Cycle Modulation Research Articles

Peningkatan Hasil Belajar Peserta Didik Menggunakan Model Value Clarification Technique (VCT) pada Pembelajaran Pendidikan Pancasila di Kelas V SD Negeri 08 Campago Ipuh Kota Bukittinggi

The research was motivated by the low learning outcomes of students in learning Pancasila education. This study aims to describe the improvement of student learning outcomes in Pancasila education learning with the Matrix Type Value Clarification Technique model in Class V SDN 08 Campago Ipuh Bukittinggi City. This research is a Classroom Action Research that uses qualitative and quantitative approaches. Carried out in two cycles, namely cycle I carried out 2 meetings and cycle II carried out 1 meeting. Each cycle includes four stages, namely planning, implementation, observation, and reflection. The subjects of this study were teachers and students of class V SDN 08 Campago Ipuh with a total of 26 students. Data collection techniques in the form of observation, tests and non-tests. The results showed an increase in a) Teaching Module cycle I with an average of 85.5% (Good), and cycle II 93% (Very Good), b) implementation of learning in the teacher aspect of cycle I with an average of 81.2%, and cycle II 93.7% (Very Good) while the implementation of learning aspects of students cycle I with an average of 81.2% and cycle II 93.7%, c) student learning outcomes in cycle I with an average of 75 (Fair) and cycle II 88 (Good). Based on these results it can be concluded that with the Value Clarification Technique Matrix Type model the learning outcomes of students in learning Pancasila Education can increase.

Use of modified human hemangioma tissue cultures and human umbilical vein endothelial cell cultures to gain mechanistic insights into imiquimod treatment for infantile hemangioma.

Infantile hemangiomas (IH) are a common entity encountered by dermatologists, otolaryngologists, and other surgeons. Oral propranolol is a mainstay of treatment for IH and is well-tolerated, though propranolol-refractory IH and other drug-related adverse events are documented and can limit its usage. There are few in vitro testing systems for putative treatment agents. To address this, we modified a tissue culture system for human hemangioma treatment testing to evaluate the treatment impact of the immune modifier, imiquimod. Human umbilical vein endothelial cells (HUVEC) and hemangioma cultures were treated with several concentrations of imiquimod followed by MTT assays, reporter gene assays, PCR, ELISA, and Western blotting for IL-8, VEGF, Cyclin D1, and IFNα and immunohistochemistry for Cyclin D1 and Ki-67. HUVEC showed acute decreases in IL-8, VEGF, and Cyclin D1 promoter activity and increases in IFNα mRNA after imiquimod treatment. Hemangioma samples showed no change in Ki-67 or Cyclin D1 staining after treatment with imiquimod after 27 d, with significantly increased IL-8 and VEGF. From this preliminary analysis, we discerned that hemangioma tissues can be grown in tissue culture and used for drug treatment studies. We also conclude acute and chronic modulation of cell cycle, angiogenesis factors, and immunostimulatory conditions may be associated with imiquimod mechanisms of action in hemangioma involution.

Zero-dimensional simulations of DC ns-pulsed plasma jet in N2 at near atmospheric pressure: validation of the vibrational kinetics

Abstract A Direct Current (DC) nanosecond (ns)-pulsed plasma jet fed with N2 at near atmospheric pressure (20 000 Pa) is studied using a transient zero-dimensional (0-D) model coupled with a two-term Boltzmann equation solver. Good agreement is observed between the simulated and measured plasma properties: including the electron density and the ratios of the N2(v = 1, 2, 3, 4) densities to the gas density. A variety of theoretical approaches are considered to determine the Vibrational-Vibrational (V-V) and Vibrational-Translational (V-T) rate coefficients. For the V-V kinetics, the simple form of an Harmonic Oscillator (sfHO), the Schwartz–Slawsky–Herzfeld (SSH) and the Forced Harmonic Oscillator (FHO) approaches are used. The SSH approach used in this study is an improved version based on the pure SSH approach. For the V-T kinetics, the sfHO, a fit function of the Semi-Classical (ffSC) calculations and a fit function of the Quasi-Classical Trajectory (ffQCT) calculations are used. The influence of these different approaches on the calculated temporal evolution profiles of the vibrational distribution functions (VDFs) within one pulse modulation cycle is revealed. It is observed that the use of these different approaches does not strongly affect the densities of the low vibrational levels (v < 5), whereas larger influences on the higher level densities are found. In addition, it is found that the simulated evolution of the VDFs are sensitive to the probabilities of the neutral wall reaction N2(v) + wall → N2(v − 1) in the range of 1 × 10−2 to 1 × 10−4. A further analysis of the wall quenching probabilities of N2(0 < v < 58) is of importance for a more accurate prediction of the VDFs.

Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase.

Itaconate is one of the most highly upregulated metabolites in inflammatory macrophages and has been shown to have immunomodulatory properties. Here, we show that itaconate promotes type I interferon production through inhibition of succinate dehydrogenase (SDH). Using pharmacological and genetic approaches, we show that SDH inhibition by endogenous or exogenous itaconate leads to double-stranded mitochondrial RNA (mtRNA) release, which is dependent on the mitochondrial pore formed by VDAC1. In addition, the double-stranded RNA sensors MDA5 and RIG-I are required for IFNβ production in response to SDH inhibition by itaconate. Collectively, our data indicate that inhibition of SDH by itaconate links TCA cycle modulation to type I interferon production through mtRNA release.

Comprehensive in silico characterization of Arabidopsis thaliana RecQl helicases through structure prediction and molecular dynamics simulations

Helicases are ubiquitous enzymes with specific functions that contribute to almost all nucleic acid metabolic processes. The RecQ helicase family is essential for integrity in all organisms through DNA replication, repair, and recombination. This study investigated five RecQ-like helicases in Arabidopsis thaliana (AtRecQl) that exhibit diverse structural and physiochemical attributes and functions. Cis-regulatory element analysis identified stress, hormone, cell cycle, and development-responsive modules involved in various events in plant growth and development. Gene ontology analysis revealed that the five AtRecQl were associated with various cellular components, molecular functions, and biological processes. Protein-protein interaction analysis also implicated some in various abiotic stress processes. Structural analysis and molecular dynamics (MD) simulations were performed to examine conformational stability through root means square deviation and radius of gyration, showing stable AtRecQl protein structures. Free energy landscape analysis validated thermodynamically stable structures throughout the MD simulation. Principle component analysis and probability density functions from MD simulations provided satisfactory structural variational data for the complexes and limited coordinate movements. These insights might greatly benefit future studies.

Mapping the climate impact of construction processes: a case study from Denmark

Abstract Construction processes comprise a significant proportion of a building’s embodied carbon and resource consumption. Life cycle assessments (LCAs) allow for calculating impacts from embedded materials throughout a building’s life cycle. However, research on life cycle modules related to transport (A4) and the construction installation process (A5) is limited. Current studies suggest that construction processes contribute between 5 and 18.5% of the climate impact but lack consistent methodological approaches and exhibit variable background data, hindering clear comparisons. This study aims to establish a basis for comparison by conducting a comprehensive LCA for a multifamily residential from Denmark, including the construction phases. Site-specific data for the case study, including transportation details, grid-based energy metering, and hauling tickets, were directly provided by the building contractor, ensuring the accuracy and completeness of data collection. The study shows that construction processes contribute 12.3% to the studied residential building’s whole-life carbon emissions (WLC). Approximately 62.5% of the total carbon emissions are attributable to upfront emissions and, thus, are emitted before the building’s occupancy, indicating significant potential for immediate emission mitigation measures. The study’s insights into carbon emissions related to construction activities highlight transportation and waste management as substantial contributors. This offers pathways for emission monitoring and facilitates a framework for further exploration to mitigate carbon emissions during the construction phase.

Identification of Key Immune and Cell Cycle Modules and Prognostic Genes for Glioma Patients through Transcriptome Analysis.

Gliomas, the most prevalent type of primary brain tumor, stand out as one of the most aggressive and lethal types of human cancer. To uncover potential prognostic markers, we employed the weighted correlation network analysis (WGCNA) on the Chinese Glioma Genome Atlas (CGGA) 693 dataset to reveal four modules significantly associated with glioma clinical traits, primarily involved in immune function, cell cycle regulation, and ribosome biogenesis. Using the least absolute shrinkage and selection operator (LASSO) regression algorithm, we identified 11 key genes and developed a prognostic risk score model, which exhibits precise prognostic prediction in the CGGA 325 dataset. More importantly, we also validated the model in 12 glioma patients with overall survival (OS) ranging from 4 to 132 months using mRNA sequencing and immunohistochemical analysis. The analysis of immune infiltration revealed that patients with high-risk scores exhibit a heightened immune infiltration, particularly immune suppression cells, along with increased expression of immune checkpoints. Furthermore, we explored potentially effective drugs targeting 11 key genes for gliomas using the library of integrated network-based cellular signatures (LINCS) L1000 database, identifying that in vitro, both torin-1 and clofarabine exhibit promising anti-glioma activity and inhibitory effect on the cell cycle, a significant pathway enriched in the identified glioma modules. In conclusion, our study provides valuable insights into molecular mechanisms and identifying potential therapeutic targets for gliomas.

Development of Novel ROCK Inhibitors via 3D-QSAR and Molecular Docking Studies: A Framework for Multi-Target Drug Design.

Background/Objectives: Alterations in the actin cytoskeleton correlates to tumor progression and affect critical cellular processes such as adhesion, migration and invasion. Rho-associated coiled-coil-containing protein kinases (ROCK1 and ROCK2), important regulators of the actin cytoskeleton, are frequently overexpressed in various malignancies. The aim of this study was therefore to identify the key structural features of ROCK1/ROCK2 inhibitors using computer-aided drug design (CADD) approaches. In addition, new developed ROCK inhibitors provided a significant framework for the development of multitarget therapeutics-ROCK/HDAC (histone deacetylases) multitarget inhibitors. Methods: 3D-QSAR (Quantitative structure-activity relationship study) and molecular docking study were employed in order to identify key structural features that positively correlate with ROCK inhibition. MDA-MB-231, HCC1937, Panc-1 and Mia PaCa-2 cells were used for evaluation of anticancer properties of synthesized compounds. Results: C-19 showed potent anti-cancer properties, especially enhancement of apoptosis and cell cycle modulation in pancreatic cancer cell lines. In addition, C-19 and C-22 showed potent anti-migratory and anti-invasive effects comparable to the well-known ROCK inhibitor fasudil. Conclusions: In light of the results of this study, we propose a novel multi-target approach focusing on developing dual HDAC/ROCK inhibitors based on the structure of both C-19 and C-22, exploiting the synergistic potential of these two signaling pathways to improve therapeutic efficacy in metastatic tumors. Our results emphasize the potential of multi-target ROCK inhibitors as a basis for future cancer therapies.

Synthesis of pH-sensitive polymeric micelle drug carries for potential cancer chemotherapy applications

Alpha mangostin, a natural xanthone derivative from mangosteen fruit pericarp, exhibits antiproliferative and apoptotic effects on different cancer cells by inhibiting cell cycle progression, inducing apoptosis, and modulating signaling pathways. However, this candidate is limited in medical treatment due to the poor water solubility. Nanoparticles have emerged as promising drug delivery systems to improve drug delivery efficiency but one of the problem of nanoparticles is the capability of endosomal escape. Therefore, pH-sensitive polymer nanosystems were utilized for targeted drug delivery, and enhanced efficacy by offering controlled release and endosomal escape capabilities. This study aimed to synthesize PEG- P(Asp-Hyd-Man) copolymer and create micelle for alpha mangostin delivery. The micelles were measured with particle size average of 80.2 ± 15 nm, and the PDI of 0.17. Additionally, the release behavior of alpha mangostin was examined in vitro that show pH-sensitive polymeric micelles rapidly release at pH 5.0 compared with the arterial pH 7.4. The findings of this study are significant in the development of an effective drug delivery system using alpha mangostin and other therapeutic agents.

A Comparative Life Cycle Assessment (LCA) of a Composite Bamboo Shear Wall System Developed for El Salvador

To meet the UN sustainable development goal targets by 2030, it is necessary to provide adequate, resilient, and affordable housing solutions which are also low-carbon. In the context of affordable housing in El Salvador, an improved vernacular construction system, following the composite bamboo shear wall (CBSW) technology, has been developed as a feasible option to fill the current housing deficit. A life cycle assessment (LCA) has been conducted comparing a house built using the CBSW system with a reinforced concrete hollow block masonry system, considering the A1 to A5 (raw material production and manufacture) and B4 (replacement) life cycle modules. The LCA scope was limited to modules where there was sufficient confidence in the inputs. End-of-life modules were excluded as there is a large degree of uncertainty in the end-of-life scenarios for these materials in the regional context. The LCA results show that the CBSW system has approximately 64% of the global warming potential (GWP) of the reinforced masonry house, and when considering biogenic carbon, this reduces to 53%. There is additional potential to minimise impacts and maximise end-of-life opportunities (e.g., re-use, biofuel, etc.) for the biomaterials within the CBSW system, if considering modules beyond the scope of this paper, and this needs further study. Nevertheless, the results from this LCA—of limited A1 to A5 and B4 scope—show that the CBSW system has significant sustainability advantages over conventional construction systems and is considered a promising solution to alleviate the housing deficit in El Salvador.

GRK2-mediated AKT activation controls cell cycle progression and G2 checkpoint in a p53-dependent manner

Cell cycle checkpoints, activated by stressful events, halt the cell cycle progression, and prevent the transmission of damaged DNA. These checkpoints prompt cell repair but also trigger cell death if damage persists. Decision-making between these responses is multifactorial and context-dependent, with the tumor suppressor p53 playing a central role. In many tumor cells, p53 alterations lead to G1/S checkpoint loss and the weakening of the G2 checkpoint, rendering cell viability dependent on the strength of the latter through mechanisms not fully characterized. Cells with a strong pro-survival drive can evade cell death despite substantial DNA lesions. Deciphering the integration of survival pathways with p53-dependent and -independent mechanisms governing the G2/M transition is crucial for understanding G2 arrest functionality and predicting tumor cell response to chemotherapy. The serine/threonine kinase GRK2 emerges as a signaling node in cell cycle modulation. In cycling cells, but not in G2 checkpoint-arrested cells, GRK2 protein levels decline during G2/M transition through a process triggered by CDK2-dependent phosphorylation of GRK2 at the S670 residue and Mdm2 ubiquitination. We report now that this downmodulation in G2 prevents the unscheduled activation of the PI3K/AKT pathway, allowing cells to progress into mitosis. Conversely, higher GRK2 levels lead to tyrosine phosphorylation by the kinase c-Abl, promoting the direct association of GRK2 with the p85 regulatory subunit of PI3K and AKT activation in a GRK2 catalytic-independent manner. Hyperactivation of AKT is conditioned by p53’s scaffolding function, triggering FOXO3a phosphorylation, impaired Cyclin B1 accumulation, and CDK1 activation, causing a G2/M transition delay. Upon G2 checkpoint activation, GRK2 potentiates early arrest independently of p53 through AKT activation. However, its ability to overcome the G2 checkpoint in viable conditions depends on p53. Our results suggest that integrating the GRK2/PI3K/AKT axis with non-canonical functions of p53 might confer a survival advantage to tumor cells.

Life cycle assessment of mycelium based composite acoustic insulation panels

Mycelium-based composites (MBC) have gained attention in research and industry as environmentally favorable substitutes for materials in various applications, including packaging inserts, textiles, automotive and even electronics. As construction materials, MBCs show promising characteristics as fully bio-based thermoacoustic insulation. To investigate the potential environmental impacts of the production, use and end-of-life of MBC acoustic insulation panels and their mounting system, we conducted a cradle-to-grave life cycle assessment (LCA) based on real-world production planning data and supplementary literature data. Life cycle modules and system boundaries were chosen following EN 15804. A life cycle impact assessment was carried out based on select impact categories from the Environmental Footprint (EF 3.1) framework. Uncertainties and sensitivities were examined based on a Monte-Carlo simulation and contribution to variance. Energy use for incubation and drying during the manufacturing stage is the most important contributor in most impact categories, including global warming potential. This is further underlined by the large sensitivity of the results to uncertainties related to energy-use. Overall, the manufacturing stage is the dominant life-cycle stage in terms of potential environmental impacts. Generally, our results agree with literature values of LCA studies on similar materials, when normalized for mass and volume. Tracing biogenic carbon throughout the product system shows an early release of over 10 % of the stored biogenic carbon during the manufacturing stage as opposed to a release of all remaining stored carbon during disposal and energetic recycling.

Cell Cycle Modulation through Physical Confinement in Micrometer-Thick Hydrogel Sheaths.

Recently, surface engineering of the cell membrane with biomaterials has attracted great attention for various biomedical applications. In this study, we investigated the possibility of modulating cell cycle progression using alginate and gelatin-based hydrogel sheaths with a thickness of ∼1 μm. The hydrogel sheath was formed on cell surfaces through cross-linking catalyzed by horseradish peroxidase immobilized on the cell surface. The hydrogel sheath did not decrease the viability (>95% during 2 days of culture) of the human cervical carcinoma cell line (HeLa) expressing the fluorescent ubiquitination-based cell cycle indicator 2 (HeLa/Fucci2). Coating the HeLa/Fucci2 cells with the hydrogel sheath resulted in a cell cycle arrest in the G2/M phase, which can be caused by the reduced F-actin formation. As a result of this cell cycle arrest, an inhibition of cell growth was observed in the HeLa/Fucci2 cells. Taken together, our results demonstrate that the hydrogel sheath coating on the cell surface is a feasible approach to modulating cell cycle progression.

Exploring the therapeutic potential of Leuconostoc mesenteroides lysates in wound healing and immune modulation on keratinocyte cells.

The skin, being the body's largest organ, primarily functions as a formidable defense mechanism against potential microbial infections. The skin's microbiota, consisting of a complex assembly of microorganisms, exerts a pivotal influence on skin homeostasis by modulating keratinocytes and their cytokine secretion, thereby playing an integral role in promoting optimal cutaneous health. Leuconostoc mesenteroides finds extensive application in the production of fermented foods and bacteriocins. Empirical studies validate the effectiveness of L. mesenteroides treatments in enhancing immune function and demonstrating notable antioxidant characteristics. This study investigates the potential of L. mesenteroides in improving skin health and wound healing. It also aims to comprehend their impact on wound healing markers, cytokine production, and cell cycle regulation compared to ferulic acid, known for its wound healing effects. Our findings indicate that L. mesenteroides lysate possesses antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa, along with the ability to mitigate their toxic effects in a pathogen-simulating model employing HaCaT keratinocyte cells. Additionally, the lysate demonstrated noteworthy wound closure after a 24-hour treatment, along with a significant reduction in interleukin-6 levels and oxidative stress index. Modulation of the cell cycle is evident by decreasing G0/G1 phases and increasing S and G2/M phases and enhanced expression of wound healing marker genes and proteins CDH1. In conclusion, L. mesenteroides lysate exhibits immune-modulating and antibacterial properties, offering potential alternatives to conventional treatments for various skin conditions. These findings contribute to the exploration of innovative approaches to enhancing human life through skin health and wound healing.

Efficient power conversion with four switch soft-switching boost integrated half-bridge dual-output series resonant converter

Soft switching reduces voltage and current stress during transitions, smoothing and quieting operations and reducing electromagnetic interference while also increasing efficiency and equipment lifespan. Circuit design, component selection, and switching frequency optimization affect power electronics soft switching. This paper proposes boost integrated half-bridge dual-output series resonant (BIHBDOSR) converter, a novel converter design and control method to increase series resonant converter performance by reducing storage element size, switch count, and switching losses. This methodology relies on soft-switching technologies like zero-voltage switching (ZVS) and zero-current switching (ZCS). These methods use class-D, class-E, series, parallel, and series–parallel resonant converter circuits to increase efficiency and minimize component stress. The proposed converter is ideal for constant voltage, constant power, and current-controlled loads with the output voltage being regulated by a closed-loop PI controller. The output voltages for two loads in the simulation depart from reference values. V01 changes from 14 to 20 V and V02 from 18 to 15 V at 300 ms owing to switching variances. The proposed converter utilizes gate driver circuits, resonant tank circuit, current sensor, FPGA board for closed-loop control, and current sensor for stability, ensuring converter stability. The proposed converter closed-loop control method modifies PWM signals to regulate both loads independently and ensure steady output voltage. Additionally, to validate the effectiveness of proposed converter, a 50-W driver circuit is designed, delivering two independent outputs of 20 W and 30 W. Frequency modulation (FM) and duty cycle control methods are employed to obtain the desired outputs.

The impact of mental health and psychological stressors on menstrual cycle modulation: exploring the influence of age and hormonal contraceptives.

The objective of this study was to analyze the influence of a stressor, a period of the Covid-19 pandemic when there were no vaccines available yet, on the psychological state of women aged 18 to 45 years; as well as the influence of mental health on the menstrual cycle, considering the influence of age and hormonal contraceptives. Online questionnaire using the Google Forms platform was used. There is a high prevalence of the onset of new psychosocial symptoms. Moreover, most women reported some type of change in their menstrual cycles. The women who were using hormonal contraceptives demonstrated a higher frequency of spotting and menstrual color alterations, while women without hormonal contraceptives demonstrated a higher frequency of cycle duration and menstrual odor alterations. Women without hormonal contraceptives were more susceptible to the development of psychosocial symptoms. Younger adult women were more affected by menstrual changes and psychosocial symptoms. Close to 90% of women who reported several psychosocial symptoms had changes in their menstrual cycles. These data suggest the impact of stressors, such as a period of the pandemic, on mental health and menstrual cycles, and younger adult women can be more susceptible. This reflects the relationship between mental and reproductive health.

Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling.

Merkel cell polyomavirus (MCPyV) is the causative agent of the majority of Merkel cell carcinomas (MCC). The virus has limited coding capacity, with its early viral proteins, large T (LT) and small T (sT), being multifunctional and contributing to infection and transformation. A fundamental difference in early viral gene expression between infection and MCPyV-driven tumorigenesis is the expression of a truncated LT (LTtr) in the tumor. In contrast, sT is expressed in both conditions and contributes significantly to oncogenesis. Here, we identified novel functions of early viral proteins by performing genome-wide transcriptome and chromatin studies in primary human fibroblasts. Due to current limitations in infection and tumorigenesis models, we mimic these conditions by ectopically expressing sT, LT or LTtr, individually or in combination, at different time points. In addition to its known function in cell cycle and inflammation modulation, we reveal a fundamentally new function of sT. We show that sT regulates the type I interferon (IFN) response downstream of the type I interferon receptor (IFNAR) by interfering with the interferon-stimulated gene factor 3 (ISGF3)-induced interferon-stimulated gene (ISG) response. Expression of sT leads to a reduction in the expression of interferon regulatory factor 9 (IRF9) which is a central component of the ISGF3 complex. We further show that this function of sT is conserved in BKPyV. We provide a first mechanistic understanding of which early viral proteins trigger and control the type I IFN response, which may influence MCPyV infection, persistence and, during MCC progression, regulation of the tumor microenvironment.

Nitrogen cycle module for INM RAS climate model

Abstract Nitrogen is one of the most abundant chemical elements on the Earth and plays an important role in global environmental change. Leading Earth system models include coupled carbon and nitrogen cycle modules of varying complexity, but the INM RAS climate model family has not yet included an explicit N-cycle description. This paper presents a parameterization of the terrestrial N-cycle based on a simplification of the JULES-CN model, adapted for coupled use with the INM-CM land C-cycle module. Numerical simulations were carried out with a standalone carbon cycle model with nitrogen feedback disabled and enabled versions for the period 1850–2100. The simulated global pools show good agreement with results of other models with an implemented N-cycle. Taking into account the N-limitation of the C-cycle, the modelled dynamics of total carbon storage in terrestrial ecosystems from 1850 to the mid-20th century is specified.

Spatial and temporal thermal management of a spintronic terahertz emitter

This work presents methods for addressing undesirable thermal effects induced by the pump beam of an oscillator laser to improve the efficiency of a terahertz (THz) spintronic emitter. We explore two approaches: spatial distribution of pump energy using a 2D lens array and temporal modulation of the pump duty cycle. Optimizing the spatial distribution approximately doubles the THz signal by increasing local heat dissipation, delaying the saturation limit. Similarly, temporal spreading of pump pulses by adjusting the duty cycle allows greater thermal relaxation within the heterostructure, enhancing the overall efficiency of THz wave generation.

Modulation of Apoptotic, Cell Cycle, DNA Repair, and Senescence Pathways by Marine Algae Peptides in Cancer Therapy.

Marine algae, encompassing both macroalgae and microalgae, have emerged as a promising and prolific source of bioactive compounds with potent anticancer properties. Despite their significant therapeutic potential, the clinical application of these peptides is hindered by challenges such as poor bioavailability and susceptibility to enzymatic degradation. To overcome these limitations, innovative delivery systems, particularly nanocarriers, have been explored. Nanocarriers, including liposomes, nanoparticles, and micelles, have demonstrated remarkable efficacy in enhancing the stability, solubility, and bioavailability of marine algal peptides, ensuring controlled release and prolonged therapeutic effects. Marine algal peptides encapsulated in nanocarriers significantly enhance bioavailability, ensuring more efficient absorption and utilization in the body. Preclinical studies have shown promising results, indicating that nanocarrier-based delivery systems can significantly improve the pharmacokinetic profiles and therapeutic outcomes of marine algal peptides. This review delves into the diverse anticancer mechanisms of marine algal peptides, which include inducing apoptosis, disrupting cell cycle progression, and inhibiting angiogenesis. Further research focused on optimizing nanocarrier formulations, conducting comprehensive clinical trials, and continued exploration of marine algal peptides holds great promise for developing innovative, effective, and sustainable cancer therapies.