptive observational study and used secondary data from medical record data at the medical record installation of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 100 research subjects participated in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients with ectopic pregnancy disorders who were treated at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, over 18 years of age and had complete medical record data. Data analysis was carried out using SPSS software version 25. Univariate analysis was performed to present the distribution frequency data for each variable test.&#x0D; Results: The majority of research subjects had an age range of 26-35 years (55%). The most common risk factors in this study were a history of abortion in a previous pregnancy (47%), parity 0 (46%), and abortion occurring in the first pregnancy (35%).&#x0D; Conclusion: Maternal age, history of abortion, parity, and gravidity are risk factors that play a role in the incidence of ectopic pregnancy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

The Relationship between Risk Factors for the Use of Oral Contraception and Sexual Activity with Cervical Cancer Incidence at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction: Cervical cancer is a malignancy of the cervix caused by the human papillomavirus (HPV). Cervical cancer often has no symptoms. Most patients are known to be positive for cervical cancer at an advanced stage. This study aimed to determine the relationship between the use of oral contraceptives and sexual activity with the incidence of cervical cancer at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.&#x0D; Methods: This study was an analytic observational case-control study. A total of 37 subjects were researched as a case group and a total of 111 subjects as a control group. This study made observations of variable age, Education, work, use of oral contraceptives, and sexual activity for the first time. Data analysis was carried out using SPSS software univariate and bivariate.&#x0D; Results: Use of oral contraceptives ≥ 5 years was not significantly associated with the incidence of cervical cancer, p&gt; 0.05. Age at first sexual intercourse &lt;18 years was significantly associated with the incidence of cervical cancer, p&lt;0.05. Age at first pregnancy &lt;18 years was significantly associated with the incidence of cervical cancer, p&lt;0.05.&#x0D; Conclusion: Sexual activity is a risk factor that plays a role in the incidence of cervical cancer at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

Overview of Clinical Symptoms of Pediatric Patients Infected with Coronavirus Disease 2019 (COVID-19) at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Introduction: COVID-19 is a disease caused by infection with a new coronavirus with the name SARS-CoV-2 and can be transmitted between humans. Transmission of COVID-19 occurs through droplets produced by infected people. Indonesia is a country affected by COVID-19, with cases reaching 2,203,108 cases. The number of cases in Indonesia also includes COVID-19 infections in children. This study aimed to present an overview of the clinical symptoms of pediatric patients infected with coronavirus disease 2019 at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This study is a descriptive observational study. A total of 50 research subjects participated in this study. Observations of sociodemographic data and observations of clinical data were carried out in this study. Univariate data analysis was performed to present the distribution of frequencies and percentages of each variable. Results: The majority of clinical symptoms of pediatric COVID-19 patients are fever. Apart from fever symptoms, the majority of clinical symptoms of child COVID-19 patients have symptoms of runny nose, shortness of breath, nausea and vomiting, and diarrhea. Conclusion: Fever is a clinical symptom of the 2019 coronavirus disease (COVID-19) infection in children at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

Correlation of Serum Vitamin D Levels with the Severity of Diabetic Foot Ulcers in Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Background: Vitamin D has a role in diabetes mellitus. Low levels of vitamin D are associated with the development of diabetic foot infections. Effects of vitamin D supplementation on wound healing, insulin resistance, inflammatory biomarkers, and oxidative stress are mediated by effects on induction of phagocytosis and bacterial killing by macrophages, suppression of interferon-gamma mediating macrophage activation, activation of insulin receptor expression, and downregulation from cytokines. This study aimed to determine the correlation between serum vitamin D levels and the severity of diabetic foot ulcers in Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.&#x0D; Methods: This study was an observational analytics study, where as many as 30 research subjects participated in this study. The study observed vitamin D levels and the severity of diabetic foot ulcers as assessed by the classification of the wound, ischemia, and foot infection (WIfI). Univariate and bivariate data analysis was carried out using SPSS.&#x0D; Results: The results of Sommer's correlation statistical test obtained a value of p = 0.001 (p &lt;0.05) with a correlation strength of r = 0.564, which means sufficient strength (r = 0.40-0.70). This means that the higher the deficiency in serum Vitamin D levels, the higher the degree of WIfI classification experienced.&#x0D; Conclusion: There is a correlation between serum vitamin D levels and the severity of diabetic foot ulcers in Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.&#x0D;

Diagnosis of Osteogenesis Imperfecta in 23 Years Old Man: A Case Report

Osteogenesis imperfecta is a disorder of the formation of collagen tissue that functions as connective tissue and is caused by a gene mutation that causes disturbances in the formation of type 1 collagen. This study aimed to describe the diagnosis of osteogenesis imperfecta. A 23-year-old man came to the rheumatology polyclinic of Dr. Mohammad Hoesin General Hospital Palembang with a complaint of recurrent fractures since ± 17 years ago. The patient also complained that the hearing in the left ear was slowly decreasing. The patient's right thigh was still pinned 2 years ago, but after being controlled by orthopedics, it was said that the bones were still not fused. Then the patient was referred to the rheumatology polyclinic for further examination and management. On examination, the patient was 145 cm tall and weighed 40 kg. He had blue-gray sclera, triangular facial appearance, right leg length 86 cm, left leg length 78 cm, blue sclera, and scoliosis, while secondary sex growth was within normal limits. From the examinations of bone survey and bone age, it was found osteoporotic bone structure, scoliosis, plate-screw in the middle 1/3 of the right femur, fracture union of the femur, bowing of the left femur, BMD Z-Score -3.0 means very low compared to the same age and gender. Management is more focused on supportive therapy with the aim of minimizing the occurrence of fractures, minimizing disability, and helping people with osteogenesis imperfecta to be independent and maintain overall health. The goal of orthopedic management is to treat osteogenesis imperfecta with fractures and prevent or correct bone deformity. In conclusion, osteogenesis imperfecta is a complex hereditary disease characterized by striking clinical variability necessitating a logical classification system. Disease management requires multidisciplinary experts and further research on therapeutic approaches such as bisphosphonates.