We demonstrate 100-Gbaud on-off-keying (OOK) transmission driven at a low voltage using an electro-optic (EO) polymer modulator combined with a silicon Mach-Zehnder interferometer waveguide. Various types of organic- and polymer-based modulators have been reported to perform efficient EO modulation and high-speed data transmission at over 100 Gbaud. However, there are critical concerns regarding the practical application of polymer devices in terms of environmental stability. In particular, long-term thermal storage and stability during operation require improvements before EO polymer modulators can be applied in practical systems. We have developed an EO polymer with enhanced thermophysical stability and used it to fabricate an efficient EO polymer modulator. In this study we extend our earlier work on high-speed EO polymer modulators by performing fiber-link 100-Gbaud OOK transmission at various operating temperatures. A thermal stability test revealed that the EO polymer modulator can survive high-temperature exposure up to 110°C. Error-free signal transmissions over a distance of 2.0 km was successfully demonstrated with a driving voltage of 1.9 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> and a bit error rate below the 7% overhead forward error correction threshold. The driving voltage, bandwidth, bit error rate, and fiber-link performance of the device are presented.